Terahertz-optical intensity grating for creating high-charge, attosecond electron bunches by Jeremy Lim, Yidong Chong, Liang Jie Wong

“…We provide two detailed examples that use realistic electron bunches and laser pulse parameters which are within the reach of current compact set-ups: one with bunches of >240 electrons contained within 20 as durations and 15 μ m radii, and one with final electron bunches of 1 fC contained within sub-400 as durations and 8 μ m radii. …”
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Terahertz-optical intensity grating for creating high-charge, attosecond electron bunches by Lim, Jeremy, Chong, Yidong, Wong, Liang Jie

“…We provide two detailed examples that use realistic electron bunches and laser pulse parameters which are within the reach of current compact set-ups: one with bunches of >240 electrons contained within 20 as durations and 15 μm radii, and one with final electron bunches of 1 fC contained within sub-400 as durations and 8 μm radii. …”
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Chemical and structural analysis of an antibody folding intermediate trapped during glycan biosynthesis by Bowden, T, Baruah, K, Coles, C, Harvey, D, Yu, X, Song, B, Stuart, D, Aricescu, A, Scanlan, C, Jones, E, Crispin, M

“…Here, we manipulate the mammalian glycan-processing pathway to trap IgG1 Fc at sequential stages of maturation, from oligomannose- to hybrid- to complex-type glycans, and show that the Fc is structurally stabilized following the transition of glycans from their hybrid- to complex-type state. …”

Crystal structure of sialylated IgG Fc: implications for the mechanism of intravenous immunoglobulin therapy. by Crispin, M, Yu, X, Bowden, T

“…To directly assess this hypothesis, we have generated α2,6-sialylated IgG1 Fc (sFc) that we both chemically verified by HPLC analysis (Fig. 1A)andstructurally characterized by X-ray crystallographic analysis to a resolution of 2.3 Å (Fig. 1 B and C, and Table 1).…”

Mechanism of glycoform specificity and in vivo protection by an anti-afucosylated IgG nanobody by Aaron Gupta, Kevin S. Kao, Rachel Yamin, Deena A. Oren, Yehuda Goldgur, Jonathan Du, Pete Lollar, Eric J. Sundberg, Jeffrey V. Ravetch

“…Based on this structure, we designed X0 fusion constructs that disrupt pathogenic afucosylated IgG1-FcγRIIIa interactions and rescue mice in a model of dengue virus infection.…”
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Flexoelectricity in amorphous hafnium oxide (HfO2) by Daniel Moreno-Garcia, Kaitlin M. Howell, Luis Guillermo Villanueva

“…This work introduces a groundbreaking methodology that accurately isolates flexoelectricity from piezoelectric, electrostrictive, and electrostatic effects, with a detection threshold extending below 1 fC/m. The robustness of this method is demonstrated through its application to amorphous hafnium oxide, successfully measuring a flexoelectric coefficient of 105 ± 10 pC/m. …”
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Detection of host cell microprotein impurities in antibody drug products by Ioanna Tzani, Marina Castro-Rivadeneyra, Paul Kelly, Lisa Strasser, Lin Zhang, Martin Clynes, Barry L. Karger, Niall Barron, Jonathan Bones, Colin Clarke

“…Mass spectrometry-based HCP analysis of eight commercial antibody drug products (7 mAbs and 1 Fc-fusion protein) using the extended protein sequence database revealed the presence of microprotein impurities. …”
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The IgG glycome of SARS-CoV-2 infected individuals reflects disease course and severity by Sterre L. Siekman, Tamas Pongracz, Wenjun Wang, Jan Nouta, Peter G. Kremsner, Peter G. Kremsner, Peter G. Kremsner, Pedro Vieira da Silva-Neto, Meral Esen, Meral Esen, Meral Esen, Andrea Kreidenweiss, Andrea Kreidenweiss, Andrea Kreidenweiss, Jana Held, Jana Held, Jana Held, Átila Alexandre Trapé, Rolf Fendel, Rolf Fendel, Rolf Fendel, Isabel Kinney Ferreira de Miranda Santos, Manfred Wuhrer, ImmunoCovid Consortium, Alessandro P. de Amorim, Jamille G M. Argolo, Rita de C.C. Barbieri, Marcelo Dias-Baruffi, Victor A F. Bastos, Vânia L D. Bonat, Cristina Ribeiro de Barros Cardoso, Ingryd Carmona-Garcia, Jonatan C S de Carvalho, Leticia F. Constant, Augusto M. Degiovani, Cassia F.S.L. Dias, Lúcia H. Faccioli, Marley R. Feitosa, Omar Feres, Ana Paula Morais Fernandes, Talita M. Fernandes, Thais F C. Fraga-Silva, Carlos Fuzo, Isabelle C. Guarneri, Cristiane M. Milanezi, Caroline T. Garbato, Gilberto Gambero Gaspar, Ângelo A.F. Júnior, Sandra R. Maruyama, Debora C. Nepomuceno, Nicola T. Neto, Camilla Narjara Simão Oliveira, Fátima M. Ostini, Rogerio S. Parra, Malena M. Pérez, Vinı́cius E. Pimentel, Giovanna da S. Porcel, José J R da Rocha, Lilian C. Rodrigues, Elisa M S. Russo, Dayane P. da Silva, Rafael C. da Silva, Carlos Arterio Sorgi, Camila O S. Souza, Diana M. Toro, Angelina L. Viana, Fernando Crivelenti Vilar, Ana C. Xavier, Kamila Zaparoli

“…Through LC-MS analysis we studied both total IgG1 and spike protein-specific IgG1 Fc glycosylation of 129 German and 163 Brazilian COVID-19 patients representing diverse patient populations. …”
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Efficient inhibition of collagen-induced platelet activation and adhesion by LAIR-2, a soluble Ig-like receptor family member. by Peter J Lenting, Geertje H A Westerlaken, Cécile V Denis, Jan Willem Akkerman, Linde Meyaard

“…LAIR-2/Fc but not LAIR-1/Fc inhibited collagen-induced platelet aggregation. …”
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Hydrodynamic gene delivery of CC chemokine binding Fc fusion proteins to target acute vascular inflammation in vivo. by McNeill, E, Iqbal, A, White, G, Patel, J, Greaves, D, Channon, K

“…We report the in vivopharmacokinetics of a broad-spectrum vaccinia virus CC chemokine binding protein (35 K) fused to human IgG1 Fc. We demonstrate that the in vivoefficacy of the protein can be interrogated using hydrodynamic gene delivery of a standard mammalian expression plasmid. …”

Effectiveness of the Influence of Selected Essential Oils on the Growth of Parasitic <i>Fusarium</i> Isolated from Wheat Kernels from Central Europe by Teresa Krzyśko-Łupicka, Sławomir Sokół, Monika Sporek, Anna Piekarska-Stachowiak, Weronika Walkowiak-Lubczyk, Adam Sudoł

“…At the second stage, on the basis of the mycelium growth rate index, the effectiveness of the EsO in limiting the development of <i>Fusarium</i> isolates from the German population (<i>F. culmorum</i> FC1D, <i>F. culmorum</i> FC2D, <i>F. graminearum</i> FG1D, <i>F. graminearum</i> FG2D and <i>F. poae</i> FP0D) was assessed. …”
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Serum Metabolomic Study on the Difference between Mild and Severe Acute Pancreatitis Based on Liquid Chromatography-tandem Mass Spectrometry by HUANG Xiangping, WU Ling, TAN Chaochao

“…This study used liquid chromatography-tandem mass spectrometry (LC-MS) , and screened out the differential metabolites between the two groups by using univariate analysis (T test, FC) , multivariate analysis (PCA, PLS-DA) , VIP&gt;1, FC &gt;1.5, and P&lt;0.05, thus analyzing the differential metabolites and metabolic pathways between the two groups. …”
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Broad immunity to SARS-CoV-2 variants of concern mediated by a SARS-CoV-2 receptor-binding domain protein vaccineResearch in context by Georgia Deliyannis, Nicholas A. Gherardin, Chinn Yi Wong, Samantha L. Grimley, James P. Cooney, Samuel J. Redmond, Paula Ellenberg, Kathryn C. Davidson, Francesca L. Mordant, Tim Smith, Marianne Gillard, Ester Lopez, Julie McAuley, Chee Wah Tan, Jing J. Wang, Weiguang Zeng, Mason Littlejohn, Runhong Zhou, Jasper Fuk-Woo Chan, Zhi-wei Chen, Airn E. Hartwig, Richard Bowen, Jason M. Mackenzie, Elizabeth Vincan, Joseph Torresi, Katherine Kedzierska, Colin W. Pouton, Tom P. Gordon, Lin-fa Wang, Stephen J. Kent, Adam K. Wheatley, Sharon R. Lewin, Kanta Subbarao, Amy W. Chung, Marc Pellegrini, Trent Munro, Terry Nolan, Steven Rockman, David C. Jackson, Damian F.J. Purcell, Dale I. Godfrey

“…We also developed an RBD-human IgG1 Fc vaccine with an RBD sequence of the immuno-evasive beta variant (N501Y, E484K, K417N). …”
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Response by Hilton-Jones, D

Review of Principles of Glacier Mechanics by Fowler, A

Candida auris in an intensive care setting by Eyre, D, Butcher, L, Jeffery, K

THE STUDY OF SURFACES AND INTERFACES ON THE REFLECTOMETER CRISP AT THE ISIS PULSED NEUTRON SOURCE by Penfold, J

Studies on the synthesis of elatenyne. by Burton, J, Sheldrake, H, Jamieson, C

Type 1 diabetes: The theme for this edition by Narendran, P, Gough, S

RAMAN AND INFRARED-SPECTRA OF TIGASE2 by Allakhverdiev, K, Sardarly, R, Wondre, F, Ryan, J