Activation of nucleus accumbens projections to the ventral tegmental area alters molecular signaling and neurotransmission in the reward system by Alaa Khayat, Rami Yaka

“…In the current study, we examined the impact of enhancing these inhibitory inputs on molecular changes and neurotransmission associated with cocaine exposure. Our results unveiled significant reductions in extracellular signal-regulated kinase (ERK) levels in the VTA and medial prefrontal cortex (mPFC) of both cocaine-treated groups compared with the saline control group. …”
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Inhibition of GABAergic Neurotransmission by HIV-1 Tat and Opioid Treatment in the Striatum Involves μ-opioid Receptors by Changqing Xu, Sylvia Fitting

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SHORT-TERM SOCIAL DEFEAT STRESS INDUCES AUTONOMIC AND BEHAVIORAL ALTERATIONS RELATED TO OXYTOCIN NEUROTRANSMISSION IN RATS. by Ivaldo Belem-Filho, Cristiane Busnardo, Gabriel Da Silva, Fernando Corrêa

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Saffron extract interferes with lipopolysaccharide-induced brain activation of the kynurenine pathway and impairment of monoamine neurotransmission in mice by Camille Monchaux de Oliveira, Camille Monchaux de Oliveira, Jennifer Morael, Alexandrine Guille, Camille Amadieu, Sylvie Vancassel, David Gaudout, Lucile Capuron, Line Pourtau, Nathalie Castanon

“…Importantly, this pretreatment also counteracted by that time the impact of LPS on several neurobiological processes contributing to inflammation-induced emotional alterations, in particular the activation of the kynurenine pathway, assessed through the expression of its main enzymes, as well as concomitant impairment of serotonergic and dopaminergic neurotransmission.ConclusionAltogether, this study provides important clues on how saffron extract interferes with brain function in conditions of immune stimulation and supports the relevance of saffron-based nutritional interventions to improve the management of inflammation-related comorbidities.…”
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Excitatory neurotransmission activates compartmentalized calcium transients in Müller glia without affecting lateral process motility by Joshua M Tworig, Chandler J Coate, Marla B Feller

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Ex Vivo Feedback Control of Neurotransmission Using a Photocaged Adenosine A1 Receptor Agonist by Erine Craey, Fabian Hulpia, Jeroen Spanoghe, Simona Manzella, Lars E. Larsen, Mathieu Sprengers, Dimitri De Bundel, Ilse Smolders, Evelien Carrette, Jean Delbeke, Kristl Vonck, Paul Boon, Serge Van Calenbergh, Wytse J. Wadman, Robrecht Raedt

“…The strength of neurotransmission is monitored as the amplitude of stimulus-evoked local field potentials. …”
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Tonic zinc inhibits spontaneous firing in dorsal cochlear nucleus principal neurons by enhancing glycinergic neurotransmission by Perez-Rosello, Tamara, Anderson, Charles T., Ling, Cindy, Lippard, Stephen J., Tzounopoulos, Thanos

“…In many synapses of the CNS, mobile zinc is packaged into glutamatergic vesicles and co-released with glutamate during neurotransmission. Following synaptic release, the mobilized zinc modulates ligand- and voltage-gated channels and receptors, functioning as an inhibitory neuromodulator. …”
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Developmental signature, synaptic connectivity and neurotransmission are conserved between vertebrate hair cells and tunicate coronal cells by Rigon, F, Gasparini, F, Shimeld, S, Candiani, S, Manni, L

C-type natriuretic peptide and NPR-B signalling inhibits cardiac sympathetic neurotransmission and autonomic function. by Buttgereit, J, Shanks, J, Li, D, Hao, G, Athwal, A, Langenickel, T, Wright, H, da Costa Goncalves, A, Monti, J, Plehm, R, Popova, E, Qadri, F, Lapidus, I, Ryan, B, Özcelik, C, Paterson, D, Bader, M, Herring, N

“…AIMS: B-type natriuretic peptide (BNP)-NPR-A receptor signalling inhibits cardiac sympathetic neurotransmission, although, C-type natriuretic peptide (CNP) is the predominant neuropeptide of the nervous system with expression in the heart and vasculature. …”

Investigating the control of striatal dopamine neurotransmission by axonal calcium channels and by striatal neuromodulators: Insights for Parkinson's disease by Brimblecombe, K, Katherine Brimblecombe

Alpha6-containing nicotinic acetylcholine receptors dominate the nicotine control of dopamine neurotransmission in nucleus accumbens. by Exley, R, Clements, M, Hartung, H, McIntosh, J, Cragg, S

“…Modulation of striatal dopamine (DA) neurotransmission plays a fundamental role in the reinforcing and ultimately addictive effects of nicotine. …”

Changes in plasma prolactin during SSRI treatment: evidence for a delayed increase in 5-HT neurotransmission. by Cowen, P, Sargent, P

“…The secretion of plasma prolactin is, in part, under the tonic regulation of serotonergic pathways and the present results therefore support animal experimental data suggesting that SSRIs produce a delayed increase in some aspects of brain serotonin neurotransmission.…”

Impaired dopaminergic neurotransmission and microtubule-associated protein tau alterations in human LRRK2 transgenic mice. by Melrose, H, Dächsel, J, Behrouz, B, Lincoln, S, Yue, M, Hinkle, K, Kent, C, Korvatska, E, Taylor, J, Witten, L, Liang, Y, Beevers, J, Boules, M, Dugger, B, Serna, V, Gaukhman, A, Yu, X, Castanedes-Casey, M, Braithwaite, A, Ogholikhan, S, Yu, N, Bass, D, Tyndall, G, Schellenberg, G, Dickson, D

“…In vivo analysis of the dopaminergic system revealed abnormal dopamine neurotransmission in both hWT and G2019S transgenic mice evidenced by a decrease in extra-cellular dopamine levels, which was detected without pharmacological manipulation. …”

Natriuretic peptides like NO facilitate cardiac vagal neurotransmission and bradycardia via a cGMP pathway. by Herring, N, Zaman, J, Paterson, D

“…Like NO, BNP and CNP facilitate vagal neurotransmission and bradycardia. This may occur via a cGMP-PDE3-dependent pathway increasing cAMP-PKA-dependent phosphorylation of presynaptic N-type calcium channels.…”

Effect of β2-adrenergic receptor agonists on neurotransmission and neuromuscular junction structure in congenital myasthenic syndromes by Vanhaesebrouck, A

“…</p> <p><em>Aims:</em> It was hypothesized that β2-adrenergic agonists improve neurotransmission by ameliorating postsynaptic structure in congenital myasthenic syndromes.…”

Protein kinase C mediates hypoxia-induced long-term potentiation of NMDA neurotransmission in the visual retinocollicular pathway by Hanna Dumanska, Nikolai Veselovsky

“…We observed that hypoxia-induced LTP of NMDA neurotransmission is associated with the shortening of current kinetics. …”
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Remodeling of Neurotransmission, Chemokine, and PI3K-AKT Signaling Genomic Fabrics in Neuropsychiatric Systemic Lupus Erythematosus by Dumitru Iacobas, Jing Wen, Sanda Iacobas, Noa Schwartz, Chaim Putterman

“…We found that the TWEAK/Fn14 pathway strongly affects the expression level, variability and coordination of the genomic fabrics responsible for neurotransmission and chemokine signaling. Dysregulation of the Phosphoinositide 3-kinase (PI3K)-AKT pathway in the MRL/<i>lpr</i> lupus strain compared with the MRL/+ control and Fn14ko mice was particularly prominent and, therefore, promising as a potential therapeutic target, although the complexity of the transcriptomic fabric highlights important considerations in in vivo experimental models.…”
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Co-exposure to lead, mercury, and cadmium induces neurobehavioral impairments in mice by interfering with dopaminergic and serotonergic neurotransmission in the striatum by Sarita Pyatha, Haesoo Kim, Daeun Lee, Kisok Kim

“…In conclusion, this study demonstrates that simultaneous exposure to different metals can impact key enzymes involved in dopaminergic and serotonergic neurotransmission processes, leading to disruptions in dopamine and serotonin homeostasis and consequently a range of detrimental neurobehavioral effects.…”
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Mild internet use is associated with epigenetic alterations of key neurotransmission genes in salivary DNA of young university students by Eugenia Annunzi, Loreta Cannito, Fabio Bellia, Francesca Mercante, Matteo Vismara, Beatrice Benatti, Alberto Di Domenico, Riccardo Palumbo, Walter Adriani, Bernardo Dell’Osso, Claudio D’Addario

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The Synergistic Effect of Thiamethoxam and Synapsin dsRNA Targets Neurotransmission to Induce Mortality in <i>Aphis gossypii</i> by Xueting Qu, Sijia Wang, Guangze Lin, Mingshan Li, Jie Shen, Dan Wang

“…To further address the function of genes related to neurotransmission, RNA interference (RNAi) was implemented by transdermal delivery of dsRNA targeting <i>synapsin</i> (<i>syn</i>), a gene regulating presynaptic vesicle clustering. …”
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