Denture-Induced carcinoma in NSND patients: A case report by Narmatha Namachivayam, Asokan Sathyamoorthy

“…There is a unique category of non-smoking non-drinking (NSND) patients reported with carcinoma which usually occurs in women. …”
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The immune microenvironment of HPV-negative oral squamous cell carcinoma from never-smokers and never-drinkers patients suggests higher clinical benefit of IDO1 and PD1/PD-L1 block... by Foy, J, Bertolus, C, Michallet, M, Deneuve, S, Incitti, R, Bendriss-Vermare, N, Albaret, M, Ortiz-Cuaran, S, Thomas, E, Colombe, A, Py, C, Gadot, N, Michot, J, Fayette, J, Viari, A, Van den Eynde, B, Goudot, P, Devouassoux-Shisheboran, M, Puisieux, A, Caux, C, Zrounba, P, Lantuejoul, S, Saintigny, P

“… <h4>Background</h4> <p>Never-smokers and never-drinkers patients (NSND) suffering from oral squamous cell carcinoma (OSCC) are epidemiologically different from smokers drinkers (SD). …”

Nonsmoking and Nondrinking Oral Squamous Cell Carcinoma Patients: A Different Entity by Zhan Yang, Wei Du, Xu Zhang, Defeng Chen, Qigen Fang, Yuezhong He, Yang Yang, Ding Li, Jie Fan

“…ObjectiveOur goal was to analyze the demographic and pathologic characteristics as well as prognosis in nonsmoking and nondrinking (NSND) oral squamous cell carcinoma (SCC) patients compared with typical oral SCC patients.Patients and MethodsA total of 353 patients were retrospectively enrolled and divided into two groups: the NSND group and the current smoking/current drinking (CSCD) group. …”
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Arguments to Support a Viral Origin of Oral Squamous Cell Carcinoma in Non-Smoker and Non-Drinker Patients by Jean-Philippe Foy, Jean-Philippe Foy, Jean-Philippe Foy, Chloé Bertolus, David Boutolleau, David Boutolleau, Henri Agut, Henri Agut, Antoine Gessain, Zdenko Herceg, Pierre Saintigny, Pierre Saintigny, Pierre Saintigny

“…In some western countries, an increasing incidence of oral squamous cell carcinoma (OSCC) has been observed in non-smoker non-drinker patients (NSND), mostly in women with HPV-negative OSCC. In the context of the unknown etiology and mechanisms of tumorigenesis of OSCC in NSND, we discuss data supporting the hypothesis of a viral origin not related to HPV. …”
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Presence of Human Papillomavirus and Epstein–Barr Virus, but Absence of Merkel Cell Polyomavirus, in Head and Neck Cancer of Non-Smokers and Non-Drinkers by Frans J. Mulder, Faisal Klufah, Faisal Klufah, Famke M. E. Janssen, Farzaneh Farshadpour, Stefan M. Willems, Stefan M. Willems, Remco de Bree, Axel zur Hausen, Mari F. C. M. van den Hout, Bernd Kremer, Ernst-Jan M. Speel

“…ObjectiveDetermine the presence and prognostic value of human papillomavirus (HPV), Epstein-Barr virus (EBV), Merkel cell polyomavirus (MCPyV), and cell cycle proteins in head and neck squamous cell carcinoma (HNSCC) of non-smokers and non-drinkers (NSND).MethodsClinical characteristics and tumors of 119 NSND with HNSCC were retrospectively collected and analyzed on tissue microarrays. …”
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Defining biomarkers in oral cancer according to smoking and drinking status by Juliette Rochefort, Juliette Rochefort, Juliette Rochefort, Ioannis Karagiannidis, Claude Baillou, Lisa Belin, Maude Guillot-Delost, Rodney Macedo, Aline Le Moignic, Véronique Mateo, Patrick Soussan, Isabelle Brocheriou, Jean-Luc Teillaud, Marie-Caroline Dieu-Nosjean, Chloé Bertolus, Chloé Bertolus, Francois Michel Lemoine, Francois Michel Lemoine, Géraldine Lescaille, Géraldine Lescaille, Géraldine Lescaille

“…Also, a higher percentage of blood CD8+ T lymphocytes among CD45+ cells in NSND patients was associated with a better disease-free survival (p=0.004).ConclusionGranulocytes, monocytes-macrophages, and CD4+ T cells expressing CD45RO and CCR6 in blood and TME as well as serum IL-6 can therefore distinguish OSCC SD and NSND patients. …”
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Investigation of viral etiology in potentially malignant disorders and oral squamous cell carcinomas in non-smoking, non-drinking patients. by Philippe Pérot, Michaël Falguieres, Laurence Arowas, Hélène Laude, Jean-Philippe Foy, Patrick Goudot, Nicole Corre-Catelin, Marie-Noëlle Ungeheuer, Valérie Caro, Isabelle Heard, Marc Eloit, Antoine Gessain, Chloé Bertolus, Nicolas Berthet

“…We tested the hypothesis of viral etiology in a series of 68 well-characterized OSCCs and 14 potentially malignant disorders (PMD) in non-smoking, non-drinking (NSND) patients using broad-range, sensitive molecular methodologies. …”
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Molecular drivers of oral cavity squamous cell carcinoma in non-smoking and non-drinking patients: what do we know so far? by Sophia Uddin, Alka Singh, Vasudha Mishra, Nishant Agrawal, Zhen Gooi, Evgeny Izumchenko

“…Additionally, there are expert opinions that oral cancer in non-smoking, non-drinking (NSND) patients have a distinct phenotype resulting in more aggressive disease presentation and poorer prognosis. …”
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GTSP1 expression in non-smoker and non-drinker patients with squamous cell carcinoma of the head and neck. by Pamela de Oliveira Soares, Patrícia Maluf Cury, Rossana Verónica Mendoza López, Cláudio Roberto Cernea, Erika Erina Fukuyama, David Livingstone Alves Figueiredo, Francisco Gorgonio da Nobrega, Otavio Alberto Curioni, Fabio Daumas Nunes, Raquel Ajub Moyses, Maria Lúcia Bueno Garcia, HEAD AND NECK GENOME PROJECT–GENCAPO

“…We studied the expression of GTSP1 in tumor and non-tumor tissue samples from patients with and without these risks to identify whether GTSP1 expression differs according to exposure to carcinogens.Non-smoker/non-drinker (NSND) and smoker/drinker (SD) patients were matched according to age, gender, tumor site, TNM stage, grade and histological variants to establish 47 pairs of patients who have been previously tested for HPV. …”
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