Effects of Risperidone and Prenatal Poly I:C Exposure on GABA_A Receptors and AKT-GSK3β Pathway in the Ventral Tegmental Area of Female Juvenile Rats by Shiyan Chen, Jiamei Lian, Yueqing Su, Chao Deng

“…This study suggests that Poly I:C-elicited maternal immune activation and risperidone differentially modulate GABAergic neurotransmission and AKT-GSK3β signaling in the VTA of adolescent rats.…”
Get full text

Dopamine pathology in schizophrenia: Analysis of total and phosphorylated tyrosine hydroxylase in the substantia nigra by EMMA ePEREZ-COSTAS, MIGUEL eMELENDEZ-FERRO, MATTHEW W RICE, ROBERT R CONLEY, ROSALINDA C ROBERTS

“…Despite the importance of dopamine neurotransmission in schizophrenia, very few studies have addressed anomalies in the mesencephalic dopaminergic neurons of the substantia nigra/ventral tegmental area (SN/VTA). …”
Get full text

Time experience in patients with schizophrenia and affective disorders by Paraskevi Mavrogiorgou, Theresa Thomaßen, Frederike Pott, Vera Flasbeck, Holmer Steinfath, Georg Juckel

“…Regarding the LDAEP, patients with schizophrenia showed a significant negative correlation to time experience in terms of a pathologically increased serotonergic neurotransmission with disturbed time feeling. Conclusions Impairment of time experience seems to play an important role in depression and schizophrenia, both subjectively and objectively, and novel neurobiological correlates have been uncovered. …”
Get full text

When the heart inhibits the brain: Cardiac phases modulate short-interval intracortical inhibition by Mario Paci, Pasquale Cardellicchio, Paolo Di Luzio, Mauro Gianni Perrucci, Francesca Ferri, Marcello Costantini

“…These results show a tight relationship between the cardiac cycle and the inhibitory neurotransmission within M1, and in particular with GABAA-ergic-mediated motor inhibition. …”
Get full text

Genetic contributions to brain serotonin transporter levels in healthy adults by Silvia Elisabetta Portis Bruzzone, Arafat Nasser, Sagar Sanjay Aripaka, Marie Spies, Brice Ozenne, Peter Steen Jensen, Gitte Moos Knudsen, Vibe Gedsoe Frokjaer, Patrick MacDonald Fisher

“…Abstract The serotonin transporter (5-HTT) critically shapes serotonin neurotransmission by regulating extracellular brain serotonin levels; it remains unclear to what extent 5-HTT levels in the human brain are genetically determined. …”
Get full text

Astrocytic Regulation of Endocannabinoid-Dependent Synaptic Plasticity in the Dorsolateral Striatum by Louise Adermark, Rosita Stomberg, Bo Söderpalm, Mia Ericson

“…While the lack of tools to disentangle astrocytes from neurons is a major limitation of this study, our data collectively support a role for astrocytes in modulating basal neurotransmission and eCB-mediated synaptic plasticity.…”
Get full text

The relation between electroconvulsive therapy and dopamine by C. A. Ciobanu, L. Ionescu, L.-M. Geafer, C.-P. Niculae, A.-M. Ciobanu

“…Over the pastyears, extensive research on primates, rodents, and humans has begun to clarify the effects of electroconvulsive seizures (ECS) and ECT on neurotransmission systems such the dopaminergic system. …”
Get full text

Alterations of Amphetamine Reward by Prior Nicotine and Alcohol Treatment: The Role of Age and Dopamine by Andrea Stojakovic, Syed Muzzammil Ahmad, Kabirullah Lutfy

“…Alterations in dopaminergic neurotransmission may be involved in this phenotype.…”
Get full text

Increased seizure sensitivity in pregnant mice with genetic knockdown of acid sensing ion channel 2a is associated with impaired hippocampal inflammatory response by Maria Jones-Muhammad, Qingmei Shao, Junie P. Warrington

“…The purpose of this study was to investigate key molecular targets involving neurotransmission and inflammation that are differentially changed following seizure exposure in pregnant ASIC2a +/- mice. …”
Get full text

Drosophila enabled promotes synapse morphogenesis and regulates active zone form and function by McNeill, Elizabeth M., Thompson, Cheryl, Berke, Brett, Chou, Vivian T., Rusch, Jannette, Duckworth, April, DeProto, Jamin, Taylor, Alicia, Gates, Julie, Gertler, Frank, Keshishian, Haig, Van Vactor, David

“…Background: Recent studies of synapse form and function highlight the importance of the actin cytoskeleton in regulating multiple aspects of morphogenesis, neurotransmission, and neural plasticity. The conserved actin-associated protein Enabled (Ena) is known to regulate development of the Drosophila larval neuromuscular junction through a postsynaptic mechanism. …”
Get full text

Changes in Brain MicroRNAs Contribute to Cholinergic Stress Reactions by Meerson, Ari, Cacheaux, Luisa, Goosens, Ki Ann, Sapolsky, Robert M., Soreq, Hermona, Kaufer, Daniela

“…Mental stress modifies both cholinergic neurotransmission and alternative splicing in the brain, via incompletely understood mechanisms. …”
Get full text

Impaired presynaptic high-affinity choline transporter causes a congenital myasthenic syndrome with episodic apnea by Bauché, S, O'Regan, S, Azuma, Y, Laffargue, F, McMacken, G, Sternberg, D, Brochier, G, Buon, C, Bouzidi, N, Topf, A, Lacène, E, Remerand, G, Beaufrere, A-M, Pebrel-Richard, C, Thevenon, J, El Chehadeh-Djebbar, S, Faivre, L, Duffourd, Y, Ricci, F, Mongini, T, Fiorillo, C, Astrea, G, Burloiu, CM, Butoianu, N, Sandu, C, Servais, L, Bonne, G, Nelson, I, Desguerre, I, Nougues, M-C, Bœuf, B, Romero, N, Laporte, J, Boland, A, Lechner, D, Deleuze, J-F, Fontaine, B, Strochlic, L, Lochmuller, H, Eymard, B, Mayer, M, Nicole, S

“…Inherited defects of peripheral neurotransmission result in congenital myasthenic syndromes (CMSs), a clinically and genetically heterogeneous group of rare diseases with fluctuating fatigable muscle weakness as the clinical hallmark. …”

Candidate Gene Studies of Attention Deficit Hyperactivity Disorder by Esra Guney, Mehmet Fatih Ceylan, Elvan Iseri

“…Molecular genetic studies support the thesis that dopaminergic, serotonergic, and noradrenergic neurotransmission pathways account for the etiology of this complex disease. …”
Get full text

Brain Disorders and Novel Therapeutics by Hanns Möhler

“…Brain function is based on a delicate balance between excitory and inhibitory neurotransmission. Selective circuits of GABAergic inhibitory transmission were targeted by introducing point mutations in defined GABAA receptor subtype genes in mice (knock-in strategy). …”
Get full text

Testosterone and schizophrenia: A clinical review by Pragya Lodha, Sagar Karia

“…DHEA and testosterone are found to influence dopaminergic, glutamatergic and GABAergic neurotransmission systems that are believed to play a role in the pathophysiology of schizophrenia. …”
Get full text

The synthesis and pharmacological evaluation of quisqualic acid and some novel excitatory amino acid mimetics by Okonkwo, P. I.

“…L-Glutamic acid and L-aspartic acid are believed to be the principal initiators of excitatory synaptic neurotransmission in the mammalian central system. A number of molecules of either natural or synthetic origin have been identified as possessing agonist or antagonist properties at glutamate binding sites. …”
Get full text

Identification of a novel perifornical-hypothalamic-area-projecting serotonergic system that inhibits innate panic and conditioned fear responses by Cristian S. Bernabe, Izabela F. Caliman, Aline R. R. de Abreu, Andrei I. Molosh, William A. Truitt, Anantha Shekhar, Philip L. Johnson

“…However, the neural mechanisms of how serotonergic neurotransmission regulates innate panic and fear brain networks are poorly understood. …”
Get full text

Sexual dimorphism in striatal dopaminergic responses promotes monogamy in social songbirds by Kirill Tokarev, Julia Hyland Bruno, Iva Ljubičić, Paresh J Kothari, Santosh A Helekar, Ofer Tchernichovski, Henning U Voss

“…Surprisingly, in unmated males but not in females, striatal dopamine neurotransmission was elevated after hearing songs. Behaviorally too, unmated males but not females persistently exchanged mild punishments in return for songs. …”
Get full text

Neuronal Gamma-Aminobutyric Acid (GABA) Type A Receptors Undergo Cognate Ligand Chaperoning in the Endoplasmic Reticulum by Endogenous GABA by Ping eWang, Randa S Eshaq, Charlie K. Meshul, Charlie K. Meshul, Cynthia eMoore, Cynthia eMoore, Rebecca L. Hood, Rebecca L. Hood, Nancy Jo Leidenheimer

“…Both the efficacy and plasticity of GABAA receptor-mediated neurotransmission depends on the number of surface GABAA receptors. …”
Get full text

Visualizing synaptic dopamine efflux with a 2D composite nanofilm by Chandima Bulumulla, Andrew T Krasley, Ben Cristofori-Armstrong, William C Valinsky, Deepika Walpita, David Ackerman, David E Clapham, Abraham G Beyene

“…Chemical neurotransmission constitutes one of the fundamental modalities of communication between neurons. …”
Get full text