Using fast-scan cyclic voltammetry to investigate monoamine release in BAC transgenic rodent models of Parkinson's Disease by Potgieter, D

“…Potential mechanisms underlying monoamine neurotransmission deficits were also investigated. Furthermore, this thesis explored the evoked release of DA in BAC transgenic rats that express the G2019S and R1441C mutant forms of the human Leucine-rich repeat kinase 2 (LRRK2) gene. …”

Schizophrenia and Depression Co-morbidity: What We Have Learned from Animal Models by James Nicholas Samsom, Albert Hung Choy Wong, Albert Hung Choy Wong, Albert Hung Choy Wong

“…Current models which demonstrate endophenotypes of both schizophrenia and depression are reviewed here, including models of: CSMD1, PDLIM5, GluD1, diabetic db/db mice, NPY, DISC1 and its interacting partners, Reelin, maternal immune activation, and social isolation. Neurotransmission, brain connectivity, the immune system, the environment, and metabolism emerge as potential common mechanisms linking these models and potentially explaining comorbid depression in schizophrenia.…”
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Dopamine Concentration Changes Associated with the Retrodialysis of Methylone and 3,4-Methylenedioxypyrovalerone (MDPV) into the Caudate Putamen by Robert Goldsmith, Amal Aburahma, Jon E. Sprague

“…The findings demonstrate that in vivo retrodialysis can be used to evaluate the effects of SPCs on neurotransmission in the brain.…”
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Are GABAergic drugs beneficial in providing neuroprotection after traumatic brain injuries? A comprehensive literature review of preclinical studies by Shyam Kumar Sudhakar

“…Drugs that target GABAergic neurotransmission are commonly used for sedation in clinical TBI yet their potential to cause neuroprotection is unclear. …”
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Aripiprazole-Induced Oculogyric Crisis: A Pediatric Case Series and A Brief Narrative Review by Pia Bernardo, Alfonso Rubino, Claudia Santoro, Carmela Bravaccio, Marco Pozzi, Simone Pisano

“…Oculogyric crisis (OGC) represent an unusual type of dystonic movement disorder, usually reported as an adverse event of antipsychotic drugs, with acute or tardive onset, likely due to a functional disruption of dopaminergic neurotransmission. It is seldom reported in children with aripiprazole, an atypical antipsychotic commonly used in youths. …”
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Gene Expression and Epigenetic Regulation in the Prefrontal Cortex of Schizophrenia by Wiktor Bilecki, Marzena Maćkowiak

“…Altered gene expression in schizophrenia is related to several biological pathways and networks (synaptic function, neurotransmission, signalling, myelination, immune/inflammatory mechanisms, energy production and response to oxidative stress). …”
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Microstructural and neurochemical plasticity mechanisms interact to enhance human perceptual decision-making. by Joseph J Ziminski, Polytimi Frangou, Vasilis M Karlaftis, Uzay Emir, Zoe Kourtzi

“…Yet, structural plasticity and functional neurotransmission are typically studied at different scales (large-scale networks, local circuits), limiting our understanding of the adaptive interactions that support learning of complex cognitive skills in the adult brain. …”
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Dopamine and norepinephrine role in alcohol-addictive behavior: from correlations to mechanisms by V. P. Grinevich, V. V. Nemets, E. M. Krupitsky, R. R. Gainetdinov, E. A. Budygin

“…Moreover, recent utilization of optogenetics in alcohol research provides with an opportunity in specifying patterns of neurotransmission within dopaminergic and noradrenergic neural circuits that govern ethanol-addictive behavior. …”
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Advances in neurexin studies and the emerging role of neurexin-2 in autism spectrum disorder by Sheraz Khoja, Mulatwa T. Haile, Lulu Y. Chen

“…Further, we discuss distinct synaptic mechanisms underlying the aberrant neurotransmission and behavioral deficits observed in different neurexin mouse models, with focus on recent discoveries from the previously overlooked neurexin-2 gene (Nrxn2 in mice and NRXN2 in humans). …”
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Making the case for prophylactic use of betaine to promote brain health in young (15–24 year old) athletes at risk for concussion by Leena S. Knight, Thomas A. Knight

“…We specifically describe the therapeutic potential of betaine and explore the potential implications of betaine on inhibition mediated by GABA and glycine neurotransmission. The influence of betaine on neurophysiology complement betaine’s role as an osmolyte and metabolite and is consistent with clinical evidence of betaine-mediated improvements to cognitive function (reported in elderly populations) and its anti-convulsant properties. …”
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Carbon Monoxide and Nitric Oxide as Examples of the Youngest Class of Transmitters by Alicja Nowaczyk, Magdalena Kowalska, Jacek Nowaczyk, Grzegorz Grześk

“…The year 2021 is the 100th anniversary of the confirmation of the neurotransmission phenomenon by Otto Loewi. Over the course of the hundred years, about 100 neurotransmitters belonging to many chemical groups have been discovered. …”
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Neuronal activity determines distinct gliotransmitter release from a single astrocyte by Ana Covelo, Alfonso Araque

“…Present results indicate that single astrocytes can decode neuronal activity and, in response, release distinct gliotransmitters to differentially regulate neurotransmission at putative single synapses.…”
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SYT1-Associated Neurodevelopmental Disorder: A Narrative Review by Edith Riggs, Zaynab Shakkour, Christopher L. Anderson, Paul R. Carney

“…Considering the significant role of SYT1 in the physiology of synaptic neurotransmission, dysfunction and degeneration of this protein can result in a severe neurological impairment. …”
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INTERMOLECULAR INTERACTIONS IN NEURONAL FUNCTIONAL SYSTEMS by A. L. Proskura, I. A. Malachin, T. A. Zapara, I. I. Turnaev, V. V. Suslov, A. S. Ratuschnyak

“…The model represents activity-dependent changes of the synaptic transmission efficiency, integration of excitation in the local dendritic network of a neuron, and prolonged maintenance of the new level of neurotransmission.…”
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Taurine Supplementation as a Neuroprotective Strategy upon Brain Dysfunction in Metabolic Syndrome and Diabetes by Zeinab Rafiee, Alba M. García-Serrano, João M. N. Duarte

“…Alterations to taurine homeostasis can impact a number of biological processes, such as osmolarity control, calcium homeostasis, and inhibitory neurotransmission, and have been reported in both metabolic and neurodegenerative disorders. …”
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Diverse Roles of Ceramide in the Progression and Pathogenesis of Alzheimer’s Disease by Md Riad Chowdhury, Hee Kyung Jin, Jae-sung Bae

“…Alzheimer’s disease (AD) is the most common neurodegenerative disorder, and is associated with several pathophysiological features, including cellular dysfunction, failure of neurotransmission, cognitive impairment, cell death, and other clinical consequences. …”
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Inhibitory Synaptic Influences on Developmental Motor Disorders by Matthew J. Fogarty

“…We then investigate the influences that GABAergic and glycinergic neurotransmission has on two major developmental neuromotor disorders: Rett syndrome and spastic cerebral palsy. …”
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Molecular Organization and Regulation of the Mammalian Synapse by the Post-Translational Modification SUMOylation by Isabel Chato-Astrain, Marie Pronot, Thierry Coppola, Stéphane Martin

“…Neurotransmission occurs within highly specialized compartments forming the active synapse where the complex organization and dynamics of the interactions are tightly orchestrated both in time and space. …”
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Aromas Influencing the GABAergic System by Neville Hartley, Craig S. McLachlan

“…The fragrance emitted from a number of plant essential oils has shown promise in recent studies in modulating GABAergic neurotransmission, with GABA_A receptors being the primary therapeutic target. …”
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Actions of Metformin in the Brain: A New Perspective of Metformin Treatments in Related Neurological Disorders by Nuojin Li, Tian Zhou, Erkang Fei

“…Besides its hypoglycemic effects, metformin also can improve cognitive or mood functions in some T2DM patients; moreover, it has been reported that metformin exerts beneficial effects on many neurological disorders, including major depressive disorder (MDD), Alzheimer’s disease (AD) and Fragile X syndrome (FXS); however, the mechanism underlying metformin in the brain is not fully understood. Neurotransmission between neurons is fundamental for brain functions, and its defects have been implicated in many neurological disorders. …”
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