Using iPSC Models to Understand the Role of Estrogen in Neuron–Glia Interactions in Schizophrenia and Bipolar Disorder by Denis Reis de Assis, Attila Szabo, Jordi Requena Osete, Francesca Puppo, Kevin S. O’Connell, Ibrahim A. Akkouh, Timothy Hughes, Evgeniia Frei, Ole A. Andreassen, Srdjan Djurovic

“…Whilst our current knowledge is that SCZ and BIP are highly heritable and share common pathophysiological mechanisms associated with cellular signaling, neurotransmission, energy metabolism, and neuroinflammation, the development of novel therapies has been hampered by the unavailability of appropriate models to identify novel targetable pathomechanisms. …”
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Neurexins in serotonergic neurons regulate neuronal survival, serotonin transmission, and complex mouse behaviors by Amy Cheung, Kotaro Konno, Yuka Imamura, Aya Matsui, Manabu Abe, Kenji Sakimura, Toshikuni Sasaoka, Takeshi Uemura, Masahiko Watanabe, Kensuke Futai

“…Our results highlight functional roles for Nrxns in 5-HT neurotransmission, 5-HT neuron survival, and the execution of complex behaviors.…”
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The Problem of Malnutrition Associated with Major Depressive Disorder from a Sex-Gender Perspective by Cielo García-Montero, Miguel A. Ortega, Miguel Angel Alvarez-Mon, Oscar Fraile-Martinez, Adoración Romero-Bazán, Guillermo Lahera, José Manuel Montes-Rodríguez, Rosa M. Molina-Ruiz, Fernando Mora, Roberto Rodriguez-Jimenez, Javier Quintero, Melchor Álvarez-Mon

“…Nevertheless, sexual hormones are not the only triggers that alter neurotransmission of monoamines and other neuropeptides. …”
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The long noncoding RNA nHOTAIRM1 is necessary for differentiation and activity of iPSC-derived spinal motor neurons by Paolo Tollis, Erika Vitiello, Francesco Migliaccio, Eleonora D’Ambra, Anna Rocchegiani, Maria Giovanna Garone, Irene Bozzoni, Alessandro Rosa, Annamaria Carissimo, Pietro Laneve, Elisa Caffarelli

“…Finally, the expression of genes essential for synaptic connectivity and neurotransmission is also profoundly impaired when nHOTAIRM1 is absent in spMNs. …”
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Subtle changes in central dopaminergic tone underlie bradykinesia in essential tremor by Donato Colella, Massimiliano Passaretti, Viviana Frantellizzi, Maria Silvia De Feo, Antonio Cannavacciuolo, Luca Angelini, Daniele Birreci, Davide Costa, Giulia Paparella, Andrea Guerra, Giuseppe De Vincentis, Alfredo Berardelli, Matteo Bologna

“…Introduction: In this research, our primary objective was to explore the correlation between basal ganglia dopaminergic neurotransmission, assessed using 123I-FP-CIT (DAT-SPECT), and finger movements abnormalities in patients with essential tremor (ET) and Parkinson’s disease (PD). …”
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Effect of Magnesium Oxide Nanoparticles on Oxidative Stress Parameters to Treat Alzheimer\'s Disease in Adult Male Wistar Rats by Tara Aminoleslamzadeh, Akram Eidi, Pejman Mortazavi, Shahrbanoo Oryan

“…Magnesium plays an important role in neurotransmission. This study aimed to examine magnesium oxide nanoparticles' effect on the parameters of oxidative stress to treat memory deficit in the rat model of Alzheimer's disease with the help of Amyloid-β. …”
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Sex-Specific Proteomic Changes Induced by Genetic Deletion of Fibroblast Growth Factor 14 (FGF14), a Regulator of Neuronal Ion Channels by Mark L. Sowers, Jessica Di Re, Paul A. Wadsworth, Alexander S. Shavkunov, Cheryl Lichti, Kangling Zhang, Fernanda Laezza

“…In the male Fgf14^{−/−} mouse, we found molecular characteristics that, in part, may explain a previously described neurotransmission and behavioral phenotype. This includes decreased levels of ALDH1A1 and protein kinase A (PRKAR2B). …”
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Synthesis and Pharmacological Characterization of 2-Aminoethyl Diphenylborinate (2-APB) Derivatives for Inhibition of Store-Operated Calcium Entry (SOCE) in MDA-MB-231 Breast Cance... by Achille Schild, Rajesh Bhardwaj, Nicolas Wenger, Dominic Tscherrig, Palanivel Kandasamy, Jan Dernič, Roland Baur, Christine Peinelt, Matthias A. Hediger, Martin Lochner

“…Calcium ions regulate a wide array of physiological functions including cell differentiation, proliferation, muscle contraction, neurotransmission, and fertilization. The endoplasmic reticulum (ER) is the major intracellular Ca²⁺ store and cellular events that induce ER store depletion (e.g., activation of inositol 1,4,5-triphosphate (IP₃) receptors) trigger a refilling process known as store-operated calcium entry (SOCE). …”
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Neuromodulation Induced by Sitagliptin: A New Strategy for Treating Diabetic Retinopathy by Hugo Ramos, Patricia Bogdanov, David Sabater, Jordi Huerta, Marta Valeri, Cristina Hernández, Rafael Simó

“…These proteins are involved in vesicle biogenesis, mobilization and docking, membrane fusion and recycling, and synaptic neurotransmission. Sitagliptin was able to significantly prevent the downregulation of all these proteins. …”
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Transcriptome of the synganglion in the tick Ixodes ricinus and evolution of the cys-loop ligand-gated ion channel family in ticks by Claude Rispe, Caroline Hervet, Nathalie de la Cotte, Romain Daveu, Karine Labadie, Benjamin Noel, Jean-Marc Aury, Steeve Thany, Emiliane Taillebois, Alison Cartereau, Anaïs Le Mauff, Claude L. Charvet, Clément Auger, Elise Courtot, Cédric Neveu, Olivier Plantard

“…Many of the genes upregulated in the synganglion were associated with neurotransmission and/or localized in neurons or the synaptic membrane. …”
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Mitochondria DNA copy number, mitochondria DNA total somatic deletions, Complex I activity, synapse number, and synaptic mitochondria number are altered in schizophrenia and bipola... by Sujan C. Das, Brooke E. Hjelm, Brandi L. Rollins, Adolfo Sequeira, Ling Morgan, Audrey A. Omidsalar, Alan F. Schatzberg, Jack D. Barchas, Francis S. Lee, Richard M. Myers, Stanley J. Watson, Huda Akil, William E. Bunney, Marquis P. Vawter

“…Abstract Mitochondrial dysfunction is a neurobiological phenomenon implicated in the pathophysiology of schizophrenia and bipolar disorder that can synergistically affect synaptic neurotransmission. We hypothesized that schizophrenia and bipolar disorder share molecular alterations at the mitochondrial and synaptic levels. …”
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Spatial Memory Training Counteracts Hippocampal GIRK Channel Decrease in the Transgenic APP_Sw,Ind J9 Alzheimer’s Disease Mouse Model by Sara Temprano-Carazo, Ana Contreras, Carlos A. Saura, Juan D. Navarro-López, Lydia Jiménez-Díaz

“…Together, our results support the evidence that GIRK2 could account for the excitatory/inhibitory neurotransmission imbalance found in AD models, and training in a cognitive hippocampal dependent task may have therapeutic benefits of reversing this effect and lessen early AD deficits.…”
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Sleep architecture in drug‐naïve adult patients with epilepsy: Comparison between focal and generalized epilepsy by Carmen Calvello, Mariana Fernandes, Clementina Lupo, Elena Maramieri, Fabio Placidi, Francesca Izzi, Alessandro Castelli, Andrea Pagano, Nicola Biagio Mercuri, Claudio Liguori

“…Therefore, these findings may be explained by the increase in awakenings and sleep stage shifts, which may be attributed to both sleep networks impairment and neurotransmission dysfunction in PWE, and also possibly triggered by paroxysmal interictal abnormalities.…”
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Neurobehavioral sex-related differences in Nf1 +/− mice: female show a “camouflaging”-type behavior by Sofia Santos, Beatriz Martins, José Sereno, João Martins, Miguel Castelo-Branco, Joana Gonçalves

“…This condition has been associated with an increase of gamma-aminobutyric acid (GABA) neurotransmission and, consequently, an excitation/inhibition imbalance associated with autistic-like behavior in both human and animal models. …”
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Effects of the a flavonoid-rich fraction on the acquisition and extinction of fear memory: Pharmacological and molecular approaches by Daniela Rodrigues de Oliveira, Claudia Raquel Zamberlam, Gizelda Maia Rêgo, Alberto J Cavalheiro, Janete Maria Cerutti, Suzete Maria Cerutti

“…The effects of flavonoids have been correlated with their ability to modulate the glutamatergic, serotoninergic and GABAergic neurotransmission; the major targets of these substances are N-methyl-D-aspartic acid receptor (NMDARs), serotonin type1A receptor (5-HT1ARs) and the gamma-aminobutyric acid type A receptors (GABAARs). …”
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NGF-Dependent Changes in Ubiquitin Homeostasis Trigger Early Cholinergic Degeneration in Cellular and Animal AD-Model by Valentina Latina, Silvia Caioli, Cristina Zona, Cristina Zona, Maria Teresa Ciotti, Antonella Borreca, Pietro Calissano, Giuseppina Amadoro, Giuseppina Amadoro

“…We previously reported that impairment of NGF/TrkA signaling pathway in cholinergic-enriched septo-hippocampal primary neurons triggers “dying-back” degenerative processes which occur prior to cell death in concomitance with loss of specific vesicle trafficking proteins, including synapsin I, SNAP-25 and α-synuclein, and with deficit in presynaptic excitatory neurotransmission. Here, we show that in this in vitro neuronal model: (i) UPS stimulation early occurs following neurotrophin starvation (-1 h up to -6 h); (ii) NGF controls the steady-state levels of these three presynaptic proteins by acting on coordinate mechanism(s) of dynamic ubiquitin-C-terminal hydrolase 1 (UCHL-1)-dependent (mono)ubiquitin turnover and UPS-mediated protein degradation. …”
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The standardized extract of Centella asiatica L. Urb attenuates the convulsant effect induced by lithium/pilocarpine without affecting biochemical and haematological parameters in... by Eduardo Rivadeneyra-Domínguez, Isaac Zamora-Bello, Juan Manuel Castañeda-Morales, Joel Jahaziel Díaz-Vallejo, Óscar Rosales-Sánchez, Juan Francisco Rodríguez-Landa

“…This imbalance increases glutamatergic neurotransmission and consequently produces epileptic activity. …”
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Structure, function and drug discovery of GPCR signaling by Lin Cheng, Fan Xia, Ziyan Li, Chenglong Shen, Zhiqian Yang, Hanlin Hou, Suyue Sun, Yuying Feng, Xihao Yong, Xiaowen Tian, Hongxi Qin, Wei Yan, Zhenhua Shao

“…Abstract G protein-coupled receptors (GPCRs) are versatile and vital proteins involved in a wide array of physiological processes and responses, such as sensory perception (e.g., vision, taste, and smell), immune response, hormone regulation, and neurotransmission. Their diverse and essential roles in the body make them a significant focus for pharmaceutical research and drug development. …”
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Cluster headache and kynurenines by Bernadett Tuka, Tamás Körtési, Nikolett Nánási, Ferenc Tömösi, Tamás Janáky, Dániel Veréb, Délia Szok, János Tajti, László Vécsei

“…Abstract Background The glutamatergic neurotransmission has important role in the pathomechanism of primary headache disorders. …”
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Beyond New Neurons in the Adult Hippocampus: Imipramine Acts as a Pro-Astrogliogenic Factor and Rescues Cognitive Impairments Induced by Stress Exposure by Ana R. Machado-Santos, Eduardo Loureiro-Campos, Patrícia Patrício, Bruna Araújo, Nuno Dinis Alves, António Mateus-Pinheiro, Joana Sofia Correia, Mónica Morais, João M. Bessa, Nuno Sousa, Ana J. Rodrigues, João Filipe Oliveira, Luísa Pinto

“…Different studies have demonstrated the important role of astrocytes in the pathophysiology of depression as modulators of neurotransmission and neurovascular coupling. This is evidenced by astrocyte impairments observed in brains of depressed patients and the appearance of depressive-like behaviors upon astrocytic dysfunctions in animal models. …”
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