Editorial: New approach methods in immunology por Thomas Hartung, Thomas Hartung, Jeffrey John Bajramovic, Susan Gibbs, Susan Gibbs, Emanuela Corsini

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Evaluation of THP-1 and Jurkat Cell Lines Coculture for the In Vitro Assessment of the Effects of Immunosuppressive Substances por Nina Franko, Marija Sollner Dolenc

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New approach methods to assess developmental and adult neurotoxicity for regulatory use: a PARC work package 5 project por Tamara Tal, Tamara Tal, Oddvar Myhre, Ellen Fritsche, Ellen Fritsche, Ellen Fritsche, Joëlle Rüegg, Kai Craenen, Kiara Aiello-Holden, Caroline Agrillo, Patrick J. Babin, Beate I. Escher, Hubert Dirven, Kati Hellsten, Kristine Dolva, Ellen Hessel, Harm J. Heusinkveld, Yavor Hadzhiev, Selma Hurem, Karolina Jagiello, Beata Judzinska, Nils Klüver, Anja Knoll-Gellida, Britta A. Kühne, Marcel Leist, Malene Lislien, Jan L. Lyche, Ferenc Müller, John K. Colbourne, Winfried Neuhaus, Winfried Neuhaus, Giorgia Pallocca, Bettina Seeger, Ilka Scharkin, Stefan Scholz, Ola Spjuth, Monica Torres-Ruiz, Kristina Bartmann, Kristina Bartmann

Assuntos: “…new approach method (NAM)…”
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Elucidating impacts of partitioning and transmembrane permeability on absorption of chemicals in human gastrointestinal tract por Shenghong Wang, Zhizhen Zhang, Dingsheng Li, Li Li

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Humanising nanotoxicology: replacement of animal-derived products in the application of integrated approaches to testing and assessment of nanomaterial inhalation hazard por Roma Fraser, Keira Campbell, Pawel Pokorski, Eve MacKinnon, Katie McAllister, Karla B. Neves, Fiona Murphy

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New Approach Methods to Assess the Enteropathogenic Potential of Strains of the <i>Bacillus cereus</i> Group, including <i>Bacillus thuringiensis</i> por Arnaud Fichant, Rachelle Lanceleur, Salma Hachfi, Alexandra Brun-Barale, Anne-Louise Blier, Olivier Firmesse, Armel Gallet, Valérie Fessard, Mathilde Bonis

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A Machine-Learning-Driven Pathophysiology-Based New Approach Method for the Dose-Dependent Assessment of Hazardous Chemical Mixtures and Experimental Validations por Sarita Limbu, Eric Glasgow, Tessa Block, Sivanesan Dakshanamurthy

“…In the second phase, we integrated AI-HNN and CPTM to establish a comprehensive new approach method (NAM) framework called AI-CPTM that is targeted at refining prediction accuracy and providing a comprehensive understanding of toxicity mechanisms. …”
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Investigating open access new approach methods (NAM) to assess biological points of departure: A case study with 4 neurotoxic pesticides por Marilyn H. Silva

Assuntos: “…New Approach Methods (NAM)…”
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Microbial pesticides – challenges and future perspectives for testing and safety assessment with respect to human health por K. Wend, L. Zorrilla, F. M. Freimoser, A. Gallet

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Chemistry domain of applicability evaluation against existing estrogen receptor high-throughput assay-based activity models por Mark D. Nelms, Todor Antonijevic, Caroline Ring, Danni L. Harris, Ronnie Joe Bever, Scott G. Lynn, David Williams, Grace Chappell, Rebecca Boyles, Susan Borghoff, Stephen W. Edwards, Kristan Markey

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Assessing human carcinogenicity risk of agrochemicals without the rodent cancer bioassay por Amber Goetz, Natalia Ryan, Alaina Sauve-Ciencewicki, Caleb C. Lord, Gina M. Hilton, Douglas C. Wolf

Assuntos: “…new approach methods…”
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A 2024 inventory of test methods relevant to thyroid hormone system disruption for human health and environmental regulatory hazard assessment [version 1; peer review: 2 approved] por Lola Bajard, Lucia Vergauwen, Ingrid Langezaal, Sabrina Tait, Alessandra Roncaglioni, Anita Sosnowska, Ann-Cathrin Haigis, Annick D van den Brand, Klára Hilscherová, Ellen Hessel, Jiří Novák, Nafsika Papaioannou, Natalia Buławska, Eliana Spilioti, Elisavet Renieri, Arno C Gutleb, Anastasia Spyropoulou, Dimitra Nikolopoulou, Henrik Holbech, Dries Knapen, Miriam N Jacobs

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In Vitro Hepatic Clearance Evaluations of Per- and Polyfluoroalkyl Substances (PFAS) across Multiple Structural Categories por David M. Crizer, Julie R. Rice, Marci G. Smeltz, Katelyn S. Lavrich, Krishna Ravindra, John F. Wambaugh, Michael DeVito, Barbara A. Wetmore

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REQUIREMENTS FOR A GENERAL INTERPRETATION THEORY por Anda Laura Lungu Petruescu

“…The present study wishes to propose a new approach method of the economic phenomena and processes based on the researches made outside the economic space- a new general interpretation theory- which is centered on the human being as the basic actor of economy. …”
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From big data mining to technical sport reports: the case of inertial measurement units por Daniel Rojas-Valverde, Carlos D Gómez-Carmona, Randall Gutiérrez-Vargas, Jose Pino-Ortega

“…This report aims to present new methods of reduction of the data and propose a new approach method for the analysis of the IMU’s outcomes.…”
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Hysteretic Energy Demand under Superposition of Bidirectional Ground Motions por Feng Wang, Jialin Shi, Pengyan Chen

“…To address the irrationality of making a structure subjected to bidirectional ground motions equivalent to an SDOF system, a new approach method is presented in this paper. The ratio between modal participation factors of the two components of the structure is expressed as γ, and the superposition of bidirectional ground motions is regarded as one-directional earthquake excitation for the equivalent SDOF system. …”
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Uplink channel power control improvement in DS-CDMA system using channel predictions por A. Othman, Ibtesam

“…To overcome these problems, a new approach method has been developed, based on linear quadratic Gaussian (LQG) control and Extended Kalman filter for channel prediction, this method dependent on the channel state instead of the current. …”
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Flexible urbanism por Anandam, Anahita

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Using targeted fetal rat testis genomic and endocrine alterations to predict the effects of a phthalate mixture on the male reproductive tract por L. Earl Gray, Jr, Christy S. Lambright, Nicola Evans, Jermaine Ford, Justin M. Conley

“…In summary, these results support the use of this New Approach Method to predict the detrimental effects of PEs and PE mixtures, replacing or reducing the need to run long-term, resource and animal use intensive extended one-generation reproduction studies for this class of chemicals.…”
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Implementing differentially pigmented skin models for predicting drug response variability across human ancestries por Sophie Zaaijer, Simon C. Groen

“…The article provides guidelines on the selection of New Approach Methods (NAMs) to foster inclusive study designs in preclinical drug development pipelines, leading to an improved level of translatability to the clinic.…”
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