Non-typeable Haemophilus Influenzae detection in the lower airways of patients with lung cancer and chronic obstructive pulmonary disease by Krishna B. Sriram, Amanda J. Cox, Pathmanathan Sivakumaran, Maninder Singh, Annabelle M. Watts, Nicholas P. West, Allan W. Cripps

“…Total IgE, IgG and specific NTHi IgG were measured by enzyme linked immunosorbent assay. …”
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e causes cellular trans-differentiation in human bronchial epithelia by Michael Glöckner, Sebastian Marwitz, Kristina Rohmann, Henrik Watz, Dörte Nitschkowski, Jan Rupp, Klaus Dalhoff, Torsten Goldmann, Daniel Drömann

“…Non-typeable Haemophilus influenzae (NTHi) is the most common respiratory pathogen in patients with chronic obstructive disease. …”
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Preparation and immunogenicity evaluation of C-HapS-P6 fusion protein vaccine against nontypeable Haemophilus influenzae in mice by Nan Hu, Weifeng Li, Zihong Zhao, Yueli Chang, Cai Wang, Yutuo Zhang

“…Nontypeable Haemophilus influenzae (NTHi) is the dominant pathogen in several infectious diseases. …”
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Evaluation of immunological responses against outer membrane vesicles (OMV) of nontypeable Haemophilus influenzae using MPLA-CpG adjuvant as a vaccine candidate by Ava Behrouzi, Reza Arabi Mianroodi, Parviz Afrough, Ahmad Ayadi, Amirarsalan Serajian

“…Currently, there is no licensed vaccine against NTHi commercially available. Many studies have been conducted on the use of OMV as a vaccine against NTHi. …”
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HrrF is the Fur-regulated small RNA in nontypeable Haemophilus influenzae. by Estevan A Santana, Alistair Harrison, Xinjun Zhang, Beth D Baker, Benjamin J Kelly, Peter White, Yunlong Liu, Robert S Munson

“…Nontypeable Haemophilus influenzae (NTHi) are Gram-negative commensal bacteria that reside in the nasopharynx. …”
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Modulation of Haemophilus influenzae interaction with hydrophobic molecules by the VacJ/MlaA lipoprotein impacts strongly on its interplay with the airways by Ariadna Fernández-Calvet, Irene Rodríguez-Arce, Goizeder Almagro, Javier Moleres, Begoña Euba, Lucía Caballero, Sara Martí, José Ramos-Vivas, Toby Leigh Bartholomew, Xabier Morales, Carlos Ortíz-de-Solórzano, José Enrique Yuste, José Antonio Bengoechea, Raquel Conde-Álvarez, Junkal Garmendia

“…Abstract Airway infection by nontypeable Haemophilus influenzae (NTHi) associates to chronic obstructive pulmonary disease (COPD) exacerbation and asthma neutrophilic airway inflammation. …”
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COPD-Related Modification to the Airway Epithelium Permits Intracellular Residence of Nontypeable Haemophilus influenzae and May Be Potentiated by Macrolide Arrest of Autophagy by Poh WP, Kicic A, Lester SE, Nguyen PT, Bakaletz LO, Reynolds PN, Hodge S, Roscioli E

“…While control AEC showed no clear evidence of intracellular NTHi, COPD-derived cultures exhibited abundant NTHi within the cytoplasm. …”
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The ToxAvapA toxin-antitoxin locus contributes to the survival of nontypeable Haemophilus influenzae during infection. by Dabin Ren, Alexis A Kordis, Daniel E Sonenshine, Dayle A Daines

“…One uncharacterized NTHi toxin-antitoxin (TA) module, NTHI1912-1913, is a host inhibition of growth (higBA) homologue. …”
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The Immunostimulatory Capacity of Nontypeable Haemophilus influenzae Lipooligosaccharide by Gabrielle N. Gaultier, Kayla N. Colledanchise, Alaa Alhazmi, Marina Ulanova

“…The results indicate that while LOS of NTHi has decreased capacity to induce pro-inflammatory responses compared to E. coli LPS or killed NTHi, this LOS has the potential to facilitate antigen presentation. …”
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High Pulmonary Levels of IL-6 and IL-1β in Children with Chronic Suppurative Lung Disease Are Associated with Low Systemic IFN-γ Production in Response to Non-Typeable Haemophilus... by Susan J Pizzutto, John W Upham, Stephanie T Yerkovich, Anne B Chang

“…Non-typeable Haemophilus influenzae (NTHi) is commonly associated with chronic suppurative lung disease in children. …”
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Bacterial regulation of macrophage bacterial recognition receptors in COPD are differentially modified by budesonide and fluticasone propionate. by Karin A Provost, Miyuki Smith, Anna Miller-Larsson, Gregory D Gudleski, Sanjay Sethi

“…SR-AI and MARCO were reduced by both NTHI and SP, whereas other receptors by either NTHI or SP. …”
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Non-typeable Haemophilus influenzae airways infection: the next treatable trait in asthma? by Mary Ashley Brown, Maisha Jabeen, Gurpreet Bharj, Timothy S.C. Hinks

“…Here we review knowledge of non-typeable H. influenzae (NTHi) in the microbiology of asthma, the immune consequences of mucosal NTHi infection, various immune evasion mechanisms, and the clinical implications of NTHi infection for phenotyping and targeted therapies in neutrophilic asthma. …”
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Haemophilus influenzae persists in biofilm communities in a smoke-exposed ferret model of COPD by Benjamin C. Hunt, Denise Stanford, Xin Xu, Jindong Li, Amit Gaggar, Steven M. Rowe, S. Vamsee Raju, W. Edward Swords

“…Rationale Non-typeable Haemophilus influenzae (NTHi) is a common inhabitant of the human nasopharynx and upper airways that can cause opportunistic infections of the airway mucosa including bronchopulmonary infections in patients with chronic obstructive pulmonary disease (COPD). …”
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Ex-vivo RNA expression analysis of vaccine candidate genes in COPD sputum samples by Cecilia Brettoni, Alessandro Muzzi, Simona Rondini, Vincent Weynants, Silvia Rossi Paccani

“…We selected 69 patients with sputum samples positive for NTHi or Mcat by PCR during at least one stable and one exacerbation visit. mRNA was isolated from the sputum, and expression of NTHi and Mcat genes was analysed with RT-PCR. …”
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Comparative efficacies of different antibiotic treatments to eradicate nontypeable <it>Haemophilus influenzae </it>infection by Ubukata Kimiko, Nakamura Masahiko, Eguchi Masahiro, Sekiya Yukie, Omura Satoshi, Matsui Hidenori

“…<p>Abstract</p> <p>Background</p> <p>Nonencapsulated and nontypeable <it>Haemophilus influenzae </it>(NTHi) is a major cause of human respiratory tract infections. …”
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Epithelial immune activation and intracellular invasion by non-typeable Haemophilus influenzae by Mary A. Brown, Sophie B. Morgan, Gillian E. Donachie, Katie L. Horton, Ian D. Pavord, Carolina V. Arancibia-Cárcamo, Timothy S. C. Hinks

“…Airways inflammation in type-2 low asthma or COPD is potentially driven by persistent bacterial colonization of the lower airways by bacteria such as non-encapsulated Haemophilus influenzae (NTHi). Although pathogenic in the lower airways, NTHi is a commensal of the upper airways. …”
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Dectin-1 Is Expressed in Human Lung and Mediates the Proinflammatory Immune Response to Nontypeable <named-content content-type="genus-species">Haemophilus influenzae</named-conten... by Kerstin A. Heyl, Tilman E. Klassert, Annina Heinrich, Mario M. Müller, Esther Klaile, Hendrik Dienemann, Christiane Grünewald, Robert Bals, Bernhard B. Singer, Hortense Slevogt

“…Nontypeable Haemophilus influenzae (NTHI), an important bacterial pathogen of the respiratory tract with significant importance in COPD, has also been proposed to be recognized by Dectin-1, suggesting a possible impact on the NTHI-dependent immune response in human airways. …”
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Nontypeable <italic toggle="yes">Haemophilus influenzae</italic> Has Evolved Preferential Use of <italic toggle="yes">N-</italic>Acetylneuraminic Acid as a Host Adaptation by Preston S. K. Ng, Christopher J. Day, John M. Atack, Lauren E. Hartley-Tassell, Linda E. Winter, Tal Marshanski, Vered Padler-Karavani, Ajit Varki, Stephen J. Barenkamp, Michael A. Apicella, Michael P. Jennings

“…ABSTRACT Nontypeable Haemophilus influenzae (NTHi) is a Gram-negative bacterial pathogen that is adapted exclusively to human hosts. …”
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Induction of Mucosal IgA–Mediated Protective Immunity Against Nontypeable Haemophilus influenzae Infection by a Cationic Nanogel–Based P6 Nasal Vaccine by Rika Nakahashi-Ouchida, Rika Nakahashi-Ouchida, Rika Nakahashi-Ouchida, Hiromi Mori, Hiromi Mori, Yoshikazu Yuki, Yoshikazu Yuki, Yoshikazu Yuki, Shingo Umemoto, Shingo Umemoto, Takashi Hirano, Yohei Uchida, Yohei Uchida, Tomonori Machita, Tomonori Machita, Tomoyuki Yamanoue, Tomoyuki Yamanoue, Shin-ichi Sawada, Masashi Suzuki, Kohtaro Fujihashi, Kohtaro Fujihashi, Kohtaro Fujihashi, Kazunari Akiyoshi, Yuichi Kurono, Hiroshi Kiyono, Hiroshi Kiyono, Hiroshi Kiyono, Hiroshi Kiyono, Hiroshi Kiyono

“…At present, there is no licensed vaccine for NTHi. Because NTHi colonizes the upper respiratory tract and forms biofilms that cause subsequent infectious events, a nasal vaccine that induces NTHi-specific secretory IgA capable of preventing biofilm formation in the respiratory tract is desirable. …”
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Real-time PCR has advantages over culture-based methods in identifying major airway bacterial pathogens in chronic obstructive pulmonary disease: Results from three clinical studie... by Sonia Schoonbroodt, Jean-Laurent Ichanté, Sophie Boffé, Nathalie Devos, Jeanne-Marie Devaster, Laura Taddei, Simona Rondini, Ashwani Kumar Arora, Thierry Pascal, Ludovic Malvaux

“…IntroductionWe compared the performance of real-time PCR with culture-based methods for identifying bacteria in sputum samples from patients with chronic obstructive pulmonary disease (COPD) in three studies.MethodsThis was an exploratory analysis of sputum samples collected during an observational study of 127 patients (AERIS; NCT01360398), phase 2 study of 145 patients (NTHI-004; NCT02075541), and phase 2b study of 606 patients (NTHI-MCAT-002; NCT03281876). …”
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