Opa proteins and CEACAMs: Pathways of immune engagement for pathogenic Neisseria by Sadarangani, M, Pollard, A, Gray-Owen, S

“…Neisseria meningitidis and Neisseria gonorrhoeae are globally important pathogens, which in part owe their success to their ability to successfully evade human immune responses over long periods. …”

Persistence of hyperinvasive meningococcal strain types during global spread as recorded in the PubMLST database by Watkins, E, Maiden, M

“…Neisseria meningitidis is a major cause of septicaemia and meningitis worldwide. …”

Gene expression profiling reveals insights into infant immunological and febrile responses to group B meningococcal vaccine by O'Connor, D, Pinto, MV, Sheerin, D, Tomic, A, Drury, RE, Channon-Wells, S, Galal, U, Dold, C, Robinson, H, Kerridge, S, Plested, E, Hughes, H, Stockdale, L, Sadarangani, M, Snape, MD, Rollier, CS, Levin, M, Pollard, AJ

“…Neisseria meningitidis is a major cause of meningitis and septicaemia. …”

Structural variation and immune recognition of the P1.2 subtype meningococcal antigen. by Tzitzilonis, C, Prince, S, Collins, R, Achtman, M, Feavers, I, Maiden, M, Derrick, J

“…Neisseria meningitidis is a globally important cause of bacterial meningitis and septicemia. …”

Development of a glycoconjugate vaccine to prevent meningitis in Africa caused by meningococcal serogroup X. by Micoli, F, Romano, MR, Tontini, M, Cappelletti, E, Gavini, M, Proietti, D, Rondini, S, Swennen, E, Santini, L, Filippini, S, Balocchi, C, Adamo, R, Pluschke, G, Norheim, G, Pollard, A, Saul, A, Rappuoli, R, MacLennan, C, Berti, F, Costantino, P

“…Neisseria meningitidis is a major cause of bacterial meningitis worldwide, especially in the African meningitis belt, and has a high associated mortality. …”

Influence of the combination and phase variation status of the haemoglobin receptors HmbR and HpuAB on meningococcal virulence. by Tauseef, I, Harrison, O, Wooldridge, K, Feavers, I, Neal, K, Gray, S, Kriz, P, Turner, D, Ala'Aldeen, D, Maiden, M, Bayliss, C

“…Neisseria meningitidis can utilize haem, haemoglobin and haemoglobin-haptoglobin complexes as sources of iron via two TonB-dependent phase variable haemoglobin receptors, HmbR and HpuAB. …”

Human B cell responses to dominant and sub-dominant antigens induced by a meningococcal outer membrane vesicle vaccine in a phase I trial by Rollier, CS, Dold, C, Marsay, L, Linder, A, Green, CA, Sadarangani, M, Norheim, G, Derrick, JP, Feavers, IM, Maiden, M, Pollard, AJ

“…Neisseria meningitidis outer membrane vesicle (OMV) vaccines are safe and provide strain-specific protection against invasive meningococcal disease (IMD) primarily by inducing serum bactericidal antibodies against the outer membrane proteins (OMP). …”

Distinct binding and immunogenic properties of the gonococcal homologue of meningococcal factor h binding protein. by Jongerius, I, Lavender, H, Tan, L, Ruivo, N, Exley, R, Caesar, J, Lea, S, Johnson, S, Tang, C

“…Neisseria meningitidis is a leading cause of sepsis and meningitis. …”

Reconstruction of dispersal pattern of hypervirulent meningococcal strains of serogroup C:cc11 by phylogenomic time tree by Lo Presti, A, Neri, A, Fazio, C, Vacca, P, Ambrosio, L, Grazian, C, Liseo, B, Rezza, G, Maiden, M, Stefanelli, P

“…Neisseria meningitidis is one of the few commensal bacteria that can even cause large epidemics of invasive meningococcal disease (IMD). …”

Emergence of serogroup X meningococcal disease in Africa: need for a vaccine. by Xie, O, Pollard, A, Mueller, J, Norheim, G

“…Neisseria meningitidis is responsible for the seasonal burden and recurrent epidemics of meningitis in an area of sub-Saharan Africa known as the meningitis belt. …”

Nonfunctional variant 3 factor H binding proteins as meningococcal vaccine candidates. by van der Veen, S, Johnson, S, Jongerius, I, Malik, T, Genovese, A, Santini, L, Staunton, D, Ufret-Vincenty, R, Pickering, M, Lea, S, Tang, C

“…Neisseria meningitidis is a human-specific pathogen and leading cause of meningitis and septicemia. …”

Control of invasive meningococcal disease: is it achievable? by Marshall, H, Wang, B, Wesselingh, S, Snape, M, Pollard, A

“…Neisseria meningitidis still leads to deaths and severe disability in children, adolescents and adults. …”