The GABA and GABA-Receptor System in Inflammation, Anti-Tumor Immune Responses, and COVID-19 by Jide Tian, Daniel L. Kaufman

“…GABA and GABA_A-receptors (GABA_A-Rs) play major roles in neurodevelopment and neurotransmission in the central nervous system (CNS). …”
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Virus infection of the CNS disrupts the immune-neural-synaptic axis via induction of pleiotropic gene regulation of host responses by Olga A Maximova, Daniel E Sturdevant, John C Kash, Kishore Kanakabandi, Yongli Xiao, Mahnaz Minai, Ian N Moore, Jeff Taubenberger, Craig Martens, Jeffrey I Cohen, Alexander G Pletnev

“…This pleiotropic gene regulation suggests an unintended off-target negative impact of virus-induced host immune responses on the neurotransmission, which may be a common feature of various viral infections of the CNS.…”
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Effect of Psilocybin and Ketamine on Brain Neurotransmitters, Glutamate Receptors, DNA and Rat Behavior by Adam Wojtas, Agnieszka Bysiek, Agnieszka Wawrzczak-Bargiela, Zuzanna Szych, Iwona Majcher-Maślanka, Monika Herian, Marzena Maćkowiak, Krystyna Gołembiowska

“…The observed changes in neurotransmission might lead to genotoxicity and increased NR2A levels, while not markedly affecting animal behavior.…”
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Terminal type-specific cannabinoid CB1 receptor alterations in patients with schizophrenia: A pilot study by Shinnyi Chou, Kenneth N. Fish, David A. Lewis, Robert A. Sweet

“…Conclusion: Given CB1R's role in suppressing neurotransmission upon activation, these results suggest an overall shift in excitatory and inhibitory balance regulation toward a net reduction of excitatory activity in schizophrenia.…”
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Critical window in autism : a study on Shank3 by Mei, Yuan (Yuan Karen)

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Enhanced inhibitory control by neuropeptide Y Y5 receptor blockade in rats by Dec, A., Lee, J., Song, D., Dale, E., Peterson, J., Zorn, S., Huang, X., Campbell, B., Lee, A. W., Robbins, T. W., West, A. R., Bari, Andrea

“…Conclusions These results suggest that the NPY system modulates inhibitory neurotransmission in brain areas important for impulse control, and may be relevant for the treatment of pathologies such as ADHD and drug abuse.…”
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Investigating the Role of Drosophila Tomosyn in Synaptic Strength and Plasticity by Sauvola, Chad W.

“…Neurotransmission is an adaptation of cellular secretion characterized by precise spatial and temporal regulation of SNARE assembly that occurs at specialized presynaptic subdomains in response to transient calcium influx following an action potential. …”
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A critical role for NMDA receptors in parvalbumin interneurons for gamma induction and behavior by Jones, S. R., Deisseroth, Karl, Carlen, Marie, Meletis, Konstantinos, Siegle, Joshua Handman, Cardin, Jessica A., Futai, Kensuke, Vierling-Claassen, Dorea L., Ruhlmann, C., Sheng, Morgan Hwa-Tze, Moore, Christopher I., Tsai, Li-Huei

“…To address the connection between NMDAR activity, FS PV interneurons, gamma oscillations and behavior, we generated mice lacking NMDAR neurotransmission only in PV cells (PV-Cre/NR1f/f mice). …”
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Regulation of N-type Voltage-Gated Calcium Channels and Presynaptic Function by Cyclin-Dependent Kinase 5 by Su, Susan C., Seo, Jinsoo, Pan, Jen Q., Samuels, Benjamin Adam, Rudenko, Andrii, Ericsson, Maria, Neve, Rachael L., Yue, David T., Tsai, Li-Huei

“…N-type voltage-gated calcium channels localize to presynaptic nerve terminals and mediate key events including synaptogenesis and neurotransmission. While several kinases have been implicated in the modulation of calcium channels, their impact on presynaptic functions remains unclear. …”
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Nonassociative learning as gated neural integrator and differentiator in stimulus-response pathways by Poon, Chi-Sang, Young, Daniel L.

“…Primary and secondary modes of nonassociative learning are distinguished by corresponding activity-dependent recall, or nonassociative gating, of neurotransmission memory. From the perspective of brain computation, nonassociative learning is a form of integral-differential calculus whereas nonassociative gating is a form of Boolean logic operator – both dynamically transforming the stimulus-response relationship. …”
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Structural studies of human GABA-A receptors by Masiulis, S

“…<p>Type-A γ-amino-butyric acid receptors (GABA_ARs) are pentameric ligand-gated ion channels (pLGICs), which mediate the majority of fast inhibitory neurotransmission in the animal central nervous system. …”

Enhanced neuronal nitric oxide synthase expression is central to cardiac vagal phenotype in exercise-trained mice. by Danson, E, Paterson, D

“…There were no differences between the HR responses to the bath-applied acetylcholine analogue carbamylcholine chloride in +EX and -EX atria (IC(50) concentrations were 5.9 +/- 0.4 microM (-EX) and 5.7 +/- 0.4 microM (+EX)), suggesting that the changes in vagal responsiveness resulted from presynaptic facilitation of neurotransmission. In conclusion, NOS-1 appears to be a key protein in generating the cardiac vagal gain of function elicited by exercise training.…”

Altered hippocampal fast oscillations and GABAergic circuits in neuregulin 1 over-expressing mice by Nissen, W

“…However, synaptic miniature glutamatergic neurotransmission was reduced in identified PV+ basket cells (BCs) and axo-axonic cells (AACs) but not in pyramidal cells. …”

Linkage disequilibrium and association analysis of alpha-synuclein and alcohol and drug dependence in two American Indian populations. by Clarimon, J, Gray, R, Williams, L, Enoch, M, Robin, R, Albaugh, B, Singleton, A, Goldman, D, Mulligan, C

“… BACKGROUND: Alpha-synuclein is involved in dopaminergic neurotransmission and has been implicated in a number of neurodegenerative disorders, such as Parkinson's disease. …”

Small-molecule inhibitors at the PSD-95/nNOS interface protect against glutamate-induced neuronal atrophy in primary cortical neurons. by Doucet, M, O'Toole, E, Connor, T, Harkin, A

“…The PSD-95/nNOS interface may be an attractive target for treating deficits in neuronal outgrowth and atrophy associated with excessive glutamatergic neurotransmission in neurodevelopmental and neurodegenerative conditions.…”

Human mutations in SLITRK3 implicated in GABAergic synapse development in mice by Stephanie Efthymiou, Stephanie Efthymiou, Wenyan Han, Muhammad Ilyas, Jun Li, Yichao Yu, Marcello Scala, Marcello Scala, Marcello Scala, Nancy T. Malintan, Muhammad Ilyas, Nikoleta Vavouraki, Nikoleta Vavouraki, Kshitij Mankad, Kshitij Mankad, Reza Maroofian, Clarissa Rocca, Vincenzo Salpietro, Shenela Lakhani, Eric J. Mallack, Timothy Blake Palculict, Hong Li, Guojun Zhang, Guojun Zhang, Faisal Zafar, Nuzhat Rana, Noriko Takashima, Hayato Matsunaga, Claudia Manzoni, Pasquale Striano, Pasquale Striano, Mark F. Lythgoe, Jun Aruga, Jun Aruga, Wei Lu, Henry Houlden

“…The hallmark of these disorders is impaired postsynaptic neurotransmission at nerve terminals; an impaired neurotransmission resulting in a wide array of (often overlapping) clinical features, including neurodevelopmental impairment, weakness, seizures, and abnormal movements. …”
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Neonatal Maternal Separation Induces Sexual Dimorphism in Brain Development: The Influence on Amino Acid Levels and Cognitive Disorders by Jolanta H. Kotlinska, Pawel Grochecki, Agnieszka Michalak, Anna Pankowska, Katarzyna Kochalska, Piotr Suder, Joanna Ner-Kluza, Dariusz Matosiuk, Marta Marszalek-Grabska

“…Thus, MS stress disturbs amino acids levels mainly in the hippocampus of adult male rats, and enhancement of glutamate neurotransmission reversed recognition memory deficits in these animals.…”
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Taming Microglia in Alzheimer’s Disease: Exploring Potential Implications of Choline Alphoscerate via α7 nAChR Modulation by Anna Flavia Cantone, Chiara Burgaletto, Giulia Di Benedetto, Anna Pannaccione, Agnese Secondo, Carlo Maria Bellanca, Egle Augello, Antonio Munafò, Paola Tarro, Renato Bernardini, Giuseppina Cantarella

“…We have previously shown that choline alphoscerate (α-GPC), a cholinergic neurotransmission-enhancing agent, protects from Aβ-mediated neurotoxicity. …”
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Testosterone regulation of sex steroid-related mRNAs and dopamine-related mRNAs in adolescent male rat substantia nigra by Purves-Tyson Tertia D, Handelsman David J, Double Kay L, Owens Samantha J, Bustamante Sonia, Weickert Cynthia

“…However, contradictions as to whether testosterone increases or decreases dopamine neurotransmission are found and most studies address this in adult animals. …”
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Longitudinal spatial mapping of lipid metabolites reveals pre-symptomatic changes in the hippocampi of Huntington's disease transgenic mice by Farheen Farzana, Malcolm J. McConville, Thibault Renoir, Shanshan Li, Shuai Nie, Harvey Tran, Anthony J. Hannan, Danny M. Hatters, Berin A. Boughton

“…Hippocampal subfields (CA1, CA3 and DG), which formed the highest density of inclusion formation in the mouse brain showed a reduction in the relative abundance of neuron-enriched lipids that have roles in neurotransmission, synaptic plasticity, neurogenesis, and ER-stress protection. …”
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