Encounter complexes and dimensionality reduction in protein–protein association by Dima Kozakov, Keyong Li, David R Hall, Dmitri Beglov, Jiefu Zheng, Pirooz Vakili, Ora Schueler-Furman, Ioannis Ch Paschalidis, G Marius Clore, Sandor Vajda

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Revisiting miRNA Association with Melanoma Recurrence and Metastasis from a Machine Learning Point of View by Aigli Korfiati, Katerina Grafanaki, George C. Kyriakopoulos, Ilias Skeparnias, Sophia Georgiou, George Sakellaropoulos, Constantinos Stathopoulos

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Persistent fasting lipogenesis links impaired ketogenesis with citrate synthesis in humans with nonalcoholic fatty liver by Xiaorong Fu, Justin A. Fletcher, Stanisław Deja, Melissa Inigo-Vollmer, Shawn C. Burgess, Jeffrey D. Browning

“…Additionally, they sustained glycogenolysis and were spared the loss of oxaloacetate to gluconeogenesis in favor of citrate synthesis, which correlated with DNL and diminished ketogenesis.CONCLUSION Metabolic flux analysis in fasted subjects indicates that shared metabolic mechanisms link the dysregulations of hepatic DNL, ketogenesis, and the TCA cycle in NAFL.TRIAL REGISTRATION Data were obtained during the enrollment/non-intervention phase of Effect of Vitamin E on Non-Alcoholic Fatty Liver Disease, ClinicalTrials.gov NCT02690792.FUNDING This work was supported by the University of Texas Southwestern NORC Quantitative Metabolism Core (NIH P30DK127984), the NIH/National Institute of Diabetes and Digestive and Kidney Diseases (R01DK078184, R01DK128168, R01DK087977, R01DK132254, and K01DK133630), the NIH/National Institute on Alcohol Abuse and Alcoholism (K01AA030327), and the Robert A. …”
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Pupal behavior emerges from unstructured muscle activity in response to neuromodulation in Drosophila by Amicia D Elliott, Adama Berndt, Matthew Houpert, Snehashis Roy, Robert L Scott, Carson C Chow, Hari Shroff, Benjamin H White

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Microbial diversity of extreme habitats in human homes by Amy M. Savage, Justin Hills, Katherine Driscoll, Daniel J. Fergus, Amy M. Grunden, Robert R. Dunn

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Multifaceted membrane interactions of human Atg3 promote LC3-phosphatidylethanolamine conjugation during autophagy by Yansheng Ye, Erin R. Tyndall, Van Bui, Maria C. Bewley, Guifang Wang, Xupeng Hong, Yang Shen, John M. Flanagan, Hong-Gang Wang, Fang Tian

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Generation of GLA-knockout human embryonic stem cell lines to model peripheral neuropathy in Fabry disease by Christine R. Kaneski, John A. Hanover, Ulrike H. Schueler Hoffman

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Development of Bicyclo[3.1.0]hexane-Based A₃ Receptor Ligands: Closing the Gaps in the Structure–Affinity Relationships by Jan Phillip Lemmerhirt, Andreas Isaak, Rongfang Liu, Max Kock, Constantin G. Daniliuc, Kenneth A. Jacobson, Laura H. Heitman, Anna Junker

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Dietary and Metabolic Control of Stem Cell Function in Physiology and Cancer by Mihaylova, Maria M., Sabatini, David M., Yilmaz, Omer, Mihaylova, Maria M., Sabatini, David

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Reconstruction of complex single-cell trajectories using CellRouter by Lummertz da Rocha, Edroaldo, Rowe, R. Grant, Lundin, Vanessa, Malleshaiah, Mohan, Jha, Deepak Kumar, Rambo, Carlos R., Li, Hu, North, Trista E., Collins, James J., Daley, George Q.

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Daisy-chain gene drives for the alteration of local populations by Noble, Charleston, Min, John, Olejarz, Jason, Buchthal, Joanna, Chavez, Alejandro, Smidler, Andrea L., DeBenedictis, Erika A., Church, George M., Nowak, Martin A., Esvelt, Kevin Michael

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A Novel Imaging Approach for Early Detection of Prostate Cancer Based on Endogenous Zinc Sensing by Ghosh, Subrata K., Kim, Pilhan, Zhang, Xiao-an, Yu, Seok-Hyun, Moore, Anna V., Lippard, Stephen J., Medarova, Zdravka

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Intrathymic programming of effector fates in three molecularly distinct γδ T cell subtypes by Narayan, Kavitha, Sylvia, Katelyn E., Malhotra, Nidhi, Yin, Catherine C., Martens, Gregory, Vallerskog, Therese, Kornfeld, Hardy, Xiong, Na, Cohen, Nadia R., Brenner, Michael B., Berg, Leslie J., Kang, Joonsoo, Immunological Genome Project Consortium, Regev, Aviv

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Calorie restriction in humans inhibits the PI3K/AKT pathway and induces a younger transcription profile by Mercken, Evi M., Crosby, Seth D., Lamming, Dudley W., JeBailey, Lellean, Krzysik-Walker, Susan, Villareal, Dennis T., Capri, Miriam, Franceschi, Claudio, Zhang, Yongqing, Becker, Kevin, de Cabo, Rafael, Fontana, Luigi, Sabatini, David

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New Methods in Tissue Engineering: Improved Models for Viral Infection by Ramanan, Vyas, Scull, Margaret A., Sheahan, Timothy P., Rice, Charles M., Bhatia, Sangeeta N

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NKp44-Derived Peptide Used in Combination Stimulates Antineoplastic Efficacy of Targeted Therapeutic Drugs by Muhammed Iraqi, Priyanka Bolel, Rhitajit Sarkar, Baisali Bhattacharya, Muhammad Abu Ahmad, Avishay Edri, Laila C. Roisman, Moshe Elkabets, Walid Shalata, Nir Peled, Angel Porgador

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Anti-Prion Systems in <i>Saccharomyces cerevisiae</i> Turn an Avalanche of Prions into a Flurry by Moonil Son, Reed B. Wickner

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Author Correction: Architectural basis for cylindrical self-assembly governing Plk4-mediated centriole duplication in human cells by Jong Il Ahn, Liang Zhang, Harsha Ravishankar, Lixin Fan, Klara Kirsch, Yan Zeng, Lingjun Meng, Jung-Eun Park, Hye-Yeoung Yun, Rodolfo Ghirlando, Buyong Ma, David Ball, Bonsu Ku, Ruth Nussinov, Jeremy D. Schmit, William F. Heinz, Seung Jun Kim, Tatiana Karpova, Yun-Xing Wang, Kyung S. Lee

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Mapping the landscape of research on insulin resistance: a visualization analysis of randomized clinical trials by Sa’ed H. Zyoud

“…Prominent funding agencies include the National Institutes of Health (n = 88; 8.17%) and the National Institute of Diabetes and Digestive and Kidney Diseases (n = 86; 7.99%). …”
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Increased Lipid Levels Improves after Treatment with Cabergolin in Patients with Prolactinoma by Mazhar Muslum Tuna, Bercem Aycicek Dogan, Mehtap Navdar Basaran, Ayse Arduc, Dilek Berker, Serdar Guler

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