Synthetic Medical Images for Robust, Privacy-Preserving Training of Artificial Intelligence by Aaron S. Coyner, PhD, Jimmy S. Chen, MD, Ken Chang, PhD, Praveer Singh, PhD, Susan Ostmo, MS, R. V. Paul Chan, MD, MSc, Michael F. Chiang, MD, MA, Jayashree Kalpathy-Cramer, PhD, J. Peter Campbell, MD, MPH

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Quantification of Early Neonatal Oxygen Exposure as a Risk Factor for Retinopathy of Prematurity Requiring Treatment by Jimmy S. Chen, MD, Jamie E. Anderson, BS, Aaron S. Coyner, PhD, Susan Ostmo, MS, Kemal Sonmez, PhD, Deniz Erdogmus, PhD, Brian K. Jordan, MD, PhD, Cynthia T. McEvoy, MD, MCR, Dmitry Dukhovny, MD, MPH, Robert L. Schelonka, MD, R.V. Paul Chan, MD, Praveer Singh, PhD, Jayashree Kalpathy-Cramer, PhD, Michael F. Chiang, MD, MA, J. Peter Campbell, MD, MPH

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Diabetic macular oedema and diode subthreshold micropulse laser (DIAMONDS): study protocol for a randomised controlled trial by Noemi Lois, Evie Gardner, Norman Waugh, Augusto Azuara-Blanco, Hema Mistry, Danny McAuley, Nachiketa Acharya, Tariq M. Aslam, Clare Bailey, Victor Chong, Louise Downey, Haralabos Eleftheriadis, Samia Fatum, Sheena George, Faruque Ghanchi, Markus Groppe, Robin Hamilton, Geeta Menon, Ahmed Saad, Sobha Sivaprasad, Marianne Shiew, David H. Steel, James Stephen Talks, Catherine Adams, Christina Campbell, Matthew Mills, Mike Clarke, On behalf of the DIAMONDS Study Group

“…Secondary outcomes (at 24 months) include change in binocular best corrected visual acuity; CST; mean deviation of the Humphrey 10–2 visual field; change in percentage of people meeting driving standards; European Quality of Life-5 Dimensions, National Eye Institute Visual Functioning Questionnaire-25 and VisQoL scores; incremental cost per quality-adjusted life year gained; side effects; number of laser treatments and use of additional therapies. …”
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Long-Term Decrease in Intraocular Pressure in Survivors of Ebola Virus Disease in the Partnership for Research on Vaccines and Infectious Diseases in Liberia (PREVAIL) III Study by Shwetha Mudalegundi, BS, BSPH, Robin D. Ross, MD, MPH, Jemma Larbelee, MD, Fred Amegashie, MD, Robert F. Dolo, BSN, BSc, Grace S. Prakalapakorn, MD, MPH, Vincent Ray, MD, Catherine Gargu, BSN, MPH, Yassah Sosu, BSN, Jennie Sackor, BSN, Precious Z. Cooper, BSN, Augustine Wallace, COPT, Ruth Nyain, BSC, MEd, Bryn Burkholder, MD, Collin Van Ryn, MS, Bionca Davis, MPH, Mosoka P. Fallah, PhD, MPH, Cavan Reilly, PhD, Rachel J. Bishop, MD, MPH, Allen O. Eghrari, MD, MPH

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Evaluation of an Artificial Intelligence System for Retinopathy of Prematurity Screening in Nepal and Mongolia by Emily Cole, MD, MPH, Nita G. Valikodath, MD, MS, Tala Al-Khaled, MD, Sanyam Bajimaya, MBBS, MD, Sagun KC, MSc, Tsengelmaa Chuluunbat, MD, Bayalag Munkhuu, MD, Karyn E. Jonas, MSN, RN-BC, Chimgee Chuluunkhuu, MD, Leslie D. MacKeen, BSc, Vivien Yap, MD, Joelle Hallak, PhD, Susan Ostmo, MSc, Wei-Chi Wu, MD, PhD, Aaron S. Coyner, PhD, Praveer Singh, PhD, Jayashree Kalpathy-Cramer, PhD, Michael F. Chiang, MD, J. Peter Campbell, MD, MPH, R. V. Paul Chan, MD

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The challenges and opportunities of offering and integrating training in clinical molecular genetics and clinical cytogenetics: A survey of LGG Fellowship Program Directors by Joshua L. Deignan, Vimla Aggarwal, Allen E. Bale, Daniel B. Bellissimo, Jessica K. Booker, Yang Cao, Kristy R. Crooks, Kristen L. Deak, Daniela Del Gaudio, Birgit Funke, Nicole L. Hoppman, Vanessa Horner, Robert B. Hufnagel, Colleen Jackson-Cook, Prasad Koduru, Marco L. Leung, Shibo Li, Pengfei Liu, Minjie Luo, Rong Mao, Heather Mason-Suares, Fady M. Mikhail, Stephen R. Moore, Rizwan C. Naeem, Laura M. Pollard, Elena A. Repnikova, Lina Shao, Brandon M. Shaw, Shashirekha Shetty, Teresa A. Smolarek, Elizabeth Spiteri, Jessica Van Ziffle, Gail H. Vance, Cindy L. Vnencak-Jones, Eli S. Williams

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SAkuraBONSAI: Protocol design of a novel, prospective study to explore clinical, imaging, and biomarker outcomes in patients with AQP4-IgG-seropositive neuromyelitis optica spectru... by Jeffrey L. Bennett, Kazuo Fujihara, Ho Jin Kim, Romain Marignier, Kevin C. O'Connor, Robert C. Sergott, Anthony Traboulsee, Heinz Wiendl, Jens Wuerfel, Jens Wuerfel, Scott S. Zamvil, Veronica G. Anania, Regine Buffels, Thomas Künzel, Annemarie N. Lekkerkerker, Siân Lennon-Chrimes, Sean J. Pittock

“…Satralizumab monotherapy (120 mg) will be administered subcutaneously at Weeks 0, 2, 4, and Q4W thereafter for a total of 92 weeks.EndpointsDisease activity related to relapses (proportion relapse-free, annualized relapse rate, time to relapse, and relapse severity), disability progression (Expanded Disability Status Scale), cognition (Symbol Digit Modalities Test), and ophthalmological changes (visual acuity; National Eye Institute Visual Function Questionnaire-25) will all be assessed. …”
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Combining brain perturbation and neuroimaging in non-human primates by P. Christiaan Klink, Jean-François Aubry, Vincent P. Ferrera, Andrew S. Fox, Sean Froudist-Walsh, Béchir Jarraya, Elisa E. Konofagou, Richard J. Krauzlis, Adam Messinger, Anna S. Mitchell, Michael Ortiz-Rios, Hiroyuki Oya, Angela C. Roberts, Anna Wang Roe, Matthew F.S. Rushworth, Jérôme Sallet, Michael Christoph Schmid, Charles E. Schroeder, Jordy Tasserie, Doris Y. Tsao, Lynn Uhrig, Wim Vanduffel, Melanie Wilke, Igor Kagan, Christopher I. Petkov

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Genome-wide screening reveals the genetic basis of mammalian embryonic eye development by Justine M. Chee, Louise Lanoue, Dave Clary, Kendall Higgins, Lynette Bower, Ann Flenniken, Ruolin Guo, David J. Adams, Fatima Bosch, Robert E. Braun, Steve D. M. Brown, H.-J. Genie Chin, Mary E. Dickinson, Chih-Wei Hsu, Michael Dobbie, Xiang Gao, Sanjeev Galande, Anne Grobler, Jason D. Heaney, Yann Herault, Martin Hrabe de Angelis, Fabio Mammano, Lauryl M. J. Nutter, Helen Parkinson, Chuan Qin, Toshi Shiroishi, Radislav Sedlacek, J-K Seong, Ying Xu, The International Mouse Phenotyping Consortium, Brian Brooks, Colin McKerlie, K. C. Kent Lloyd, Henrik Westerberg, Ala Moshiri

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Cold protection allows local cryotherapy in a clinical-relevant model of traumatic optic neuropathy by Yikui Zhang, Mengyun Li, Bo Yu, Shengjian Lu, Lujie Zhang, Senmiao Zhu, Zhonghao Yu, Tian Xia, Haoliang Huang, WenHao Jiang, Si Zhang, Lanfang Sun, Qian Ye, Jiaying Sun, Hui Zhu, Pingping Huang, Huifeng Hong, Shuaishuai Yu, Wenjie Li, Danni Ai, Jingfan Fan, Wentao Li, Hong Song, Lei Xu, Xiwen Chen, Tongke Chen, Meng Zhou, Jingxing Ou, Jian Yang, Wei Li, Yang Hu, Wencan Wu

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Chromosomal microarray analysis supplements exome sequencing to diagnose children with suspected inborn errors of immunity by Breanna J. Beers, Morgan N. Similuk, Rajarshi Ghosh, Bryce A. Seifert, Leila Jamal, Michael Kamen, Michael R. Setzer, Colleen Jodarski, Rylee Duncan, Devin Hunt, Madison Mixer, Wenjia Cao, Weimin Bi, Weimin Bi, Daniel Veltri, Eric Karlins, Lingwen Zhang, Zhiwen Li, Andrew J. Oler, Kathleen Jevtich, Yunting Yu, Haley Hullfish, Bibiana Bielekova, Pamela Frischmeyer-Guerrerio, An Dang Do, Laryssa A. Huryn, Kenneth N. Olivier, Helen C. Su, Jonathan J. Lyons, Christa S. Zerbe, V. Koneti Rao, Michael D. Keller, Alexandra F. Freeman, Steven M. Holland, Luis M. Franco, Magdalena A. Walkiewicz, Jia Yan

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Standard threshold laser versus subthreshold micropulse laser for adults with diabetic macular oedema: the DIAMONDS non-inferiority RCT by Noemi Lois, Christina Campbell, Norman Waugh, Augusto Azuara-Blanco, Mandy Maredza, Hema Mistry, Danny McAuley, Nachiketa Acharya, Tariq M Aslam, Clare Bailey, Victor Chong, Louise Downey, Haralabos Eleftheriadis, Samia Fatum, Sheena George, Faruque Ghanchi, Markus Groppe, Robin Hamilton, Geeta Menon, Ahmed Saad, Sobha Sivaprasad, Marianne Shiew, David H Steel, James Stephen Talks, Paul Doherty, Clíona McDowell, Mike Clarke

“…Secondary outcomes included the mean change from baseline to 24 months in the following: binocular best-corrected visual acuity; central retinal subfield thickness; the mean deviation of the Humphrey 10–2 visual field in the study eye; the percentage of people meeting driving standards; and the EuroQol-5 Dimensions, five-level version, National Eye Institute Visual Function Questionnaire – 25 and Vision and Quality of Life Index scores. …”
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