Determination of steady-state transcriptome modifications associated with repeated homotypic stress in the rat rostral posterior hypothalamic region by Serge Campeau, Connor McNulty, Jacob T. Stanley, Jacob T. Stanley, Anthony N. Gerber, Anthony N. Gerber, Sarah K. Sasse, Robin D. Dowell, Robin D. Dowell, Robin D. Dowell

“…Gene ontology analyses indicated multiple significant functional terms related to neuron differentiation, neural membrane potential, pre- and post-synaptic elements, chemical synaptic transmission, vesicles, axon guidance and projection, glutamatergic and GABAergic neurotransmission. Some of the differentially expressed genes (Myt1l, Zmat4, Dlx6, Csrnp3) encode transcription factors that were independently predicted by transcription factor enrichment analysis to target other differentially regulated genes in this study. …”
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Association between DRD2/ANKK1 TaqIA Allele Status and Striatal Dopamine D2/3 Receptor Availability in Alcohol Use Disorder by Gianna Spitta, Lena E. Fliedner, Tobias Gleich, Tristan Zindler, Miriam Sebold, Ralph Buchert, Andreas Heinz, Jürgen Gallinat, Eva Friedel

“…Background: The association between blunted dopaminergic neurotransmission and alcohol use disorder (AUD) is well-known. …”
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Human cytomegalovirus induces significant structural and functional changes in terminally differentiated human cortical neurons by Jacob W. Adelman, Suzette Rosas-Rogers, Megan L. Schumacher, Rebekah L. Mokry, Scott S. Terhune, Allison D. Ebert

“…Finally, we demonstrate that HCMV disrupts calcium signaling and decreases neurotransmission, with action potential generation effectively silenced after 15 days post-infection. …”
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Neuronal hyperexcitability and ion channel dysfunction in CDKL5-deficiency patient iPSC-derived cortical organoids by Wei Wu, Hang Yao, Priscilla D. Negraes, Juan Wang, Cleber A. Trujillo, Janaina S. de Souza, Alysson R. Muotri, Gabriel G. Haddad

“…In contrast to neuronal properties, we found that glutamatergic neurotransmission and the electrophysiological properties of glial cells were not altered in CDD organoids. …”
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Transient Receptor Potential (TRP) and Thermoregulation in Animals: Structural Biology and Neurophysiological Aspects by Karina Lezama-García, Daniel Mota-Rojas, Alfredo M. F. Pereira, Julio Martínez-Burnes, Marcelo Ghezzi, Adriana Domínguez, Jocelyn Gómez, Ana de Mira Geraldo, Pamela Lendez, Ismael Hernández-Ávalos, Isabel Falcón, Adriana Olmos-Hernández, Dehua Wang

“…This review presents and analyzes recent scientific findings on the structure, physiology, and neurotransmission mechanisms of transient receptor potential (TRP) and their function in the thermoregulation of mammals. …”
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The adipocyte hormone leptin sets the emergence of hippocampal inhibition in mice by Camille Dumon, Diabe Diabira, Ilona Chudotvorova, Francesca Bader, Semra Sahin, Jinwei Zhang, Christophe Porcher, Gary Wayman, Igor Medina, Jean-Luc Gaiarsa

“…Brain computations rely on a proper balance between excitation and inhibition which progressively emerges during postnatal development in rodent. γ-Aminobutyric acid (GABA) neurotransmission supports inhibition in the adult brain but excites immature rodent neurons. …”
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Disease stage-dependent changes in brain levels and neuroprotective effects of neuroactive steroids in Parkinson's disease by Sabina Luchetti, Philippe Liere, Antoine Pianos, Ronald W.H. Verwer, Arja Sluiter, Inge Huitinga, Michael Schumacher, Dick F. Swaab, Matthew R.J. Mason

“…RNA expression of genes involved in neuroprotection, neuroinflammation and neurotransmission was analysed after 5 days of incubation with each steroid. …”
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Are Microplastics Impairing Marine Fish Larviculture?—Preliminary Results with <i>Argyrosomus regius</i> by Diana Campos, Andreia C. M. Rodrigues, Rui J. M. Rocha, Roberto Martins, Ana Candeias-Mendes, Sara Castanho, Florbela Soares, Pedro Pousão-Ferreira, Amadeu M. V. M. Soares, Carlos Gravato, Ana L. Patrício Silva

“…Such larvae also presented increased energy consumption potentially related to oxidative damage prevention and decreased neurotransmission. Biochemical responses of fed larvae showed a similar trend, except for LPO, which remained unaffected, except at 0.1 mg/PE-MPs/L. …”
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Motoneuron Wnts regulate neuromuscular junction development by Chengyong Shen, Lei Li, Kai Zhao, Lei Bai, Ailian Wang, Xiaoqiu Shu, Yatao Xiao, Jianmin Zhang, Kejing Zhang, Tiankun Hui, Wenbing Chen, Bin Zhang, Wei Hsu, Wen-Cheng Xiong, Lin Mei

“…We show when Wnt secretion is abolished from motoneurons by mutating the Wnt ligand secretion mediator (Wls) gene, mutant mice showed muscle weakness and neurotransmission impairment. NMJs were unstable with reduced synaptic junctional folds and fragmented AChR clusters. …”
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Altered Blood Brain Barrier Permeability and Oxidative Stress in <em>Cntnap2</em> Knockout Rat Model by Idil Memis, Rahul Mittal, Emily Furar, Isaiah White, Rebecca S. Eshraghi, Jeenu Mittal, Adrien A. Eshraghi

“…In addition, CNTNAP2 mediated signaling is generally considered to play a role in neurological disorders due to its critical role in neurodevelopment, neurotransmission, and synaptic plasticity. In this investigation, we studied BBB integrity and oxidative stress in <i>Cntnap2</i>^{−<i>/</i>−} rats. …”
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Ventral striatum dopamine release encodes unique properties of visual stimuli in mice by L Sofia Gonzalez, Austen A Fisher, Shane P D'Souza, Evelin M Cotella, Richard A Lang, J Elliott Robinson

“…Less well characterized is the role of dopaminergic neurotransmission in the response to surprising or alerting sensory events. …”
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Dopamine Dynamics and Neurobiology of Non-Response to Antipsychotics, Relevance for Treatment Resistant Schizophrenia: A Systematic Review and Critical Appraisal by Felice Iasevoli, Camilla Avagliano, Luigi D’Ambrosio, Annarita Barone, Mariateresa Ciccarelli, Giuseppe De Simone, Benedetta Mazza, Licia Vellucci, Andrea de Bartolomeis

“…Dopamine-related neurobiological mechanisms of TRS may be multiple and putatively subdivided into three biological points: (1) D2R-related, including increased D2R levels; increased density of D2Rs in the high-affinity state; aberrant D2R dimer or heteromer formation; imbalance between D2R short and long variants; extrastriatal D2Rs; (2) presynaptic dopamine, including low or normal dopamine synthesis and/or release compared to responder patients; and (3) exaggerated postsynaptic D2R-mediated neurotransmission. Future points to be addressed are: (i) a more neurobiologically-oriented phenotypic categorization of TRS; (ii) implementation of neurobiological studies by directly comparing treatment resistant vs. treatment responder patients; (iii) development of a reliable animal model of non-response to antipsychotics.…”
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2235 15N-Leucine transport across the blood brain barrier is significantly impaired in the glutamine synthetase-inhibited brain by Shaun E. Gruenbaum, Roni Dhaher, Kevin Behar, Hitten Zaveri, Mark Erfe, Tore Eid

“…Perturbations in the expression and activity of GS are thought to play a causative role in the pathogenesis of several conditions of abnormal neurotransmission. Although the long-term consequences of GS inhibition on amino acid homeostasis in the brain are unknown, it is thought that amino acid influx in the brain is tightly coupled with glutamine efflux via the L-type amino acid transporter. …”
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Investigation of antiparkinsonian activity of new imidazole-4,5-dicarboxylic acid derivatives on the experimental model of catalepsy by Vladimir D. Dergachev, Ekaterina E. Yakovleva, Maria A. Brusina, Evgeny R. Bychkov, Levon B. Piotrovskiy, Petr D. Shabanov

“…Discussion: Basing on the results of our work and similar experiments, we can conclude that the studied compounds, which are not channel blockers, have an active effect on dopaminergic neurotransmission, because of which the symptoms of catalepsy that occur when haloperidol is injected to rats were stopped to one degree or another. …”
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Genetic Insights into the Molecular Pathophysiology of Depression in Parkinson’s Disease by Efthalia Angelopoulou, Anastasia Bougea, Yam Nath Paudel, Vasiliki Epameinondas Georgakopoulou, Sokratis G. Papageorgiou, Christina Piperi

“…<i>Results</i>: in particular, polymorphisms in genes related to the serotoninergic pathway (sodium-dependent serotonin transporter gene, <i>SLC6A4</i>, tryptophan hydrolase-2 gene, <i>TPH2</i>), dopamine metabolism and neurotransmission (dopamine receptor D3 gene, <i>DRD3</i>, aldehyde dehydrogenase 2 gene, <i>ALDH2)</i>, neurotrophic factors (brain-derived neurotrophic factor gene, <i>BDNF</i>), endocannabinoid system (cannabinoid receptor gene, CNR1), circadian rhythm (thyrotroph embryonic factor gene, <i>TEF</i>), the sodium-dependent neutral amino acid transporter B(0)AT2 gene, <i>SLC6A15</i>), and <i>PARK16</i> genetic locus were detected as altering susceptibility to depression among PD patients. …”
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Longitudinal early epigenomic signatures inform molecular paths of therapy response and remission in depressed patients by Evelien Van Assche, Christa Hohoff, Johannes Zang, Matthew J. Knight, Bernhard T. Baune, Bernhard T. Baune, Bernhard T. Baune

“…The most significant CpG in the differential methylation analysis comparing response versus non-response was in the IQSEC1 gene (cg01601845; p = 1.53 × 10–6), linked to neurotransmission. The most significant GO-terms were linked to telomeres. …”
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Diagnosis and Treatment of Neuroleptic Malignant Syndrome in the Intensive Care Unit: A Case Report by Ana Maia, Gonçalo Cotovio, Bernardo Barahona-Corrêa, Albino J. Oliveira-Maia

“… Neuroleptic malignant syndrome is a neurological emergency caused by dysregulation of dopaminergic neurotransmission. While it is typically characterized by muscle rigidity, fever and altered mental status, it may have a heterogeneous and non-specific presentation, leading to delays in diagnosis and treatment. …”
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Morphological changes in perisynaptic astrocytes induced by dopamine neuronal degeneration in the striatum of rats by Liping Sun, Xuefeng Zheng, Yichen Che, Ye Zhang, Ziyun Huang, Linju Jia, Yaofeng Zhu, Wanlong Lei, Guoqing Guo, Chunkui Shao

“…Introduction: The typical functionality of astrocytes was previously shown to be disrupted by Parkinson's disease (PD), which actively regulates synaptic neurotransmission. However, the morphological changes in astrocytes wrapping glutamatergic synapses in the striatum after dopamine (DA) neuronal degeneration is unclear. …”
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Dysfunction of Glutamate Delta-1 Receptor-Cerebellin 1 Trans-Synaptic Signaling in the Central Amygdala in Chronic Pain by Pauravi J. Gandhi, Dinesh Y. Gawande, Gajanan P. Shelkar, Sukanya G. Gakare, Takaki Kiritoshi, Guangchen Ji, Bishal Misra, Ratnamala Pavuluri, Jinxu Liu, Volker Neugebauer, Shashank M. Dravid

“…Deletion of GluD1 impairs excitatory neurotransmission at the PB-CeLC synapses. In inflammatory and neuropathic pain models, GluD1 and its partner cerebellin 1 (Cbln1) are downregulated while AMPA receptor is upregulated. …”
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Cerebrospinal fluid exploratory proteomics and ketamine metabolite pharmacokinetics in human volunteers after ketamine infusion by Ruin Moaddel, Cristan A. Farmer, Mani Yavi, Bashkim Kadriu, Min Zhu, Jinshui Fan, Qinghua Chen, Elin Lehrmann, Giovanna Fantoni, Supriyo De, Caio H. Mazucanti, Elia E. Acevedo-Diaz, Peixiong Yuan, Todd D. Gould, Lawrence T. Park, Josephine M. Egan, Luigi Ferrucci, Carlos A. Zarate, Jr.

“…Proteins in the classes of tyrosine kinases, cellular adhesion molecules, and growth factors, including insulin, were most affected, suggesting an interplay of altered neurotransmission, neuroplasticity, neurogenesis, synaptogenesis, and neural network functions following ketamine administration.…”
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