Drug Repurposing to Inhibit Histamine <i>N</i>-Methyl Transferase by Elvia Mera Jiménez, Teresa Żołek, Paola Gabriela Hernández Perez, Rene Miranda Ruvalcaba, María Inés Nicolás-Vázquez, Maricarmen Hernández-Rodríguez

“…Thus, the enhancement of histaminergic neurotransmission by inhibition of histamine <i>N</i>-methyl transferase (HNMT), which degrades histamine, appears as an important approach. …”
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Inhibitory and excitatory synaptic neuroadaptations in the diazepam tolerant brain by Joshua M. Lorenz-Guertin, Nadya Povysheva, Caitlyn A. Chapman, Matthew L. MacDonald, Marco Fazzari, Aparna Nigam, Jessica L. Nuwer, Sabyasachi Das, Megan L. Brady, Katarina Vajn, Matthew J. Bambino, Susan T. Weintraub, Jon W. Johnson, Tija C. Jacob

“…Thus, reduced inhibitory GABAergic tone and elevated glutamatergic neurotransmission contribute to disrupted excitation/inhibition balance and reduced BZ therapeutic power with benzodiazepine tolerance.…”
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Genes Involved by Dexamethasone in Prevention of Long-Term Memory Impairment Caused by Lipopolysaccharide-Induced Neuroinflammation by Galina T. Shishkina, Tatyana S. Kalinina, Dmitriy A. Lanshakov, Veta V. Bulygina, Natalya P. Komysheva, Anita V. Bannova, Ulyana S. Drozd, Nikolay N. Dygalo

“…DEX pretreatment did not change the expression of these genes, but significantly affected the expression of genes encoding ion channels, primarily calcium and potassium channels, regulators of glutamate (<i>Slc1a2</i>, <i>Grm5</i>, <i>Grin2a</i>), and GABA (<i>Gabrr2</i>, <i>Gabrb2</i>) neurotransmission, which enriched in such GO biological processes as “Regulation of transmembrane transport”, “Cognition”, “Learning”, “Neurogenesis”, and “Nervous system development”. …”
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Therapeutic Effects of a Novel Form of Biotin on Propionic Acid-Induced Autistic Features in Rats by Kazim Sahin, Cemal Orhan, Serdar Karatoprak, Mehmet Tuzcu, Patrick Brice Defo Deeh, Ibrahim Hanifi Ozercan, Nurhan Sahin, Merve Yilmaz Bozoglan, Sarah Sylla, Sara Perez Ojalvo, James R. Komorowski

“…In addition, MgB treatment significantly regulated the neurotoxicity-related cytokines and neurotransmission-related markers. For instance, MgB significantly decreased the expression level of TNF-α, IL-6, IL-17, CCL-3, CCL-5, and CXCL-16 in the brain, compared to the control group (<i>p</i> < 0.05). …”
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The Long-Term Pannexin 1 Ablation Produces Structural and Functional Modifications in Hippocampal Neurons by Carolina Flores-Muñoz, Francisca García-Rojas, Miguel A. Pérez, Odra Santander, Elena Mery, Stefany Ordenes, Javiera Illanes-González, Daniela López-Espíndola, Arlek M. González-Jamett, Marco Fuenzalida, Agustín D. Martínez, Álvaro O. Ardiles

“…The Panx1 channel ablation alters the hippocampus’s glutamatergic neurotransmission, synaptic plasticity, and memory flexibility. …”
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Neuregulins: subcellular localization, signaling pathways and their relationship with neuroplasticity and neurological diseases by Marines Longart, Christian Calderón, Manuel González, María Elena Grela, Juan Carlos Martínez

“…These factors are involved in the regulation of neurotransmission pathways and the modulation of several forms of synaptic plasticity. …”
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Connexin Expression Is Altered in Liver Development of <i>Yotari</i> (<i>dab1 -/-</i>) Mice by Vlatka Paštar, Mirela Lozić, Nela Kelam, Natalija Filipović, Branka Bernard, Yu Katsuyama, Katarina Vukojević

“…Disabled-1 (Dab1) protein is an intracellular adaptor of reelin signaling required for prenatal neuronal migration, as well as postnatal neurotransmission, memory formation and synaptic plasticity. …”
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Genetic labeling reveals spatial and cellular expression pattern of neuregulin 1 in mouse brain by Chen-Yun Ding, Yan-Ting Ding, Haifeng Ji, Yao-Yi Wang, Xinwen Zhang, Dong-Min Yin

“…Nrg1 has broad functions ranging from regulating neurodevelopment to neurotransmission in the nervous system. However, the expression pattern of Nrg1 at the cellular and circuit levels in rodent brain is not full addressed. …”
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Neurotoxicity of bisphenol A exposure on Caenorhabditis elegans induced by disturbance of neurotransmitter and oxidative damage by Yun Wang, Tingting Gai, Lianfeng Zhang, Liangwen Chen, Shunchang Wang, Tao Ye, Weiru Zhang

“…Altogether, the neurobehavioral and developmental toxicity of BPA may be induced by neurotransmission abnormity and oxidative damage. The present data imply that oxidative stress is linked to neuronal damage and neurobehavioral harm resulting from developmental BPA exposure.…”
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Chemogenetic activation of prefrontal astroglia enhances recognition memory performance in rat by Sarah Delcourte, Amel Bouloufa, Renaud Rovera, Cécile Bétry, Erika Abrial, Ouria Dkhissi-Benyahya, Christophe Heinrich, Guillaume Marcy, Olivier Raineteau, Nasser Haddjeri, Guillaume Lucas, Adeline Etiévant

“…Astrocytes are involved in several brain functions, such as homeostasis, neurotransmission, synaptogenesis. However, their role in PFC-mediated modulation of memory has yet to be studied. …”
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Seizures in PPT1 Knock-In Mice Are Associated with Inflammatory Activation of Microglia by Xusheng Zhang, Mengting Wang, Bingyan Feng, Qiuyu Zhang, Jia Tong, Mingyong Wang, Chengbiao Lu, Shiyong Peng

“…These results indicate that seizure in PPT1 KI mice may be associated with microglial activation involved in ATP-sensitive P2X7R signaling and impaired inhibitory neurotransmission.…”
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Involvement of the GABAA Receptor in the Antidepressant-Like Effects Produced by Low and High Doses of the Flavonoid Chrysin in the Rat: A Longitudinal Study by Gabriel Guillén-Ruiz, Blandina Bernal-Morales, Ana Karen Limón-Vázquez, Oscar Jerónimo Olmos-Vázquez, Juan Francisco Rodríguez-Landa

“…The mechanism for the antidepressant-like effect of low chrysin appears to be GABAergic, whereas the effect of high dose chrysin may involve other neurotransmission and neuromodulation systems related to the serotonergic system.…”
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Nogo-A antibody delivery through the olfactory mucosa mitigates experimental autoimmune encephalomyelitis in the mouse CNS by Vincent Pernet, Sandrine Joly, Sebastian Spiegel, Ivo Meli, Sherif Idriss, Frank Maigler, Julius Baya Mdzomba, Anna K. Roenneke, Alessandra Franceschini, Ludovico Silvestri, Francesco S. Pavone, Martino Calamai, Katharina Schindowski, Andrew Chan

“…In the brain of EAE score-matched animals, 11C7 modified the expression of genes that can influence neurotransmission and cognitive functions, independently of the demyelination phenotype in the spinal cord. …”
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Aland Island Eye Disease with Retinoschisis in the Clinical Spectrum of <i>CACNA1F</i>-Associated Retinopathy—A Case Report by Dorota Wyględowska-Promieńska, Marta Świerczyńska, Dorota Śpiewak, Dorota Pojda-Wilczek, Agnieszka Tronina, Mariola Dorecka, Adrian Smędowski

“…They result from mutations in the <i>CACNA1F</i> gene encoding the α_1F subunit of the Cav1.4 channel, which plays a key role in neurotransmission from rod and cone photoreceptors to bipolar cells. …”
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A C. elegans neuron both promotes and suppresses motor behavior to fine tune motor output by Zhaoyu Li, Zhaoyu Li, Jiejun Zhou, Jiejun Zhou, Khursheed A. Wani, Khursheed A. Wani, Teng Yu, Teng Yu, Elizabeth A. Ronan, Beverly J. Piggott, Beverly J. Piggott, Jianfeng Liu, X.Z. Shawn Xu

“…This dual function is achieved via the excitation and inhibition of the same motor circuit by electrical and chemical neurotransmission, respectively. Additionally, this bi-directional regulation contributes to motor adaptation in animals placed in novel environments. …”
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Coexistence of chronic hyperalgesia and multilevel neuroinflammatory responses after experimental SCI: a systematic approach to profiling neuropathic pain by Lei Wang, Mehmet A. Gunduz, Ana T. Semeano, Enis C. Yılmaz, Feras A. H. Alanazi, Ozan B. Imir, Ulas Yener, Christian A. Arbelaez, Esteban Usuga, Yang D. Teng

“…We hypothesized that multilocus neuroinflammation (NIF) might be a driver of SCI NP, and tested it by investigating whether NP coexisted with central NIF, neurotransmission (NTM), neuromodulation (NML) and neuroplasticity (NPL) changes post-SCI. …”
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Multi-Omics Approach to Elucidate Cerebrospinal Fluid Changes in Dogs with Intervertebral Disc Herniation by Anita Horvatić, Andrea Gelemanović, Boris Pirkić, Ozren Smolec, Blanka Beer Ljubić, Ivana Rubić, Peter David Eckersall, Vladimir Mrljak, Mark McLaughlin, Marko Samardžija, Marija Lipar

“…Together with metabolic pathways related to amino acids and lipid metabolism and coagulation cascades, our integromics prediction model identified the key features in IVDH, namely the proteins follistatin Like 1 (FSTL1), secretogranin V (SCG5), nucleobindin 1 (NUCB1), calcitonin re-ceptor-stimulating peptide 2 precursor (CRSP2) and the metabolites N-acetyl-D-glucosamine and adenine, involved in neuropathic pain, myelination, and neurotransmission and inflammatory response, respectively. …”
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p21-activated kinase 1 restricts tonic endocannabinoid signaling in the hippocampus by Shuting Xia, Zikai Zhou, Celeste Leung, Yuehua Zhu, Xingxiu Pan, Junxia Qi, Maria Morena, Matthew N Hill, Wei Xie, Zhengping Jia

“…We show here that disruption of PAK1 in mice suppresses inhibitory neurotransmission through an increase in tonic, but not phasic, secretion of endocannabinoids (eCB). …”
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A Study on the Combination of Enzyme Stabilizers and Low Temperatures in the Long-Term Storage of Glutamate Biosensor by Andrea Bacciu, Paola Arrigo, Rossana Migheli, Alessandra T. Peana, Gaia Rocchitta, Pier Andrea Serra

“…The importance of physiological glutamate has been widely demonstrated in cognitive and memory processes, as well as in neurotransmission. The involvement of physiological glutamate in several pathologies has also been established. …”
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D-limonene Inhibits Pentylenetetrazole-Induced Seizure via Adenosine A2A Receptor Modulation on GABAergic Neuronal Activity by Sowoon Seo, Yunjeong Song, Sun Mi Gu, Hyun Kyu Min, Jin Tae Hong, Hye Jin Cha, Jaesuk Yun

“…Furthermore, the adenosine A2A antagonist SCH58261 and ZM241385 inhibited anticonvulsant activity and gamma-aminobutyric acid (GABA)ergic neurotransmission-induced by D-limonene. Conclusion: These results suggest that D-limonene exhibits anticonvulsant activity through modulation of adenosine A2A receptors on GABAergic neuronal function.…”
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