Actividad bactericida frente a la Neisseria meningitidis serogrupo C en población vacunada y no vacunada de Andalucía by Delgado Torralbo Elena, Berrón Sonsoles, García León Javier, Gonzalez Enríquez Jesús, Martinez Navarro Ferrán

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Development of a robust and quantitative high-throughput screening method for assessing phenotypic variation in large Neisseria meningitidis isolate collections by Robeena Farzand, Megan De Ste Croix, Neelam Dave, Christopher D. Bayliss

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B Part of It study: a longitudinal study to assess carriage of Neisseria meningitidis in first year university students in South Australia by Mark McMillan, Luke Walters, Turra Mark, Andrew Lawrence, Lex E. X. Leong, Thomas Sullivan, Geraint B. Rogers, Ross M. Andrews, Helen S. Marshall

Subjects: “…neisseria meningitidis…”
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Sphingosine kinase 1/S1P receptor signaling axis is essential for cellular uptake of Neisseria meningitidis in brain endothelial cells. by Ingo Fohmann, Alina Weinmann, Fabian Schumacher, Simon Peters, Agata Prell, Cynthia Weigel, Sarah Spiegel, Burkhard Kleuser, Alexandra Schubert-Unkmeir

“…Invasion of brain endothelial cells (BECs) is central to the pathogenicity of Neisseria meningitidis infection. Here, we established a key role for the bioactive sphingolipid sphingosine-1-phosphate (S1P) and S1P receptor (S1PR) 2 in the uptake process. …”
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Changes in Invasive <i>Neisseria meningitidis</i> and <i>Haemophilus influenzae</i> Infections in France during the COVID-19 Pandemic by Ala-Eddine Deghmane, Muhamed-Kheir Taha

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The Epidemiology of Meningococcal Disease and Carriage, Genotypic Characteristics and Antibiotic Resistance of Neisseria meningitidis Isolates in Zhejiang Province, China, 2011–2021 by Yunyi Zhang, Xuan Deng, Yan Jiang, Junyan Zhang, Li Zhan, Lingling Mei, Hangjing Lu, Pingping Yao, Hanqing He

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Pangenome graphs in infectious disease: a comprehensive genetic variation analysis of Neisseria meningitidis leveraging Oxford Nanopore long reads by Zuyu Yang, Andrea Guarracino, Andrea Guarracino, Patrick J. Biggs, Patrick J. Biggs, Michael A. Black, Nuzla Ismail, Jana Renee Wold, Tony R. Merriman, Tony R. Merriman, Pjotr Prins, Erik Garrison, Joep de Ligt

“…We demonstrate that using a pangenome graph, instead of a single linear reference genome, improves mapping rates and variant calling for both simulated and real datasets of the pathogen Neisseria meningitidis. Overall, pangenome graphs offer a promising approach for comparative genomics and comprehensive genetic variation analysis in infectious disease. …”
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Identificación de Haemophilus influenzae, Streptococcus pneumoniae y Neisseria meningitidis por reacción en cadena de la polimerasa by Eliana Parra, Elizabeth Castañeda, Jaime Moreno

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Optimized fluorescent labeling to identify memory B cells specific for Neisseria meningitidis serogroup B vaccine antigens ex vivo by Nair, Nitya, Buti, Ludovico, Faenzi, Elisa, Buricchi, Francesca, Nuti, Sandra, Sammicheli, Chiara, Tavarini, Simona, Popp, Maximilian W.L., Ploegh, Hidde, Berti, Francesco, Pizza, Mariagrazia, Castellino, Flora, Finco, Oretta, Rappuoli, Rino, Del Giudice, Giuseppe, Galli, Grazia, Bardelli, Monia

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Identification of non-LPS bacterial ligands for the class A macrophage scavenger receptor on Neisseria meningitidis using a novel assay by Peiser, L, Makepeace, K, Pluddemann, A, Savino, S, Pizza, M, Rappuoli, R, Moxon, E, Gordon, S

Structure of the regulatory domain of the LysR family regulator NMB2055 (MetR-like protein) from Neisseria meningitidis. by Sainsbury, S, Ren, J, Saunders, N, Stuart, D, Owens, R

“…The crystal structure of the regulatory domain of NMB2055, a putative MetR regulator from Neisseria meningitidis, is reported at 2.5 Å resolution. The structure revealed that there is a disulfide bond inside the predicted effector-binding pocket of the regulatory domain. …”

Genomic analysis of urogenital and rectal Neisseria meningitidis isolates reveals encapsulated hyperinvasive meningococci and coincident multi-drug resistant gonococci. by Harrison, O, Cole, K, Peters, J, Cresswell, F, Dean, G, Eyre, D, Paul, J, Maiden, M

Structure of the regulatory domain of the LysR family regulator NMB2055 (MetR-like protein) from Neisseria meningitidis by Sainsbury, S, Ren, J, Saunders, N, Stuart, D, Owens, R

“…The crystal structure of the regulatory domain of NMB2055, a putative MetR regulator from Neisseria meningitidis, is reported at 2.5 Å resolution. The structure revealed that there is a disulfide bond inside the predicted effector-binding pocket of the regulatory domain. …”

The structure of CrgA from Neisseria meningitidis reveals a new octameric assembly state for LysR transcriptional regulators. by Sainsbury, S, Lane, L, Ren, J, Gilbert, R, Saunders, N, Robinson, C, Stuart, D, Owens, R

“…The LTTR, CrgA, from the human pathogen Neisseria meningitidis, is upregulated during bacterial-host cell contact. …”

Sequence, distribution and chromosomal context of class I and class II pilin genes of Neisseria meningitidis identified in whole genome sequences. by Wörmann, M, Horien, C, Bennett, J, Jolley, K, Maiden, M, Tang, C, Aho, E, Exley, R

“…BACKGROUND: Neisseria meningitidis expresses type four pili (Tfp) which are important for colonisation and virulence. …”

The structure of CrgA from Neisseria meningitidis reveals a new octameric assembly state for LysR transcriptional regulators by Sainsbury, S, Lane, L, Ren, J, Gilbert, R, Saunders, N, Robinson, C, Stuart, D, Owens, R

“…The LTTR, CrgA, from the human pathogen <strong>Neisseria meningitidis</strong>, is unregulated during bacterial-host cell contact. …”

Nasal inoculation of the commensal Neisseria lactamica inhibits carriage of Neisseria meningitidis by young adults: A controlled human infection study. by Deasy, A, Guccione, E, Dale, A, Andrews, N, Evans, C, Bennett, J, Bratcher, H, Maiden, M, Gorringe, A, Read, R

“…Given the inverse epidemiological association between colonization by commensalNeisseria lactamicaand meningococcal disease, we investigated whether controlled infection of human volunteers withN. lactamicaprevents colonization byNeisseria meningitidis.</p> <h4>Methods</h4> <p>In a block-randomized human challenge study, 310 university students were inoculated with 10^4 colony-forming units ofN. lactamicaor were sham-inoculated, and carriage was monitored for 26 weeks, after which all participants were reinoculated withN. lactamicaand resampled 2 weeks later.…”

Structural basis for recognition and repair of the 3′-phosphate by NExo, a base excision DNA repair nuclease from Neisseria meningitidis by Silhan, J, Zhao, Q, Boura, E, Thomson, H, Forster, A, Tang, C, Freemont, P, Baldwin, G

“…NExo is an enzyme from Neisseria meningitidis that is specialized in the removal of the 3′-phosphate and other 3′-lesions, which are potential blocks for DNA repair. …”

Genomic analysis of serogroup Y Neisseria meningitidis isolates reveals extensive similarities between carriage-associated and disease-associated organisms by Oldfield, N, Harrison, O, Bayliss, C, Maiden, M, Ala'Aldeen, D, Turner, D

“…Neisseria meningitidis is a frequent colonizer of the human nasopharynx, with asymptomatic carriage providing the reservoir for invasive, disease-causing strains. …”

High sensitivity and specificity of the Pastorex latex agglutination test for Neisseria meningitidis serogroup A during a clinical trial in Niger. by Borel, T, Rose, A, Guillerm, M, Sidikou, F, Gerstl, S, Djibo, A, Nathan, N, Chanteau, S, Guerin, P

“…During a randomised clinical trial conducted during an epidemic of Neisseria meningitidis serogroup A in Niger in 2003, the sensitivity and specificity of the Pastorex latex agglutination test for this serogroup under optimal field conditions were assessed, using culture and/or PCR as the gold standard. …”