Assessing the role of sodium fluorescein in peripheral nerve sheath tumors and mimicking lesions surgery: An update after 142 cases by Vittoria Nazzi, Niccolò Innocenti, Nicolò Castelli, Irene Tramacere, Marica Eoli, Vittoria Cojazzi, Laura Gatti, Francesco Acerbi, Jacopo Falco, Ignazio G. Vetrano, Ignazio G. Vetrano, Ignazio G. Vetrano

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Gas Plasma Exposure of Glioblastoma Is Cytotoxic and Immunomodulatory in Patient-Derived GBM Tissue by Sander Bekeschus, Mikael Ispirjan, Eric Freund, Frederik Kinnen, Juliane Moritz, Fariba Saadati, Jacqueline Eckroth, Debora Singer, Matthias B. Stope, Kristian Wende, Christoph A. Ritter, Henry W. S. Schroeder, Sascha Marx

“…In summary, the immuno-modulatory and proapoptotic action shown in this study might be an important step forward to first clinical observational studies on the future discovery of gas plasma technology’s potential in neurosurgery and neuro-oncology especially in putative adjuvant or combinatory GBM treatment settings.…”
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Genomics of MPNST (GeM) Consortium: Rationale and Study Design for Multi-Omic Characterization of NF1-Associated and Sporadic MPNSTs by David T. Miller, Isidro Cortés-Ciriano, Nischalan Pillay, Angela C. Hirbe, Matija Snuderl, Marilyn M. Bui, Katherine Piculell, Alyaa Al-Ibraheemi, Brendan C. Dickson, Jesse Hart, Kevin Jones, Justin T. Jordan, Raymond H. Kim, Daniel Lindsay, Yoshihiro Nishida, Nicole J. Ullrich, Xia Wang, Peter J. Park, Adrienne M. Flanagan

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Dermatologic Effects of Selumetinib in Pediatric Patients with Neurofibromatosis Type 1: Clinical Challenges and Therapeutic Management by Paola Borgia, Gianluca Piccolo, Andrea Santangelo, Cristina Chelleri, Gianmaria Viglizzo, Corrado Occella, Carlo Minetti, Pasquale Striano, Maria Cristina Diana

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Bevacizumab in recurrent WHO grades II–III glioma by Soufyan Annakib, Soufyan Annakib, Valérie Rigau, Valérie Rigau, Amélie Darlix, Amélie Darlix, Catherine Gozé, Catherine Gozé, Catherine Gozé, Hugues Duffau, Hugues Duffau, Luc Bauchet, Luc Bauchet, Marta Jarlier, Michel Fabbro

“…Efficacy was assessed using the high-grade glioma 2017 Response Assessment in Neuro-Oncology criteria. Progression-free survival (PFS) and overall survival (OS) were estimated using the Kaplan–Meier method.ResultsEighty-one patients were included (M/F ratio: 1.7, median age at diagnosis: 38 years) among whom 46 (56.8%) had an initial diagnosis of grade II glioma. …”
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Time to surgery after radiological diagnosis of brain tumours in Pakistan: A nationwide cross-sectional study by Mohammad Hamza Bajwa, Mashal Murad Shah, Muhammad Usman Khalid , Muhammad Shahzad Shamim, Erum Baig , Naveed Zaman Akhunzada, Altaf Ali Laghari , Muhammad Faraz Raghib, Saad bin Anis, Sameen Siddiqi , Syed Ather Enam

“…Keywords: Treatment delay, Neuro-oncology, Time to surgery, Neurosurgery. …”
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Meningioma Surgery in Patients ≥70 Years of Age: Clinical Outcome and Validation of the SKALE Score by Daniel Monden, Florian J. Raimann, Vanessa Neef, Daniel Dubinski, Florian Gessler, Fee Keil, Marie-Thérèse Forster, Michael W. Ronellenfitsch, Patrick N. Harter, Thomas M. Freiman, Elke Hattingen, Volker Seifert, Christian Senft, Peter Baumgarten

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Perilesional edema diameter associated with brain metastases as a predictive factor of response to radiotherapy in non-small cell lung cancer by Oscar Arrieta, Laura Margarita Bolaño-Guerra, Enrique Caballé-Pérez, Luis Lara-Mejía, Jenny G. Turcott, Salvador Gutiérrez, Francisco Lozano-Ruiz, Luis Cabrera-Miranda, Andrés Mauricio Arroyave-Ramírez, Federico Maldonado-Magos, Luis Corrales, Claudio Martín, Ana Pamela Gómez-García, Bernardo Cacho-Díaz, Andrés F. Cardona

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Phase 2 study of pembrolizumab in patients with recurrent and residual high-grade meningiomas by Priscilla K. Brastianos, Albert E. Kim, Anita Giobbie-Hurder, Eudocia Quant Lee, Nancy Wang, April F. Eichler, Ugonma Chukwueke, Deborah A. Forst, Isabel C. Arrillaga-Romany, Jorg Dietrich, Zachary Corbin, Jennifer Moliterno, Joachim Baehring, Michael White, Kevin W. Lou, Juliana Larson, Magali A. de Sauvage, Kathryn Evancic, Joana Mora, Naema Nayyar, Jay Loeffler, Kevin Oh, Helen A. Shih, William T. Curry, Daniel P. Cahill, Fred G. Barker, Elizabeth R. Gerstner, Sandro Santagata

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A DNA Repair and Cell Cycle Gene Expression Signature in Pediatric High-Grade Gliomas: Prognostic and Therapeutic Value by Natacha Entz-Werlé, Laetitia Poidevin, Petr V. Nazarov, Olivier Poch, Benoit Lhermitte, Marie Pierre Chenard, Hélène Burckel, Eric Guérin, Quentin Fuchs, David Castel, Georges Noel, Laurence Choulier, Monique Dontenwill, Eric Van Dyck

“…Background: Pediatric high-grade gliomas (pHGGs) are the leading cause of mortality in pediatric neuro-oncology, displaying frequent resistance to standard therapies. …”
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Histopathologically confirmed radiation-induced damage of the brain – an in-depth analysis of radiation parameters and spatio-temporal occurrence by Mario R. P. Kossmann, Felix Ehret, Siyer Roohani, Sebastian F. Winter, Pirus Ghadjar, Güliz Acker, Carolin Senger, Simone Schmid, Daniel Zips, David Kaul

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Immunotherapy and Modern Radiotherapy Technique for Older Patients with Locally Advanced Head and Neck Cancer: A Proposed Paradigm by the International Geriatric Radiotherapy Group by Nam P. Nguyen, Lyndon Kim, Juliette Thariat, Brigitta G. Baumert, Thandeka Mazibuko, Olena Gorobets, Vincent Vinh-Hung, Huan Giap, Tahir Mehmood, Felix Vincent, Alexander Chi, Trinanjan Basu, Gokoulakrichenane Loganadane, Mohammad Mohammadianpanah, Ulf Karlsson, Eromosele Oboite, Joan Oboite, Ahmed Ali, Brandi R. Page

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Systemic and local immunosuppression in glioblastoma and its prognostic significance by Aleksei A. Stepanenko, Aleksei A. Stepanenko, Anastasiia O. Sosnovtseva, Anastasiia O. Sosnovtseva, Marat P. Valikhov, Marat P. Valikhov, Anastasia A. Chernysheva, Olga V. Abramova, Konstantin A. Pavlov, Vladimir P. Chekhonin, Vladimir P. Chekhonin

“…We call for the inclusion of dynamic assessment of NLR and other blood inflammatory markers (e.g., absolute/total lymphocyte count, platelet-to-lymphocyte ratio, lymphocyte-to-monocyte ratio, systemic immune-inflammation index, and systemic immune response index) in all neuro-oncology studies for rigorous evaluation and comparison of their individual and combinatorial prognostic/predictive significance and relative superiority.…”
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Rescue procedure for isolated dystonia after the secondary failure of globus pallidus internus deep brain stimulation by Suzhen Lin, Lingbing Wang, Yimei Shu, Shunyu Guo, Tao Wang, Hongxia Li, Chencheng Zhang, Bomin Sun, Dianyou Li, Yiwen Wu

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Tumor Mutation Burden, Expressed Neoantigens and the Immune Microenvironment in Diffuse Gliomas by Guangyang Yu, Ying Pang, Mythili Merchant, Chimene Kesserwan, Vineela Gangalapudi, Abdalla Abdelmaksoud, Alice Ranjan, Olga Kim, Jun S. Wei, Hsien-Chao Chou, Xinyu Wen, Sivasish Sindiri, Young K. Song, Liqiang Xi, Rosandra N. Kaplan, Terri S. Armstrong, Mark R. Gilbert, Kenneth Aldape, Javed Khan, Jing Wu

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Detection of gene mutations and gene–gene fusions in circulating cell‐free DNA of glioblastoma patients: an avenue for clinically relevant diagnostic analysis by Vikrant Palande, Tali Siegal, Rajesh Detroja, Alessandro Gorohovski, Rainer Glass, Charlotte Flueh, Andrew A. Kanner, Yoseph Laviv, Sagi Har‐Nof, Adva Levy‐Barda, Marcela Viviana Karpuj, Marina Kurtz, Shira Perez, Dorith Raviv Shay, Milana Frenkel‐Morgenstern

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Effects of Reoperation Timing on Survival among Recurrent Glioblastoma Patients: A Retrospective Multicentric Descriptive Study by Ondrej Kalita, Tomas Kazda, Stefan Reguli, Radim Jancalek, Pavel Fadrus, Marek Slachta, Petr Pospisil, Lukas Krska, Jana Vrbkova, Lumir Hrabalek, Martin Smrcka, Radim Lipina

“…A consecutive cohort of unselected patients (real-world data) from three neuro-oncology cancer centers was analyzed (a total of 109 patients). …”
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The clinical significance of sub-total surgical resection in childhood medulloblastoma: a multi-cohort analysis of 1100 patientsResearch in context by Claire Keeling, Simon Davies, Jack Goddard, Vijay Ramaswamy, Edward C. Schwalbe, Simon Bailey, Debbie Hicks, Steven C. Clifford

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Incidence of malignant brain and other central nervous system tumors (С70–C72) in Siberia and the Russian Far East by L. D. Zhuikova, E. L. Choynzonov, O. A. Ananina, L. V. Pikalova, I. N. Odintsova, G. A. Kononova

“…The development and implementation of a Neuro-Oncology Registry in accordance with the international standards will allow full analysis of the epidemiological situation of malignant brain and other central nervous system tumors.…”
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Single‐cell profiling and zebrafish avatars reveal LGALS1 as immunomodulating target in glioblastoma by Lise Finotto, Basiel Cole, Wolfgang Giese, Elisabeth Baumann, Annelies Claeys, Maxime Vanmechelen, Brecht Decraene, Marleen Derweduwe, Nikolina Dubroja Lakic, Gautam Shankar, Madhu Nagathihalli Kantharaju, Jan Philipp Albrecht, Ilse Geudens, Fabio Stanchi, Keith L Ligon, Bram Boeckx, Diether Lambrechts, Kyle Harrington, Ludo Van Den Bosch, Steven De Vleeschouwer, Frederik De Smet, Holger Gerhardt

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