Immunogenicity of a tetravalent meningococcal glycoconjugate vaccine in infants: a randomized controlled trial. by Snape, MD, Perrett, K, Ford, K, John, T, Pace, D, Yu, L, Langley, J, McNeil, S, Dull, P, Ceddia, F, Anemona, A, Halperin, SA, Dobson, S, Pollard, A

“…INTERVENTION: UK infants received a primary course of MenACWY (at 2, 3, and 4 months or 2 and 4 months) or Neisseria meningitidis serogroup C monovalent meningococcal glycoconjugate vaccine (MenC) (at 2 and 4 months). …”

Global, regional, and national burden of meningitis and its aetiologies, 1990-2019: a systematic analysis for the Global Burden of Disease Study 2019 by Roberts, T

“…For aetiology estimation, data from multiple causes of death, vital registration, hospital discharge, microbial laboratory, and literature studies were analysed by use of a network analysis model to estimate the proportion of meningitis deaths and cases attributable to the following aetiologies: Neisseria meningitidis, Streptococcus pneumoniae, Haemophilus influenzae, group B Streptococcus, Escherichia coli, Klebsiella pneumoniae, Listeria monocytogenes, Staphylococcus aureus, viruses, and a residual other pathogen category.…”

Immunogenicity and safety of a combination pneumococcal-meningococcal vaccine in infants: a randomized controlled trial. by Buttery, J, Riddell, A, McVernon, J, Chantler, T, Lane, L, Bowen-Morris, J, Diggle, L, Morris, R, Harnden, A, Lockhart, S, Pollard, A, Cartwright, K, Moxon, E

“…CONTEXT: The success of conjugate vaccines in decreasing invasive disease due to Streptococcus pneumoniae and group C Neisseria meningitidis has placed pressure on crowded infant immunization schedules, making development of combination vaccines a priority. …”

Dynamics of community-acquired meningitis syndrome outbreaks in southern France by Madjid Morsli, Madjid Morsli, Florian Salipante, Quentin Kerharo, Agathe Boudet, Robin Stephan, Catherine Dunyach-Remy, Christine Zandotti, Christine Zandotti, Jean-Philippe Lavigne, Michel Drancourt, Michel Drancourt, Michel Drancourt

“…Bacterial meningitis accounted for 20% of cases, mostly caused by Streptococcus pneumoniae (27.4% of cases), Neisseria meningitidis (12.5%), and Haemophilus influenzae (9.5%) with bacteria/virus coinfection (0.9%), and only six cases of documented fungal meningitis. …”
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ARACNOIDITE ADESIVA DE CAUDA EQUINA ASSOCIADA À MENINGOCOCCEMIA GRAVE CAUSANDO PARAPLEGIA - RELATO DE CASO DE UMA COMPLICAÇÃO RARA by Ana Carolina Baptista Salmistraro, Carolina Oliveira Venturotti, Isabel Cristina Melo Mendes, Rafael Mello Galliez, Clarisse Pimentel

“…Na análise liquórica por PCR multiplex, foi isolada Neisseria meningitidis do tipo C, sendo mantido o tratamento guiado por 7 dias, com boa resposta evolutiva e posterior extubação, apesar de ainda manter feridas sequelares em pés. …”
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PREVALÊNCIA E ÓBITOS DA INFECÇÃO MENINGOCÓCICA NA INFÂNCIA NO BRASIL ENTRE OS ANOS DE 2017 E 2022 by Milena Alves Barboza, Júlia Arcanjo Ferreira, Geraldo Zanotelli Neto, Leandra Lima Xavier, Lucas Veras Rodrigues, Lucas Araújo Ferreira

“…Introdução: A infecção meningocócica é causada pela bactéria Neisseria meningitidis. Existem ao menos 13 sorogrupos meningocócicos definidos e seis (A, B, C, W, X, Y) são responsáveis pela maior carga de doenças clínicas. …”
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Trends in invasive bacterial diseases during the first 2 years of the COVID-19 pandemic: analyses of prospective surveillance data from 30 countries and territories in the IRIS Con... by Shaw, D, Abad, R, Amin-Chowdhury, Z, Bautista, A, Bennett, D, Broughton, K, Cao, B, Casanova, C, Choi, EH, Chu, Y-W, Claus, H, Coelho, J, Corcoran, M, Cottrell, S, Cunney, R, Cuypers, L, Dalby, T, Davies, H, de Gouveia, L, Deghmane, A-E, Demczuk, W, Desmet, S, Domenech, M, Drew, R, du Plessis, M, Duarte, C, Erlendsdóttir, H, Fry, NK, Fuursted, K, Hale, T, Henares, D, Henriques-Normark, B, Hilty, M, Hoffmann, S, Humphreys, H, Ip, M, Jacobsson, S, Johnson, C, Johnston, J, Jolley, KA, Kawabata, A, Kozakova, J, Kristinsson, KG, Krizova, P, Kuch, A, Ladhani, S, Lâm, T-T, León, ME, Lindholm, L, Litt, D, Brueggemann, AB

“…<strong>Background<br></strong> The Invasive Respiratory Infection Surveillance (IRIS) Consortium was established to assess the impact of the COVID-19 pandemic on invasive diseases caused by Streptococcus pneumoniae, Haemophilus influenzae, Neisseria meningitidis, and Streptococcus agalactiae. We aimed to analyse the incidence and distribution of these diseases during the first 2 years of the COVID-19 pandemic compared to the 2 years preceding the pandemic. …”

Molecular Detection of Colistin Resistance <i>mcr</i>-<i>1</i> Gene in Multidrug-Resistant <i>Escherichia coli</i> Isolated from Chicken by Md Bashir Uddin, Mohammad Nurul Alam, Mahmudul Hasan, S. M. Bayejed Hossain, Mita Debnath, Ruhena Begum, Mohammed A. Samad, Syeda Farjana Hoque, Md. Shahidur Rahman Chowdhury, Md. Mahfujur Rahman, Md. Mukter Hossain, Mohammad Mahmudul Hassan, Åke Lundkvist, Josef D. Järhult, Mohamed E. El Zowalaty, Syed Sayeem Uddin Ahmed

“…Furthermore, sequencing and phylogenetic analyses revealed a similarity between the catalytic domain of <i>Neisseria meningitidis</i> lipooligosaccharide phosphoethanolamine transferase A (LptA) and MCR proteins, indicating that the six tested isolates were colistin resistant. …”
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Bacterial meningitis in Africa by Tatiana Barichello, Tatiana Barichello, Carlos Henrique Rocha Catalão, Carlos Henrique Rocha Catalão, Ursula K. Rohlwink, Ursula K. Rohlwink, Ursula K. Rohlwink, Martijn van der Kuip, Dan Zaharie, Dan Zaharie, Regan S. Solomons, Ronald van Toorn, Marceline Tutu van Furth, Rodrigo Hasbun, Federico Iovino, Vivian Ssonko Namale, Vivian Ssonko Namale

“…Streptococcus pneumoniae (pneumococcus) and Neisseria meningitidis (meningococcus) are the main etiological agents of bacterial meningitis in adults and children above the age of one. …”
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Streptococcus agalactiae serotype Ia capsular polysaccharide production from a Brazilian strain by Ellen Jessouroun, Marcélio de Moura Oliveira, Bárbara Araújo Nogueira, Ozéias de Lima Leitão, Elizabete Pereira de Figueredo, Maria de Lourdes M Leal, Marilza Batista Corrêa, Bárbara V. Silva

“…Such prophylactic alternatives can be constructed from capsular polysaccharides.Based on the experience in the production and purification of Neisseria meningitidis polysaccharides for vaccines, Bio-Manguinhos developed a process for the production, purification and characterization of S. agalactiae Ia polysaccharides. …”
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The contribution of the alternative pathway in complement activation on cell surfaces depends on the strength of classical pathway initiation by Esther CW deBoer, Astrid JF Thielen, Jeroen D Langereis, Angela Kamp, Mieke C Brouwer, Nienke Oskam, Marlieke L Jongsma, April J Baral, Robbert M Spaapen, Sacha Zeerleder, Gestur Vidarsson, Theo Rispens, Diana Wouters, Richard B Pouw, Ilse Jongerius

“…Moreover, we studied complement activation on Neisseria meningitidis and Escherichia coli. The effect of the AP was examined using either AP‐depleted sera or antibodies against factor B and factor D. …”
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Pediatric central nervous system infections in the Amazon: clinical and laboratory profiles by Eveny Perlize Melo Marinho, Ewerton da Silva Ferreira, Caio Cesar Leiva Bastos Barrionuevo, Sabrina Araújo Melo, Jady Shayenne Mota Cordeiro, Sergio Damasceno Pinto, Rossicleia Lins Monte, Valderjane Aprígio da Silva, Yasmin Ferreira Martins, Monique Freire Reis, Monique Freire Reis, Samantha dos Santos Tufic-Garutti, Vanderson de Souza Sampaio, Daniel Barros de Castro, Daniel Barros de Castro, Pablo Vinicius Silveira Feitoza, Pablo Vinicius Silveira Feitoza, Lucia Alves da Rocha, Lucia Alves da Rocha, Luiz Carlos de Lima Ferreira, Michele de Souza Bastos, Michele de Souza Bastos

“…The most common bacterial pathogens isolated from the culture were Neisseria meningitidis serogroup C in 19, Streptococcus pneumoniae in 11, and Haemophilus influenzae in seven samples. …”
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Systematic evaluation of CRISPR-Cas systems reveals design principles for genome editing in human cells by Wang, Yuanming, Liu, Ivy Kaiwen, Sutrisnoh, Norfala-Aliah, Srinivasan, Harini, Zhang, Junyi, Li, Jia, Zhang, Fan, Lalith, Charles Richard John, Xing, Heyun, Shanmugam, Raghuvaran, Foo, Jia Nee, Yeo, Hwee Ting, Ooi, Kean Hean, Bleckwehl, Tore, Par, Rachel Yi Yun, Lee, Shi Mun, Ismail, Nur Nadiah, Sanwari, Nur Aidah, Lee, Vanessa Si Ting, Lew, Jan, Tan, Meng How

“…Besides observing a trade-off between cleavage efficiency and target specificity for these natural endonucleases, we find that the editing activities of the smaller Cas9 enzymes from Staphylococcus aureus (SaCas9) and Neisseria meningitidis (NmCas9) are less affected by gene expression than the other larger Cas proteins. …”
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Life-threatening infections in children in Europe (the EUCLIDS Project): a prospective cohort study by Martinón-Torres, F, Salas, A, Rivero-Calle, I, Cebey-López, M, Pardo-Seco, J, Herberg, J, Boeddha, N, Klobassa, D, Secka, F, Paulus, S, de Groot, R, Schlapbach, L, Driessen, G, Anderson, S, Emonts, M, Zenz, W, Carrol, E, Van der Flier, M, Levin, M, Levin, M, Coin, L, Gormley, S, Hamilton, S, Herberg, J, Hourmat, B, Hoggart, C, Kaforou, M, Sancho-Shimizu, V, Wright, V, Abdulla, A, Agapow, P, Bartlett, M, Bellos, E, Eleftherohorinou, H, Galassini, R, Inwald, D, Mashbat, M, Menikou, S, Mustafa, S, Nadel, S, Rahman, R, Thakker, C, Bokhandi, S, Power, S, Barham, H, Pathan, N, Ridout, J, White, D, Thurston, S, Faust, S, Patel, S, McCorkell, J, Davies, P, Crate, L, Navarra, H, Carter, S, Ramaiah, R, Patel, R, Tuffrey, C, Gribbin, A, McCready, S, Peters, M, Hardy, K, Standing, F, O'Neill, L, Abelake, E, Deep, A, Nsirim, E, Pollard, A, Willis, L, Young, Z, Royad, C, White, S, Fortune, P, Hudnott, P, Martinón-Torres, F, Salas Ellacuriaga, A, Álvez González, F, Barral-Arca, R, Cebey-López, M, Curras-Tuala, M, García, N, García Vicente, L, Gómez-Carballa, A, Gómez Rial, J, Grela Beiroa, A, Justicia Grande, A, Leboráns Iglesias, P, Santos, M, Martinón-Torres, N, Martinón Sánchez, J, Morillo Gutiérrez, B

“…The causal microorganism was identified in 1359 (47·8%) children, with the most prevalent ones being Neisseria meningitidis (in 259 [9·1%] patients), followed by Staphylococcus aureus (in 222 [7·8%]), Streptococcus pneumoniae (in 219 [7·7%]), and group A streptococcus (in 162 [5·7%]). 1070 (37·6%) patients required admission to a paediatric intensive care unit. …”

Multidrug Antimicrobial Resistance and Molecular Detection of <i>mcr-1</i> Gene in <i>Salmonella</i> Species Isolated from Chicken by Md Bashir Uddin, S.M. Bayejed Hossain, Mahmudul Hasan, Mohammad Nurul Alam, Mita Debnath, Ruhena Begum, Sawrab Roy, Ahmed Harun-Al-Rashid, Md. Shahidur Rahman Chowdhury, Md. Mahfujur Rahman, Md. Mukter Hossain, Fazle Elahi, Mohammed Yousuf Elahi Chowdhury, Josef D. Järhult, Mohamed E. El Zowalaty, Syed Sayeem Uddin Ahmed

“…Sequencing and phylogenetic analysis revealed a divergent evolutionary relationship between the catalytic domain of <i>Neisseria meningitidis</i> lipooligosaccharide phosphoethanolamine transferase A (LptA) and MCR proteins, rendering them resistant to colistin. …”
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Safety and Immunogenicity of a Human Epidermal Growth Factor Receptor 1 (HER1)-Based Vaccine in Prostate Castration-Resistant Carcinoma Patients: A Dose-Escalation Phase I Study Tr... by Iraida Caballero, Lazaro E. Aira, Anabel Lavastida, Xitlally Popa, Javier Rivero, Joaquín González, Mónica Mesa, Narjara González, Kelly Coba, Patricia Lorenzo-Luaces, Barbara Wilkinson, Yuliannis Santiesteban, Yanela Santiesteban, Mayelin Troche, Eduardo Suarez, Tania Crombet, Belinda Sánchez, Angel Casacó, Amparo Macías, Zaima Mazorra

“…CRPC patients (n = 24) were intramuscularly vaccinated with HER1 vaccine consisting of the extracellular domain of HER1 molecule (ECD) and very small size proteoliposome from Neisseria meningitidis (VSSP) and Montanide ISA-51 VG as adjuvants. …”
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Real-time metagenomics-based diagnosis of community-acquired meningitis: A prospective series, southern France by Madjid Morsli, Agathe Boudet, Quentin Kerharo, Robin Stephan, Florian Salipante, Catherine Dunyach-Remy, Linda Houhamdi, Pierre-Edouard Fournier, Jean Philippe Lavigne, Michel Drancourt

“…Findings: Over eight months, routine multiplex RT-PCR yielded 49/52 positive CSFs, including 21 Streptococcus pneumoniae, nine Neisseria meningitidis, eight Haemophilus influenzae, three Streptococcus agalactiae, three Herpesvirus-1, two Listeria monocytogenes, and one each of Escherichia coli, Staphylococcus aureus and Varicella-Zoster Virus. …”
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Vacinação extra-PNV dos 2-4 anos de idade: fatores associados à não realização e perspetiva do pediatra vs médico de família by Joana Teixeira, Maria Miguel Gomes, Marina Gonçalves, Ana Gomes

“…Verificamos uma maior vacinação contra Neisseria meningitidis do serogrupo B e contra o vírus da hepatite A (VHA) na ausência de insuficiência económica (p value de Fisher=0,008 e p=0,046, respetivamente). …”
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Desertomycin G, a New Antibiotic with Activity against <i>Mycobacterium tuberculosis</i> and Human Breast Tumor Cell Lines Produced by <i>Streptomyces althioticus</i> MSM3, Isolate... by Alfredo F. Braña, Aida Sarmiento-Vizcaíno, Ignacio Pérez-Victoria, Jesús Martín, Luis Otero, Juan José Palacios-Gutiérrez, Jonathan Fernández, Yamina Mohamedi, Tania Fontanil, Marina Salmón, Santiago Cal, Fernando Reyes, Luis A. García, Gloria Blanco

“…Desertomycin G also displays moderate antibiotic activity against relevant Gram-negative clinical pathogens such as <i>Bacteroides fragilis</i>, <i>Haemophilus influenzae</i> and <i>Neisseria meningitidis</i>. In addition, the compound affects viability of tumor cell lines, such as human breast adenocarcinoma (MCF-7) and colon carcinoma (DLD-1), but not normal mammary fibroblasts.…”
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Point-of-Care approaches for meningitis diagnosis in a low-resource setting (Southwestern Uganda) : observational cohort study protocol of the "PI-POC" trial by Gaudenzi, Giulia, Kumbakumba, Elias, Rasti, Reza, Nanjebe, Deborah, Réu, Pedro, Nyehangane, Dan, Mårtensson, Andreas, Nassejje, Milly, Karlsson, Jens, Mzee, John, Nilsson, Peter, Businge, Stephen, Loh, Edmund, Yap, Boum II, Andersson-Svahn, Helene, Gantelius, Jesper, Mwanga-Amumpaire, Juliet, Alfvén, Tobias

“…In addition, the carriage and invasive rate of Neisseria meningitidis will be recorded and serotyped, and the expression of its major virulence factor (polysaccharide capsule) will be investigated. …”
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