Cerebral Glutamate Regulation and Receptor Changes in Perioperative Neuroinflammation and Cognitive Dysfunction by Yan Zhang, John-Man-Tak Chu, Gordon-Tin-Chun Wong

“…We will first summarize the current data regarding glutamate in neurotransmission, its receptors, and their regulation and trafficking. …”
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GABABR silencing of nerve terminals by Daniel C Cook, Timothy A Ryan

“…Control of neurotransmission efficacy is central to theories of how the brain computes and stores information. …”
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The cholinergic hypothesis of Alzheimer's disease: a review of progress. by Francis, P, Palmer, A, Snape, M, Wilcock, G

“…Such studies have resulted in the discovery of an association between a decline in learning and memory, and a deficit in excitatory amino acid (EAA) neurotransmission, together with important roles for the cholinergic system in attentional processing and as a modulator of EAA neurotransmission. …”

Sex-dependent sensitivity to positive allosteric modulation of GABA action in an APP knock-in mouse model of Alzheimer's disease: Potential epigenetic regulation by James Auta, Andrea Locci, Alessandro Guidotti, John M. Davis, Hongxin Dong

“…Conflicting evidence suggest that perturbations of GABAergic neurotransmission play crucial roles in disrupting cortical neuronal network oscillations, memory, and cognitive deficits in Alzheimer's disease (AD). …”
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Targeting VGLUT2 in Mature Dopamine Neurons Decreases Mesoaccumbal Glutamatergic Transmission and Identifies a Role for Glutamate Co-release in Synaptic Plasticity by Increasing Ba... by Maria Papathanou, Meaghan Creed, Matthijs C. Dorst, Zisis Bimpisidis, Sylvie Dumas, Hanna Pettersson, Camilla Bellone, Gilad Silberberg, Christian Lüscher, Christian Lüscher, Åsa Wallén-Mackenzie

“…Alterations in DA neurotransmission in the mesoaccumbal pathway has been proposed to contribute to these behavioral alterations but the underlying molecular mechanism remains largely elusive. …”
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Circuit-Selective Striatal Synaptic Dysfunction in the Sapap3 Knockout Mouse Model of Obsessive-Compulsive Disorder by Wan, Yehong, Ade, Kristen K., Caffall, Zachary, Ilcim Ozlu, M., Eroglu, Cagla, Feng, Guoping, Calakos, Nicole

“…Neurotransmission defects in either or both of these circuits could potentially contribute to the OCD-like behaviors of Sapap3 knockout (KO) mice. …”
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Caffeine Delays Ethanol-Induced Sedation in <i>Drosophila</i> by Sonia Tremblay, Yanqiqi Zeng, Aixin Yue, Kiana Chabot, Abigail Mynahan, Stephanie Desrochers, Sarra Bridges, S. Tariq Ahmad

“…Conversely, ethanol is a sedative because it promotes GABAergic neurotransmission, inhibits glutamatergic neurotransmission, and increases the amount of adenosine in the brain. …”
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The involvement of the sigma-1 receptor in neurodegeneration and neurorestoration by Karsten Ruscher, Tadeusz Wieloch

“…Neuroprotection appears to be due to inhibition of cellular Ca2+ toxicity and/or inflammation, and neurorestoration may include balancing abberant neurotransmission or stimulation of synaptogenesis, thus remodelling brain connectivity. …”
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Mechanism of Action of Atypical Antipsychotic Drugs in Mood Disorders by Daniil Grinchii, Eliyahu Dremencov

“…The multimodal stimulatory effect on central monoamine neurotransmission may be thus primarily responsible for the combined antidepressant and antipsychotic therapeutic potential of certain central nervous system (CNS) drugs.…”
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A brain imaging study of dopamine receptor D2 availability in cannabis dependent users after recovery from cannabis-induced psychosis by Aviv M. Weinstein

“…There is increased risk of psychosis associated with cannabis use disorder and the interaction of THC with dopamine neurotransmission is complex. It is important to investigate the recovery from cannabis-induced psychosis and its effects on the brain’s dopamine neurotransmission. …”
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RNA sequencing reveals novel transcripts from sympathetic stellate ganglia during cardiac sympathetic hyperactivity by Bardsley, E, Davis, H, Ajijola, O, Buckler, K, Ardell, J, Shivkumar, K, Paterson, D

“…Enhanced sympathetic activity is a well-established contributor to the pathophysiology of hypertension, however the cellular and molecular changes that increase sympathetic neurotransmission are not known. The aim of this study was to identify key changes in the transcriptome in normotensive and spontaneously hypertensive rats. …”

Serotonin transporter (5-HTT) promoter genotype may influence the prolactin response to clomipramine. by Whale, R, Quested, D, Laver, D, Harrison, P, Cowen, P

“…CONCLUSION: Our findings suggest that acute 5-HT reuptake blockade produces a greater increase in 5-HT neurotransmission in subjects with the ll genotype than in those with an ss genotype. …”

Baseline reward circuitry activity and trait reward responsiveness predict expression of opioid analgesia in healthy subjects. by Wanigasekera, V, Lee, M, Rogers, R, Kong, Y, Leknes, S, Andersson, J, Tracey, I

“…For example, genetic variability of the μ-opioid receptor (MOR)-encoding gene introduces variability in MOR function and endogenous opioid neurotransmission. Emerging evidence suggests that personality trait related to the experience of reward is linked to endogenous opioid neurotransmission. …”

Alternative splicing and RNA editing of the Complexin C-terminus regulates neurotransmitter release in Drosophila by Brija, Elizabeth A.

“…Edit variant N130S contains a phospho-competent residue located in a similar C-terminal region to the Cpx7B PKA phosphorylation site, but the functional significance of Cpx7A RNA editing in regulating neurotransmission and structural plasticity is unknown. …”
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Quantitative Proteomics Reveals Significant Differences between Mouse Brain Formations in Expression of Proteins Involved in Neuronal Plasticity during Aging by Dominika Drulis-Fajdasz, Kinga Gostomska-Pampuch, Przemysław Duda, Jacek Roman Wiśniewski, Dariusz Rakus

“…Here, we present a quantitative analysis of proteins involved in neurotransmission in three brain regions, namely, the hippocampus, the cerebral cortex and the cerebellum, in mice aged 1 and 22 months, using the total protein approach technique. …”
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Understanding the mechanism of action and clinical effects of neuroactive steroids and GABAergic compounds in major depressive disorder by Andrew J. Cutler, Gregory W. Mattingly, Vladimir Maletic

“…Second, as there has been intense interest in treatment approaches for depression that target dysregulated GABAergic neurotransmission, we discuss NASs approved or currently in clinical development for the treatment of depression. …”
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The adenosine hypothesis of schizophrenia into its third decade: From neurochemical imbalance to early life etiological risks by Philipp Singer, Benjamin K. Yee, Benjamin K. Yee

“…The adenosine hypothesis of schizophrenia was conceptualized about two decades ago in an attempt to integrate two prominent theories of neurochemical imbalance that attribute the pathogenesis of schizophrenia to hyperfunction of the mesocorticolimbic dopamine neurotransmission and hypofunction of cortical glutamate neurotransmission. …”
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Breaking Barriers: Exploring Neurotransmitters through In Vivo vs. In Vitro Rivalry by Gabriel Philippe Lachance, Dominic Gauvreau, Élodie Boisselier, Mounir Boukadoum, Amine Miled

“…The innovation of compact, in vivo instruments for neurotransmission analysis holds the potential to reshape disease management. …”
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REAC Antalgic Neuro Modulation in Chronic Post Herpetic Neuralgia by Ana Rita Pinheiro Barcessat, Lucas dos Santos Nunes, Rebeca Góes Gonçalves, Danyela Darienso

“…The chronicity of this symptomatology can be conditioned by the epigenetic modifications induced by the virus on the processes of neurotransmission and sensitivity to pain. The aim of this study is to investigate whether manipulating endogenous bioelectrical activity (EBA), responsible for neurotransmission processes and contributing to the induction of epigenetic modifications, can alleviate pain symptoms. …”
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Dopamine drives Drosophila sechellia adaptation to its toxic host by Sofía Lavista-Llanos, Aleš Svatoš, Marco Kai, Thomas Riemensperger, Serge Birman, Marcus C Stensmyr, Bill S Hansson

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