Imbalanced media portrayal: a content analysis of precision medicine in US news of 2015–2021 by Wei Peng, Hae Yeon Seo, Juwhan Choi, Xiaofeng Jia

“…Potential risks or concerns, non-cancer diseases, and non-treatment issues that could be important to diverse populations were less covered. …”
Get full text

Cancer Pain Management: A Narrative Review of Current Concepts, Strategies, and Techniques by François Mestdagh, Arnaud Steyaert, Patricia Lavand’homme

“…Cancer pain management is now closer to the management of chronic non-cancer pain, i.e., “an integrative and supportive pain care” aiming to improve patient’s quality of life.…”
Get full text

Oxygen tension-dependent variability in the cancer cell kinome impacts signaling pathways and response to targeted therapies by Adedeji K. Adebayo, Poornima Bhat-Nakshatri, Christopher Davis, Steven P. Angus, Cihat Erdogan, Hongyu Gao, Nick Green, Brijesh Kumar, Yunlong Liu, Harikrishna Nakshatri

“…We developed an approach that allows collection, processing, and evaluation of cancer and non-cancer cells under physioxia, while preventing exposure to ambient air. …”
Get full text

Doxorubicin–transferrin conjugate alters mitochondrial homeostasis and energy metabolism in human breast cancer cells by Paulina Wigner, Krzysztof Zielinski, Magdalena Labieniec-Watala, Agnieszka Marczak, Marzena Szwed

“…The effect of DOX–Tf was the most pronounced in MDA-MB-231, triple-negative breast cancer cells, whereas non-cancer endothelial HUVEC-ST cells were more resistant to DOX–Tf conjugate than to free DOX treatment. …”
Get full text

Untargeted ultra-high-resolution mass spectrometry metabolomic profiling of blood serum in bladder cancer by Joanna Nizioł, Krzysztof Ossoliński, Aneta Płaza-Altamer, Artur Kołodziej, Anna Ossolińska, Tadeusz Ossoliński, Tomasz Ruman

“…In this study, ultra-high-performance liquid chromatography coupled with ultra-high-resolution mass spectrometry was employed for non-targeted metabolomic profiling of 200 human serum samples to identify biochemical signatures that differentiate BC from non-cancer controls (NCs). Univariate and multivariate statistical analyses with external validation revealed twenty-seven metabolites that differentiate between BC patients from NCs. …”
Get full text

Zinc-finger protein 382 antagonises CDC25A and ZEB1 signaling pathway in breast cancer by Shuman Li, Xiaoqian He, Yan Wang, Weihong Chen, Ran Sun, Shaorong Tian, Sanxiu He, Chunyun Pu, Chen Li, Dishu Zhou, Yu Jiang, Qian Tao, Lili Li, Lin Ye, Yue Wu, Weiyan Peng, Tingxiu Xiang

“…Our results revealed that ZNF382 was significantly down-regulated in breast cancer tissues compared with adjacent non-cancer tissues. Restoration of ZNF382 expression in silenced breast cancer cells not only inhibited tumor cell colony formation, viability, migration and invasion, and epithelial-mesenchymal-transition (EMT), but also induced apoptosis and G0/G1 arrest. …”
Get full text

High-Resolution Magic-Angle-Spinning NMR in Revealing Hepatoblastoma Hallmarks by Ljubica Tasic, Nataša Avramović, Milka Jadranin, Melissa Quintero, Danijela Stanisic, Lucas G. Martins, Tássia Brena Barroso Carneiro Costa, Estela Novak, Vicente Odone, Maria Rivas, Talita Aguiar, Dirce Maria Carraro, Isabela Werneck da Cunha, Cecilia Maria Lima da Costa, Mariana Maschietto, Ana Krepischi

“…Using this technique, we studied the alterations among tissue metabolites of ex vivo samples from (a) HBL and non-cancer liver tissues (NCL), (b) HBL and adjacent non-tumor samples, and (c) two regions of the same HBL samples, one more centralized and the other at the edge of the tumor. …”
Get full text

Protection of Mitochondrial Potential and Activity by Oxyprenylated Phenylpropanoids by Francesco Epifano, Salvatore Genovese, Lucia Palumbo, Chiara Collevecchio, Serena Fiorito

“…While not showing an appreciable in vitro antioxidant activity, and virtually no or a little effect on the viability of non-cancer cell lines BEAS-2B and SHSY-5Y, all phytochemicals exhibited a marked protective effect on mitochondrial potential and activity, with values that were comparable to resveratrol. …”
Get full text

VARIANTS AND PERSPECTIVES OF DRUG REPURPOSING FOR CANCER TREATMENT by A. V. Savinkova, E. M. Zhidkova, L. R. Tilova, M. D. Lavrova, E. S. Lylova, K. A. Kuzin, A. Yu. Portyannikova, V. P. Maximova, A. V. Kholodova, O. A. Vlasova, T. I. Fetisov, K. I. Kirsanov, G. A. Belitskiy, M. G. Yakubovskaya, E. A. Lesovaya

“…In cancer research drug repurposing includes screening for medicines used nowadays for the treatment of patients with non-cancer diseases which possess anticancer activity or able to enhance the effects of the standard anticancer chemotherapy, and  search for new applications of known anticancer drugs for the  treatment of different cancer types. …”
Get full text

Preventive Effect of Nutrition Support on Peroneal Neuropathy in Cancer Patients by Hiroyuki Fukuda, Aiko Yamashita, Toru Imai, Hiromi Tsumaki, Namiko Nagata, Hiroshi Ishikawa, Masahiro Niihara, Yasuhiro Tsubosa, Yusuke Onozawa

“…Background: The occurrence of peroneal neuropathy was reported to be higher in cancer patients than in non-cancer patients. Cancer patients should have their nutritional intake carefully managed in order to minimize weight loss and avoid the occurrence of peroneal neuropathy. …”
Get full text

Use of the Analysis of the Volatile Faecal Metabolome in Screening for Colorectal Cancer. by Claire A Batty, Michael Cauchi, Célia Lourenço, John O Hunter, Claire Turner

“…Subjects subsequently had colonoscopies performed to classify them into low risk (non-cancer) and high risk (colorectal cancer) groups. …”
Get full text

Concise Review of Nickel Human Health Toxicology and Ecotoxicology by Samuel Buxton, Emily Garman, Katherine E. Heim, Tara Lyons-Darden, Christian E. Schlekat, Michael D. Taylor, Adriana R. Oller

“…Notable human health toxicity effects identified from human and/or animal studies include respiratory cancer, non-cancer toxicity effects following inhalation, dermatitis, and reproductive effects. …”
Get full text

Natural products modulate phthalate-associated miRNAs and targets by Ya-Ting Chuang, Ching-Yu Yen, Tsu-Ming Chien, Fang-Rong Chang, Kuo-Chuan Wu, Yi-Hong Tsai, Jun-Ping Shiau, Hsueh-Wei Chang

“…In this paper, we review the adverse effects and potential targets of phthalates on reproductive systems as well as cancer and non-cancer responses. Information on natural products that attenuate the adverse effects of phthalates is retrieved through a search of Google Scholar and the miRDB database. …”
Get full text

Obstetric outcomes in cancer survivors. by Clark, H, Kurinczuk, J, Lee, A, Bhattacharya, S

“…Preterm delivery (at less than 37 weeks of gesation) was also found to be higher in this group compared with non-cancer women (OR 1.33, 95% CI 1.01-1.76). CONCLUSION: While largely reassuring to women intending to become pregnant after surviving cancer, the results indicate areas of increased risk that require additional surveillance.…”

The imidazoacridinone C-1311 induces p53-dependent senescence or p53-independent apoptosis and sensitizes cancer cells to radiation by Skwarska, A, Ramachandran, S, Dobrynin, G, Leszczynska, K, Hammond, E

“…Here, we investigated the molecular signaling which determines the response to C-1311 in both cancer and non-cancer cell lines. For the first time we demonstrate that the tumor suppressor, p53 plays a key role in cell fate determination after C-1311 treatment. …”

Development and validation of an integrated system for lung cancer screening and post-screening pulmonary nodules management: a proof-of-concept study (ASCEND-LUNG)Research in cont... by Yichen Jin, Wei Mu, Yezhen Shi, Qingyi Qi, Wenxiang Wang, Yue He, Xiaoran Sun, Bo Yang, Peng Cui, Chengcheng Li, Fang Liu, Yuxia Liu, Guoqiang Wang, Jing Zhao, Yuzi Zhang, Shuaitong Zhang, Caifang Cao, Chao Sun, Nan Hong, Shangli Cai, Jie Tian, Fan Yang, Kezhong Chen

“…A dataset of 465 participants (216 cancer, 47 benign, 202 non-cancer control) were used for the two models’ development phase. …”
Get full text

Increased adipose tissue is associated with improved overall survival, independent of skeletal muscle mass in non‐small cell lung cancer by Junli Tao, Jiayang Fang, Lihua Chen, Changyu Liang, Bohui Chen, Zhenyu Wang, Yongzhong Wu, Jiuquan Zhang

“…Abstract Background The prognostic significance of non‐cancer‐related prognostic factors, such as body composition, has gained extensive attention in oncological research. …”
Get full text

Gastric Cancer Diagnostic Model Based on Convolutional Neural Network by WANG Jixian, GUI Kun, CHEN Bingxian, RU Guoqing, ZHAO Di, CHEN Wanyuan, ZHANG Zhiyong

“…This model was used for image stitching to generate the cancerous heat map of WSIs and extract the slide-level cancer and non-cancer classification features of the heat map. …”
Get full text

DETECTION OF OXIDATIVE STRESS, APOPTOSIS AND MOLECULAR LESIONS IN HUMAN OVARIAN CANCER CELLS by H. I. Falfushynska

“…The aim of this study is to clarify the relationship between antioxidant/pro-oxidant ratio and the signs of molecular lesions and apoptosis rate in blood of ovarian cancer patients and non-cancer ones. Results. The ovarian cancer group is marked by antioxidant/prooxidant balance shifting to oxidative damage in blood as the consequence of overexpression of oxyradicals (by 300%). …”
Get full text

Zinc in Prostate Health and Disease: A Mini Review by Nishi Karunasinghe

“…Zn deficiencies were recorded in serum, hair, and prostate tissue of men with prostate cancer compared to non-cancer controls. Zn gut absorption, albumin binding, and storage compete with various factors. …”
Get full text