A Tumor Suppressive Role of CYLD as a Novel Potential DUB of Aurora B in Cervical Cancer by Yufan Huang, Wei Zhang, Zhihui Yu, Hongkai Su, Bin Zeng, Jinsong Piao, Jing Wang, Juan Wu

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Relevance of the Updated Recursive Partitioning Analysis (U-RPA) Classification in the Contemporary Care of Patients with Brain Metastases by Camilo E. Fadul, Guneet Sarai, Joseph A. Bovi, Alissa A. Thomas, Wendy Novicoff, Roger Anderson, Ryan F. Amidon, Samantha Schuetz, Rohit Singh, Amy Chang, Ryan D. Gentzler, Elizabeth M. Gaughan, Jason P. Sheehan

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Development of Randomized Trials in Adults with Medulloblastoma—The Example of EORTC 1634-BTG/NOA-23 by Peter Hau, Didier Frappaz, Elizabeth Hovey, Martin G. McCabe, Kristian W. Pajtler, Benedikt Wiestler, Clemens Seidel, Stephanie E. Combs, Linda Dirven, Martin Klein, Antoinette Anazodo, Elke Hattingen, Silvia Hofer, Stefan M. Pfister, Claus Zimmer, Rolf-Dieter Kortmann, Marie-Pierre Sunyach, Ronan Tanguy, Rachel Effeney, Andreas von Deimling, Felix Sahm, Stefan Rutkowski, Anna S. Berghoff, Enrico Franceschi, Estela Pineda, Dagmar Beier, Ellen Peeters, Thierry Gorlia, Maureen Vanlancker, Jacoline E. C. Bromberg, Julien Gautier, David S. Ziegler, Matthias Preusser, Wolfgang Wick, Michael Weller

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LOGGIC/FIREFLY-2: a phase 3, randomized trial of tovorafenib vs. chemotherapy in pediatric and young adult patients with newly diagnosed low-grade glioma harboring an activating RA... by Cornelis M. van Tilburg, Lindsay B. Kilburn, Sébastien Perreault, Rene Schmidt, Amedeo A. Azizi, Ofelia Cruz-Martínez, Michal Zápotocký, Katrin Scheinemann, Antoinette Y. N. Schouten-van Meeteren, Astrid Sehested, Enrico Opocher, Pablo Hernáiz Driever, Shivaram Avula, David S. Ziegler, David Capper, Arend Koch, Felix Sahm, Jiaheng Qiu, Li-Pen Tsao, Samuel C. Blackman, Peter Manley, Till Milde, Ruth Witt, David T. W. Jones, Darren Hargrave, Olaf Witt

“…The type II RAF inhibitor, tovorafenib (formerly DAY101, TAK-580, MLN2480), has shown promising activity and good tolerability in patients with BRAF-altered pLGG in the phase 2 FIREFLY-1 study, with an objective response rate (ORR) per Response Assessment in Neuro-Oncology high-grade glioma (RANO-HGG) criteria of 67%. …”
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Negative regulation of miR‐1275 by H3K27me3 is critical for glial induction of glioblastoma cells by Jialuo Mai, Jiayu Gu, Ying Liu, Xincheng Liu, Ke Sai, Zhijie Chen, Wanjun Lu, Xiaozhi Yang, Jingyi Wang, Cui Guo, Shuxin Sun, Fan Xing, Longxiang Sheng, Bingzheng Lu, Zhu Zhu, Hongjiaqi Sun, Dongdong Xue, Yuan Lin, Jing Cai, Yaqian Tan, Chuntao Li, Wei Yin, Lin Cao, Ying Ou‐yang, Pengxin Qiu, Xingwen Su, Guangmei Yan, Jiankai Liang, Wenbo Zhu

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Genotype-Phenotype Correlations in Neurofibromatosis Type 1: A Single-Center Cohort Study by Marcello Scala, Irene Schiavetti, Francesca Madia, Cristina Chelleri, Gianluca Piccolo, Andrea Accogli, Antonella Riva, Vincenzo Salpietro, Renata Bocciardi, Guido Morcaldi, Marco Di Duca, Francesco Caroli, Antonio Verrico, Claudia Milanaccio, Gianmaria Viglizzo, Monica Traverso, Simona Baldassari, Paolo Scudieri, Michele Iacomino, Gianluca Piatelli, Carlo Minetti, Pasquale Striano, Maria Luisa Garrè, Patrizia De Marco, Maria Cristina Diana, Valeria Capra, Marco Pavanello, Federico Zara

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The design and evaluation of hybrid controlled trials that leverage external data and randomization by Steffen Ventz, Sean Khozin, Bill Louv, Jacob Sands, Patrick Y. Wen, Rifaquat Rahman, Leah Comment, Brian M. Alexander, Lorenzo Trippa

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Reverse Takotsubo cardiomyopathy after orthotopic liver transplantation. A case report by Mihalcea Lucian, Sebastian Isac, Simion-Cotorogea Mihail, Klimko Artsiom, Droc Gabriela

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Evolution of Systemic Therapy in Medulloblastoma Including Irradiation-Sparing Approaches by Naureen Mushtaq, Rahat Ul Ain, Syed Ahmer Hamid, Eric Bouffet

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Author Correction: Genomic analysis as a tool to infer disparate phylogenetic origins of dysembryoplastic neuroepithelial tumors and their satellite lesions by Yeajina Lee, Jeyul Yang, Seung Ah Choi, Seung‐Ki Kim, Sung-Hye Park, Hyun Joo Park, Jong-Il Kim, Ji Hoon Phi

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Immune checkpoint blockade in glioblastoma: from tumor heterogeneity to personalized treatment by Víctor A. Arrieta, Crismita Dmello, Daniel J. McGrail, Daniel J. Brat, Catalina Lee-Chang, Amy B. Heimberger, Dhan Chand, Roger Stupp, Adam M. Sonabend

“…Immune checkpoint blockade (ICB) has revolutionized modern cancer therapy, arousing great interest in the neuro-oncology community. While several reports show that subsets of patients with glioma exhibit durable responses to immunotherapy, the efficacy of this treatment has not been observed for unselected patient populations, preventing its broad clinical implementation for gliomas and glioblastoma (GBM). …”
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Assessing Versatile Machine Learning Models for Glioma Radiogenomic Studies across Hospitals by Risa K. Kawaguchi, Masamichi Takahashi, Mototaka Miyake, Manabu Kinoshita, Satoshi Takahashi, Koichi Ichimura, Ryuji Hamamoto, Yoshitaka Narita, Jun Sese

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ZEB1 Is a Transcription Factor That Is Prognostic and Predictive in Diffuse Gliomas by Lincoln A. Edwards, Sungjin Kim, Mecca Madany, Miriam Nuno, Tom Thomas, Aiguo Li, Dror Berel, Bong-Sup Lee, Minzhi Liu, Keith L. Black, Xuemo Fan, Wei Zhang, John S. Yu

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Correction: Italian adaptation of the Uniform Data Set Neuropsychological Test Battery (I‑UDSNB 1.0): development and normative data by Francesca Conca, Valentina Esposito, Francesco Rundo, Davide Quaranta, Cristina Muscio, Rosa Manenti, Giulia Caruso, Ugo Lucca, Alessia Antonella Galbussera, Sonia Di Tella, Francesca Baglio, Federica L’Abbate, Elisa Canu, Valentina Catania, Massimo Filippi, Giulia Mattavelli, Barbara Poletti, Vincenzo Silani, Raffaele Lodi, Maddalena De Matteis, Michelangelo Stanzani Maserati, Andrea Arighi, Emanuela Rotondo, Antonio Tanzilli, Andrea Pace, Federica Garramone, Carlo Cavaliere, Matteo Pardini, Cristiano Rizzetto, Sandro Sorbi, Roberta Perri, Pietro Tiraboschi, Nicola Canessa, Maria Cotelli, Raffaele Ferri, Sandra Weintraub, Camillo Marra, Fabrizio Tagliavini, Eleonora Catricalà, Stefano Francesco Cappa

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The Hallmarks of Glioblastoma: Heterogeneity, Intercellular Crosstalk and Molecular Signature of Invasiveness and Progression by Filippo Torrisi, Cristiana Alberghina, Simona D’Aprile, Anna M. Pavone, Lucia Longhitano, Sebastiano Giallongo, Daniele Tibullo, Michelino Di Rosa, Agata Zappalà, Francesco P. Cammarata, Giorgio Russo, Massimo Ippolito, Giacomo Cuttone, Giovanni Li Volti, Nunzio Vicario, Rosalba Parenti

“…Among the adult-type diffuse gliomas, glioblastoma represents most primary brain tumors in the neuro-oncology practice of adults. Despite massive efforts in the field of neuro-oncology diagnostics to ensure a proper taxonomy, the identification of glioblastoma-tumor subtypes is not accompanied by personalized therapies, and no improvements in terms of overall survival have been achieved so far, confirming the existence of open and unresolved issues. …”
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Epigenetic Role of Histone Lysine Methyltransferase and Demethylase on the Expression of Transcription Factors Associated with the Epithelial-to-Mesenchymal Transition of Lung Aden... by Young Min Lee, Seok Hyun Kim, Minseok S. Kim, Dae Cheol Kim, Eun Hee Lee, Ju Suk Lee, Sung-Hun Lee, Young Zoon Kim

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Combined Assessment of Preoperative Frailty and Sarcopenia Allows the Prediction of Overall Survival in Patients with Lung Cancer (NSCLC) and Surgically Treated Brain Metastasis by Inja Ilic, Anton Faron, Muriel Heimann, Anna-Laura Potthoff, Niklas Schäfer, Christian Bode, Valeri Borger, Lars Eichhorn, Frank A. Giordano, Erdem Güresir, Andreas H. Jacobs, Yon-Dschun Ko, Jennifer Landsberg, Felix Lehmann, Alexander Radbruch, Ulrich Herrlinger, Hartmut Vatter, Patrick Schuss, Matthias Schneider

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Targeting TGF-β signaling in the multiple myeloma microenvironment: Steering CARs and T cells in the right direction by Priyanka S. Rana, Priyanka S. Rana, David C. Soler, Jeries Kort, Jeries Kort, Jeries Kort, James J. Driscoll, James J. Driscoll, James J. Driscoll

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A Multigene Signature Associated with Progression-Free Survival after Treatment for IDH Mutant and 1p/19q Codeleted Oligodendrogliomas by Julia Gilhodes, Adèle Meola, Bastien Cabarrou, Guillaume Peyraga, Caroline Dehais, Dominique Figarella-Branger, François Ducray, Claude-Alain Maurage, Delphine Loussouarn, Emmanuelle Uro-Coste, Elizabeth Cohen-Jonathan Moyal, POLA Network

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Extracellular Vesicles from Cerebrospinal Fluid of Leptomeningeal Metastasis Patients Deliver MiR-21 and Induce Methotrexate Resistance in Lung Cancer Cells by Ji Hye Im, Kyue-Yim Lee, Yoona Seo, Jiho Rhim, Yun-Sik Dho, Byong Chul Yoo, Jong Bae Park, Sang Hoon Shin, Heon Yoo, Jong Heon Kim, Ho-Shin Gwak

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