Should cancer pain still be considered a separate category alongside acute pain and chronic non-cancer pain? Reflections on ICD-11 by Emmanuel Bäckryd

“…IntroductionTraditionally, cancer pain has often been viewed as an independent third major category in pain medicine alongside acute pain and chronic non-cancer pain. However, the new chronic pain category MG30 in the eleventh version of International Classification of Diseases (ICD-11) includes cancer-related pain as one of its seven subgroups. …”
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Permitted water pollution discharges and population cancer and non-cancer mortality: toxicity weights and upstream discharge effects in US rural-urban areas by Hendryx Michael, Conley Jamison, Fedorko Evan, Luo Juhua, Armistead Matthew

“…Effects for kidney mortality and total non-cancer mortality were stronger in rural areas than urban areas. …”
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Palliative Performance Scale and survival in patients with cancer and non-cancer diagnoses needing a palliative care consultation: a retrospective cohort study by Patcharaporn Prompantakorn, Chaisiri Angkurawaranon, Kanokporn Pinyopornpanish, Lalita Chutarattanakul, Chanchanok Aramrat, Chanapat Pateekhum, Nisachol Dejkriengkraikul

“…The objective was to determine the associations between the PPS and survival time among cancer and non-cancer patients in Thailand. Methods This is a retrospective cohort study. …”
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Low-dose Initiation of Buprenorphine/naloxone for the Management of Chronic Non-cancer Pain in Patients on Long-term Opioid Therapy: A Case Series by Maya Rattanavong, Donica Kwan, Derek Jorgenson, Eric Landry, Radhika Marwah, Katelyn Halpape

“…The mean Clinical Global Impression–Improvement score after initiation was 2 (1–5).Conclusion Low-dose initiation is an effective approach to transition patients with chronic non-cancer pain from long-term opioid therapy to buprenorphine/naloxone without major complications or worsening pain.…”
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Cross-sectional study of the prevalence of prescription opioids misuse in French patients with chronic non-cancer pain: An update with the French version of the POMI scale by Nicolas Kerckhove, Nicolas Kerckhove, Noémie Delage, Noémie Delage, Célian Bertin, Célian Bertin, Célian Bertin, Emmanuelle Kuhn, Nathalie Cantagrel, Caroline Vigneau, Jessica Delorme, Céline Lambert, Bruno Pereira, Chouki Chenaf, Chouki Chenaf, Chouki Chenaf, Nicolas Authier, Nicolas Authier, Nicolas Authier, Poma Network, Debbah Abdelouahab, Peyre Alexandre, Simon Anna, Defeuillet Catherine, Wiart Catherine, Sureau Christophe, Vulser Cristofini Claire, Bouhassira Didier, Touchard Emmanuelle, Collin Elisabeth, Serra Eric, Perez-Varlan Evelyne, Mohy Frédérique, Peyriere Hélène, Le Borgne Jean-Marie, Poinsignon Jean Paul, Micallef Joëlle, Dy Lénaïg, Amilhaud Marlène, Venard Maria, Dorsner-Binard Marie, Berrier Oui Marie, Martial Maud, Feuillet Maryline, De Rijk Pablo, Ginies Patrick, Kieffert Patrick, Giraud Pierric, Aerts Raluca, Le Boisselier Reynald, Cauchin Sonia, Pouplin Sophie, Corand Virginie, Perier Yannick, Poujol Yves

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Carbosilane Dendrimers Loaded with siRNA Targeting Nrf2 as a Tool to Overcome Cisplatin Chemoresistance in Bladder Cancer Cells by Leanne Ambrosio, Monica Argenziano, Marie Angèle Cucci, Margherita Grattarola, Inge A.M. de Graaf, Chiara Dianzani, Giuseppina Barrera, Javier Sánchez Nieves, Rafael Gomez, Roberta Cavalli, Stefania Pizzimenti

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A comparison of symptoms in older hospitalised cancer and non-cancer patients in need of palliative care: a secondary analysis of two cross-sectional studies by Aurélie Van Lancker, Ann Van Hecke, Sofie Verhaeghe, Matthias Mattheeuws, Dimitri Beeckman

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All-cause mortality in patients with long-term opioid therapy compared with non-opioid analgesics for chronic non-cancer pain: a database study by Winfried Häuser, Tino Schubert, Tobias Vogelmann, Christoph Maier, Mary-Ann Fitzcharles, Thomas Tölle

“…Abstract Background Hitherto only studies with selected populations have found an increased all-cause mortality of some selected opioids compared to selected non-opioids for chronic non-cancer pain (CNCP). We have examined the all-cause mortality for CNCP associated with all established opioids compared to non-opioid analgesic therapy (anticonvulsants, antidepressants, dipyrone, non-steroidal agents). …”
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Barriers and enablers to monitoring and deprescribing opioid analgesics for chronic non-cancer pain: protocol for a qualitative evidence synthesis using the Theoretical Domains Framework by Rachelle Buchbinder, Amanda J Cross, Christopher Maher, Denise A O’Connor, Stephanie Mathieson, Allison Bourne, Chung-Wei C Lin

“…Introduction The over-prescription and overuse of opioid analgesics for chronic non-cancer pain (CNCP) is a growing issue. Synthesis of evidence about the barriers and enablers to reducing long-term opioid prescribing and use will enable the development of tailored interventions to address both problems.Objective To synthesise the barriers and enablers to monitoring the ongoing appropriateness of opioid treatment and deprescribing opioids for CNCP from the clinician, patient and general public point of view, and to map the findings to the Theoretical Domains Framework (TDF).Methods and analysis We will perform a qualitative evidence synthesis using the TDF. …”
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Exceeding the guideline-recommended maximum daily dose of opioids for long-term treatment of non-cancer pain in Germany – a large retrospective observational study by Nils Frederik Schrader, Anja Niemann, Milena Weitzel, Christian Speckemeier, Carina Abels, Nikola Blase, Godwin Denk Giebel, Cordula Riederer, Joachim Nadstawek, Wolfgang Straßmeir, Jürgen Wasem, Silke Neusser

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Primary care-based interventions for secondary prevention of opioid dependence in patients with chronic non-cancer pain taking pharmaceutical opioids: a systematic review by Clare E French, David M Troy, Sarah Dawson, Michael N Dalili, Matthew Hickman, Kyla H Thomas

“…Background: Globally, almost one-third of adults with chronic non-cancer pain (CNCP) are prescribed opioids. Prevention of opioid dependence among these patients is a public health priority. …”
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Higher Body Mass Index Is a Simple Favorable Non-cancer Prognostic Marker for Japanese Elderly Colorectal Cancer Patients after Curative Resection by Hiroshi Takeyama, Shingo Noura, Yozo Suzuki, Kazuki Odagiri, Yoshitomo Yanagimoto, Masafumi Yamashita, Junzo Shimizu, Tomono Kawase, Hiroshi Imamura, Takashi Iwazawa, Naohiro Tomita, Keizo Dono

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Interventional treatments for chronic, axial or radicular, non-cancer, spinal pain: a protocol for a systematic review and network meta-analysis of randomised trials by Xiaoqin Wang, Jason W Busse, Behnam Sadeghirad, Gordon H Guyatt, Thomas Agoritsas, Ivan D Florez, Yaping Chang, Elena Kum, Y Raja Rampersaud, D Norman Buckley, Andrea J Darzi, Grace Martin, Rachel J Couban, Holly N Crandon, Meisam Abdar Esfahani, Laxsanaa Sivananthan, Fatemeh Mehrabi, Neil K Sengupta, Preksha Rathod, Rami Z Morsi, Christopher J Standaert

“…Introduction Chronic, non-cancer, axial or radicular spinal pain is a common condition associated with considerable socioeconomic burden. …”
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Avoidance and Endurance Responses to Pain Before and with Advanced Chronification: Preliminary Results from a Questionnaire Survey in Adult Patients with Non-Cancer Pain Conditions by Teichmüller K, Kübler A, Rittner HL, Kindl GK

“…The present study aims to investigate potential differences in avoidance and endurance responses to pain before and with advanced chronification.Patients and Methods: Two samples of adults with non-cancer pain at two different stages of chronicity were compared: One with pain and risk factors for chronicity (n=26, part of the PAIN2020 project) and one with chronic pain (n=33 from a pain day care clinic). …”
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Pain experiences and intrapersonal change among patients with chronic non-cancer pain after using a pain diary: a mixed-methods study by Charoenpol F, Tontisirin N, Leerapan B, Seangrung R, Finlayson RJ

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Efficacy And Safety Of Controlled-Release Oxycodone For The Management Of Moderate-To-Severe Chronic Non-Cancer Pain In Japanese Patients: Results From An Open-Label Study by Kawamata M, Iseki M, Kawakami M, Yabuki S, Sasaki T, Ishida M, Nishiyori A, Hida H, Kikuchi S

“…Mikito Kawamata,1 Masako Iseki,2 Mamoru Kawakami,3 Shoji Yabuki,4 Takuma Sasaki,5 Mitsuhiro Ishida,5 Atsushi Nishiyori,5 Hideaki Hida,6 Shin-ichi Kikuchi4 1Department of Anesthesiology and Resuscitology, Shinshu University School of Medicine, Matsumoto, Japan; 2Department of Anesthesiology and Pain Medicine, Juntendo University Faculty of Medicine, Tokyo, Japan; 3Spine Care Center, Wakayama Medical University Kihoku Hospital, Wakayama, Japan; 4Department of Orthopaedic Surgery, Fukushima Medical University School of Medicine, Fukushima, Japan; 5Clinical Development Department, Shionogi & Co., Ltd., Osaka, Japan; 6Biostatistics Center, Shionogi & Co., Ltd., Osaka, JapanCorrespondence: Takuma SasakiClinical Development Department, Shionogi & Co., Ltd., 12F, Hankyu Terminal Bld., 1-4, Shibata 1-chome, Kita-ku, Osaka 530-0012, JapanTel +81-6-6485-5090Fax +81-6-6375-5780Email Takuma.sasaki@shionogi.co.jpPurpose: To assess the efficacy and safety of S-8117, an oral, controlled-release formulation of oxycodone hydrochloride, in Japanese patients with chronic non-cancer pain (CNCP).Patients and methods: In this multicenter, non-randomized, open-label, 2-part (part 1, dose-titration followed by maintenance period; part 2, long-term administration period) study at 38 centers in Japan (2013–2015), adult patients with CNCP for ≥12 weeks were administered S-8117. …”
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Trends in opioid and non-opioid treatment for chronic non-cancer pain and cancer pain among privately insured adults in the United States, 2012-2019. by Sachini Bandara, Mark C Bicket, Emma E McGinty

“…Recent clinical guidelines have emphasized non-opioid treatments in lieu of prescription opioids for chronic non-cancer pain, exempting cancer patients from these recommendations. …”
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Association of chiropractic integration in an Ontario community health centre with prescription opioid use for chronic non-cancer pain: a mixed methods study protocol by Lawrence Mbuagbaw, Jason W Busse, Mark Oremus, Peter C Emary

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Competing Risks of Cancer and Non-Cancer Mortality When Accompanied by Lifestyle-Related Factors—A Prospective Cohort Study in Middle-Aged and Older Adults by Pawel Macek, Pawel Macek, Malgorzata Biskup, Malgorzata Biskup, Malgorzata Terek-Derszniak, Marta Manczuk, Halina Krol, Halina Krol, Edyta Naszydlowska, Jolanta Smok-Kalwat, Stanislaw Gozdz, Stanislaw Gozdz, Marek Zak

“…Non-cancer mortality was strongly associated with obesity and hypertension. …”
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Understanding how children and young people with chronic non-cancer pain and their families experience living with pain, pain management and services: a meta-ethnography by Mayara Silveira Bianchim, Line Caes, Liz Forbat, Abbie Jordan, Jane Noyes, Katie Thomson, Ruth Turley, Isabelle Uny, Emma F France

“…We integrated findings with 14 Cochrane treatment effectiveness reviews on children’s chronic non-cancer pain. Results We synthesised 43 studies sampled from 170 eligible studies reported in 182 publications. …”
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