The future of Funds for Innovative Medicines: results from a Delphi Study by Claudio Jommi, Patrizio Armeni, Arianna Bertolani, Francesco Costa, Monica Otto

“…Introduction: Dedicated Funds for Innovative Medicines were introduced in 2017 for cancer and non-cancer drugs in Italy. After three years, their impact on patient access to the relevant treatments and critical issues about their management has been poorly investigated. …”
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Competing risk analysis of cardiovascular death in patients with primary gallbladder cancer by Chong Chen, Fengshuo Xu, Shiqi Yuan, Xuenuo Zhao, Mengmeng Qiao, Didi Han, Jun Lyu

“…Abstract Background Developments in medical technology are resulting in continuous decreases in the cancer mortality rate of patients with gallbladder cancer, while non‐cancer deaths in cancer patients are becoming more common. …”
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Evaluation of Carcinogenic and Non-Carcinogenic Risk of Heavy Metals Due to the Consumption of Vegetables Produced in the Greenhouse of Markazi Province by Kourosh Mokhtari, Hossein Mazaheri, Amir Hossein Baghaie, Ali Hassani Joshaghani

“…Methods: In this descriptive study, sampling of cucumber, tomato, and bell pepper produced in the greenhouses of Markazi province was done randomly and the concentration of Pb, Cd, Cu, Ni and NO 3 of them were determined. Non-cancer risk related to heavy metals and NO 3 sorption from vegetables was evaluated using the EPA method for men and women. …”
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LncRNA PLAC 2 downregulated miR-21 in non-small cell lung cancer and predicted survival by Huan Xia, Ming Xiu, Jinying Gao, Hongyu Jing

“…Results PLAC2 was down-regulated, while miR-21 was up-regulated in NSCLC tissues compared to non-cancer tissues. Low PLAC2 levels in NSCLC tissues were associated with poor survival of NSCLC patients. …”
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Biological Monitoring of Glyphosate Exposure among Knapsack Sprayers in Khon Kaen, Thailand by Sunisa Chaiklieng, Kodchakorn Uengchuen, Netsirin Gissawong, Supalax Srijaranai, Herman Autrup

“…The internal dose ranged from 0.0001 to 0.0021 mg/kg b.w./day. The non-cancer HQ showed no potential health risk concerns (HQ < 1). …”
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Systematic characterization of germline variants from the DiscovEHR study endometrial carcinoma population by Jason E. Miller, Raghu P. Metpally, Thomas N. Person, Sarathbabu Krishnamurthy, Venkata Ramesh Dasari, Manu Shivakumar, Daniel R. Lavage, Adam M. Cook, David J. Carey, Marylyn D. Ritchie, Dokyoon Kim, Radhika Gogoi, on behalf of the DiscovEHR collaboration

“…Results Eight genes were identified as having increased burden in the EMCA cohort relative to the non-cancer control cohort. None of the eight genes had an increased burden in the other hormone related cancer cohort from GHS, suggesting they can help characterize the underlying genetic variation that gives rise to EMCA. …”
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Meeting Physician Compliance Recommendations in the Management of Opioids in Chronic Pain: The Chronic Pain Management Registry (CPMR) by Paul Langley

“…The purpose of the present commentary is to expand upon the role of the CPMR in the management of opioids in detailing the concordance of the CPMR data collection requirements with the latest recommendations of the American Society of Interventional Pain Physicians (ASIPP) for responsible, safe and effective opioid prescribing in chronic non-cancer pain. Given ongoing concerns with opioid misuse and abuse, the opioid epidemic, physician practices are at risk for what may be judged as poor therapy decisions in evaluating medical necessity and a failure to monitor effectively response to therapy. …”
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Establishing Credibility for Medical Marijuana: The Proposed Prometheus Dispensary Registry for Botanical Cannabis by Paul Langley

“…The registry tracks and reports on patients over the course of treatment with botanical cannabis with the focus on severe or chronic non-cancer pain, severe nausea, persistent muscle spasms and seizures, together with prevalent comorbidities – fatigue, anxiety, depression and sleep. …”
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Sacrococcygeal teratoma: evaluation of its approach, treatment and follow-up in two reference children cancer centers in Brazil / Rio de Janeiro by VANESSA DO NASCIMENTO SANTOS, SIMONE DE OLIVEIRA COELHO, ALAN ARAUJO VIEIRA

“…Conclusion: the characteristic of being a non-cancer center can interfere with the full application of the current protocol for the treatment of sacrococcygeal teratoma. …”
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Immune- and Non-Immune-Mediated Adverse Effects of Monoclonal Antibody Therapy: A Survey of 110 Approved Antibodies by Brian A. Baldo

“…Of the 110 mAbs preparations currently approved by the FDA and/or EMA, 46 (including 13 antibody–drug conjugates) recognizing 29 different targets are indicated for the treatment of cancers, and 66, recognizing 48 different targets, are indicated for non-cancer disorders. Despite their specific targeting with the expected accompanying reduced collateral damage for normal healthy non-involved cells, mAbs, may cause types I (anaphylaxis, urticaria), II (e.g., hemolytic anemia, possibly early-onset neutropenia), III (serum sickness, pneumonitis), and IV (Stevens–Johnson syndrome, toxic epidermal necrolysis) hypersensitivities as well as other cutaneous, pulmonary, cardiac, and liver adverse events. …”
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An evaluation of the tumour endothelial marker CLEC14A as a therapeutic target in solid tumours by Joseph Robinson, Katharine Whitworth, Elizabeth Jinks, Zsuzsanna Nagy, Roy Bicknell, Steven P Lee

“…Elevated levels of CLEC14A transcripts were identified in some non‐cancer pathologies; such comorbidities may need to be excluded from trials of therapies targeting this marker. …”
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Evaluation of N-NOSE as a surveillance tool for recurrence in gastric and esophageal cancers: a prospective cohort study by Sayuri Iitaka, Akihiro Kuroda, Tomonori Narita, Hideyuki Hatakeyama, Masayo Morishita, Umbhorn Ungkulpasvich, Takaaki Hirotsu, Eric di Luccio, Koichi Yagi, Yasuyuki Seto

“…While N-NOSE has been validated to distinguish between cancer and non-cancer, and its performance compared to traditional markers has been proven, it has not been studied for recurrence. …”
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Influence of Immune Microenvironment on Diagnosis and Prognosis of Head and Neck Squamous Cell Carcinoma by Guohong Liu, Chunjue Yuan, Jiaojiao Ma, Yunbao Pan, Yunbao Pan, Haibo Xu

“…We assessed the relative proportion of 22 Infiltrating immune cell types in both HNSCC and adjacent non-cancer tissues using Cell-type Identification By Estimating Relative Subsets Of RNA Transcripts (CIBERSORT) method, identifying the influence of the immune cells content in tumor staging and survival prediction. …”
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Phenolic Compounds from Humulus lupulus as Natural Antimicrobial Products: New Weapons in the Fight against Methicillin Resistant Staphylococcus aureus, Leishmania mexicana and Try... by Laetitia Bocquet, Sevser Sahpaz, Natacha Bonneau, Claire Beaufay, Séverine Mahieux, Jennifer Samaillie, Vincent Roumy, Justine Jacquin, Simon Bordage, Thierry Hennebelle, Feng Chai, Joëlle Quetin-Leclercq, Christel Neut, Céline Rivière

“…Their cytotoxic activity was assessed both on cancer and non-cancer human cell lines.…”
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Opioid-induced respiratory depression and risk factors in a tertiary hospital: A retrospective study by Nabil A. Almouaalamy, Majed Alshamrani, Waleed K. Alnejadi, Ziyad M. Alharbi, Faisal M. Aldosari, Enad F. Alsulimani, Saif A. Saif, Mohammed K. Aldawsari

“…Background: Opioids are potent analgesics used for the treatment of moderate to severe acute and chronic cancer and non-cancer pain. However, opioid usage may be limited by negative side effects, such as potentially life-threatening respiratory depression. …”
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Cognitive effects of low dose of ionizing radiation – Lessons learned and research gaps from epidemiological and biological studies by Elisa Pasqual, François Boussin, Dimitry Bazyka, Arvid Nordenskjold, Michiko Yamada, Kotaro Ozasa, Simonetta Pazzaglia, Laurence Roy, Isabelle Thierry-Chef, Florent de Vathaire, Mohammed Abderrafi Benotmane, Elisabeth Cardis

“…The last decades have seen increased concern about the possible effects of low to moderate doses of ionizing radiation (IR) exposure on cognitive function.An interdisciplinary group of experts (biologists, epidemiologists, dosimetrists and clinicians) in this field gathered together in the framework of the European MELODI workshop on non-cancer effects of IR to summarise the state of knowledge on the topic and elaborate research recommendations for future studies in this area.Overall, there is evidence of cognitive effects from low IR doses both from biology and epidemiology, though a better characterization of effects and understanding of mechanisms is needed.There is a need to better describe the specific cognitive function or diseases that may be affected by radiation exposure. …”
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Resentful, Resigned and Respectful: Opioid Analgesics, Pain and Control, a Qualitative Study by Richard Cooper, Catriona Matheson, Emily Pagan, Helen Radford

“…This study aimed to explore non-cancer patients’ experiences and views of taking opioid analgesics to manage their pain. …”
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Tissue Microbiome Profiling Identifies an Enrichment of Specific Enteric Bacteria in Opisthorchis viverrini Associated Cholangiocarcinoma by Kern Rei Chng, Sock Hoai Chan, Amanda Hui Qi Ng, Chenhao Li, Apinya Jusakul, Denis Bertrand, Andreas Wilm, Su Pin Choo, Damien Meng Yew Tan, Kiat Hon Lim, Roy Soetinko, Choon Kiat Ong, Dan G. Duda, Simona Dima, Irinel Popescu, Chaisiri Wongkham, Zhu Feng, Khay Guan Yeoh, Bin Tean Teh, Puangrat Yongvanit, Sopit Wongkham, Vajaraphongsa Bhudhisawasdi, Narong Khuntikeo, Patrick Tan, Chawalit Pairojkul, Joanne Ngeow, Niranjan Nagarajan

“…Systemic perturbation of the microbiome was noted in tumor and paired normal samples (vs non-cancer normals) for several bacterial families with a significant increase in Stenotrophomonas species distinguishing tumors vs paired normals. …”
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Understanding the Attitudes and Beliefs of Oncologists Regarding the Transitioning and Sharing of Survivorship Care by Courtney H. Coschi, Daryl Bainbridge, Jonathan Sussman

“…Understanding these issues is critical to developing policies supporting comprehensive survivorship care models that address both cancer and non-cancer health needs. The demonstrated feasibility of this project warrants a larger-scale survey of oncologists with respect to the transition of survivorship care to PCPs, to further inform effective interventions to support high-quality survivorship care.…”
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Advances in Brain Tumor Surgery for Glioblastoma in Adults by Montserrat Lara-Velazquez, Rawan Al-Kharboosh, Stephanie Jeanneret, Carla Vazquez-Ramos, Deependra Mahato, Daryoush Tavanaiepour, Gazanfar Rahmathulla, Alfredo Quinones-Hinojosa

“…In an attempt to achieve optimal safe resection, advances in approaches allowing intraoperative analysis of cancer and non-cancer tissue have been developed and applied in humans resulting in improved outcomes. …”
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