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    Natural Compound α-PGG and Its Synthetic Derivative 6Cl-TGQ Alter Insulin Secretion: Evidence for Diminishing Glucose Uptake as a Mechanism by Chen X, Daniels NA, Cottrill D, Cao Y, Wang X, Li Y, Shriwas P, Qian Y, Archer MW, Whitticar NB, Jahan I, Nunemaker CS, Guo A

    Published 2021-02-01
    “…Xiaozhuo Chen,1– 7 Nigel A Daniels,1,4,5,8 David Cottrill,2,3 Yanyang Cao,2,3 Xuan Wang,2,3 Yunsheng Li,2 Pratik Shriwas,2,3 Yanrong Qian,2 Michael W Archer,1,4 Nicholas B Whitticar,4,9 Ishrat Jahan,1,4 Craig S Nunemaker,1,3– 5 Aili Guo10 1The Diabetes Institute at Ohio University, Athens, OH, 45701, USA; 2The Edison Biotechnology Institute, Athens, OH, 45701, USA; 3Department of Biological Sciences, Athens, OH, 45701, USA; 4Department of Biomedical Sciences, Athens, OH, 45701, USA; 5Heritage College of Osteopathic Medicine, Athens, OH, 45701, USA; 6Interdisciplinary Graduate Program in Molecular and Cellular Biology, Athens, OH, 45701, USA; 7Department of Chemistry and Biochemistry, Athens, OH, 45701, USA; 8Department of Specialty Medicine, Athens, OH, 45701, USA; 9Translational Biomedical Sciences Program, Ohio University, Athens, OH, 45701, USA; 10Department of Internal Medicine, Division of Endocrinology, Diabetes and Metabolism, University of California at Davis (UC Davis) School of Medicine, UC Davis Health Science, Sacramento, CA, 95817, USACorrespondence: Aili GuoDepartment of Internal Medicine, Division of Endocrinology, Diabetes and Metabolism, University of California at Davis (UC Davis) School of Medicine, UC Davis Health Science, PSSB, G400, 4150 V St., Sacramento, CA, 95817, USATel +1 916-734-3730Fax +1 916-734-2292Email alguo@ucdavis.eduCraig S NunemakerDepartment of Biomedical Sciences, 1 Ohio University, Athens, OH, 45701, USATel +1 740-593-2387Fax +1 740-593-4795Email nunemake@ohio.eduPurpose: Previously we showed that natural compound α-penta-galloyl-glucose (α-PGG) and its synthetic derivative 6-chloro-6-deoxy-1,2,3,4-tetra-O-galloyl-α-D-glucopyranose (6Cl-TGQ) act to improve insulin signaling in adipocytes by increasing glucose transport. …”
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