Editorial: Post COVID-19: the nucleoside-modified messenger RNA (modRNA) platform by Luca Roncati, Luca Roncati, Qun Treen Huo, Qun Treen Huo

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A Three-Case Series of Thrombotic Deaths in Patients over 50 with Comorbidities Temporally after modRNA COVID-19 Vaccination by Luca Roncati, Antonio Manenti, Lorenzo Corsi

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Restoration of Motor Function through Delayed Intraspinal Delivery of Human IL-10-Encoding Nucleoside-Modified mRNA after Spinal Cord Injury by László Gál, Tamás Bellák, Annamária Marton, Zoltán Fekécs, Drew Weissman, Dénes Török, Rachana Biju, Csaba Vizler, Rebeka Kristóf, Mitchell B. Beattie, Paulo J.C. Lin, Norbert Pardi, Antal Nógrádi, Krisztián Pajer

“…Efficient in vivo delivery of anti-inflammatory proteins to modulate the microenvironment of an injured spinal cord and promote neuroprotection and functional recovery is a great challenge. Nucleoside-modified messenger RNA (mRNA) has become a promising new modality that can be utilized for the safe and efficient delivery of therapeutic proteins. …”
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ASL mRNA-LNP Therapeutic for the Treatment of Argininosuccinic Aciduria Enables Survival Benefit in a Mouse Model by Owen Daly, Azita Josefine Mahiny, Sara Majeski, Kevin McClintock, Julia Reichert, Gábor Boros, Gábor Tamás Szabó, Jonas Reinholz, Petra Schreiner, Steve Reid, Kieu Lam, Marlen Lepper, Melanie Adler, Tracy Meffen, James Heyes, Katalin Karikó, Pete Lutwyche, Irena Vlatkovic

“…Here we describe a novel therapeutic approach for treating ASA, based on nucleoside-modified messenger RNA (modRNA) formulated in lipid nanoparticles (LNP). …”
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Safety of Vaccines against SARS-CoV-2 among Polish Patients with Multiple Sclerosis Treated with Disease-Modifying Therapies by Agata Czarnowska, Joanna Tarasiuk, Olga Zajkowska, Marcin Wnuk, Monika Marona, Klaudia Nowak, Agnieszka Słowik, Anna Jamroz-Wiśniewska, Konrad Rejdak, Beata Lech, Małgorzata Popiel, Iwona Rościszewska-Żukowska, Adam Perenc, Halina Bartosik-Psujek, Mariola Świderek-Matysiak, Małgorzata Siger, Agnieszka Ciach, Agata Walczak, Anna Jurewicz, Mariusz Stasiołek, Karolina Kania, Klara Dyczkowska, Alicja Kalinowska-Łyszczarz, Weronika Galus, Anna Walawska-Hrycek, Ewa Krzystanek, Justyna Chojdak-Łukasiewicz, Jakub Ubysz, Anna Pokryszko-Dragan, Katarzyna Kapica-Topczewska, Monika Chorąży, Marcin Bazylewicz, Anna Mirończuk, Joanna Kulikowska, Jan Kochanowicz, Marta Białek, Małgorzata Stolarz, Katarzyna Kubicka-Bączyk, Natalia Niedziela, Natalia Morawiec, Monika Adamczyk-Sowa, Aleksandra Podlecka-Piętowska, Monika Nojszewska, Beata Zakrzewska-Pniewska, Elżbieta Jasińska, Jacek Zaborski, Marta Milewska-Jędrzejczak, Jacek Zwiernik, Beata Zwiernik, Andrzej Potemkowski, Waldemar Brola, Alina Kułakowska

“…The statistical analyses were performed using STATA 15 software. (3) Of the 2261 sampled patients, 1862 (82.4%) were vaccinated with nucleoside-modified messenger RNA (mRNA) vaccines. Mild symptoms after immunization, often after the first dose, were reported in 70.6% of individuals. …”
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