Two human antibodies to a meningococcal serogroup B vaccine antigen enhance binding of complement Factor H by stabilizing the Factor H binding site. by Nathaniel A Sands, Peter T Beernink

“…The bacterial pathogen Neisseria meningitidis, or meningococcus, binds several complement regulators, including human Factor H (FH). …”
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Comparative analysis of two <it>Neisseria gonorrhoeae </it>genome sequences reveals evidence of mobilization of Correia Repeat Enclosed Elements and their role in regulation by Cole Jeff A, Snyder Lori AS, Pallen Mark J

“…Due to the previously demonstrated role of these elements in altering transcriptional control and the findings from comparing the two gonococcal genome sequences, it is suggested that regulatory differences orchestrated by CREE contribute to the differences between strains and also between the closely related yet clinically distinct species <it>N. gonorrhoeae</it>, <it>Neisseria meningitidis</it>, and <it>Neisseria lactamica</it>.…”
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Evaluation of robenidine analog NCL195 as a novel broad-spectrum antibacterial agent. by Abiodun D Ogunniyi, Manouchehr Khazandi, Andrew J Stevens, Sarah K Sims, Stephen W Page, Sanjay Garg, Henrietta Venter, Andrew Powell, Karen White, Kiro R Petrovski, Geraldine Laven-Law, Eliane G Tótoli, Hérida R Salgado, Hongfei Pi, Geoffrey W Coombs, Dean L Shinabarger, John D Turnidge, James C Paton, Adam McCluskey, Darren J Trott

“…NCL195 was bactericidal against Acinetobacter spp and Neisseria meningitidis and also demonstrated potent activity against A. baumannii, Pseudomonas aeruginosa, Escherichia coli, Klebsiella pneumoniae and Enterobacter spp. in the presence of sub-inhibitory concentrations of ethylenediaminetetraacetic acid (EDTA) and polymyxin B. …”
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Pattern of the meningococcal meningitis outbreak in Northern Nigeria, 2009 by Bassey Enya Bassey, Rui Gama Vaz, Alex Ntale Gasasira, Fiona Braka, Goitom Weldegriebriel, Williams Komakech, Maleghemi Sylvester Toritseju, Akinola Ayoola Fatiregun, Angela Okocha-Ejeko

“…The pattern of the epidemic meningococcal meningitis outbreak in Northern Nigeria in 2009 and the Neisseria meningitidis strains responsible for this epidemic are described here. …”
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Common Cell Shape Evolution of Two Nasopharyngeal Pathogens. by Frédéric J Veyrier, Nicolas Biais, Pablo Morales, Nouria Belkacem, Cyril Guilhen, Sylvia Ranjeva, Odile Sismeiro, Gérard Péhau-Arnaudet, Eduardo P Rocha, Catherine Werts, Muhamed-Kheir Taha, Ivo G Boneca

“…The nasopharynx is the portal of entry and the ecological niche of many microorganisms, of which some are pathogenic to humans, such as Neisseria meningitidis and Moraxella catarrhalis. These microbes possess several surface structures that interact with the actors of the innate immune system. …”
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Clinical use of multiplex-PCR for the diagnosis of acute bacterial meningitis by Nupur Sharma, Hitender Gautam, Sonu Tyagi, Shahid Raza, Sarita Mohapatra, Seema Sood, Benu Dhawan, Arti Kapil, Bimal K Das

“…We designed and evaluated two sets of multiplex-PCR assays for the simultaneous detection of six major etiologies of ABM i.e., Streptococcus pneumoniae, Haemophilus influenzae type b, and Neisseria meningitidis in one set and Listeria monocytogenes, Streptococcus agalactiae, and Escherichia coli in another set of multiplex-PCR in CSF of patients with suspected ABM. …”
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OpcA and PorB are novel bactericidal antigens of the 4CMenB vaccine in mice and humans by Viola Viviani, Adele Fantoni, Sara Tomei, Sara Marchi, Enrico Luzzi, Margherita Bodini, Alessandro Muzzi, Marzia M. Giuliani, Domenico Maione, Jeremy P. Derrick, Isabel Delany, Mariagrazia Pizza, Alessia Biolchi, Erika Bartolini

“…Abstract The ability of Neisseria meningitidis Outer Membrane Vesicles (OMV) to induce protective responses in humans is well established and mainly attributed to Porin A (PorA). …”
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Distinct binding and immunogenic properties of the gonococcal homologue of meningococcal factor h binding protein. by Ilse Jongerius, Hayley Lavender, Lionel Tan, Nicola Ruivo, Rachel M Exley, Joseph J E Caesar, Susan M Lea, Steven Johnson, Christoph M Tang

“…Neisseria meningitidis is a leading cause of sepsis and meningitis. …”
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Structures of NHBA elucidate a broadly conserved epitope identified by a vaccine induced antibody. by Martina Maritan, Daniele Veggi, Roberta Cozzi, Lucia Dello Iacono, Erika Bartolini, Paola Lo Surdo, Giulietta Maruggi, Glen Spraggon, Matthew J Bottomley, Enrico Malito

“…Neisserial heparin binding antigen (NHBA) is one of three main recombinant protein antigens in 4CMenB, a vaccine for the prevention of invasive meningococcal disease caused by Neisseria meningitidis serogroup B. NHBA is a surface-exposed lipoprotein composed of a predicted disordered N-terminal region, an arginine-rich region that binds heparin, and a C-terminal domain that folds as an anti-parallel β-barrel and that upon release after cleavage by human proteases alters endothelial permeability. …”
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A comparative study between children and adults with bacterial neuroinfections by Petya K. Argirova, Yordan I. Kalchev, Ivan P. Boev, Nikolay T. Vatev, Marianna A. Murdjeva, Mariyana S. Vartigova

“…The etiological structure in children was different: Neisseria meningitidis (20%), Streptococcus pneumoniae (16%), Klebsiella pneumoniae (8%), Enterococcus faecium (8%), Streptococcus salivarius (4%), and Mycobacterium tuberculosis (4%). …”
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Audit of antibiotic therapy in surgical neonates in a tertiary hospital in Benin City, Nigeria by Osifo Osarumwense, Aghahowa Sylvester

“…Polymicrobial postoperative wound infections and sepsis caused by <i>Staphylococcus aureus</i>, <i>Escherichia coli</i>, <i>Neisseria meningitidis</i>, <i>Klebsiella pneumonia</i>, <i>Pseudomonas aeroginosa</i> and anaerobes, were mainly encountered. …”
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Tracing the Negative Results of Multiplex Real-Time PCR Assay for Diagnosis of Bacterial Pediatrics Meningitis by Abdollah Karimi, Sedigheh Rafiei Tabatabaei, Leila Azimi, Nasim Almasian Tehrani, Fatemeh Fallah, Iman Faghihian

“…This study aimed to trace the false-negative results of multiplex RT-PCR to detect Streptococcus pneumoniae, Haemophilus influenzae, and Neisseria meningitidis serogroup by two different molecular methods. …”
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Défice de Fator H: Um Caso com Apresentação Atípica by Ana Paula Rocha, Madalena Borges, Conceição Neves, João Farela Neves

“…Esta criança não teve nenhuma das manifestações típicas, nomeadamente doença invasiva por Neisseria meningitidis ou doença renal (glomerulonefrite e síndrome hemolítica urémica atípica). …”
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Neonatal sepsis, clinical manifestation, diagnosis and treatment by Uliana Ivanivna Marusyk, Olena Vasylivna Vlasova, Maryana Ivanivna Hrytsiuk, Valentyna Volodymyrivna Bebykh

“…Bacteria such as Streptococcus pneumoniae, Haemophilus influenzae, Staphylococcus aureus, Escherichia coli, Salmonella and Neisseria meningitidis are the most common etiological pathogens. …”
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In vivo and in vitro characterization of the immune stimulating activity of the Neisserial porin PorB. by Andrew Platt, Heather MacLeod, Paola Massari, Xiuping Liu, Lee Wetzler

“…To this end, we have undertaken a study of the essential signaling pathways involved in the innate and adaptive immune responses to the Neisseria meningitidis outer membrane protein Porin B (PorB). …”
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Alternative vaccine administration by powder injection: Needle-free dermal delivery of the glycoconjugate meningococcal group Y vaccine. by Nikolas T Weissmueller, Leanne Marsay, Heiko A Schiffter, Robert C Carlisle, Christine S Rollier, Robert K Prud'homme, Andrew J Pollard

“…In a capsular group Y Neisseria meningitidis serum bactericidal assay (SBA) with human serum complement, the needle free vaccine, which contained no alum adjuvant, induced functional protective antibody responses in vivo of similar magnitude to the conventional vaccine injected by hypodermic needle and syringe and containing alum adjuvant. …”
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Characterization of the AcrIIC1 anti‒CRISPR protein for Cas9‒based genome engineering in E. coli by Despoina Trasanidou, Ana Potocnik, Patrick Barendse, Prarthana Mohanraju, Evgenios Bouzetos, Efthymios Karpouzis, Amber Desmet, Richard van Kranenburg, John van der Oost, Raymond H. J. Staals, Ioannis Mougiakos

“…We then demonstrate that the AcrIIC1 protein from Neisseria meningitidis robustly inhibits their DNA cleavage activity, but not their DNA binding capacity. …”
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High-dimensional assessment of B-cell responses to quadrivalent meningococcal conjugate and plain polysaccharide vaccine. by O'Connor, D, Clutterbuck, E, Thompson, A, Snape, M, Ramasamy, M, Kelly, D, Pollard, A

“… <h4>Background</h4> <p>Neisseria meningitidis is a globally important cause of meningitis and septicaemia. …”

Comparative whole-genome analyses reveal over 100 putative phase-variable genes in the pathogenic Neisseria spp. by Snyder, L, Butcher, SA, Saunders, N

“…Previously, a complete genome analysis of Neisseria meningitidis strain MC58 revealed the largest repertoire of putative phase-variable genes described in any species to date. …”

Neisseria cinerea Expresses a Functional Factor H Binding Protein Which Is Recognized by Immune Responses Elicited by Meningococcal Vaccines by Lavender, H, Poncin, K, Tang, C

“… Neisseria meningitidis is a major cause of bacterial meningitis and sepsis worldwide. …”