A preliminary study on transforming growth factor⁃β combined with CD3+, CD4+, CD8+ T cells in detecting the immune microenvironment of glioblastoma by LIU Min⁃ting, DAI Li⁃jun, ZHANG Zhen⁃bin, SHAO Yuan, LAI Ming⁃yao, ZHANG Xiao⁃tan

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Diencephalic syndrome in childhood, a challenging cause of failure to thrive: miniseries and literature review by Sandra Trapani, Barbara Bortone, Martina Bianconi, Chiara Rubino, Iacopo Sardi, Paolo Lionetti, Giuseppe Indolfi

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Targeting miRNA by CRISPR/Cas in cancer: advantages and challenges by Bashdar Mahmud Hussen, Mohammed Fatih Rasul, Snur Rasool Abdullah, Hazha Jamal Hidayat, Goran Sedeeq Hama Faraj, Fattma Abodi Ali, Abbas Salihi, Aria Baniahmad, Soudeh Ghafouri-Fard, Milladur Rahman, Mark C. Glassy, Wojciech Branicki, Mohammad Taheri

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Caveolae-Mediated Extracellular Vesicle (CMEV) Signaling of Polyvalent Polysaccharide Vaccination: A Host–Pathogen Interface Hypothesis by Shengwen Calvin Li, Mustafa H. Kabeer

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The Role of RNA and DNA Aptamers in Glioblastoma Diagnosis and Therapy: A Systematic Review of the Literature by Silvia Nuzzo, Valentina Brancato, Alessandra Affinito, Marco Salvatore, Carlo Cavaliere, Gerolama Condorelli

“…Despite advances in surgical and medical neuro-oncology, the median survival is about 15 months. …”
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Clustering Functional Magnetic Resonance Imaging Time Series in Glioblastoma Characterization: A Review of the Evolution, Applications, and Potentials by Matteo De Simone, Giorgio Iaconetta, Giuseppina Palermo, Alessandro Fiorindi, Karl Schaller, Lucio De Maria

“…This article emphasizes the importance of incorporating cutting-edge data analysis techniques into neuroimaging and neuro-oncology research. By providing a detailed perspective, this approach may guide future investigations and boost the development of tailored therapeutic strategies for GBM.…”
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Imaging Timing After Surgery for Glioblastoma (INTERVAL GB): A multi-centre, UK and Ireland retrospective cohort study by Emily Rose Bligh, Conor Gillespie, Michael T.C. Poon, Georgios Solomou, Melissa Gough, Abdurrahman I. Islim, Christopher P. Millward, Ola Rominiyi, Rasheed Zakaria, Stephen J. Price, Colin Watts, Sophie Camp, Thomas C. Booth, Gerard Thompson, Samantha J. Mills, Adam Waldman, Paul Brennan, Michael D. Jenkinson

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Astrocytic uptake of neuronal corpses promotes cell-to-cell spreading of tau pathology by Tobias Mothes, Benjamin Portal, Evangelos Konstantinidis, Khalid Eltom, Sylwia Libard, Linn Streubel-Gallasch, Martin Ingelsson, Jinar Rostami, Maria Lindskog, Anna Erlandsson

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Extranodal lymphoma: pathogenesis, diagnosis and treatment by Hua Yang, Yang Xun, Chao Ke, Kensuke Tateishi, Hua You

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A Multi-Disciplinary Approach to Diagnosis and Treatment of Radionecrosis in Malignant Gliomas and Cerebral Metastases by Julian Mangesius, Stephanie Mangesius, Matthias Demetz, Christian Uprimny, Gianpaolo Di Santo, Malik Galijasevic, Danijela Minasch, Elke R. Gizewski, Ute Ganswindt, Irene Virgolini, Claudius Thomé, Christian F. Freyschlag, Johannes Kerschbaumer

“…Additionally, we provide the experience of a tertiary tumor center with this important issue in neuro-oncology and provide an institutional pathway dealing with this problem.…”
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Association of Circadian Clock Gene Expression with Glioma Tumor Microenvironment and Patient Survival by Julianie De La Cruz Minyety, Dorela D. Shuboni-Mulligan, Nicole Briceno, Demarrius Young, Mark R. Gilbert, Orieta Celiku, Terri S. Armstrong

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Clinical Decision Support Systems for Brain Tumour Diagnosis and Prognosis: A Systematic Review by Teesta Mukherjee, Omid Pournik, Sarah N. Lim Choi Keung, Theodoros N. Arvanitis

“…This review also examines various CDSS tool types, system features, techniques, accuracy, and outcomes, to provide the latest evidence available in the field of neuro-oncology. An overview of such CDSSs used to support clinical decision-making in the management and treatment of brain tumours, along with their benefits, challenges, and future perspectives has been provided. …”
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Assessment of the hypervascularized fraction of glioblastomas using a volume analysis of dynamic susceptibility contrast-enhanced MRI may help to identify pseudoprogression. by Margaux Roques, Isabelle Catalaa, Magali Raveneau, Justine Attal, Aurore Siegfried, Jean Darcourt, Christophe Cognard, Nicolas Menjot de Champfleur, Fabrice Bonneville

“…<h4>Results</h4>Out of 25 patients, 11 (44%) were classified with pseudoprogression and 14 (56%) with true progression based on the Response Assessement in Neuro-Oncology criteria. rCBVmax was lower for pseudoprogression (3.4 vs. 7.6; p = 0.033) on early follow-up MRI. …”
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Targeting Heat Shock Proteins in Malignant Brain Tumors: From Basic Research to Clinical Trials by Aisha Babi, Karashash Menlibayeva, Torekhan Bex, Aidos Doskaliev, Serik Akshulakov, Maxim Shevtsov

“…Indeed, for several proteins (i.e., HSP10, HSPB1, DNAJC10, HSPA7, HSP90), a direct correlation between the protein level expression and poor overall survival prognosis for patients was demonstrated that provides a possibility to employ them as prognostic markers in neuro-oncology. Although small molecular inhibitors for HSPs, particularly for HSP27, HSP70, and HSP90 families, were studied in various solid and hematological malignancies demonstrating therapeutic potential, still their potential was not yet fully explored in CNS tumors. …”
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A Delphi study to determine the epidemiology and clinical management of patients treated with HDMTX who develop methotrexate (MTX) delayed elimination in France, Germany, Italy, an... by Stefan Bielack, Christopher P. Fox, Khê Hoang‐Xuan, Ariadna Giró‐Perafita, Carmelo Rizzari

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Astrocytic accumulation of tau fibrils isolated from Alzheimer’s disease brains induces inflammation, cell-to-cell propagation and neuronal impairment by Khalid Eltom, Tobias Mothes, Sylwia Libard, Martin Ingelsson, Anna Erlandsson

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PHF6 loss reduces leukemia stem cell activity in an acute myeloid leukemia mouse model by Shengnan Yuan, Mingming Gao, Yizhou Wang, Yanjie Lan, Mengrou Li, Yuwei Du, Yue Li, Wen Ju, Yujin Huang, Ke Yuan, Lingyu Zeng

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Cell-Population Dynamics in Diffuse Gliomas during Gliomagenesis and Its Impact on Patient Survival by Pavel V. Nikitin, Guzel R. Musina, Stanislav I. Pekov, Andrey A. Kuzin, Igor A. Popov, Artem Y. Belyaev, Gregory L. Kobyakov, Dmitry Y. Usachev, Viktor N. Nikolaev, Valentin P. Mikhailov

“…Diffuse gliomas continue to be an important problem in neuro-oncology. To solve it, studies have considered the issues of molecular pathogenesis from the intratumoral heterogeneity point. …”
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In Vivo Quantitative Imaging of Glioma Heterogeneity Employing Positron Emission Tomography by Cristina Barca, Claudia Foray, Bastian Zinnhardt, Alexandra Winkeler, Ulrich Herrlinger, Oliver M. Grauer, Andreas H. Jacobs

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Health Care Burden of Spinal Diseases in the Republic of Korea: Analysis of a Nationwide Database From 2012 Through 2016 by Chang-Hyun Lee, Chun Kee Chung, Chi Heon Kim, Ji-Woong Kwon

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