Personalised decision making to predict absolute metastatic risk in cutaneous squamous cell carcinoma: development and validation of a clinico-pathological modelResearch in context by Barbara Rentroia-Pacheco, Selin Tokez, Edo M. Bramer, Zoe C. Venables, Harmen J.G. van de Werken, Domenico Bellomo, David van Klaveren, Antien L. Mooyaart, Loes M. Hollestein, Marlies Wakkee

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Semi-automatic thresholding of RV trabeculation improves repeatability and diagnostic value in suspected pulmonary hypertension by Alistair Macdonald, Alistair Macdonald, Mahan Salehi, Mahan Salehi, Samer Alabed, Samer Alabed, Samer Alabed, Ahmed Maiter, Ahmed Maiter, Ze Ming Goh, Ze Ming Goh, Krit Dwivedi, Krit Dwivedi, Chris Johns, Marcella Cogliano, Faisal Alandejani, Robin Condliffe, James M. Wild, David G. Kiely, David G. Kiely, Pankaj Garg, Andrew J. Swift, Andrew J. Swift

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The association between tocilizumab therapy and the development of thrombosis in critically ill patients with COVID-19: a multicenter, cohort study by Ohoud Aljuhani, Khalid Al Sulaiman, Ghazwa B. Korayem, Ali F. Altebainawi, Samiah Alsohimi, Rahaf Alqahtani, Saeedah Alfaifi, Aisha Alharbi, Azzah AlKhayrat, Ahmed Hattan, Meshal Albassam, Omar A. Almohammed, Atheer Alkeraidees, Dhay A. Alonazi, Weam F. Alsalman, Ghaliah Aldamegh, Rasha Alshahrani, Ramesh Vishwakarma

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Social prescribing for people living with dementia (PLWD) and their carers: what works, for whom, under what circumstances and why – protocol for a complex intervention systematic... by Lee Shepstone, Louise Robinson, Euan Sadler, Katherine Bradbury, Martin Orrell, Sarah Walker, Chris Fox, Jane Cross, Esme Moniz-Cook, Anthony Avery, Antonieta Medina-Lara, Emma Wolverson, Fiona Poland, Louise Allan, Jane L Cross, Joanne Reeve, George Rook, Evie Papavasiliou, Marie J Polley, Jessica Marshall, Matthew Hawkes, Anne Irvine, Aimee Pick, Nia Morrish, Marie Polley, Amy Rathbone, Dame Louise Robinson, Kritika Samsi

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A randomised feasibility study of serial magnetic resonance imaging to reduce treatment times in Charcot neuroarthropathy in people with diabetes (CADOM) by Catherine Gooday, Frances Game, Jim Woodburn, Fiona Poland, Erika Sims, Ketan Dhatariya, Lee Shepstone, Garry Barton, Wendy Hardeman

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Euglena International Network (EIN): Driving euglenoid biotechnology for the benefit of a challenged world by ThankGod Echezona Ebenezer, Ross S. Low, Ellis Charles O'Neill, Ishuo Huang, Antonio DeSimone, Scott C. Farrow, Robert A. Field, Michael L. Ginger, Sergio Adrián Guerrero, Michael Hammond, Vladimír Hampl, Geoff Horst, Takahiro Ishikawa, Anna Karnkowska, Eric W. Linton, Peter Myler, Masami Nakazawa, Pierre Cardol, Rosina Sánchez-Thomas, Barry J. Saville, Mahfuzur R. Shah, Alastair G. B. Simpson, Aakash Sur, Kengo Suzuki, Kevin M. Tyler, Paul V. Zimba, Neil Hall, Mark C. Field

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Snacktivity™ to promote physical activity and reduce future risk of disease in the population: protocol for a feasibility randomised controlled trial and nested qualitative study by Amanda J. Daley, Ryan A. Griffin, Catherine A. Moakes, James P. Sanders, Magdalena Skrybant, Natalie Ives, Ben Maylor, Sheila M. Greenfield, Kajal Gokal, Helen M. Parretti, Stuart J. H. Biddle, Colin Greaves, Ralph Maddison, Nanette Mutrie, Dale W. Esliger, Lauren Sherar, Charlotte L. Edwardson, Tom Yates, Emma Frew, Sarah Tearne, Kate Jolly

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Advancements in cardiac structures segmentation: a comprehensive systematic review of deep learning in CT imaging by Turki Nasser Alnasser, Turki Nasser Alnasser, Lojain Abdulaal, Ahmed Maiter, Ahmed Maiter, Michael Sharkey, Krit Dwivedi, Krit Dwivedi, Mahan Salehi, Pankaj Garg, Andrew James Swift, Andrew James Swift, Samer Alabed, Samer Alabed, Samer Alabed

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Health-Related Quality of Life Impairment Among Patients with Severe Chronic Rhinosinusitis with Nasal Polyps in the SINUS-24 Trial by Maspero JF, Khan AH, Philpott C, Hellings PW, Hopkins C, Wagenmann M, Siddiqui S, Msihid J, Nash S, Chuang CC, Kamat S, Rowe PJ, Deniz Y, Jacob-Nara JA

“…Jorge F Maspero,1 Asif H Khan,2 Carl Philpott,3 Peter W Hellings,4 Claire Hopkins,5 Martin Wagenmann,6 Shahid Siddiqui,7 Jérôme Msihid,8 Scott Nash,7 Chien-Chia Chuang,9 Siddhesh Kamat,7 Paul J Rowe,10 Yamo Deniz,7 Juby A Jacob-Nara10 1Allergy & Respiratory Research Unit, Fundación CIDEA, Buenos Aires, Argentina; 2Global Medical Affairs, Sanofi, Chilly-Mazarin, France; 3Rhinology and ENT Research Group, Norwich Medical School, University of East Anglia, Norwich, UK; 4Department of Otorhinolaryngology – Head and Neck Surgery, University Hospitals Leuven, Leuven, Belgium; 5Department of Otorhinolaryngology, King’s College London, London, UK; 6Department of Otorhinolaryngology, Düsseldorf University Hospital (UKD), Düsseldorf, Germany; 7Medical Affairs, Regeneron Pharmaceuticals Inc., Tarrytown, NY, USA; 8Health Economics and Value Assessment, Sanofi, Chilly-Mazarin, France; 9Health Economics and Value Assessment, Sanofi, Cambridge, MA, USA; 10Global Medical Affairs, Sanofi, Bridgewater, NJ, USACorrespondence: Jorge F Maspero, Allergy & Respiratory Research Unit, Fundación CIDEA, Paraguay 2035, 2SS, Buenos Aires, Argentina, Tel +54 9 11 4183-7294, Email jorge.maspero@fundacioncidea.org.arPurpose: Chronic rhinosinusitis with nasal polyps (CRSwNP) is a predominantly type 2 inflammatory disease with a high symptom burden. …”
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Protein intake and bone mineral density: Cross‐sectional relationship and longitudinal effects in older adults by Inge Groenendijk, Pol Grootswagers, Aurelia Santoro, Claudio Franceschi, Alberto Bazzocchi, Nathalie Meunier, Aurélie Caille, Corinne Malpuech‐Brugere, Agata Bialecka‐Debek, Barbara Pietruszka, Susan Fairweather‐Tait, Amy Jennings, Lisette C.P.G.M. deGroot

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Dementia patients have greater anti-cholinergic drug burden on discharge from hospital: A multicentre cross-sectional study by J. Randall, A. Hook, C-M. Grubb, N. Ellis, J. Wellington, A. Hemmad, A. Zerdelis, B. Geers, B. Sykes, C. Auty, C. Vinchenzo, C. Thorburn, D. Asogbon, E. Granger, H. Boagey, J. Raphael, K. Patel, K. Bhargava, M.-K. Dolley, M. Maden, M. Shah, Q. Lee, R. Vaidya, S. Sehdev, S. Barai, S. Roche, U. Khalid, J. Harrison, D. Codling

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The clinical outcomes of COVID-19 critically ill patients co-infected with other respiratory viruses: a multicenter, cohort study by Khalid Al Sulaiman, Ohoud Aljuhani, Hisham A. Badreldin, Ghazwa B. Korayem, Abeer A. Alenazi, Ahlam H. Alharbi, Albandari Alghamdi, Alaa Alhubaishi, Ali F. Altebainawi, Mohammad Bosaeed, Rand Alotaibi, Ahad Alawad, Nirvana Alnajjar, Khalid Bin Saleh, Walaa A. Sait, Samiah Alsohimi, Meshari M. Alanizy, Sarah A. Almuqbil, Ibrahim Al Sulaihim, Ramesh Vishwakarma, Mai Alalawi, Fatimah Alhassan, Suliman Alghnam

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Hair regrowth treatment efficacy and resistance in androgenetic alopecia: A systematic review and continuous Bayesian network meta-analysis by Peter R. Feldman, Peter R. Feldman, Pietro Gentile, Charles Piwko, Hendrik M. Motswaledi, Samantha Gorun, Samantha Gorun, Jacob Pesachov, Michael Markel, Maxwell I. Silver, Maxwell I. Silver, Megan Brenkel, Oriel J. Feldman, Oriel J. Feldman, Corey L. Kamen, Elizabeth Uleryk, Jaime Guevara-Aguirre, Jaime Guevara-Aguirre, Jaime Guevara-Aguirre, Jaime Guevara-Aguirre, Klaus M. Fiebig

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Incidence and Clinical Outcomes of New-Onset Atrial Fibrillation in Critically Ill Patients with COVID-19: A Multicenter Cohort Study by Raed Kensara BSc.Pharm, SCC-CCP, BCPS, Ohoud Aljuhani PharmD, Ghazwa B Korayem PharmD, Hadeel Alkofide PhD, Sumaya N Almohareb PharmD, Yousef S Alosaimi PharmD, Ali F Altebainawi PharmD, Khalid Bin saleh PharmD, Norah Al Andas PharmD, MClinPharm, Shmeylan Al Harbi PharmD, Abdullah F Al Harthi PharmD, BCCCP, Uhood Ashkan PharmD, Rema Alghamdi PharmD, Hisham A Badreldin PharmD, Awatif Hafiz PharmD, Mashael AlFaifi PharmD, Rahaf A Alqahtani PharmD, Ramesh Vishwakarma PhD, Abeer A Alenazi PharmD, Mai Alalawi PharmD, Reem mahboob BSc.pharm, Renad A Alfouzan PharmD, Layan B Al Tuhayni PharmD, Nouf Al Qahtani BSc.pharm, MSc Med. Ed, Khalid Al Sulaiman BCCCP, BCNSP, MBA, FCCM

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SMAD3 mutation in LDS3 causes bone fragility by impairing the TGF-β pathway and enhancing osteoclastogenesis by Ahmed El-Gazzar, Heeseog Kang, Nadja Fratzl-Zelman, Emma Webb, Aileen M. Barnes, Milena Jovanovic, Sarju G. Mehta, Vipan Datta, Vrinda Saraff, Ryan K. Dale, Frank Rauch, Joan C. Marini, Wolfgang Högler

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Standard dosing of enoxaparin versus unfractionated heparin in critically ill patient with COVID-19: a multicenter propensity-score matched study by Khalid Al Sulaiman, Ohoud Aljuhani, Ghazwa B. Korayem, Awatif Hafiz, Mai Alalawi, Hisham A. Badreldin, Ali F. Altebainawi, Ramesh Vishwakarma, Abdulrahman Alissa, Albandari Alghamdi, Abeer A. Alenazi, Huda Al Enazi, Shahad Alanazi, Abdullah Alhammad, Jahad Alghamdi, Mashael AlFaifi, Faisal A. Al Sehli, Maram A. Aldossari, Alaa A. Alhubaishi, Anfal Y. Al-Ali, Hasan M. Al-Dorzi

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The interplay between metabolic alterations, diastolic strain rate and exercise capacity in mild heart failure with preserved ejection fraction: a cardiovascular magnetic resonance... by Masliza Mahmod, Nikhil Pal, Jennifer Rayner, Cameron Holloway, Betty Raman, Sairia Dass, Eylem Levelt, Rina Ariga, Vanessa Ferreira, Rajarshi Banerjee, Jurgen E. Schneider, Christopher Rodgers, Jane M. Francis, Theodoros D. Karamitsos, Michael Frenneaux, Houman Ashrafian, Stefan Neubauer, Oliver Rider

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Saturated fat and human health: a protocol for a methodologically innovative systematic review and meta-analysis to inform public health nutrition guidelines by Bradley C. Johnston, Dena Zeraatkar, Jeremy Steen, Diego Rada Fernandez de Jauregui, Hongfei Zhu, Mingyao Sun, Matthew Cooper, Malgorzata Maraj, Anna Prokop-Dorner, Boris Castro Reyes, Claudia Valli, Dawid Storman, Giorgio Karam, Joanna Zajac, Long Ge, Mateusz J. Swierz, Nirjhar Ghosh, Robin W. M. Vernooij, Yaping Chang, Yunli Zhao, Lehana Thabane, Gordon H. Guyatt, Pablo Alonso-Coello, Lee Hooper, Malgorzata M. Bala

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The use of Tocilizumab in COVID-19 critically ill patients with renal impairment: a multicenter, cohort study by Ohoud Aljuhani, Khalid Al Sulaiman, Ghazwa B Korayem, Aisha Alharbi, Ali F. Altebainawi, Shatha A. Aldkheel, Sarah G. Alotaibi, Ramesh Vishwakarma, Hanan Alshareef, Samiah Alsohimi, Mashael AlFaifi, Abdulrahman Al Shaya, Haifa A. Alhaidal, Raghad M. Alsubaie, Hessah Alrashidi, Khalid J. Albarqi, Dalal T. Alangari, Reem M. Alanazi, Noora M. Altaher, Hasan M. Al-Dorzi

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The safety and efficacy of balloon-expandable versus self-expanding trans-catheter aortic valve replacement in high-risk patients with severe symptomatic aortic stenosis by Nagendra Boopathy Senguttuvan, Nagendra Boopathy Senguttuvan, Hemal Bhatt, Hemal Bhatt, Vinod Kumar Balakrishnan, Parasuram Krishnamoorthy, Sunny Goel, Pothireddy M. K. Reddy, Vinodhini Subramanian, Bimmer E. Claessen, Bimmer E. Claessen, Ashish Kumar, Monil Majmundar, Richard Ro, Stamatios Lerakis, Ramamoorthi Jayaraj, Ankur Kalra, Ankur Kalra, Marcus Flather, George Dangas

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