Exploring molecular signatures related to the mechanism of aging in different brain regions by integrated bioinformatics by Xie Su, Lu Xie, Jing Li, Xinyue Tian, Bing Lin, Menghua Chen

“…Enrichment analysis indicated molecular changes related to leukocyte invasion, abnormal neurotransmission, and impaired neurogenesis due to inflammation as the major signatures of the CX, HC, and CB. …”
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Native-state proteomics of Parvalbumin interneurons identifies unique molecular signatures and vulnerabilities to early Alzheimer’s pathology by Prateek Kumar, Annie M. Goettemoeller, Claudia Espinosa-Garcia, Brendan R. Tobin, Ali Tfaily, Ruth S. Nelson, Aditya Natu, Eric B. Dammer, Juliet V. Santiago, Sneha Malepati, Lihong Cheng, Hailian Xiao, Duc D. Duong, Nicholas T. Seyfried, Levi B. Wood, Matthew J. M. Rowan, Srikant Rangaraju

“…Furthermore, we demonstrated pre-synaptic defects in PV-to-excitatory neurotransmission, validating our proteomic findings. Overall, in this study we present native-state proteomes of PV-INs, revealing molecular insights into their unique roles in cognitive resiliency and AD pathogenesis.…”
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Serotonin 4 receptor brain binding and oxytocin-promoted affective and social cognition in healthy women – A randomized controlled trial by Vibeke Høyrup Dam, Sidsel Høgsgaard Andersen, Sofie Trolle Pedersen, Dea Siggaard Stenbæk, Vibe Gedsoe Frokjaer

“…Serotonin (5-HT) neurotransmission is also involved in emotional and social behaviors and appear to work in concert with oxytocin. …”
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Striatal increase of dopamine receptor 2 density in idiopathic and syndromic mouse models of autism spectrum disorder by Stuti Chhabra, Stuti Chhabra, Leonardo Nardi, Petra Leukel, Clemens J. Sommer, Clemens J. Sommer, Michael J. Schmeisser, Michael J. Schmeisser

“…In these models, and in humans with ASD, alterations in dopaminergic metabolism and neurotransmission were highlighted. Still, accurate knowledge about the distribution of dopamine receptor densities in the basal ganglia is lacking. …”
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Neuronal Calcium Sensor-1 Protects Cortical Neurons from Hyperexcitation and Ca²⁺ Overload during Ischemia by Protecting the Population of GABAergic Neurons by Elena G. Varlamova, Egor Y. Plotnikov, Egor A. Turovsky

“…Neuronal calcium sensor-1 (NCS-1) is a signaling protein that is expressed in all types of neurons and is involved in the regulation of neurotransmission. The role of NCS-1 in the protection of neurons and especially their individual populations from ischemia and hyperexcitation has not been practically studied. …”
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Genetic removal of synaptic Zn2+ impairs cognition, alters neurotrophic signaling and induces neuronal hyperactivity by Emily C. Vogler, Matthew Mahavongtrakul, Kristianna Sarkan, Ryan C. Bohannan, Silvina Catuara-Solarz, Jorge Busciglio, Jorge Busciglio, Jorge Busciglio

“…We used both sexes of a transgenic mouse model lacking synaptic Zn2+ (ZnT3KO) that develops AD-like cognitive impairment and neurodegeneration to study the effects of disruption of Zn2+ modulation of neurotransmission in cognition, protein expression and activation, and neuronal excitability. …”
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Effects of Reduced Seawater pH and Oil Contamination on Bacterial Communities and Biochemical Markers of Estuarine Animal Hosts by António Louvado, Victor Galhano, Fernanda Lima, Daniel F. R. Cleary, Isabel Lopes, Newton C. M. Gomes, Francisco J. R. C. Coelho

“…The response of host-associated bacterial communities was assessed using the high-throughput sequencing of the 16S rRNA gene and several biochemical markers related to host metabolic pathways, e.g., neurotransmission, anaerobic metabolism, biotransformation, oxidative stress, and energy consumption. …”
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Analysis of volatile ingredients of selected essential oils listing relaxing action by Małgorzata Kucharska, Jadwiga A. Szymańska, Wiktor Wesołowski, Barbara Frydrych, Elżbieta Bruchajzer

“…Despite the different chemical structure of active substances contained in the tested oils, it is suggested that the mechanism of the relaxing effect is identical and is associated with the inhibition of glutamatergic neurotransmission, similar to the action of benzodiazepines. …”
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The Role of Vitamin D as a Biomarker in Alzheimer’s Disease by Giulia Bivona, Bruna Lo Sasso, Caterina Maria Gambino, Rosaria Vincenza Giglio, Concetta Scazzone, Luisa Agnello, Marcello Ciaccio

“…Vitamin D helps synaptic plasticity and neurotransmission in dopaminergic neural circuits and exerts anti-inflammatory and neuroprotective activities within the brain by reducing the synthesis of pro-inflammatory cytokines and the oxidative stress load. …”
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Chronic Alcohol Use Induces Molecular Genetic Changes in the Dorsomedial Thalamus of People with Alcohol-Related Disorders by Andreas-Christian Hade, Mari-Anne Philips, Ene Reimann, Toomas Jagomäe, Kattri-Liis Eskla, Tanel Traks, Ele Prans, Sulev Kõks, Eero Vasar, Marika Väli

“…The most prevalent functional categories of upregulated genes were related to glutamatergic and GABAergic neurotransmission, cellular metabolism, and neurodevelopment. …”
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Investigation of Antidepressant Properties of Yohimbine by Employing Structure-Based Computational Assessments by Munazzah Tasleem, Abdulwahed Alrehaily, Tahani M. Almeleebia, Mohammad Y. Alshahrani, Irfan Ahmad, Mohammed Asiri, Nadiyah M. Alabdallah, Mohd Saeed

“…Yohimbine, a natural compound, has been used to treat various ailments, including neurological conditions, since ancient times. Serotonergic neurotransmission plays a crucial role in the pathogenesis of depression; thus, serotonergic receptor agonist/antagonistic drugs are promising anti-depressants. …”
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New Omics—Derived Perspectives on Retinal Dystrophies: Could Ion Channels-Encoding or Related Genes Act as Modifier of Pathological Phenotype? by Luigi Donato, Concetta Scimone, Simona Alibrandi, Ebtesam Mohamed Abdalla, Karim Mahmoud Nabil, Rosalia D’Angelo, Antonina Sidoti

“…However, because such variants did not completely explain the phenotype manifested by each patient, we proceed to further investigate possible related genes carrying mutations that might complement previously found data, based on the common aspect linked to neurotransmission impairments. We found 10 mutated genes whose variants might alter important ligand binding sites differently distributed through all considered patients. …”
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Radiotherapy of the Hepatocellular Carcinoma in Mice Has a Time-Of-Day-Dependent Impact on the Mouse Hippocampus by Mona Yassine, Soha A. Hassan, Simon Sommer, Lea Aylin Yücel, Hanna Bellert, Johanna Hallenberger, Dennis Sohn, Horst-Werner Korf, Charlotte von Gall, Amira A. H. Ali

“…Chronic liver diseases including hepatocellular carcinoma (HCC) create a state of chronic inflammation that affects the brain via the liver–brain axis leading to an alteration of neurotransmission and cognition. However, little is known about the effects of HCC on the hippocampus, the key brain region for learning and memory. …”
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Association of <i>PIP4K2A</i> Polymorphisms with Alcohol Use Disorder by Olga Yu. Fedorenko, Ekaterina V. Mikhalitskaya, Valentina A. Toshchakova, Anton J. M. Loonen, Nikolay A. Bokhan, Svetlana A. Ivanova

“…Background: Alcohol use disorder (AUD) not only influences individuals and families but also has a lasting social impact on communities at the national level. Dopaminergic neurotransmission is involved in excessive alcohol consumption. …”
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An Anthranilate Derivative Inhibits Glutamate Release and Glutamate Excitotoxicity in Rats by Cheng-Wei Lu, Chen-Jung Lin, Pei-Wen Hsieh, Kuan-Ming Chiu, Ming-Yi Lee, Tzu-Yu Lin, Su-Jane Wang

“…The neurotransmitter glutamate plays an essential role in excitatory neurotransmission; however, excessive amounts of glutamate lead to excitotoxicity, which is the most common pathogenic feature of numerous brain disorders. …”
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A case of Pathological Laughter in a patient with recurrent stroke by S. Lakhotia, M. N. Parikh

“…The aetiology of PLC is unknown; monoaminergic neurotransmission may be altered in post stroke PLC. SSRIs are regarded as first choice treatment agents, given their greater tolerability overall. …”
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Adaptogenic property of Asparagus racemosus: Future trends and prospects by Neha Singh, Meenakshi Garg, Priyanka Prajapati, Priyanka Kumari Singh, Rajni Chopra, Anita Kumari, Avneesh Mittal

“…The literature review has also suggested that A. racemosus administration at varied levels alleviates depression by modulating the HPA axis, increasing BDNF levels, and monoaminergic and GABAergic neurotransmission.Alongside, spikes the level of antioxidant enzymes, SOD, GSH peroxidase, GSH, and catalase in distinct brain regions (i.e., hippocampus, prefrontal cortex, amygdala, and hypothalamus) and promote neurogenesis and neuroplasticity. …”
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Effects of antipsychotic and anticholinergic medications on cognition in chronic patients with schizophrenia by Chadia Haddad, Pascale Salameh, Hala Sacre, Jean-Pierre Clément, Benjamin Calvet

“…More studies are needed to explain the role of cholinergic neurotransmission and general neurochemical mechanisms in the cognitive impairment of patients with schizophrenia.…”
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Exposure to Commercial Cigarette Smoke Produces Psychomotor Sensitization via Hyperstimulation of Glutamate Response in the Dorsal Striatum by In Soo Ryu, Jieun Kim, Ju Hwan Yang, Su Yeon Seo, Sumin Sohn, Sunghyun Kim, Kyuhong Lee, Joung-Wook Seo, Eun Sang Choe

“…Exposure to cigarette smoke enhances tobacco dependence by potentiating glutamatergic neurotransmission via stimulation of nicotinic acetylcholine receptors (nAChRs). …”
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The dark side of cannabis - synthetic cannabinoids as the „legal high” by Małgorzata Piechaczek, Magdalena Smolik, Beata Bystrowska

“…Δ9-tetrahydrocannabinol (Δ9-THC), and then the discovery of the neurotransmission system based on the interaction of cannabinoid receptors and their endogenous ligands (endocannabinoids), resulted in enormous interest in these compounds and their potential application in medicine. …”
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