Reduced Striatal Dopamine Transporter Availability and Heightened Response to Natural and Pharmacological Stimulation in CCK-1R-Deficient Obese Rats by Sevag Hamamah, Andras Hajnal, Mihai Covasa

“…Alterations in dopamine neurotransmission are associated with obesity and food preferences. …”
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Lafutidine Facilitates Calcitonin Gene-Related Peptide (CGRP) Nerve-Mediated Vasodilation via Vanilloid-1 Receptors in Rat Mesenteric Resistance Arteries by Tetsuhiro Sugiyama, Yukako Hatanaka, Yukiko Iwatani, Xin Jin, Hiromu Kawasaki

“…The present study examined the effect of lafutidine on neurotransmission of capsaicin-sensitive calcitonin gene-related peptide (CGRP)-containing vasodilator nerves (CGRPergic nerves) in rat mesenteric resistance arteries. …”
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Early Life Stress Alters Expression of Glucocorticoid Stress Response Genes and Trophic Factor Transcripts in the Rodent Basal Ganglia by Cynthia Haidee Tran, Cynthia Shannon Weickert, Thomas Wesley Weickert, Duncan Sinclair

“…Our results suggest that early life stress has long-lasting impacts on brain regions involved in dopamine neurotransmission, changing the trophic environment and potentially altering responsiveness to subsequent stressful events in a sex-specific pattern.…”
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Design, Synthesis and Characterization of a New Series of Fluorescent Metabotropic Glutamate Receptor Type 5 Negative Allosteric Modulators by Víctor Fernández-Dueñas, Mingcheng Qian, Josep Argerich, Carolina Amaral, Martijn D.P. Risseeuw, Serge Van Calenbergh, Francisco Ciruela

“…Accordingly, novel allosteric ligands are being explored in order to finely regulate glutamate neurotransmission, especially in the brain. However, before testing the activity of these new ligands in the clinic or even in animal disease models, it is common to characterize their ability to bind mGlu₅Rs in vitro. …”
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Cross-species comparative analysis of single presynapses by Eloïse Berson, Chandresh R. Gajera, Thanaphong Phongpreecha, Amalia Perna, Syed A. Bukhari, Martin Becker, Alan L. Chang, Davide De Francesco, Camilo Espinosa, Neal G. Ravindra, Nadia Postupna, Caitlin S. Latimer, Carol A. Shively, Thomas C. Register, Suzanne Craft, Kathleen S. Montine, Edward J. Fox, C. Dirk Keene, Sean C. Bendall, Nima Aghaeepour, Thomas J. Montine

“…Integrative analysis of the abundance of 20 presynaptic proteins revealed near-complete separation between primates and mice involving synaptic pruning, cellular energy, lipid metabolism, and neurotransmission. In addition, our analysis revealed a strong overlap between the presynaptic composition of human and macaque in the cerebral cortex and neostriatum. …”
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Functional recovery with peripheral nerve block versus general anesthesia for upper limb surgery: a systematic review by Jennifer Héroux, Pierre-Olivier Bessette, Emilie Belley-Côté, Daphnée Lamarche, Pablo Échavé, Marie-Josée Loignon, Nicolas Patenaude, Jean-Patrice Baillargeon, Frédérick D’Aragon

“…Injection of local anesthetics around the target nerve inhibits the action of voltage-dependent sodium channels, inhibiting neurotransmission of pain impulses and providing motor immobility. …”
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The Novel Monoacylglycerol Lipase Inhibitor MJN110 Suppresses Neuroinflammation, Normalizes Synaptic Composition and Improves Behavioral Performance in the Repetitive Traumatic Bra... by Prabhuanand Selvaraj, Mikiei Tanaka, Jie Wen, Yumin Zhang

“…Our results suggest that augmentation of the endogenous levels of 2-AG can be therapeutically useful in the treatment of TBI by suppressing neuroinflammation and maintaining the balance between excitatory and inhibitory neurotransmission.…”
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In silico evaluation of the role of lisdexamfetamine on attention-deficit/hyperactivity disorder common psychiatric comorbidities: mechanistic insights on binge eating disorder and... by José Ramón Gutiérrez-Casares, Cristina Segú-Vergés, Cristina Segú-Vergés, Juncal Sabate Chueca, Tamara Pozo-Rubio, Mireia Coma, Carmen Montoto, Javier Quintero

“…In BED, vLDX was modeled to act upon neurotransmission and neuroplasticity regulators, and, in depression, vLDX regulated the hypothalamic-pituitary-adrenal axis, neuroinflammation, oxidative stress, and glutamatergic excitotoxicity. …”
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Characterization of a novel positive allosteric modulator of the α1A-Adrenergic receptor by Robert S. Papay, Jonathan D. Macdonald, Shaun R. Stauffer, Dianne M. Perez

“…α1-Adrenergic Receptors (ARs) are G-protein Coupled Receptors (GPCRs) that regulate the sympathetic nervous system via the binding and activation of norepinephrine (NE) and epinephrine (Epi). α1-ARs control various aspects of neurotransmission, cognition, cardiovascular functions as well as other organ systems. …”
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Evaluation of Recombinant Botulinum Neurotoxin Type A1 Efficacy in Peripheral Inflammatory Pain in Mice by Beatrice Oehler, Beatrice Oehler, Cindy Périer, Vincent Martin, Amy Fisher, Stéphane Lezmi, Mikhail Kalinichev, Stephen B. McMahon

“…Well-established efficacy of botulinum neurotoxin type A (BoNT/A) in aesthetic dermatology and neuromuscular hyperactivity disorders relies on canonical interruption of acetylcholine neurotransmission at the neuromuscular junction at the site of the injection. …”
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Acupoint Catgut Embedding Diminishes Fibromyalgia Pain through TRPV1 in the Mouse Brain by Po-Chih Lai, Chia-Ming Yen, I-Han Hsiao, Yung-Hsiang Chen, Yi-Wen Lin

“…Imaging data have demonstrated that central sensitization often occurs in the brain of patients with chronic pain, which arises from imbalanced neurotransmission in the central nervous system. Transient receptor potential vanilloid 1 (TRPV1) is an ion channel to serve as an inflammatory detector in the brain. …”
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Isolation of living dopaminergic neurons labeled with a fluorescent ligand of the dopamine transporter from mouse substantia nigra as a new tool for basic and applied research by Dmitry Troshev, Victor Blokhin, Valeria Ukrainskaya, Anna Kolacheva, Michael Ugrumov

“…A stumbling block in the study of DNs in the whole substantia nigra (SN) is the lack of tools to analyze the expression of most of the genes involved in neurotransmission, neurodegeneration, and neuroplasticity, since they are also expressed in other cells of the SN. …”
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Chronic tianeptine induces tolerance in analgesia and hyperlocomotion via mu-opioid receptor activation in mice by Florence Allain, Florence Allain, Aliza T. Ehrlich, Michael McNicholas, Florence Gross, Weiya Ma, Brigitte L. Kieffer, Brigitte L. Kieffer, Emmanuel Darcq, Emmanuel Darcq

“…In addition to its activity on serotonin and glutamate neurotransmission, tianeptine has been proven to be a mu-opioid receptor (MOR) agonist, but only a few preclinical studies have characterized the opioid-like behavioral effects of tianeptine.MethodsIn this study, we tested tianeptine activity on G protein activation using the [S35] GTPγS binding assay in brain tissue from MOR+/+ and MOR−/− mice. …”
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Neuroimaging in the pre-ictal or premonitory phase of migraine: a narrative review by Nazia Karsan, Peter J. Goadsby

“…Early dysfunctional pain, sensory, limbic and homeostatic processing via monoaminergic and peptidergic neurotransmission likely manifests in the heterogeneous PS phenotype. …”
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Synaptotagmin 2 Mutations Cause an Autosomal-Dominant Form of Lambert-Eaton Myasthenic Syndrome and Nonprogressive Motor Neuropathy by Herrmann, David N., Horvath, Rita, Sowden, Janet E., Gonzales, Michael, Sanchez-Mejias, Avencia, Whittaker, Roger G., Almodovar, Jorge L., Lane, Maria, Bansagi, Boglarka, Pyle, Angela, Boczonadi, Veronika, Lochmüller, Hanns, Griffin, Helen, Chinnery, Patrick F., Lloyd, Thomas E., Zuchner, Stephan, Guan, Zhuo, Littleton, J. Troy

“…Synaptotagmin 2 is a synaptic vesicle protein that functions as a calcium sensor for neurotransmission but has not been previously associated with human disease. …”
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Regulation of synaptic function and plasticity by cyclin-dependent kinase 5 by Su, Susan C. (Susan Chih-Chieh)

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Genetic analysis of the Complexin trans-clamping model for cross-linking SNARE complexes in vivo by Littleton, J. Troy, Kummel, Daniel, Baguley, Stephanie Wood, Coleman, Jeff, Rothman, James E., Cho, Richard W., Li, Feng, 1968 Oct. 24-

“…Complexin (Cpx) is a SNARE-binding protein that regulates neurotransmission by clamping spontaneous synaptic vesicle fusion in the absence of Ca[superscript 2+] influx while promoting evoked release in response to an action potential. …”
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Discovery and characterization of novel peptide biologics in herbal medicine by Nguyen, Kien Truc Giang

“…They display a wide range of biological activities such as antimicrobial, immunomodulation, neurotransmission and hormonal functions. Most biologics are derived from animal sources with few representatives from plants. …”
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Investigating the function of a pentameric ligand-gated ion channel with molecular simulation by Dämgen, MA

“…<p>Pentameric ligand-gated ion channels (pLGICs) are key players in mediating fast neurotransmission. Upon neurotransmitter binding, they undergo conformational changes that lead to the opening of the channel pore, allowing ions to flow in or out of the cell. …”

A novel congenital myasthenic syndrome due to decreased acetylcholine receptor ion-channel conductance by Webster, R, Maxwell, S, Spearman, H, Tai, K, Beckstein, O, Sansom, M, Beeson, D

“…Muscle acetylcholine receptor ion channels mediate neurotransmission by depolarizing the postsynaptic membrane at the neuromuscular junction. …”