Memory NK Cell Features Exploitable in Anticancer Immunotherapy by Cristina Capuano, Chiara Pighi, Simone Battella, Angela Santoni, Gabriella Palmieri, Ricciarda Galandrini

“…Besides their innate ability to rapidly produce effector cytokines and kill virus-infected or transformed cells, natural killer (NK) cells display a strong capability to adapt to environmental modifications and to differentiate into long-lived, hyperfunctional populations, dubbed memory or memory-like NK cells. …”
Get full text

NK cell defects: implication in acute myeloid leukemia by Selma Z. D’Silva, Meenakshi Singh, Meenakshi Singh, Andrea S. Pinto

“…Recently, different Natural Killer cell therapies have been implicated in treating AML, such as the adoptive NK cell transfer, Chimeric antigen receptor-modified NK (CAR-NK) cell therapy, antibodies, cytokine, and drug treatment. …”
Get full text

Advances in CAR-NK cell therapy for hematological malignancies by Rui Yang, Yun Yang, Yun Yang, Rui Liu, Yiwen Wang, Ruoyu Yang, Aili He, Aili He

Subjects: Get full text

The role of NK cells in selectin-dependent tumor suppression by Sobolev, Olga, Ph. D. Massachusetts Institute of Technology

Get full text

NK cell compartment in patients with coronary heart disease. by Hak, Ł, Myśliwska, J, Wieckiewicz, J, Szyndler, K, Trzonkowski, P, Siebert, J, Myśliwski, A

“…Thus, the main aim of our study was to determine NK cell compartment in patients with CHD undergoing coronary artery by-pass grafting. …”

Ligand dimensions are important in controlling NK-cell responses. by Brzostek, J, Chai, J, Gebhardt, F, Busch, D, Zhao, R, Van Der Merwe, P, Gould, K

“…Importantly, H60a elongation did not affect NKG2D binding, as determined by soluble NKG2D tetramer staining, and by examining NK-cell target cell conjugate formation. CHO cells are efficient at activating NK cells from C57BL/6 mice, and expression of a single chain form of H-2K(b), a ligand for the mouse inhibitory receptor Ly49C, strongly inhibited such activation of Ly49C/I positive NK cells. …”

Expanded NK cells used for adoptive cell therapy maintain diverse clonality and contain long-lived memory-like NK cell populations by David S.J. Allan, Chuanfeng Wu, Ryland D. Mortlock, Mala Chakraborty, Katayoun Rezvani, Jan K. Davidson-Moncada, Cynthia E. Dunbar, Richard W. Childs

Subjects: Get full text

Elotuzumab Enhances CD16-Independent NK Cell-Mediated Cytotoxicity against Myeloma Cells by Upregulating Several NK Cell-Enhancing Genes by Yan-Hua Wang, Shotaro Hagiwara, Hiroshi Kazama, Yuki Iizuka, Norina Tanaka, Junji Tanaka

“…However, the antitumor effects and genes involved in the direct promotion of NK cell-mediated activation using Elo in CD16-independent NK cells are not clearly known. …”
Get full text

iPSC-derived cells lack immune tolerance to autologous NK-cells due to imbalance in ligands for activating and inhibitory NK-cell receptors by Margarita E. Bogomiakova, Elizaveta K. Sekretova, Ksenia S. Anufrieva, Polina O. Khabarova, Anastasia N. Kazakova, Pavel A. Bobrovsky, Tatiana V. Grigoryeva, Artem V. Eremeev, Olga S. Lebedeva, Alexandra N. Bogomazova, Maria A. Lagarkova

Subjects: Get full text

Prognostic significance of perioperative circulating CD56bright NK cell and recovery of NK cell activity in patients with colorectal cancer undergoing radical surgery by Jeng-Fu You, Cheng-Chi Lee, Yun-Shien Lee, Yih-Jong Chern, Chun-Kai Liao, Hung-Chih Hsu

Subjects: Get full text

Understanding the Synergy of NKp46 and Co-Activating Signals in Various NK Cell Subpopulations: Paving the Way for More Successful NK-Cell-Based Immunotherapy by Loris Zamai, Genny Del Zotto, Flavia Buccella, Sara Gabrielli, Barbara Canonico, Marco Artico, Claudio Ortolani, Stefano Papa

Subjects: “…nk cell biology…”
Get full text

Phenotypic Changes in T and NK Cells Induced by Sputnik V Vaccination by Anna A. Boyko, Maria O. Ustiuzhanina, Julia D. Vavilova, Maria A. Streltsova, Sofya A. Kust, Andrei E. Siniavin, Irina V. Astrakhantseva, Marina S. Drutskaya, Elena I. Kovalenko

Subjects: Get full text

The Memories of NK Cells: Innate-Adaptive Immune Intrinsic Crosstalk by Sara Gabrielli, Claudio Ortolani, Genny del Zotto, Francesca Luchetti, Barbara Canonico, Flavia Buccella, Marco Artico, Stefano Papa, Loris Zamai

“…Although NK cells are considered part of the innate immune system, a series of evidences has demonstrated that they possess characteristics typical of the adaptive immune system. …”
Get full text

Combined use of NK cells and radiotherapy in the treatment of solid tumors by Wang Zheng, Sunkai Ling, Yuandong Cao, Chunlin Shao, Xinchen Sun

“…Natural killer (NK) cells are innate lymphocytes possessing potent tumor surveillance and elimination activity. …”
Get full text

Epstein-Barr Virus-Associated T and NK-Cell Lymphoproliferative Diseases by Wook Youn Kim, Wook Youn Kim, Ivonne A. Montes-Mojarro, Falko Fend, Leticia Quintanilla-Martinez

Subjects: Get full text

Natural Killer (NK) cells in immunotherapy and perspectives in antitumour approaches by Lu Yihua

“…Natural Killer (NK) cells comprise a group of specialized innate lymphoid cells endowed with multiple cytotoxicity mechanisms while also harnessed with the ability to enhance other immune cells with cytokine production. …”
Get full text

Main NK cell receptors and their ligands: regulation by microRNAs by Stefano Regis, Fabio Caliendo, Alessandra Dondero, Francesca Bellora, Beatrice Casu, Cristina Bottino, Roberta Castriconi

Subjects: “…NK cells| microRNAs| NK receptors| NK receptor ligands| TGF-β1…”
Get full text

The different paradigms of NK cell death in patients with severe trauma by Te-Ding Chang, Deng Chen, Jia-Liu Luo, Yu-Man Wang, Cong Zhang, Shun-Yao Chen, Zhi-Qiang Lin, Pei-Dong Zhang, Ting-Xuan Tang, Hui Li, Li-Ming Dong, Ning Wu, Zhao-Hui Tang

“…Previous research indicates that the reduction in the number of NK cells is closely associated with the process of cell death. …”
Get full text

Recruitment of activation receptors at inhibitory NK cell immune synapses. by Nicolas Schleinitz, Michael E March, Eric O Long

“…Natural killer (NK) cell activation receptors accumulate by an actin-dependent process at cytotoxic immune synapses where they provide synergistic signals that trigger NK cell effector functions. …”
Get full text

Immune complex deposition promotes NK cell accumulation in the kidney. by Abigail De la Cruz, Marco Garcés, Emiliano Larios, Iris K Madera-Salcedo, José C Crispín, Florencia Rosetti

“…Depletion of NK cells transiently ameliorated disease, suggesting NK cells may play a role in lupus nephritis and other immune complex-mediated conditions.…”
Get full text