Orthogonal projections to latent structures as a strategy for microarray data normalization by Moritz Thomas, Jansson Stefan, Sjödin Andreas, Eriksson Daniel, Bylesjö Max, Trygg Johan

“…On the illustrated data sets, the OPLS normalization strategy exhibits leading average true negative and true positive rates in comparison to other evaluated methods.…”
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Piecewise multivariate modelling of sequential metabolic profiling data by Rantalainen, M, Cloarec, O, Ebbels, T, Lundstedt, T, Nicholson, J, Holmes, E, Trygg, J

“…A set of piecewise Orthogonal Projections to Latent Structures (OPLS) models are estimated, describing changes between successive time points. …”

Energetics of endurance exercise in young horses determined by nuclear magnetic resonance metabolomics by Margaux Marie-Hélène, Olivia Luck, Laurence eLe Moyec, Eric eBarrey, Eric eBarrey, Mohamed Nawfal Triba, Nadia eBouchemal, Philippe eSAVARIN, Céline eROBERT, Céline eROBERT

“…An OPLS model was calculated to compare spectra obtained on plasma taken after the race from 6-year-old horses and from experienced horses (cross-validated ANOVA p-value < 0.001). …”
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PLS-based and regularization-based methods for the selection of relevant variables in non-targeted metabolomics data by Renata Bujak, Emilia Daghir-Wojtkowiak, Roman Kaliszan, Michal Jan Markuszewski

“…For the RH study, OPLS-DA model built without multiple testing correction, selected 46 and 218 variables based on VIP criteria using Pareto and UV scaling, respectively. …”
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Inhibition of mTOR signaling and clinical activity of metformin in oral premalignant lesions by J. Silvio Gutkind, Alfredo A. Molinolo, Xingyu Wu, Zhiyong Wang, Daniela Nachmanson, Olivier Harismendy, Ludmil B. Alexandrov, Beverly R. Wuertz, Frank G. Ondrey, Denise Laronde, Leigha D. Rock, Miriam Rosin, Charles Coffey, Valerie D. Butler, Lisa Bengtson, Chiu-Hsieh Hsu, Julie E. Bauman, Stephen M. Hewitt, Ezra E.W. Cohen, H-H. Sherry Chow, Scott M. Lippman, Eva Szabo

“…Here, we conducted a single-arm, open-label phase IIa clinical trial in individuals with oral premalignant lesions (OPLs) to explore the potential of metformin to target PI3K/mTOR signaling for HNSCC prevention.METHODS Individuals with OPLs, but who were otherwise healthy and without diabetes, underwent pretreatment and posttreatment clinical exam and biopsy. …”
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Evaluation of Internet-based pharmaceutical care effect on young and middle-aged patients with hypertension by the principal component analysis and the Markov cohort during COVID-1... by Xinmei Li, Wenxiu Xu, Xiaofeng Mo, Fan Wu, Minghong Qu, Junxian Ye, Wenxing Wu, Haizhi Li, Te Li

“…The questionnaire analysis method based on PCA and OPLS-DA is an effective method to evaluate the effect of the IPC method. …”
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Profiling of volatile compounds in beef, rat, and wild boar meat using SPME-GC/ MS by Lia Amalia, Kusnandar, Feri, Nancy Dewi Yuliana, Purwantiningsih Sugita

“…Correlation coefficients and VIP values were used to determine the volatile marker compounds for each meat in the OPLS-DA classes. The OPLS-DA results that the most robust marker in the beef class was dimethylfulvene, benzyl alcohol in the rat class, and 1,3,5-cycloheptatriene in the wild boar class. …”
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Gene features selection for three-class disease classification via multiple orthogonal partial least square discriminant analysis and S-plot using microarray data. by Mingxing Yang, Xiumin Li, Zhibin Li, Zhimin Ou, Ming Liu, Suhuan Liu, Xuejun Li, Shuyu Yang

“…For three classes in parallel, we employed three OPLS-DA models and S-plots to choose marker genes for each class. …”
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Greenness-sustainability metrics for assessment smart-chemometric spectrophotometric strategy for evaluation of the combination of six gastric proton-pump inhibitors with two selec... by Khanda F.M. Amin

“…Smart chemometric spectrophotometric techniques, including orthogonal partial least square (OPLS), variable selection such as genetic algorithm (GA-OPLS), and interval selection (i-OPLS), were utilized. …”
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Drying of oil palm lumber by combining air-force and modified super fast drying method by Mohd Nazip, Muhammad Nadzim

“…Having a unique wood structure and very high moisture content (MC), the drying has been one of big challenges in the utilization of oil-palm lumber (OPL). Drying of OPL took very long time and creates many defects. …”
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Magnetic resonance metabolic profiling of breast cancer tissue obtained with core needle biopsy for predicting pathologic response to neoadjuvant chemotherapy. by Ji Soo Choi, Hyeon-Man Baek, Suhkmann Kim, Min Jung Kim, Ji Hyun Youk, Hee Jung Moon, Eun-Kyung Kim, Youn Ki Nam

“…In multivariate analysis, the OPLS-DA models built with HR-MAS MR metabolic profiles showed visible discrimination between the pathologic response groups. …”
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A Comparative Study on Processed <i>Panax ginseng</i> Products Using HR-MAS NMR-Based Metabolomics by Dahye Yoon, Woo Cheol Shin, Young-Seob Lee, Suhkmann Kim, Nam-In Baek, Dae Young Lee

“…For effective clustering, orthogonal partial least squares discriminant analyses (OPLS-DA) with a 1:1 comparison were conducted and all OPLS models were validated using the permutation test, the root mean square error of estimation (RMSEE), and the root mean square error of prediction (RMSEP). …”
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A multiplex metabolomic approach for quality control of Spirulina supplement and its allied microalgae (Amphora & Chlorella) assisted by chemometrics and molecular networking by Nesrine Hegazi, Amira R. Khattab, Hamada H. Saad, Bishoy Abib, Mohamed A. Farag

“…Despite being of low discriminatory potential, UV/Vis OPLS-DA modeling showed that Spirulina was distinguished with the UV absorbances of carotenoids and chlorophyll pigments, as indicated by its OPLS-DA derived S-plot. …”
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Serum metabolic profiling of human gastric cancer based on gas chromatography/mass spectrometry by Hu Song, Jun-Sheng Peng, Yao Dong-Sheng, Zu-Li Yang, Huan-Liang Liu, Yi-Ke Zeng, Xian-Ping Shi, Bi-Yan Lu

“…The OPLS-DA model showed adequate discrimination between cancer and non-cancer cohorts while the model failed to discriminate different pathological stages (I-IV) of gastric cancer patients. …”
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Over-expression of 14-3-3zeta is an early event in oral cancer by Gupta Siddhartha D, Duggal Ritu, Bahadur Sudhir, Matta Ajay, Ralhan Ranju

“…</p> <p>Results</p> <p>Intense immunostaining of 14-3-3ζ protein was observed in 61/89 (69%) OPLs and 95/120 (79%) OSCCs. Immunohistochemistry showed significant increase in expression of 14-3-3ζ protein from normal mucosa to OPLs to OSCCs (p_trend< 0.001). …”
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All-atomic and coarse-grained molecular dynamics investigation of deformation in semi-crystalline lamellar polyethylene by Olsson, Pär AT, in ’t Veld, Pieter J, Andreasson, Eskil, Bergvall, Erik, Persson Jutemar, Elin, Petersson, Viktor, Rutledge, Gregory C, Kroon, Martin

“…To this end, specifically the all-atomic optimized potential for liquid simulations (OPLS-AA) and the coarse-grained united-atom (UA) force-fields are used to simulate the yielding and tensile behaviour for the lamellar separation mode. …”
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Distinct plasma metabolomic signatures differentiate autoimmune encephalitis from drug‐resistant epilepsy by Xiong, W, Yeo, T, May, JTM, Demmers, T, Ceronie, B, Ramesh, A, McGinty, RN, Michael, S, Torzillo, E, Sen, A, Anthony, DC, Irani, SR, Probert, F

“…Further, pairwise OPLS‐DA models were able to stratify the three AE subtypes. …”

Evaluating the physiological and biochemical responses of melon plants to NaCl salinity stress using supervised and unsupervised statistical analysis by Behrooz Sarabi, Jaleh Ghashghaie

“…Further, supervised analysis with OPLS-DA easily discriminates samples according to genotype and salinity. …”
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Application of FT-IR spectroscopy and chemometric technique for the identification of three different parts of Camellia nitidissima and discrimination of its authenticated product by Wan Yin Tew, Wan Yin Tew, Chen Ying, Chen Ying, Zhang Wujun, Liu Baocai, Tiem Leong Yoon, Mun Fei Yam, Mun Fei Yam, Chen Jingying

“…In addition, PCA-class and OPLS-DA obtained scores of 27/32 and 26/32, respectively, for detecting adulterated and other TCM reference flower samples from C. nitidissima. …”
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元素分析-稳定同位素质谱法结合化学计量学 鉴别橄榄油掺假Olive oil adulteration identification using elemental analysis-stable isotope ratio mass spectrometer coupled with chemometrics... by 侯颖烨1，王志元1，谢建军1，王璐1，陈文锐1，蔡翠玲1，奚星林1，丁博2，曾广丰1 HOU Yingye1, WANG Zhiyuan1, XIE Jianjun1, WANG Lu1, CHEN Wenrui1, CAI Cuiling1, XI Xinglin1, DING Bo2, ZENG Guangfeng1

“…采用主成分分析（PCA）和正交偏最小二乘法判别分析（OPLS-DA）两种统计分析方法建立不同油脂的鉴别模型和橄榄油掺假鉴别模型。结果表明：橄榄油的δ13C、δ18O和δ2H范围分别在-30.411×10-3~-28.996×10-3、23.583×10-3~25.581×10-3、-163.611×10-3~-132.251×10-3 之间；橄榄油与玉米油、猪油、牛油和鸭油的OPLS-DA鉴别模型准确性稍好，3个变量δ13C、δ2H和δ18O对不同油脂区分的贡献度VIP值分别为1.056、0.997和0.943；使用其他4种油脂对橄榄油进行掺假时，OPLS-DA鉴别模型可明显区分橄榄油与掺假油；PCA-Class鉴别模型对橄榄油掺入玉米油、猪油、牛油和鸭油的检测限分别为5.8%、5.6%、6.4%和12.5%，盲样验证鉴别准确率可达100%。…”
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