A novel congenital myasthenic syndrome due to decreased acetylcholine receptor ion-channel conductance. by Webster, R, Maxwell, S, Spearman, H, Tai, K, Beckstein, O, Sansom, M, Beeson, D

“…Muscle acetylcholine receptor ion channels mediate neurotransmission by depolarizing the postsynaptic membrane at the neuromuscular junction. …”

The A30P α-synuclein mutation decreases subventricular zone proliferation by Zhang, X-M, Anwar, S, Kim, Y, Brown, J, Comte, I, Cai, H, Cai, N-N, Wade-Martins, R, Szele, FG

“…Alpha-synuclein (α-syn or <em>Snca</em>) modulates dopaminergic neurotransmission, and <em>SNCA</em> mutations cause familial PD, but how α-syn and its mutations affect adult neurogenesis is unclear. …”

Unveiling amyloid-β1–42 interaction with zinc in water and mixed hexafluoroisopropanol solution in Alzheimer’s disease by Ghani, Nur Syafiqah Abdul, Karjiban, Roghayeh Abedi, Basri, Mahiran, Faujan, Nur Hana, Wui, Zhuan Lim

“…High concentrations of Zn are normally released during neurotransmission process. The release of Zn might cause the aggregation of Aβ leading to AD. …”
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The effects of zolpidem on spatial memory, cellular and ionic co-transporters (KCC2/NKCC1) in the hippocampus of lithium-pilocarpine rat model by Othman, Muhammad Zulfadhli

“…These results suggest that despite unobservable overt recovery in learning and memory impairment and histopathological changes, zolpidem may partly involve in molecular restoration especially through KCC2 and NKCC1 protein expression in the hippocampus, which is vital for an efficient inhibitory neurotransmission in the brain.…”
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Binge alcohol drinking alters the differential control of cholinergic interneurons over nucleus accumbens D1 and D2 medium spiny neurons by Jenya Kolpakova, Jenya Kolpakova, Vincent van der Vinne, Pablo Gimenez-Gomez, Timmy Le, Timmy Le, Gilles E. Martin

“…In the nucleus accumbens (NAc), a brain region that mediates rewarding properties of substance abuse, acetylcholine regulates glutamatergic, dopaminergic, and GABAergic neurotransmission in naïve mice. However, it is unclear how ChIs orchestrate the control of these neurotransmitters/modulators to determine the synaptic excitability of medium spiny neurons (MSNs), the only projecting neurons that translate accumbens electrical activity into behavior. …”
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Behavioral and neuro-functional consequences of eliminating the KCNQ3 GABA binding site in mice by Kiki J. Chen, Ryan Yoshimura, Clarissa Adriana Edmundo, Tri Minh Truong, Olivier Civelli, Amal Alachkar, Amal Alachkar, Amal Alachkar, Geoffrey W. Abbott

“…We previously found that GABA directly binds to and activates channels containing KCNQ3, challenging the traditional understanding of inhibitory neurotransmission. To investigate the functional significance and behavioral role of this direct interaction, mice with a mutated KCNQ3 GABA binding site (Kcnq3-W266L) were generated and subjected to behavioral studies. …”
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Glyphosate: Impact on the microbiota-gut-brain axis and the immune-nervous system, and clinical cases of multiorgan toxicity by Jarosław Mazuryk, Katarzyna Klepacka, Włodzimierz Kutner, Piyush Sindhu Sharma

“…According to preclinical and clinical studies covered in the present review, poisoning with GLP, GLP-SH, and GBHs devastatingly affects gut microbiota and the microbiota-gut-brain (MGB) axis, leading to dysbiosis and gastrointestinal (GI) ailments, as well as immunosuppression and inappropriate immunostimulation, cholinergic neurotransmission dysregulation, neuroendocrinal system disarray, and neurodevelopmental and neurobehavioral alterations. …”
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Effect of Noise and Music on Neurotransmitters in the Amygdala: The Role Auditory Stimuli Play in Emotion Regulation by Haoyang Nian, Susu Ding, Yanru Feng, Honggui Liu, Jianhong Li, Xiang Li, Runxiang Zhang, Jun Bao

“…We hypothesized that long-term noise exposure would induce anxiety and cause acute stress, exhibited by alterations in neurotransmission in the amygdala. A total of 72 hybrid piglets (Large White × Duroc × Min Pig) were randomly divided into three groups, including noise (exposed to mechanical noise, 80–85 dB), control (blank, exposed to natural background sound, <40 dB), and music (positive control, exposed to Mozart K.448, 60–70 dB) groups. …”
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Understanding How Physical Exercise Improves Alzheimer’s Disease: Cholinergic and Monoaminergic Systems by Boyi Zong, Boyi Zong, Fengzhi Yu, Fengzhi Yu, Xiaoyou Zhang, Xiaoyou Zhang, Wenrui Zhao, Wenrui Zhao, Peng Sun, Peng Sun, Shichang Li, Shichang Li, Lin Li, Lin Li

“…Maintenance of normal neurotransmission is essential to halt AD progression. …”
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Combined transcranial magnetic stimulation and electroencephalography reveals alterations in cortical excitability during pain by Nahian Shahmat Chowdhury, Alan KI Chiang, Samantha K Millard, Patrick Skippen, Wei-Ju Chang, David A Seminowicz, Siobhan M Schabrun

“…These results suggest that the N45 TEP peak, which indexes GABAergic neurotransmission, is implicated in pain perception and is a potential marker of individual differences in pain sensitivity.…”
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Shared genetic susceptibilities for irritable bowel syndrome and depressive disorder in Chinese patients uncovered by pooled whole-exome sequencing by Shiwei Zhu, Meibo He, Zuojing Liu, Zelian Qin, Zhiren Wang, Liping Duan

“…The genes of these variants are important in neurogenesis and neurotransmission. In addition, we found COL6A1 rs13051496, a unique risk variation for IBS-D. …”
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Allosteric modulation of serotonin and dopamine transporters: New insights from computations and experiments by Hoang Nguyen, Mary Hongying Cheng, Ji Young Lee, Shaili Aggarwal, Ole Valente Mortensen, Ivet Bahar

“…Human monoamine transporters (MATs) are critical to regulating monoaminergic neurotransmission by translocating their substrates from the synaptic space back into the presynaptic neurons. …”
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Acute sleep deprivation preconditions the heart against ischemia/ reperfusion injury: the role of central GABA-A receptors by Hoda Parsa, Alireza Imani, Mahdieh Faghihi, Esmail Riahi, Mohammad Badavi, Abbas Shakoori, Tayebeh Rastegar, Marjan Aghajani, Sulail Fatima Rajani

“…Objective(s): Central γ-aminobutyric acid (GABA) neurotransmission modulates cardiovascular functions and sleep. …”
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Isolation and monoculture of functional primary astrocytes from the adult mouse spinal cord by Ingrid L. Peterson, Ingrid L. Peterson, Austin D. Thompson, Austin D. Thompson, Austin D. Thompson, Natalie E. Scholpa, Natalie E. Scholpa, Tally Largent-Milnes, Rick G. Schnellmann, Rick G. Schnellmann, Rick G. Schnellmann, Rick G. Schnellmann, Rick G. Schnellmann

“…Astrocytes are a widely heterogenic cell population that play major roles in central nervous system (CNS) homeostasis and neurotransmission, as well as in various neuropathologies, including spinal cord injury (SCI), traumatic brain injury, and neurodegenerative diseases, such as amyotrophic lateral sclerosis. …”
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Neurokinin-2 receptor negatively modulates substance P responses by forming complex with Neurokinin-1 receptor by Lan Phuong Nguyen, Minyeong Cho, Thai Uy Nguyen, Hee-Kyung Park, Huong Thi Nguyen, Kateryna Mykhailova, Sunghoon Hurh, Hong-Rae Kim, Jae Young Seong, Cheol Soon Lee, Byung-Joo Ham, Jong-Ik Hwang

“…Abstract Background Tachykinins and their cognate receptors, neurokinin receptors (NKs) including NK1, NK2, and NK3 play vital roles in regulating various physiological processes including neurotransmission, nociception, inflammation, smooth muscle contractility, and stimulation of endocrine and exocrine gland secretion. …”
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Trace Amine-Associated Receptor 1 (TAAR1) Is a Positive Prognosticator for Epithelial Ovarian Cancer by Tilman L. R. Vogelsang, Aurelia Vattai, Elisa Schmoeckel, Till Kaltofen, Anca Chelariu-Raicu, Mingjun Zheng, Sven Mahner, Doris Mayr, Udo Jeschke, Fabian Trillsch

“…Trace amine-associated receptor 1 (TAAR1) is a G_αs- protein coupled receptor that plays an important role in the regulation of the immune system and neurotransmission in the CNS. In ovarian cancer cell lines, stimulation of TAAR1 via 3-iodothyronamine (T₁AM) reduces cell viability and induces cell death and DNA damage. …”
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Neurons and glial cells acquire a senescent signature after repeated mild traumatic brain injury in a sex-dependent manner by Nicole Schwab, Nicole Schwab, Daria Taskina, Emily Leung, Emily Leung, Brendan T. Innes, Brendan T. Innes, Gary D. Bader, Gary D. Bader, Lili-Naz Hazrati, Lili-Naz Hazrati

“…Cell-type specific changes were also present with evidence of brain immune activation, neurotransmission alterations in both excitatory and inhibitory neurons, and vascular dysfunction. …”
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Inhibition of Enzymes Involved in Neurodegenerative Disorders and A<i>β</i>_1–40 Aggregation by <i>Citrus limon</i> Peel Polyphenol Extract by Rosaria Arcone, Antonio D’Errico, Rosarita Nasso, Rosario Rullo, Annarita Poli, Paola Di Donato, Mariorosario Masullo

“…In this article, we analyzed the effect of polyphenols obtained from the agro-food industry waste of <i>Citrus limon</i> peel (LPE) on key enzymes of cholinergic and aminergic neurotransmission, such as butyryl cholinesterase (BuChE) and monoamine oxidases (MAO)-A/B, on A<i>β</i>_1–40 aggregation and on superoxide dismutase (SOD) 1/2 that affect oxidative stress. …”
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The Novel Analogue of Modafinil CE-158 Protects Social Memory against Interference and Triggers the Release of Dopamine in the Nucleus Accumbens of Mice by Karl Ebner, Simone B. Sartori, Rita Murau, Fabian Kopel, Predrag Kalaba, Vladimir Dragačević, Johann J. Leban, Nicolas Singewald, Mario Engelmann, Gert Lubec

“…Taken together, our findings suggest promnestic effects of the novel dopamine-transporter-inhibitor CE-158 in a social recognition memory test that may be in part mediated via increased dopamine-neurotransmission in the nucleus accumbens. Thus, selective-dopamine-transporter-inhibitors such as CE-158 may represent interesting drug candidates for the treatment of memory complaints observed in humans with cognitive impairments and dementia.…”
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Gallic acid and hesperidin elevate neurotransmitters level and protect against oxidative stress, inflammation and apoptosis in aluminum chloride-induced Alzheimer's disease in rats by Bidemi Emmanuel Ekundayo, Tajudeen Olabisi Obafemi, Blessing Ariyo Afolabi, Olusola Bolaji Adewale, Amos Onasanya, Olukemi Adetutu Osukoya, John Adeolu Falode, Christopher Akintayo, Isaac Adekola Adu

“…Moreover, gallic acid or hesperidin significantly prevented deficits in neurotransmission, oxidative stress and inflammation, while also lowering brain caspase-3 level. …”
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