Creating and Activating an Implementation Community to Drive HPV Vaccine Uptake in Texas: The Role of an NCI-Designated Cancer Center by Rosalind S. Bello, Michael T. Walsh, Blake Harper, Charles E. Amos, Katherine Oestman, Stephanie Nutt, Marcita Galindez, Kaitlyn Block, Ruth Rechis, Erica M. Bednar, Jennifer Tektiridis, Lewis Foxhall, Mark Moreno, Sanjay Shete, Ernest Hawk

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Structure and integration of specialty palliative care in three NCI-designated cancer centers: a mixed methods case study by Karen E. Schifferdecker, Rebecca L. Butcher, Genevra F. Murray, Kristin E. Knutzen, Nirav S. Kapadia, Gabriel A. Brooks, Garrett T. Wasp, Susan Eggly, Laura C. Hanson, Gabrielle B. Rocque, Amanda N. Perry, Amber E. Barnato

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P095: Recontacting patients with a CHEK2 or ATM pathogenic variant for updated NCCN screening guidelines: Report from an NCI-designated cancer center by Katie Neimeyer, Lauren Brown, Sidney Ching, Cynthia Handford, Britta Sjoding, Kevin Tatunay, Marianne Dubard-Gault

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PSGL-1 attenuates early TCR signaling to suppress CD8+ T cell progenitor differentiation and elicit terminal CD8+ T cell exhaustion by Jennifer L. Hope, Dennis C. Otero, Eun-Ah Bae, Christopher J. Stairiker, Ashley B. Palete, Hannah A. Faso, Michelle Lin, Monique L. Henriquez, Sreeja Roy, Hyungseok Seo, Xue Lei, Eric S. Wang, Savio Chow, Roberto Tinoco, Gregory A. Daniels, Kevin Yip, Alexandre Rosa Campos, Jun Yin, Peter D. Adams, Anjana Rao, Linda M. Bradley

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PP 5.4 – 00184 Optimization of Smac Mimetics as HIV-1 Latency Reversing Agents by L. Pache, J. Kim, M. Marsden, F. Layng, A. Limpert, D. Heimann, W. Thienphrapa, N. Cosford, J. Zack, S. Chanda

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Development of a Robust High-Throughput Screening Platform for Inhibitors of the Striatal-Enriched Tyrosine Phosphatase (STEP) by Lester J Lambert, Stefan Grotegut, Maria Celeridad, Palak Gosalia, Laurent JS De Backer, Andrey A Bobkov, Sumeet Salaniwal, Thomas DY Chung, Fu-Yue Zeng, Ian Pass, Paul J Lombroso, Nicholas DP Cosford, Lutz Tautz

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Enzyme mechanistic studies of NMA1982, a protein tyrosine phosphatase and potential virulence factor in Neisseria meningitidis by Shuangding Wu, Mathieu Coureuil, Xavier Nassif, Lutz Tautz

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Development and use of a high-throughput screen to identify novel modulators of the corticotropin releasing factor binding protein by Carolina L. Haass-Koffler, T. Chase Francis, Pauravi Gandhi, Reesha Patel, Mohammad Naemuddin, Carsten K. Nielsen, Selena E. Bartlett, Antonello Bonci, Stefan Vasile, Becky L. Hood, Eigo Suyama, Michael P. Hedrick, Layton H. Smith, Allison S. Limpert, Marisa Roberto, Nicholas D.P. Cosford, Douglas J. Sheffler

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A long-read sequencing strategy with overlapping linkers on adjacent fragments (OLAF-Seq) for targeted resequencing and enrichment by Lahari Uppuluri, Christina Huan Shi, Dharma Varapula, Eleanor Young, Rachel L. Ehrlich, Yilin Wang, Danielle Piazza, Joshua Chang Mell, Kevin Y. Yip, Ming Xiao

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Hispanic Breast Cancer Patients Travel Further for Equitable Surgical Care at a Comprehensive Cancer Center by Rachel L. Yang, Irene Wapnir

“…On average, these minorities are less likely to utilize National Cancer Institute (NCI)-designated cancer centers and travel shorter distances to receive care. …”
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Caspase-9 inhibition confers stronger neuronal and vascular protection compared to VEGF neutralization in a mouse model of retinal vein occlusion by Maria I. Avrutsky, Claire W. Chen, Jacqueline M. Lawson, Scott J. Snipas, Guy S. Salvesen, Carol M. Troy, Carol M. Troy, Carol M. Troy

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Developmental basis of SHH medulloblastoma heterogeneity by Maxwell P. Gold, Winnie Ong, Andrew M. Masteller, David R. Ghasemi, Julie Anne Galindo, Noel R. Park, Nhan C. Huynh, Aneesh Donde, Veronika Pister, Raul A. Saurez, Maria C. Vladoiu, Grace H. Hwang, Tanja Eisemann, Laura K. Donovan, Adam D. Walker, Joseph Benetatos, Christelle Dufour, Livia Garzia, Rosalind A. Segal, Robert J. Wechsler-Reya, Jill P. Mesirov, Andrey Korshunov, Kristian W. Pajtler, Scott L. Pomeroy, Olivier Ayrault, Shawn M. Davidson, Jennifer A. Cotter, Michael D. Taylor, Ernest Fraenkel

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Sporadic Inclusion Body Myositis at the Crossroads between Muscle Degeneration, Inflammation, and Aging by Valeria Guglielmi, Marta Cheli, Paola Tonin, Gaetano Vattemi

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Drug target prediction through deep learning functional representation of gene signatures by Hao Chen, Frederick J. King, Bin Zhou, Yu Wang, Carter J. Canedy, Joel Hayashi, Yang Zhong, Max W. Chang, Lars Pache, Julian L. Wong, Yong Jia, John Joslin, Tao Jiang, Christopher Benner, Sumit K. Chanda, Yingyao Zhou

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3313 “My research is their business, but I’m not their business”: Patient and Oncologist Perspectives on the Commercialization of Research Data by Kayte Spector-Bagdady, Chris Krenz, Michele Gornick, Collin Brummel, Madison Kent, J. Chad Brenner, J. Scott Roberts, Andrew G. Shuman

“…METHODS/STUDY POPULATION: This qualitative analysis was nested within a prospective precision oncology genomic sequencing study in an NCI-designated cancer center. We conducted paired, semi-structured interviews with enrolled participants with head & neck cancer and with their doctors (medical oncologists, surgical oncologists, and radiation oncologists). …”
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Impact and Diagnostic Gaps of Comprehensive Genomic Profiling in Real-World Clinical Practice by Aditi P. Singh, Elaine Shum, Lakshmi Rajdev, Haiying Cheng, Sanjay Goel, Roman Perez-Soler, Balazs Halmos

“…Methods: we conducted a retrospective study of all patients that underwent CGP as part of routine cancer management from January 2013 to June 2017 at an academic community-based NCI-designated cancer center. CGP was done in addition to established first tier reflex molecular testing as per national guidelines (e.g., <i>EGFR</i>/<i>ALK</i> for non-small cell lung cancer (NSCLC) and extended-<i>RAS</i> for colorectal cancer). …”
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Detection of Genomic Structural Variations Associated with Drug Sensitivity and Resistance in Acute Leukemia by Darren Finlay, Rabi Murad, Karl Hong, Joyce Lee, Andy Wing Chun Pang, Chi-Yu Lai, Benjamin Clifford, Carol Burian, James Mason, Alex R. Hastie, Jun Yin, Kristiina Vuori

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Traditional risk factors and cancer-related factors associated with cardiovascular disease risk in head and neck cancer patients by Amrita Mukherjee, Amrita Mukherjee, Howard W. Wiener, Russell L. Griffin, Carrie Lenneman, Arka Chatterjee, Lisle M. Nabell, Cora E. Lewis, Sadeep Shrestha

“…We assessed the association of HNSCC-related factors and traditional risk factors with 1- and 5-year CVD risk in HNSCC patients without prevalent CVD at cancer diagnosis.MethodsA clinical cohort of 1,829 HNSCC patients diagnosed between 2012 and 2018, at a National Cancer Institute (NCI)-designated cancer center was included. Information on HNSCC-related factors [HNSCC anatomical subsite, stage at diagnosis, treatment, and tumor human papillomavirus (HPV) status] were extracted from the tumor registry. …”
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Association between the Preoperative Standard Uptake Value (SUV) and Survival Outcomes after Robotic-Assisted Segmentectomy for Resectable Non-Small Cell Lung Cancer (NSCLC) by Aihab Aboukheir Aboukheir, Emilio Q. Villanueva, Joseph R. Garrett, Carla C. Moodie, Jenna R. Tew, Eric M. Toloza, Jacques P. Fontaine, Jobelle J. A. R. Baldonado

“…We investigate here the perioperative and long-term outcomes of patients who underwent robotic-assisted segmentectomy (RAS) at an NCI-designated cancer center and aim to show associations between the preoperative standard update value (SUV) to tumor stage, recurrence patterns, and overall survival. …”
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The use of Instagram by gynecologic oncology providers as a patient education tool for patients at high-risk of gynecologic cancer by Sharonne Holtzman, Caitlin Carr, Kristen Zeligs, Stephanie V. Blank

“…Seventy-one NCI-Designated Cancer Centers, their gynecologic oncology divisions and hereditary gynecologic cancer related posts were searched on Instagram. …”
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