Evaluating large language models as agents in the clinic by Nikita Mehandru, Brenda Y. Miao, Eduardo Rodriguez Almaraz, Madhumita Sushil, Atul J. Butte, Ahmed Alaa

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Early Onset Epilepsy Caused by Low-Grade Epilepsy-Associated Tumors and Focal Meningeal Involvement by Luca De Palma, Chiara Pepi, Alessandro De Benedictis, Nicola Pietrafusa, Angela Mastronuzzi, Antonella Cacchione, Giusy Carfì-Pavia, Camilla Rossi-Espagnet, Francesca Diomedi-Camassei, Sabrina Rossi, Antonio Napolitano, Andrea Carai, Giovanna Stefania Colafati, Daniela Longo, Paolo Curatolo, Federico Vigevano, Carlo Efisio Marras, Nicola Specchio

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Hybrid PET/MRI in Cerebral Glioma: Current Status and Perspectives by Karl-Josef Langen, Norbert Galldiks, Jörg Mauler, Martin Kocher, Christian Peter Filß, Gabriele Stoffels, Cláudia Régio Brambilla, Carina Stegmayr, Antje Willuweit, Wieland Alexander Worthoff, Nadim Jon Shah, Christoph Lerche, Felix Manuel Mottaghy, Philipp Lohmann

“…A key factor for the benefit of PET/MRI in neuro-oncology is a multimodal approach that provides decisive improvements in the diagnostics of brain tumours compared with a single modality. …”
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Sporadic spinal psammomatous malignant melanotic nerve sheath tumor: A case report and literature review by Giulio Bonomo, Giulio Bonomo, Giulio Bonomo, Alessandro Gans, Alessandro Gans, Elio Mazzapicchi, Elio Mazzapicchi, Emanuele Rubiu, Emanuele Rubiu, Paolo Alimonti, Marica Eoli, Rosina Paterra, Bianca Pollo, Guglielmo Iess, Guglielmo Iess, Francesco Restelli, Francesco Restelli, Jacopo Falco, Jacopo Falco, Francesco Acerbi, Marco Paolo Schiariti, Paolo Ferroli, Morgan Broggi

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MicroRNA-218 instructs proper assembly of hippocampal networks by Seth R Taylor, Mariko Kobayashi, Antonietta Vilella, Durgesh Tiwari, Norjin Zolboot, Jessica X Du, Kathryn R Spencer, Andrea Hartzell, Carol Girgiss, Yusuf T Abaci, Yufeng Shao, Claudia De Sanctis, Gian Carlo Bellenchi, Robert B Darnell, Christina Gross, Michele Zoli, Darwin K Berg, Giordano Lippi

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Endocrine and non-endocrine causes of fatigue in adults with Neurofibromatosis type 1 by Anna G. W. Rosenberg, Ké Mochèl, Lorena M. Hähner, Lara Ruules, Kirsten Davidse, Anja G. Bos-Roubos, Sarah A. van Dijk, Sarah A. van Dijk, M. Carola Zillikens, M. Carola Zillikens, M. Carola Zillikens, M. Carola Zillikens, Walter Taal, Walter Taal, Aart J. van der Lely, Aart J. van der Lely, Laura C. G. de Graaff, Laura C. G. de Graaff, Laura C. G. de Graaff

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Italian adaptation of the Uniform Data Set Neuropsychological Test Battery (I-UDSNB 1.0): development and normative data by Francesca Conca, Valentina Esposito, Francesco Rundo, Davide Quaranta, Cristina Muscio, Rosa Manenti, Giulia Caruso, Ugo Lucca, Alessia Antonella Galbussera, Sonia Di Tella, Francesca Baglio, Federica L’Abbate, Elisa Canu, Valentina Catania, Massimo Filippi, Giulia Mattavelli, Barbara Poletti, Vincenzo Silani, Raffaele Lodi, Maddalena De Matteis, Michelangelo Stanzani Maserati, Andrea Arighi, Emanuela Rotondo, Antonio Tanzilli, Andrea Pace, Federica Garramone, Carlo Cavaliere, Matteo Pardini, Cristiano Rizzetto, Sandro Sorbi, Roberta Perri, Pietro Tiraboschi, Nicola Canessa, Maria Cotelli, Raffaele Ferri, Sandra Weintraub, Camillo Marra, Fabrizio Tagliavini, Eleonora Catricalà, Stefano Francesco Cappa

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Preclinical and early clinical studies of a novel compound SYHA1813 that efficiently crosses the blood–brain barrier and exhibits potent activity against glioblastoma by Yingqiang Liu, Zhengsheng Zhan, Zhuang Kang, Mengyuan Li, Yongcong Lv, Shenglan Li, Linjiang Tong, Fang Feng, Yan Li, Mengge Zhang, Yaping Xue, Yi Chen, Tao Zhang, Peiran Song, Yi Su, Yanyan Shen, Yiming Sun, Xinying Yang, Yi Chen, Shanyan Yao, Hanyu Yang, Caixia Wang, Meiyu Geng, Wenbin Li, Wenhu Duan, Hua Xie, Jian Ding

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Comparative analysis of image enhancement techniques for braintumor segmentation: contrast, histogram, and hybrid approaches by Saifullah Shoffan, Pranolo Andri, Dreżewski Rafał

“…Results highlight its superior accuracy (0.9982, 0.9939, 0.9936 for training, testing, and validation, respectively) and robust segmentation overlap, with Jaccard values of 0.9862, 0.9847, and 0.9864, and Dice values of 0.993, 0.9923, and 0.9932 for the same phases, emphasizing its potential in neuro-oncological applications. The study concludes with a call for refinement in segmentation methodologies to further enhance diagnostic precision and treatment planning in neuro-oncology.…”
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Immunotherapeutic Strategies for the Treatment of Glioblastoma: Current Challenges and Future Perspectives by Ilaria Salvato, Antonio Marchini

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Neurological Complications of Conventional and Novel Anticancer Treatments by Paola Alberti, Alessandro Salvalaggio, Andreas A. Argyriou, Jordi Bruna, Andrea Visentin, Guido Cavaletti, Chiara Briani

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Modern Management and Diagnostics in HER2+ Breast Cancer with CNS Metastasis by Surbhi Warrior, Adam Cohen-Nowak, Priya Kumthekar

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Low-dose linac-based stereotactic radiosurgery for skull base meningiomas by Irina Kruchok, Olga Chuvashova, Lyudmila Verbova, Andrey Gryazov

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D-2-Hydroxyglutarate in Glioma Biology by Fu-Ju Chou, Yang Liu, Fengchao Lang, Chunzhang Yang

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Coordinated medical care for children with neurofibromatosis type 1 and related RASopathies in Poland by Marek W. Karwacki, Mariusz Wysocki, Marta Perek-Polnik, Agnieszka Jatczak-Gaca

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Possibilities of boron neutron capture therapy in the treatment of malignant brain tumors by V. V. Kanygin, A. I. Kichigin, N. V. Gubanova, S. Yu Taskaev

“…Clinical interest in BNCT focuses in neuro-oncology on therapy for gliomas, glioblastoma in particular, and BNCT may be used in brain metastatic involvement. …”
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Advancements in Neuroimaging to Unravel Biological and Molecular Features of Brain Tumors by Francesco Sanvito, Antonella Castellano, Andrea Falini

“…Novel findings from diffusion MRI (dMRI), perfusion-weighted imaging (PWI), and MR spectroscopy (MRS) are hereby sifted in order to evaluate the role of quantitative imaging in neuro-oncology as a tool for predicting molecular profiles, stratifying prognosis, and characterizing tumor tissue microenvironments. …”
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The epitranscriptome of high-grade gliomas: a promising therapeutic target with implications from the tumor microenvironment to endogenous retroviruses by Christian K. Ramsoomair, Michele Ceccarelli, John D. Heiss, Ashish H. Shah

“…However, studying RNA modifications, or RNA epitranscriptomics, is a new frontier within neuro-oncology. RNA epitranscriptomics was discovered in the 1970s, but in the last decade, the extent of modification of mRNA and various non-coding RNAs has emerged and been implicated in transposable element activation and many other oncogenic processes within the tumor microenvironment. …”
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The Application of Long-Read Sequencing to Cancer by Luca Ermini, Patrick Driguez

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Pediatric and adult brain stem and cerebellar robotic biopsies: technical note and preliminary results of a feasibility, safety, and accuracy study by Federico Legnani, Luca Mattei, Andrea Saladino, Edoardo Porto, Paola Gaviani, Tommaso Galbiati, Francesco Prada, Cecilia Casali, Alessandro Perin, Ignazio Vetrano, Francesco DiMeco

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