Effective Multivalent Oriented Presentation of Meningococcal NadA Antigen Trimers by Self-Assembling Ferritin Nanoparticles by Daniele Veggi, Lucia Dello Iacono, Enrico Malito, Giulietta Maruggi, Fabiola Giusti, Panchali Goswami, Werner Pansegrau, Sara Marchi, Sara Tomei, Enrico Luzzi, Matthew James Bottomley, Federico Fontani, Ilaria Ferlenghi, Maria Scarselli

“…Here, we present the rational design, structural analysis, and immunogenicity of self-assembling ferritin nanoparticles displaying eight copies of the <i>Neisseria meningitidis</i> trimeric adhesin NadA. We engineered constructs consisting of two different NadA fragments, head only and head with stalk, that we fused to ferritin and expressed in <i>Escherichia coli</i>. …”
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An open-label randomised controlled trial evaluating the efficacy of a meningococcal serogroup B (4CMenB) vaccine on Neisseria gonorrhoeae infection in gay and bisexual men: the Me... by Caroline Thng, Evgeny A. Semchenko, Ian Hughes, Maree O’Sullivan, Kate L. Seib

“…Development of a gonorrhoea vaccine has been challenging, however there is observational evidence that serogroup B meningococcal vaccines, used to protect against the closely related bacteria Neisseria meningitidis, could provide cross-protection against N. gonorrhoeae. …”
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Whole Genome Analyses Accurately Identify <i>Neisseria</i> spp. and Limit Taxonomic Ambiguity by May Khoder, Marwan Osman, Issmat I. Kassem, Rayane Rafei, Ahmad Shahin, Pierre Edouard Fournier, Jean-Marc Rolain, Monzer Hamze

“…To determine the phylogenetic relationships among these strains and other <i>Neisseria</i> spp. and to confirm their identity at the genomic level, we compared the genomes of these four isolates with the complete genome sequences of <i>Neisseria gonorrhoeae</i> and <i>Neisseria meningitidis</i> and the draft genomes of <i>Neisseria flavescens</i>, <i>Neisseria perflava</i>, <i>Neisseria mucosa</i>, and <i>Neisseria macacae</i> that are available in the NCBI Genbank database. …”
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Bacterial meningitis in adults: a retrospective study among 148 patients in an 8-year period in a university hospital, Finland by Sakke Niemelä, Laura Lempinen, Eliisa Löyttyniemi, Jarmo Oksi, Jussi Jero

“…The most common pathogens in CSF culture were Streptococcus pneumoniae (11, 7.4%), Staphylococcus epidermidis (7, 4.7%), Staphylococcus aureus (6, 4.1%) and Neisseria meningitidis (6, 4.1%). Thirty-nine patients (26.4%) presented with the triad of fever, headache, and neck stiffness. …”
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Structural basis for the toxic activity of MafB2 from maf genomic island 2 (MGI-2) in N. meningitidis B16B6 by So Hyeon Park, Sun Ju Jeong, Sung Chul Ha

“…Abstract The Maf polymorphic toxin system is involved in conflict between strains found in pathogenic Neisseria species such as Neisseria meningitidis and Neisseria gonorrhoeae. The genes encoding the Maf polymorphic toxin system are found in specific genomic islands called maf genomic islands (MGIs). …”
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Analysis of Bacterial Phosphorylcholine-Related Genes Reveals an Association between Type-Specific Biosynthesis Pathways and Biomolecules Targeted for Phosphorylcholine Modificatio... by Yuan Zhang, Freda E.-C. Jen, Jennifer L. Edwards, Michael P. Jennings

“…For example, the well-studied Lic-1 pathway is absent in some ChoP-expressing bacteria, such as Neisseria meningitidis and Neisseria gonorrhoeae. This raises a question as to the origin of the ChoP used for macromolecule biosynthesis in these species. …”
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Cryo-EM structures of type IV pili complexed with nanobodies reveal immune escape mechanisms by David Fernandez-Martinez, Youxin Kong, Sylvie Goussard, Agustin Zavala, Pauline Gastineau, Martial Rey, Gabriel Ayme, Julia Chamot-Rooke, Pierre Lafaye, Matthijn Vos, Ariel Mechaly, Guillaume Duménil

“…However, bacteria have evolved efficient strategies to evade type IV pili-directed antibody responses. Neisseria meningitidis are prototypical type IV pili-expressing Gram-negative bacteria responsible for life threatening sepsis and meningitis. …”
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VSSP abrogates murine ovarian tumor-associated myeloid cell-driven immune suppression and induces M1 polarization in tumor-associated macrophages from ovarian cancer patients by Khan, ANM N. H., Emmons, Tiffany R., Magner, William J., Alqassim, Emad, Singel, Kelly L., Ricciuti, Jason, Eng, Kevin H., Odunsi, Kunle, Tomasi, Thomas B., Lee, Kelvin, Abrams, Scott I., Mesa, Circe, Segal, Brahm H.

“…Very small size particles (VSSP), comprised of the ganglioside NAcGM3 and Neisseria meningitidis derived outer membrane vesicles, is being developed as a nanoparticulated modulator of innate immunity. …”
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Genetic and molecular analyses reveal an evolutionary trajectory for glycan synthesis in a bacterial protein glycosylation system by Børud, Bente, Viburiene, Raimonda, Paulsen, Berit Smestad, Egge-Jacobsen, Wolfgang, Koomey, Michael, Hartley, Meredith D., Imperiali, Barbara

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A novel combined Hib-MenC-TT glycoconjugate vaccine as a booster dose for toddlers: a phase 3 open randomised controlled trial by Pace, D, Snape, M, Westcar, S, Oluwalana, C, Yu, L, Begg, N, Wysocki, J, Czajka, H, Maechler, G, Boutriau, D, Pollard, A

“…Objective: To study the immunogenicity and reactogenicity of a combined Haemophilus influenzae type b and Neisseria meningitidis serogroup C tetanus toxoid conjugate vaccine (Hib-MenC-TT) when administered as a booster dose in combination with a measles, mumps and rubella vaccine (MMR). …”

A prospective observational study of community-acquired bacterial bloodstream infections in Metro Manila, the Philippines by Saito, N, Solante, RM, Guzman, FD, Telan, EO, Umipig, DV, Calayo, JP, Frayco, CH, Lazaro, JC, Ribo, MR, Dimapilis, AQ, Dimapilis, VO, Villanueva, AM, Mauhay, JL, Suzuki, M, Yasunami, M, Koizumi, N, Kitashoji, E, Sakashita, K, Yasuda, I, Nishiyama, A, Smith, C, Ariyoshi, K, Parry, CM

“…S. aureus, including a significant number of MRSA (USA1100 clones), S. enterica Typhi, E.coli and Neisseria meningitidis were frequently identified pathogens.…”

Rare genetic variants and susceptibility to severe bacterial diseases by Ndungu, A

“…Streptococcus pneumoniae</p> and <em>Neisseria meningitidis</em> are major causes of severe bacterial disease which can manifest as invasive disease such as bacteraemia and meningitis. …”

A novel combined Hib-MenC-TT glycoconjugate vaccine as a booster dose for toddlers: a phase 3 open randomised controlled trial. by Pace, D, Snape, M, Westcar, S, Oluwalana, C, Yu, L, Begg, N, Wysocki, J, Czajka, H, Maechler, G, Boutriau, D, Pollard, A

“… OBJECTIVE: To study the immunogenicity and reactogenicity of a combined Haemophilus influenzae type b and Neisseria meningitidis serogroup C tetanus toxoid conjugate vaccine (Hib-MenC-TT) when administered as a booster dose in combination with a measles, mumps and rubella vaccine (MMR). …”

Of mice and MenB: assessing the immune mechanisms underlying meningococcal capsular group B vaccines in mice by Sheerin, D

“…<p><em>Neisseria meningitidis</em> is the causative agent of invasive meningococcal disease (IMD) which claims between 50,000 and 135,000 lives worldwide annually. …”

Development and application of genome-wide association studies in bacteria by Earle, S, Wilson, D

“…The first, carriage vs invasive disease in <em>Neisseria meningitidis</em>, identified the known hyperinvasive ST-11 lineage to be associated with invasive disease, and suggested that newly-reported variants in genes involved in capsule production and phase variation play an important role in the virulence potential of meningococci in natural populations. …”

Recurrent bacterial meningitis in children in the Netherlands: a nationwide surveillance study by Arie van der Ende, Matthijs C Brouwer, Diederik van de Beek, Linde Snoek, Merel N van Kassel, Diederik L H Koelman, Nina M van Sorge, Merijn W Bijlsma

“…Predictors of recurrent meningitis were assessed using Cox proportional hazards regression.Results Sixty-three (0.6%) of the 9731 children with a first bacterial meningitis episode contracted recurrent meningitis. Neisseria meningitidis was the leading pathogen for first meningitis episodes (52%) and Streptococcus pneumoniae for recurrent episodes (52%). …”
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Structured Benefit-Risk Assessment of a New Quadrivalent Meningococcal Conjugate Vaccine (MenACYW-TT) in Individuals Ages 12 Months and Older by David Neveu, Tamala Mallett Moore, Betzana Zambrano, Aiying Chen, Marie-Laure Kürzinger, Lydie Marcelon, Mandeep Singh Dhingra

“…We present a structured semi-quantitative benefit-risk analysis of MenACYW-TT, a quadrivalent meningococcal conjugate vaccine against Neisseria meningitidis serogroups, A, C, W and Y versus licensed comparators in individuals aged ≥ 12 months. …”
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Microbisporicin (NAI-107) protects Galleria mellonella from infection with Neisseria gonorrhoeae by Nele Hofkens, Zina Gestels, Said Abdellati, Irith De Baetselier, Philippe Gabant, Anandi Martin, Christopher Kenyon, Sheeba Santhini Manoharan-Basil

“…In this study, we determined the in vitro activities of 65 bacteriocins from the PARAGEN collection along with microbisporicin (NAI-107) against 14 WHO reference isolates of Neisseria gonorrhoeae, one isolate of Neisseria meningitidis, and four commensal Neisseria spp. …”
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Immunogenicity of a novel anti-allergic vaccine based on house dust mite purified allergens and a combination adjuvant in a murine prophylactic model by Wendy Ramírez, Damarys Torralba, Virgilio Bourg, Miriam Lastre, Oliver Perez, Alain Jacquet, Alexis Labrada

“…The outer-membrane-derived proteoliposome (PL) of Neisseria meningitidis has been reported as a potent vaccine adjuvant, inducing a Th1-skewed response. …”
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Implantation of engineered human microvasculature to study human infectious diseases in mouse models by Sophia Schönherr-Hellec, Eirini Chatzopoulou, Jean-Philippe Barnier, Yoann Atlas, Sébastien Dupichaud, Thomas Guilbert, Yves Dupraz, Julie Meyer, Catherine Chaussain, Caroline Gorin, Xavier Nassif, Stephane Germain, Laurent Muller, Mathieu Coureuil

“…We describe the implantation in mice of engineered human mature microvasculature consisting of endothelial and perivascular cells embedded in collagen hydrogel that allows investigation of pathogen interactions with the endothelium, including in vivo functional studies. Using Neisseria meningitidis as a paradigm of human-restricted infection, we demonstrated the strength and opportunities associated with the use of this approach.…”
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