Neisseria cinerea isolates can adhere to human epithelial cells by Type IV pilus-independent mechanisms. by Wörmann, M, Horien, C, Johnson, E, Liu, G, Aho, E, Tang, C, Exley, R

“…This non-pathogenic species shares a close taxonomic relationship to the pathogen Neisseria meningitidis, and also colonises the human oropharyngeal cavity. …”

Real-time PCR for detection of Streptococcus suis serotype 2 in cerebrospinal fluid of human patients with meningitis. by Nga, T, Nghia, H, Tu, L, Diep, T, Mai, N, Chau, T, Sinh, D, Phu, N, Nga, T, Chau, N, Campbell, J, Hoa, N, Chinh, N, Hien, T, Farrar, J, Schultsz, C

“…S. suis serotype 2 infection was more common than infections with Streptococcus pneumoniae and Neisseria meningitidis combined. Our results strikingly illustrate the additional diagnostic value of PCR in patients who are pretreated with antimicrobial agents and demonstrate the extremely high prevalence of S. suis infections among Vietnamese adult patients with bacterial meningitis.…”

Association of a bacteriophage with meningococcal disease in young adults. by Bille, E, Ure, R, Gray, S, Kaczmarski, E, McCarthy, N, Nassif, X, Maiden, M, Tinsley, C

“…Despite being the agent of life-threatening meningitis, Neisseria meningitidis is usually carried asymptomatically in the nasopharynx of humans and only occasionally causes disease. …”

Four component meningococcal capsular Group B vaccine in preterm infants. by Sadarangani, M, Barlow, S, Anthony, M, Pollard, A

“…<p>The 4CMenB vaccine was introduced into the routine immunization schedule in the UK in September 2015 to protect against group B Neisseria meningitidis meningitis and septicemia. The vaccine is reactogenic in young infants, causing fever in 51-65% when co-administered with other vaccines [1, 2]. …”

NalP-mediated proteolytic release of lactoferrin-binding protein B from the meningococcal cell surface. by Roussel-Jazédé, V, Jongerius, I, Bos, M, Tommassen, J, van Ulsen, P

“…Bacteria have developed several mechanisms for iron uptake during colonization of mammalian hosts, where the availability of free iron is limiting for growth. Neisseria meningitidis expresses under iron-limiting conditions a receptor complex consisting of the lactoferrin-binding proteins A (LbpA) and LbpB to acquire iron from lactoferrin, which is abundantly present on the mucosal surfaces of the human nasopharynx. …”

Recombination within natural populations of pathogenic bacteria: short-term empirical estimates and long-term phylogenetic consequences. by Feil, E, Holmes, E, Bessen, D, Chan, MS, Day, N, Enright, M, Goldstein, R, Hood, D, Kalia, A, Moore, C, Zhou, J, Spratt, BG

“…We have used statistical tests of congruence between gene trees to examine the extent and significance of recombination in six bacterial pathogens. For Neisseria meningitidis, Streptococcus pneumoniae, Streptococcus pyogenes, and Staphylococcus aureus, the congruence between the maximum likelihood trees reconstructed using seven house-keeping genes was in most cases no better than that between each tree and trees of random topology. …”

NeissLock provides an inducible protein anhydride for covalent targeting of endogenous proteins by Scheu, A, Lim, S, Metzner, F, Mohammed, S, Howarth, M

“…The Neisseria meningitidis protein FrpC contains a self-processing module (SPM) undergoing autoproteolysis via an aspartic anhydride. …”

The next chapter for group B meningococcal vaccines by Wang, N, Pollard, A

“…The majority of invasive meningococcal disease (IMD) in the developed world is caused by capsular group B Neisseria meningitidis, however success with vaccination against organisms bearing this capsule has previously been restricted to control of geographically limited clonal outbreaks. …”

A Comparative Structure/Function Analysis of Two Type IV Pilin DNA Receptors Defines a Novel Mode of DNA Binding. by Berry, J, Xu, Y, Ward, P, Lea, S, Matthews, S, Pelicic, V

“…These proteins can act as DNA receptors as demonstrated by the finding that Neisseria meningitidis ComP minor pilin has intrinsic DNA-binding ability. …”

Neisseria lactamica Y92-1009 complete genome sequence. by Pandey, AK, Cleary, DW, Laver, JR, Maiden, MCJ, Didelot, X, Gorringe, A, Read, RC

“…This Gram negative, dipplococcoid bacterium is an organism of worldwide clinical interest because human nasopharyngeal carriage is related inversely to the incidence of meningococcal disease, caused by Neisseria meningitidis. The organism sequenced was isolated during a school carriage survey in Northern Ireland in 1992 and has been the subject of a variety of laboratory and clinical studies. …”

Specific DNA recognition mediated by a type IV pilin. by Cehovin, A, Simpson, P, McDowell, M, Brown, DR, Noschese, R, Pallett, M, Brady, J, Baldwin, G, Lea, S, Matthews, S, Pelicic, V

“…Therefore, model naturally transformable gram-negative bacteria, including the human pathogen Neisseria meningitidis, have evolved means to preferentially take up homotypic DNA containing short and genus-specific sequence motifs. …”

AP endonuclease paralogues with distinct activities in DNA repair and bacterial pathogenesis. by Carpenter, E, Corbett, A, Thomson, H, Adacha, J, Jensen, K, Bergeron, J, Kasampalidis, I, Exley, R, Winterbotham, M, Tang, C, Baldwin, G, Freemont, P

“…We have identified and characterised two apurinic/apyrimidinic (AP) endonuclease paralogues in the human pathogen Neisseria meningitidis. The presence of multiple versions of DNA repair enzymes in a single organism is usually thought to reflect redundancy in activities that are essential for cellular viability. …”

Construction And Characterization Of A Burkholderia Pseudomallei Wzm Deletion Mutant by Yuen, Chee Wah

“…The amino acid sequence of wzm shows high similarity to CtrC (Neisseria Meningitidis), BexB (Haemophilus Influenzae) and KpsM (Escherichia coli). …”
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National and regional differences in meningococcal vaccine recommendations for individuals at an increased risk of meningococcal disease by Cynthia Burman, Jamie Findlow, Helen S. Marshall, Marco A.P. Safadi

“…Introduction Invasive meningococcal disease (IMD) is a severe, life-threatening condition caused by infection with Neisseria meningitidis. Currently available vaccines offer protection against the five most common meningococcal disease-causing serogroups and include monovalent and quadrivalent conjugate vaccines (MenA, MenC, MenACWY vaccines) and outer membrane vesicle- and/or recombinant protein-based vaccines (MenB vaccines). …”
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AgdbNet – antigen sequence database software for bacterial typing by Maiden Martin CJ, Jolley Keith A

“…The software is currently in use on at least five public databases for the typing of <it>Neisseria meningitidis</it>, <it>Campylobacter jejuni </it>and <it>Streptococcus equi </it>and can be set up to query internal isolate tables or suitably-configured external isolate databases, such as those used for multilocus sequence typing. …”
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Development of a collection of bacteria causing meningitis in Rio de Janeiro from 1990 to 1991 by I. de Filippis, B. E. C Soares, J. C Valentim, A. E. C. C. de Almeida

“…From March 1990 to December 1992, the National Institute for Quality Control of Health-INCQS Research Collection received 1476 bacterial samples isolated from human cerebrospinal fluid of patients suspect of meningitis in Rio de Janeiro, from the São Sebastião State Institute of Infectious Diseases (IEISS). Neisseria meningitidis was found in most of these materials, followed in smaller number by Haemophilus sp. and Streptococcus pneumoniae. …”
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[Meningococcal meningitis: a case of serogroup W in an underage migrant] by Silvia Dari, Anna Maria Cassano, Sabrina Di Lorenzo, Marta Testa, Silvia Aquilani

“…In Europe and Italy, the most frequent capsular serogroups of Neisseria meningitidis are B and C. The incidence of the disease is higher in 0-4-year-old children and very significant (or elevated) also in adolescents and young adults. …”
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A universal UHPLC-CAD platform for the quantification of polysaccharide antigens by A. Corrado, M. De Martino, V. Bordoni, S. Giannini, F. Rech, S. Cianetti, F. Berti, C. Magagnoli, R. De Ricco

“…Herein, we report the development of a universal UHPLC-CAD method (UniQS) for the quantification and quality evaluation of polysaccharide antigens (e.g., Streptococcus Pneumoniae, Neisseria meningitidis and Staphylococcus aureus). This work laid the foundation for a universal UHPLC-CAD format that could play an important role in future vaccine research and development helping to reduce time, efforts, and costs.…”
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From Immunologically Archaic to Neoteric Glycovaccines by Marco Cavallari, Gennaro De Libero

“…As only 23 of more than 90 pneumococcal serotypes and 4 of 13 clinically relevant Neisseria meningitidis serogroups are covered by available vaccines there is still tremendous clinical need for PS vaccines. …”
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Meningocoxemic Septic Shock; A Case Report and Review of the Literature by Murat Özkale, Naime Gökay, Dinçer Yıldızdaş

“…It is one of the most important emergent diseases of the infectious diseases. Neisseria meningitidis has 13 serogroups. A, B, C, Y and W135 are the most common cause of invasive diseases among these serogroups. …”
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