Epigenetic regulation in major depression and other stress-related disorders: molecular mechanisms, clinical relevance and therapeutic potential by Minlan Yuan, Biao Yang, Gerson Rothschild, J. John Mann, Larry D. Sanford, Xiangdong Tang, Canhua Huang, Chuang Wang, Wei Zhang

“…These epigenetic modification alterations contribute to abnormal neuroendocrine responses, neuroplasticity impairment, neurotransmission and neuroglia dysfunction, which are involved in the pathophysiology of MDD. …”
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Heat Shock Factor 1 Directly Regulates Postsynaptic Scaffolding PSD-95 in Aging and Huntington’s Disease and Influences Striatal Synaptic Density by Nicole Zarate, Taylor A. Intihar, Dahyun Yu, Jacob Sawyer, Wei Tsai, Maha Syed, Luke Carlson, Rocio Gomez-Pastor

“…PSD-95 (<i>Dlg4</i>) is an ionotropic glutamate receptor scaffolding protein essential in synapse stability and neurotransmission. PSD-95 levels are reduced during aging and in neurodegenerative diseases like Huntington’s disease (HD), and it is believed to contribute to synaptic dysfunction and behavioral deficits. …”
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Involvement of the Protein Ras Homolog Enriched in the Striatum, Rhes, in Dopaminergic Neurons’ Degeneration: Link to Parkinson’s Disease by Marcello Serra, Annalisa Pinna, Giulia Costa, Alessandro Usiello, Massimo Pasqualetti, Luigi Avallone, Micaela Morelli, Francesco Napolitano

“…<i>Rhes</i> is one of the most interesting genes regulated by thyroid hormones that, through the inhibition of the striatal cAMP/PKA pathway, acts as a modulator of dopamine neurotransmission. <i>Rhes mRNA</i> is expressed at high levels in the dorsal striatum, with a medial-to-lateral expression gradient reflecting that of both dopamine D₂ and adenosine A_2A receptors. …”
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Disrupted sleep in dystonia depends on cerebellar function but not motor symptoms in mice by Luis E. Salazar Leon, Luis E. Salazar Leon, Luis E. Salazar Leon, Roy V. Sillitoe, Roy V. Sillitoe, Roy V. Sillitoe, Roy V. Sillitoe, Roy V. Sillitoe

“…In both models, excitatory climbing fiber to Purkinje cell neurotransmission is blocked, but only the Ptf1aCre;Vglut2fx/fx mice have severe twisting. …”
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Distinct neurochemical influences on fMRI response polarity in the striatum by Domenic H. Cerri, Daniel L. Albaugh, Lindsay R. Walton, Brittany Katz, Tzu-Wen Wang, Tzu-Hao Harry Chao, Weiting Zhang, Randal J. Nonneman, Jing Jiang, Sung-Ho Lee, Amit Etkin, Catherine N. Hall, Garret D. Stuber, Yen-Yu Ian Shih

“…Our results emphasize the necessity of considering vasoactive neurotransmission alongside neuronal activity when interpreting fMRI signal.…”
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Once induced, it lasts for a long time: the structural and molecular signatures associated with depressive-like behavior after neonatal immune activation by Julia N. Khantakova, Julia N. Khantakova, Natalia P. Bondar, Natalia P. Bondar, Elena V. Antontseva, Vasiliy V. Reshetnikov, Vasiliy V. Reshetnikov

“…Neuroinflammation can lead to disturbances of neurotransmission and to reprogramming of astroglial and microglial brain cells; when combined, the two problems can cause changes in the cytoarchitecture of individual regions of the brain. …”
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<i>N</i>-Hydroxy-<i>N</i>-Propargylamide Derivatives of Ferulic Acid: Inhibitors of Cholinesterases and Monoamine Oxidases by Óscar M. Bautista-Aguilera, José M. Alonso, Marco Catto, Isabel Iriepa, Damijan Knez, Stanislav Gobec, José Marco-Contelles

“…Alzheimer’s disease (AD) is a complex disorder characterized by impaired neurotransmission in cholinergic and monoaminergic neurons, which, in combination with the accumulation of misfolded proteins and increased oxidative stress, leads to the typical features of the disease at the biomolecular level. …”
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Impact of fasting on stress systems and depressive symptoms in patients with major depressive disorder: a cross-sectional study by Britta Stapel, Daniela Fraccarollo, Mechthild Westhoff-Bleck, Johann Bauersachs, Ralf Lichtinghagen, Kirsten Jahn, Alexandra Burkert, Vanessa Buchholz, Stefan Bleich, Helge Frieling, Xiao-Qi Ding, Kai G. Kahl

“…Common antidepressants target neurotransmission and neuronal plasticity, which require adequate energy supply. …”
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Upside down: dissecting impulsivity in attention-deficit hyperactivity disorder through genotype-phenotype association analyses by L. Balogh, A. Pulay, N. Angyal, K. Vincze, T. Kilencz, Z. Nemoda, J. Réthelyi

“…Objectives In our study we investigated whether different forms of impulsivity (attentive, motor, and nonplanning) and polymorphisms in genes of the noradrenergic, serotonergic, and dopaminergic neurotransmission, i.e. dopamine transporter-1 (DAT1), cathecoloamin-O-metiltransferase (COMT), and serotonin receptor-1B (HTR1B genes show association. …”
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Sensorineural Hearing Loss in a Child with Succinic Semialdehyde Dehydrogenase Deficiency by Parezanović M, Ilić N, Ostojić S, Stevanović G, Ječmenica J, Maver A, Sarajlija A

“…It is known that central auditory processing depends on a delicate balance between excitatory and inhibitory neurotransmission, and GABA is known to play a significant role in this process. …”
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Noradrenaline blockade specifically enhances metacognitive performance by Tobias U Hauser, Micah Allen, Nina Purg, Michael Moutoussis, Geraint Rees, Raymond J Dolan

“…This enhancement points to a regulatory role for noradrenergic neurotransmission in perceptual metacognition.…”
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Kinetics and computational study of butyrylcholinesterase inhibition by methylrosmarinate: relevance to Alzheimer’s disease treatment by Sani Muhammad Uzairu, Yahaya Tijani, Madu Adamu Gadaka, Babagana Modu, Miriam Watafua, Hadiza Ali Ahmad, Umar Abdullahi Zakariya, Aminu Ibrahim, Aliyu Daja, Hassan Zanna, Abdullahi Balarabe Sallau

“…Experimental studies have shown that the function of BChE in the attenuation of cholinergic neurotransmission is essentially altered in brains of advanced AD patients. …”
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Maniform episode related to memantine therapy: unraveling of an unknown adverse side effect? by Catarina da Costa Campos, Joana Mesquita

“…Memantine reduces abnormal activation of glutamate neurotransmission and thus interferes with the pathophysiology of AD, improves cognitive function, and slows the rate of decline over time. …”
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Quantitative Analysis of the Membrane Affinity of Local Anesthetics Using a Model Cell Membrane by Wanjae Choi, Hyunil Ryu, Ahmed Fuwad, Seulmini Goh, Chaoge Zhou, Jiwook Shim, Masahiro Takagi, Soonjo Kwon, Sun Min Kim, Tae-Joon Jeon

“…Local anesthesia is a drug that penetrates the nerve cell membrane and binds to the voltage gate sodium channel, inhibiting the membrane potential and neurotransmission. It is mainly used in clinical uses to address the pain of surgical procedures in the local area. …”
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Loss of the Synuclein Family Members Differentially Affects Baseline- and Apomorphine-Associated EEG Determinants in Single-, Double- and Triple-Knockout Mice by Vasily Vorobyov, Alexander Deev, Iuliia Sukhanova, Olga Morozova, Zoya Oganesyan, Kirill Chaprov, Vladimir L. Buchman

“…The modulation of various presynaptic mechanisms of neurotransmission is an important function of synucleins, and therefore, it is feasible that their deficiency might affect global electrical activity detected of the brain. …”
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Spinal cord dorsal horn sensory gate in preclinical models of chemotherapy-induced painful neuropathy and contact dermatitis chronic itch becomes less leaky with Kcc2 gene expressi... by Michele Yeo, Qiaojuan Zhang, LeAnne Ding, Xiangjun Shen, Yong Chen, Wolfgang Liedtke

“…Low intraneuronal chloride in spinal cord dorsal horn (SCDH) pain relay neurons is of critical relevance for physiological transmission of primary sensory afferents because low intraneuronal chloride dictates GABA-ergic and glycin-ergic neurotransmission to be inhibitory. If neuronal chloride rises to unphysiological levels, the primary sensory gate in the spinal cord dorsal horn becomes corrupted, with resulting behavioral hallmarks of hypersensitivity and allodynia, for example in pathological pain. …”
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The opposite effect of convulsant drugs on neuronal and endothelial nitric oxide synthase – A possible explanation for the dual proconvulsive/anticonvulsive action of nitric oxide... by Vega Rasgado Lourdes A., Ramón-Gallegos Eva, Rodríguez-Páez Lorena, Alcántara-Farfán Verónica

“…Nitric oxide (NO) participates in processes such as endothelium-dependent vasodilation and neurotransmission/neuromodulation. The role of NO in epilepsy is controversial, attributing it to anticonvulsant but also proconvulsant properties. …”
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Novel crosstalk mechanisms between GluA3 and Epac2 in synaptic plasticity and memory in Alzheimer's disease by Tong Zhang, Amalia M. Dolga, Ulrich L.M. Eisel, Martina Schmidt

“…GluA3 containing α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors (AMPARs) are one of key receptors involved in rapid neurotransmission and synaptic plasticity. Recent studies revealed a novel form of GluA3 involved in neuronal plasticity that is dependent on cyclic adenosine monophosphate (cAMP), rather than N-methyl-d-aspartate (NMDA). …”
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In silico molecular docking and dynamic simulation of anti-cholinesterase compounds from the extract of Catunaregam spinosa for possible treatment of Alzheimer's disease by Sathish Thandivel, Poovarasan Rajan, Tamizharasan Gunasekar, Abisek Arjunan, Sulekha Khute, Srinivasa Rao Kareti, Subash Paranthaman

“…This research has investigated the potential compounds from Catunaregam spinosa as AChE inhibitors as a treatment option for AD, aiming to enhance cholinergic neurotransmission and alleviate cognitive decline. Tacrine, the FDA's first approved treatment for AD, is no longer in use due to its hepatotoxicity. …”
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IL-18 and S100A12 Are Upregulated in Experimental Central Retinal Vein Occlusion by Lasse Jørgensen Cehofski, Anders Kruse, Svend Kirkeby, Alexander Nørgård Alsing, Jonas Ellegaard Nielsen, Kentaro Kojima, Bent Honoré, Henrik Vorum

“…Our findings also suggest that RVO results in compromised neurotransmission and a downregulation of proteins involved in visual perception.…”
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