Utilising anhydride reactivity to target endogenous human proteins by Lim, SYT

“…I developed NeissLock, a technology that uses the self-processing module (SPM) of the FrpC protein from Neisseria meningitidis. SPM is fused to the C-terminus of the binder protein so that the anhydride generated upon calcium-induced activation reacts with proximal nucleophiles on the target. …”

Structural alterations in a component of cytochrome c oxidase and molecular evolution of pathogenic Neisseria in humans. by Aspholm, M, Aas, F, Harrison, O, Quinn, D, Vik, A, Viburiene, R, Tønjum, T, Moir, J, Maiden, M, Koomey, M

“…Three closely related bacterial species within the genus Neisseria are of importance to human disease and health. Neisseria meningitidis is a major cause of meningitis, while Neisseria gonorrhoeae is the agent of the sexually transmitted disease gonorrhea and Neisseria lactamica is a common, harmless commensal of children. …”

Distribution and diversity of the haemoglobin-haptoglobin iron-acquisition systems in pathogenic and non-pathogenic Neisseria. by Harrison, O, Bennett, J, Derrick, J, Maiden, M, Bayliss, C

“…HpuAB was widely present in a range of Neisseria species whereas HmbR was mainly limited to the pathogenic species Neisseria meningitidis and Neisseria gonorrhoeae. Patterns of sequence variation in sequences from HpuAB proteins were suggestive of recombination and diversifying selection consistent with strong immune selection. …”

The burden of vaccine-preventable invasive bacterial infections and pneumonia in children admitted to hospital in urban Nepal. by Kelly, D, Thorson, S, Maskey, M, Mahat, S, Shrestha, U, Hamaluba, M, Williams, E, Dongol, S, Werno, A, Portess, H, Yadav, B, Adhikari, N, Guiver, M, Thomas, K, Murdoch, DR, Pollard, A

“… BACKGROUND: Protein-polysaccharide vaccines have made a significant impact on the burden of disease caused by encapsulated bacteria such as Streptococcus pneumoniae, Haemophilus influenzae, Neisseria meningitidis, and have the potential to do so for Salmonella Typhi. …”

The use of dried cerebrospinal fluid filter paper spots as a substrate for PCR diagnosis of the aetiology of bacterial meningitis in the Lao PDR. by Elliott, I, Dittrich, S, Paris, D, Sengduanphachanh, A, Phoumin, P, Newton, P

“…A prospective clinical evaluation for S. pneumoniae, S. suis and Neisseria meningitidis was performed. Culture and PCR performed on fresh liquid CSF from patients admitted with a clinical diagnosis of meningitis (n = 73) were compared with results derived from dried CSF spots. …”

Bacterial meningtis: a five year (2001-2005) retrospective study at University Malaya Medical Centre (UMMC), Kuala Lumpur, Malaysia by Erleena Nur, H., Jamaiah, I., Rohela, M., Nissapatorn, V.

“…Cerebrospinal fluid (CSF) cultures were positive for Streptococcus pneumoniae (23), Haemophilus influenzae (15), Escherichia coli (8.5), Neisseria meningitidis (4) and Streptococcus spp (2). CSF investigations were not done on 47 of cases due to contraindications. …”
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Immune responses to Neisseria gonorrhoeae and implications for vaccine development by Thomas Belcher, Christine S. Rollier, Christina Dold, Jonathan D. C. Ross, Calman A. MacLennan

“…However, the finding that the Neisseria meningitidis serogroup B vaccines, elicit cross-protection against gonorrhea has invigorated the gonococcal vaccine field. …”
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Cumulative annual coverage of meningococcal B vaccination in Australian general practice for three at-risk groups, 2014 to 2019 by Juliana de Oliveira Costa, Christopher Gianacas, Frank Beard, David Gonzalez-Chica, Kendal Chidwick, Rawa Osman, C. Raina MacIntyre, Alys Havard

“…Neisseria meningitidis serogroup B (MenB) is the most common cause of meningococcal disease in adolescents and young adults. …”
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Studying the Sensitivity of Bacteria Isolated From Respiratory Tract Infections To Peanut and Various Antibiotics

“…These bacteria included 5 gram- negativespecies: Klebsiella pneumoniae (1 isolate), K. oxytoca (1 isolate), Pseudomonasaeruginosa (6 isolates), Escherichia coli (2 isolates) and Neisseria meningitidis (1isolate), while gram- positive bacteria included: Staphylococcus aureus (6 isolates),Streptococcus pneumoniae (6 isolates), Micrococcus antarcticus, coagulasenegativeStaphylococci (CNS) and Corynebacterium spp., one isolate of each. …”
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Comparative Analysis of Gram Stain, Culture and Bacterial Antigen Detection in Cerebrospinal Fluid Samples for Laboratory Diagnosis of Acute Bacterial Meningitis in Pediatric Popul... by V. Dillirani, J. Jayachitra, K. Chandrasekaran, T. Monisha

“…Among the organisms identified, Streptococcus pneumoniae was the most common isolate in 5(38.46%) cases followed by Neisseria meningitidis, Klebsiella pneumoniae and Acinetobacter baumannii in 2(15.38%) cases each and Escherichia coli and Group B Streptococcus in 1(7.69%) case each. …”
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Highly Immunogenic Nanoparticles Based on a Fusion Protein Comprising the M2e of Influenza A Virus and a Lipopeptide by Anna A. Zykova, Elena A. Blokhina, Roman Y. Kotlyarov, Liudmila A. Stepanova, Liudmila M. Tsybalova, Victor V. Kuprianov, Nikolai V. Ravin

“…In this study, we obtained recombinant mosaic proteins containing tandem copies of M2e fused to a lipopeptide from <i>Neisseria meningitidis</i> surface lipoprotein Ag473 and alpha-helical linkers and analyzed their immunogenicity. …”
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Characterization of Competitive ELISA and Formulated Alhydrogel Competitive ELISA (FAcE) for Direct Quantification of Active Ingredients in GMMA-Based Vaccines by Omar Rossi, Maria Grazia Aruta, Alessandra Acquaviva, Francesca Mancini, Francesca Micoli, Francesca Necchi

“…The same methods, already extended to GMMA from nontyphoidal <i>Salmonella</i> and <i>Neisseria meningitidis</i>, could be potentially extended to any antigen formulated on Alhydrogel.…”
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Algunas caracteristicas Clinico-Epidemiologica de las meningoencefalitis bacterianas.Hospital Docente Pediatrico Provincial.2000-20004. by Yamilka Miranda Pérez, Ivette González Fajardo, Nadia Arteche Díaz.

“…Se concluyó que los principales agentes causales de MEB, fueron Neisseria meningitidis y Streptococcus pneumoniae, con una letalidad de 5 paciente menores  de un año. …”
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Whom and where are we not vaccinating? Coverage after the introduction of a new conjugate vaccine against group A meningococcus in Niger in 2010. by Sung Hye Kim, Lorenzo Pezzoli, Harouna Yacouba, Tiekoura Coulibaly, Mamoudou H Djingarey, William A Perea, Thomas F Wierzba

“…MenAfriVac is a new conjugate vaccine against Neisseria meningitidis serogroup A developed for the African "meningitis belt". …”
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Microarrays – new possibilities for detecting biological factors hazardous for humans and animals, and for use in environmental protection by Tomasz Mirski, Michał Bartoszcze, Agata Bielawska-Drózd, Romuald Gryko, Janusz Kocik, Marcin Niemcewicz, Krzysztof Chomiczewski

“…Orthopoxvirus group, noroviruses, influenza A and B viruses, rhino- and enteroviruses responsible for the FRI (Febrile Respiratory Illness), European bunyaviruses, and SARS-causing viruses), and bacteria ([i]Mycobacterium spp., Yersinia spp., Campylobacter spp., Streptococcus pneumoniae, Salmonella typhi, Salmonella enterica, Staphylococcus aureus, Neisseria meningitidis, Clostridium difficile , Helicobacter pylori[/i]), including multiple antibiotic-resistant strains. …”
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Risk factors for invasive meningococcal disease: a retrospective analysis of the French national public health insurance database by Muhamed-Kheir Taha, Catherine Weil-Olivier, Stéphane Bouée, Corinne Emery, Gaëlle Nachbaur, Céline Pribil, Véronique Loncle-Provot

“…Vaccination of at-risk populations against Neisseria meningitidis is an important strategy to prevent invasive meningococcal disease (IMD). …”
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Interactions between the Aggregatibacter actinomycetemcomitans secretin HofQ and host cytokines indicate a link between natural competence and interleukin-8 uptake by Tuuli Ahlstrand, Annamari Torittu, Heli Elovaara, Hannamari Välimaa, Marja T. Pöllänen, Sergo Kasvandik, Martin Högbom, Riikka Ihalin

“…By structural comparison, relateda type I KH domain with a similar interaction site was detected in the Neisseria meningitidis secretin PilQ, which has been shown to participate in IL-8 uptake. …”
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A processive rotary mechanism couples substrate unfolding and proteolysis in the ClpXP degradation machinery by Zev A Ripstein, Siavash Vahidi, Walid A Houry, John L Rubinstein, Lewis E Kay

“…Here, we present cryo-EM structures of the substrate-bound ClpXP complex from Neisseria meningitidis at 2.3 to 3.3 Å resolution. The structures allow development of a model in which the sequential hydrolysis of ATP is coupled to motions of ClpX loops that lead to directional substrate translocation and ClpX rotation relative to ClpP. …”
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Social and behavioral predictors of two-doses 4CMenB vaccine series among adolescents enrolled in a cluster randomized controlled trial in Australia by Hassen Mohammed, Mark McMillan, Helen S. Marshall

“…Social and behavioral predictors of non-vaccination or incomplete MenB doses were also known risk factors for carriage of Neisseria meningitidis. Immunization strategies to improve MenB vaccination completion need to be tailored to social behavior of adolescents.…”
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Elevated levels of maternal anti-tetanus toxin antibodies do not suppress the immune response to a Haemophilus influenzae type b polyribosylphosphate-tetanus toxoid conjugate vacci... by C. Panpitpat, U. Thisyakorn, T. Chotpitayasunondh, E. Fürer, J.U. Que, T. Hasler, S.J. Cryz Jr

“…A group of Thai infants (n = 177) born to women immunized against tetanus during pregnancy were vaccinated with either a combined diphtheria-tetanus- pertussis (DTP) PRP-T vaccine or DTP and a PRP-conjugate vaccine using Neisseria meningitidis group B outer-membrane proteins as a carrier (PedVax HIB). …”
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