Alcohol Withdrawal and Brain Injuries: Beyond Classical Mechanisms by Marianna E. Jung, Daniel B. Metzger

“…In addition to well known hyperexcitatory neurotransmissions, ethanol withdrawal (EW) provokes the intense generation of reactive oxygen species (ROS) and the activation of stress-responding protein kinases, which are the focus of this review article. …”
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Alterations in hyperpolarization-activated cyclic nucleotidegated cation channel (HCN) expression in the hippocampus following pilocarpine-induced status epilepticus by Yun-Jung Oh, Jongju Na, Ji-Heon Jeong, Dae-Kyoon Park, Kyung-Ho Park, Jeong-Sik Ko & Duk-Soo Kim*

“…Taken together, our findings suggestthat altered expressions of HCN1 following SE may be mainlyinvolved in the imbalances of neurotransmissions to hippocampalcircuits; thus, it is proposed that HCN1 may play animportant role in the epileptogenic period as a compensatoryresponse.…”
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Phyto-Carbazole Alkaloids from the Rutaceae Family as Potential Protective Agents against Neurodegenerative Diseases by Mario A. Tan, Niti Sharma, Seong Soo A. An

“…The main pathophysiological indicators of NDs comprise increasing atypical protein folding, oxidative stresses, mitochondrial dysfunctions, deranged neurotransmissions and neuronal losses. Phyto-carbazole alkaloids can be investigated for exerting multitarget approaches to ameliorating NDs. …”
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Precision Medicine Care in ADHD: The Case for Neural Excitation and Inhibition by Ping C. Mamiya, Anne B. Arnett, Mark A. Stein

“…Current pharmacological options targeting catecholamine neurotransmissions have effectively alleviated symptoms in some, but not all affected individuals, leaving clinicians to implement trial-and-error approach to treatment. …”
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Depolarizing GABAergic conductances regulate the balance of excitation to inhibition in the developing retinotectal circuit in vivo. by Akerman, C, Cline, H

“…Neurotransmission during development regulates synaptic maturation in neural circuits, but the contribution of different neurotransmitter systems is unclear. …”

Possible role of NO/NMDA pathway in the autistic-like behaviors induced by maternal separation stress in mice. by Fatemeh Khaledi, Hossein Tahmasebi Dehkordi, Elham Zarean, Mehrdad Shahrani, Hossein Amini-Khoei

“…Altered glutamatergic and nitrergic neurotransmissions may contribute to the pathophysiology of ASD. …”
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Altered mRNA Levels of Stress-Related Peptides in Mouse Hippocampus and Caudate-Putamen in Withdrawal after Long-Term Intermittent Exposure to Tobacco Smoke or Electronic Cigarette... by Lucia Carboni, Luisa Ponzoni, Daniela Braida, Mariaelvina Sala, Cecilia Gotti, Michele Zoli

“…The aim of this study was to investigate the alterations in key neurotransmissions after 60 days of withdrawal from seven weeks of intermittent cigarette smoke, e-cigarette vapours, or an e-cigarette vehicle. …”
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5-HT_1A Serotonergic, α-Adrenergic and Opioidergic Receptors Mediate the Analgesic Efficacy of Vortioxetine in Mice by Nazlı Turan Yücel, Ümmühan Kandemir, Ümide Demir Özkay, Özgür Devrim Can

“…Obtained findings indicated that vortioxetine-induced analgesia is mediated by 5-HT_1A serotonergic, α-adrenergic and opioidergic receptors, and contributions of central serotonergic and catecholaminergic neurotransmissions are critical for this effect.…”
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Trapping of Syntaxin1a in Presynaptic Nanoclusters by a Clinically Relevant General Anesthetic by Adekunle T. Bademosi, James Steeves, Shanker Karunanithi, Oressia H. Zalucki, Rachel S. Gormal, Shu Liu, Elsa Lauwers, Patrik Verstreken, Victor Anggono, Frederic A. Meunier, Bruno van Swinderen

“…Keywords: super-resolution microscopy, sptPALM, propofol, etomidate, SNARE, Drosophila melanogaster, PC12, syntaxin1A, SNAP-25, neurotransmission…”
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Role of neurotoxicants in the pathogenesis of Alzheimer’s disease: a mechanistic insight by Fatema Yasmin Nisa, Md. Atiar Rahman, Md. Amjad Hossen, Mohammad Forhad Khan, Md. Asif Nadim Khan, Mumtahina Majid, Farjana Sultana, Md. Areeful Haque

“…This review, therefore, aimed to address several essential mechanisms and signalling cascades, including Wnt (wingless and int.) signalling pathway, autophagy, mammalian target of rapamycin (mTOR), protein kinase C (PKC) signalling cascades, cellular redox status, energy metabolism, glutamatergic neurotransmissions, immune cell stimulations (e.g. microglia, astrocytes) as well as an amyloid precursor protein (APP), presenilin-1 (PSEN1), presenilin-2 (PSEN2) and other AD-related gene expressions that have been pretentious and modulated by the various neurotoxicants. …”
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New Paradigms of Old Psychedelics in Schizophrenia by Danish Mahmood, Sattam K. Alenezi, Md. Jamir Anwar, Faizul Azam, Kamal A. Qureshi, Mariusz Jaremko

“…Findings from recent studies have suggested that serotoninergic and glutamatergic neurotransmissions are very closely connected in producing pharmacological responses to psychedelics and antipsychotic medication. …”
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Simultaneous Blockade of Histamine H₃ Receptors and Inhibition of Acetylcholine Esterase Alleviate Autistic-Like Behaviors in BTBR T+ tf/J Mouse Model of Autism by Nermin Eissa, Petrilla Jayaprakash, Holger Stark, Dorota Łażewska, Katarzyna Kieć-Kononowicz, Bassem Sadek

“…These initial overall results observed in an idiopathic ASD mice model show that E100 (5 mg/kg) alleviated the assessed behavioral deficits and demonstrate that simultaneous targeting of brain histaminergic and cholinergic neurotransmissions is crucial for palliation of ASD-like features, albeit further in vivo assessments on its effects on brain levels of ACh as well as HA are still needed.…”
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Exploring the paradigm of depressive disorders through an evolutionary and biopsychosocial lens by T. Ochi, A. J. Loonen, G. G. Simutkin, N. A. Bokhan, A. N. Kornetov, S. A. Ivanova

“…Our investigations looked at polymorphisms impacting serotonergic, dopaminergic and adrenergic neurotransmissions and enzymes. While some associations were found, it did not match our literature findings. …”
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