Functional and genetic analysis of haplotypic sequence variation at the nicastrin genomic locus. by Hamilton, G, Killick, R, Lambert, J, Amouyel, P, Carrasquillo, M, Pankratz, V, Graff-Radford, N, Dickson, D, Petersen, R, Younkin, S, Powell, J, Wade-Martins, R

“…Nicastrin (NCSTN) is a component of the γ-secretase complex and therefore potentially a candidate risk gene for Alzheimer's disease. …”

Functional and genetic analysis of haplotypic sequence variation at the nicastrin genomic locus. by Hamilton, G, Killick, R, Genetic, A, Translational, G, Lambert, J, Amouyel, P, European, A, Carrasquillo, M, Pankratz, V, Graff-Radford, N, Dickson, D, Petersen, R, Younkin, S, Powell, J, Wade-Martins, R

“…Nicastrin (NCSTN) is a component of the γ-secretase complex and therefore potentially a candidate risk gene for Alzheimer's disease. …”

Functional and genetic analysis of haplotypic sequence variation at the nicastrin genomic locus by Hamilton, G, Killick, R, Lambert, J, Amouyel, P, Carrasquillo, M, Pankratz, V, Graff-Radford, N, Dickson, D, Petersen, R, Younkin, S, Powell, J, Wade-Martins, R

“…Nicastrin (NCSTN) is a component of the γ-secretase complex and therefore potentially a candidate risk gene for Alzheimer's disease. …”

Electron microscopic structure of purified, active gamma-secretase reveals an aqueous intramembrane chamber and two pores. by Lazarov, V, Fraering, P, Ye, W, Wolfe, MS, Selkoe, D, Li, H

“…Gamma-secretase occurs as a large complex containing presenilin (bearing the active site aspartates), nicastrin, Aph-1, and Pen-2. Because the complex contains at least 18 transmembrane domains, crystallographic approaches to its structure are difficult and remote. …”

Expression profiling of lymphocyte plasma membrane proteins. by Peirce, M, Wait, R, Begum, S, Saklatvala, J, Cope, A

“…These included three unexpected proteins; nicastrin, osteoclast inhibitory lectin, and a transmembrane domain-containing hypothetical protein of 11.4 kDa. …”