COMPREHENSIVE TREATMENT OF PATIENTS WITH CHRONIC BRAIN ISCHEMIA. PURPOSEFUL CORRECTION OF COGNITIVE IMPAIRMENT AND RECOVERY OF MOTOR FUNCTIONS AFTER A STROKE by T.V. Cherniy, D.A. Fokina, V.I. Cherniy

“…Perspective direction of protection of the brain from chronic ischemia – direct influence on the systems of neurotransmitters and neuromodulators of the brain, normalization of the ratio of the processes of excitatory and inhibitory neurotransmission, individual approach to the restoration of impaired functions, activation of additional reserves of the brain, based on different treatments. …”
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Green Synthesis, Characterization and Antiepileptic Activity of Herbal Nanoparticles of Mimusops Elengi in Mice by Jayaraman Rajangam, Pushpalatha Sampathi, Narahari Narayan Palei, Anna Balaji, Shyam Sundar A., Bibhash Chandra Mohanta, Vasanth Raj Palanimuthu

“…In both models, MEME-B and MEHNPs exhibited significant anti-epileptic properties, which could be attributed to suppressing excitatory neurohumoral transmission and enhanced inhibitory neurotransmission, as well as a significant increase in antioxidant status. …”
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Axonal energy metabolism, and the effects in aging and neurodegenerative diseases by Sen Yang, Jung Hyun Park, Hui-Chen Lu

“…Axons, key components of the connectome, have high metabolic needs to support neurotransmission and other essential activities. Long-range axons are particularly vulnerable to injury, neurotoxin exposure, protein stress, lysosomal dysfunction, etc. …”
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Paeonol Protection Against Intrastriatal 6-Hydroxydopamine Rat Model of Parkinson\'s Disease by Jamileh Ghalami, Tourandokht Baluchnejad Mojarad, Monireh Mansouri, Safoura Khamse, Mehrdad Roghani

“…Paeonol is a phenolic chemical agent that has shown antioxidant and anti-inflammatory effects in different disorders and promising effects on metabotropic glutamate receptors (mGluR)- and GABAA-mediated neurotransmission. In this research, we tried to show the neuroprotective potential of paeonol in rat PD model induced by intrastriatal 6-hydroxydopamine (6-OHDA). …”
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The Effect of Intrahippocampal Insulin Injection on Scopolamine-induced Spatial Memory Impairment and Extracellular Signal-regulated Kinases Alteration by Ahmad Jahanmahin, Zahra Abbasnejad, Abbas Haghparast, Abolhassan Ahmadiani, Rasoul Ghasemi

“…In addition, the neuromodulator effect of insulin is not potent enough to overwhelm scopolamine-mediated disruptions of synaptic neurotransmission.…”
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Long-Term Shaping of Corticostriatal Synaptic Activity by Acute Fasting by Federica Campanelli, Daniela Laricchiuta, Giuseppina Natale, Gioia Marino, Valeria Calabrese, Barbara Picconi, Laura Petrosini, Paolo Calabresi, Veronica Ghiglieri

“…Here, we explored whether we could retrieve long-term signs of changes in AMPARs subunit composition in dorsal striatal neurons of mice acutely deprived for 12 hours/day for two consecutive days by analyzing glutamatergic neurotransmission and the principal forms of dopamine and glutamate-dependent synaptic plasticity. …”
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Differential effects of SARS-CoV-2 variants on central nervous system cells and blood–brain barrier functions by Alizé Proust, Christophe J. Queval, Ruth Harvey, Lorin Adams, Michael Bennett, Robert J. Wilkinson

“…Lastly wild-type virus increases blood–brain barrier permeability and all variants, except Beta, modulate extracellular glutamate concentration, which can lead to excitotoxicity or altered neurotransmission. Conclusions These results suggest that SARS-CoV-2 is neurotropic, with deleterious consequences for the blood–brain barrier integrity and central nervous system cells, which could underlie neurological disorders following SARS-CoV-2 infection.…”
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Role of mitochondria in brain functions and related disorders by Monu Yadav, Mini Dahiya, Jyoti Dagar, Narender Singh, Nidhi Sharma, Nitin Rawat, Pratibha Dhakla, Neha Minocha, Anil Kumar

“…Mitochondria are important organelles for high energy synthesis, reactive oxygen species balancing, antiapoptotic molecule production, membrane stability, intracellular calcium buffering, neuroplasticity and neurotransmission. Dysfunction in mitochondria is considered to be involved in the pathophysiology of mental problems. …”
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Synthesis and Receptor Binding Studies of α5 GABA_AR Selective Novel Imidazodiazepines Targeted for Psychiatric and Cognitive Disorders by Dishary Sharmin, Md Yeunus Mian, Michael Marcotte, Thomas D. Prevot, Etienne Sibille, Jeffrey M. Witkin, James M. Cook

“…Dysregulation of GABAergic neurotransmission is associated with several psychiatric disorders, including depression, anxiety, and schizophrenia. …”
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Curcumin-Protected PC12 Cells Against Glutamate-Induced Oxidative Toxicity by Chi-Huang Chang, Hua-Xin Chen, George Yü, Chiung-Chi Peng, Robert Y. Peng

“…The glutamate/cystine antiporter system xc– connects the antioxidant defense with neurotransmission and behaviour. Overactivation of ionotropic glutamate receptors induces neuronal death, a pathway called excitotoxicity. …”
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Effects of OnabotulintoxinA on Habituation of Laser Evoked Responses in Chronic Migraine by Marina de Tommaso, Marianna Delussi, Katia Ricci, Anna Montemurno, Irene Carbone, Eleonora Vecchio

“…Neurotoxin may exert a modulating effect on trigeminal nociception, normalizing central neurotransmission.…”
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N-glycoproteomics of brain synapses and synaptic vesicles by Mazdak M. Bradberry, Trenton M. Peters-Clarke, Evgenia Shishkova, Edwin R. Chapman, Joshua J. Coon

“…Summary: At mammalian neuronal synapses, synaptic vesicle (SV) glycoproteins are essential for robust neurotransmission. Asparagine (N)-linked glycosylation is required for delivery of the major SV glycoproteins synaptophysin and SV2A to SVs. …”
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Short- and Long-Term Social Recognition Memory Are Differentially Modulated by Neuronal Histamine by Barbara Rani, Bruna Silva-Marques, Rob Leurs, Maria Beatrice Passani, Patrizio Blandina, Gustavo Provensi

“…Here we demonstrate that disruption or potentiation of histaminergic neurotransmission differentially affects short (STM) and long-term (LTM) social recognition memory. …”
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Behavioral phenotype, intestinal microbiome, and brain neuronal activity of male serotonin transporter knockout mice by Hirotaka Shoji, Kazutaka Ikeda, Tsuyoshi Miyakawa

“…Abstract The serotonin transporter (5-HTT) plays a critical role in the regulation of serotonin neurotransmission. Mice genetically deficient in 5-HTT expression have been used to study the physiological functions of 5-HTT in the brain and have been proposed as a potential animal model for neuropsychiatric and neurodevelopmental disorders. …”
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Non-canonical pathways in the pathophysiology and therapeutics of bipolar disorder by Rodrigo Machado-Vieira, Alan C. Courtes, Carlos A. Zarate, Ioline D. Henter, Husseini K. Manji

“…Diverse pharmacological and non-pharmacological approaches targeting neurobiological pathways other than neurotransmission have also been tested in mood disorders. …”
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Age-related changes of GAD1 mRNA expression in the central inferior colliculus by Christina C. Koehler, Laila S. Almassri, Nick Tokar, Amir M. Mafi, Mitchell J. O'Hara, Jesse W. Young, Jeffrey G. Mellott

“…However, the age-related reduction of GABAergic neurotransmission in the IC interrupts temporal precision and likely contributes to presbycusis. …”
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Lipids in Psychiatric Disorders: Functional and Potential Diagnostic Role as Blood Biomarkers by Yana Zorkina, Valeria Ushakova, Aleksandra Ochneva, Anna Tsurina, Olga Abramova, Valeria Savenkova, Anna Goncharova, Irina Alekseenko, Irina Morozova, Daria Riabinina, Georgy Kostyuk, Anna Morozova

“…They are involved in cell function, myelination of neuronal projections, neurotransmission, neural plasticity, energy metabolism, and neuroinflammation. …”
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Long-Interval Intracortical Inhibition and the Cortical Silent Period in Youth by Kelly B. Ahern, Juan F. Garzon, Deniz Yuruk, Maria Saliba, Can Ozger, Jennifer L. Vande Voort, Paul E. Croarkin

“…Background: The cortical silent period (CSP) and long-interval intracortical inhibition (LICI) are putative markers of γ-aminobutyric acid receptor type B (GABA_B)-mediated inhibitory neurotransmission. We aimed to assess the association between LICI and CSP in youths. …”
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Rational metabolic engineering of <i>Corynebacterium glutamicum</i> to create a producer of L-valine by M. E. Sheremetieva, K. E. Anufriev, T. M. Khlebodarova, N. A. Kolchanov, A. S. Yanenko

“…This amino acid not only serves as a building block for proteins, but also regulates protein and energy metabolism and participates in neurotransmission. L-Valine is used in the food and pharmaceutical industries, medicine and cosmetics, but primarily as an animal feed additive. …”
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Reduction of the Morphine Maintenance by Blockade of the NMDA Receptors during Extinction Period in Conditioned Place Preference Paradigm of Rats by Ali Siahposht-Khachaki, Zahra Fatahi, Abbas Haghparast

“…Blockade of glutamatergic neurotransmission reduces the&nbsp;expression of conditioned place preference (CPP) induced by morphine. …”
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