Enhanced neuronal degradation of amyloid-β oligomers allows synapse regeneration by Clive Bate

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Amyloid management by chaperones: The mystery underlying protein oligomers’ dual functions by Payam Arghavani, Mitra Pirhaghi, Faezeh Moosavi-Movahedi, Fatemeh Mamashli, Elnaz Hosseini, Ali Akbar Moosavi-Movahedi

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Unconventional secretion of α-synuclein mediated by palmitoylated DNAJC5 oligomers by Shenjie Wu, Nancy C Hernandez Villegas, Daniel W Sirkis, Iona Thomas-Wright, Richard Wade-Martins, Randy Schekman

“…We propose that DNAJC5 forms a palmitoylated oligomer to accommodate and export α-syn.…”
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Direct Synthesis of Chain-End Toluene Functionalized Hyperbranched Ethylene Oligomers by Jianhai Chen, Zhengpeng Yan, Zhongyuan Li, Shengyu Dai

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Fully automated fast-flow synthesis of antisense phosphorodiamidate morpholino oligomers by Li, Chengxi, Callahan, Alex J., Simon, Mark, Totaro, Kyle A., Mijalis, Alexander James, Phadke, Kruttika-Suhas, Zhang, Genwei, Hartrampf, Nina, Schissel, Carly K., Zhou, Ming, Zong, Hong, Hanson, Gunnar J., Loas, Andrei Ioan, Pohl, Nicola L. B., Verhoeven, David E., Pentelute, Bradley L.

“…Antisense phosphorodiamidate morpholino oligomers (PMOs) are promising candidates to fill such a role, but their challenging synthesis limits their widespread application. …”
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Bridged-triarylamine starburst oligomers as hole transporting materials for electroluminescent devices by Fang, Zhen, Chellappan, Vijila, Webster, Richard David, Ke, Lin, Zhang, Tianfu, Liu, Bin, Lai, Yee-Hing

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Multistep DNA-templated reactions for the synthesis of functional sequence controlled oligomers. by Mckee, M, Milnes, P, Bath, J, Stulz, E, Turberfield, A, O'Reilly, R

“…Biomimetic: A strand displacement mechanism was designed to permit DNA-templated synthesis of functional oligomers of arbitrary length (see scheme). Key features of the mechanism are that successive coupling reactions take place in near-identical environments and that purification is only necessary in the last synthesis step. © 2010 WILEY-VCH Verlag GmbH and Co. …”

Building molecular wires from the colours of life: conjugated porphyrin oligomers by Anderson, H

“…Close collaboration between synthetic organic chemists, chemical physicists and theoreticians has yielded new insights into the electronic structure of these remarkable materials. Alkyne-linked oligomers have been most intensively investigated. …”

High-purity discrete PEG-oligomer crystals allow structural insight. by French, A, Thompson, A, Davis, B

“…To great (monodisperse) lengths: An improved synthesis of purer ethylene glycol (EG) oligomers allows access to 16- and 32-mers pure enough for multiple incorporation, and also to the longest (48-mer) discrete EG oligomer yet reported. …”

Amino-borane oligomers bound to a Rh(I) metal fragment. by Dallanegra, R, Chaplin, AB, Tsim, J, Weller, A

Determination of the triplet state energies of a series of conjugated porphyrin oligomers. by Kuimova, M, Hoffmann, M, Winters, M, Eng, M, Balaz, M, Clark, I, Collins, H, Tavender, S, Wilson, C, Albinsson, B, Anderson, H, Parker, A, Phillips, D

“…We report a systematic study of the photophysical parameters relevant to photodynamic therapy (PDT) by a new type of sensitizers, conjugated porphyrin oligomers. Due to the strong nonlinear properties of oligomers containing 2, 4 and 8 porphyrin units, these molecules are attractive candidates for PDT via multiphoton excitation. …”

Synthesis And Mesomorphic Properties Of Symmetric And Non-Symmetric Multi-Functionalized Oligomers by Hng, Tiang Chuan

“…Six series of novel symmetric and non-symmetric oligomers with multi-functional groups have been synthesized and characterized. …”
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Synthesis, Characterization And Mesomorphic Properties Of Symmetric And Non-Symmetric Isoflavone Oligomers by Chan, Tze Nee

“…Four new series of symmetric and non-symmetric isoflavone-based liquid crystal oligomers have been synthesized and characterized. …”
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Alzheimer's therapeutics targeting amyloid beta 1-42 oligomers I: Abeta 42 oligomer binding to specific neuronal receptors is displaced by drug candidates that improve cognitive deficits. by Nicholas J Izzo, Agnes Staniszewski, Lillian To, Mauro Fa, Andrew F Teich, Faisal Saeed, Harrison Wostein, Thomas Walko, Anisha Vaswani, Meghan Wardius, Zanobia Syed, Jessica Ravenscroft, Kelsie Mozzoni, Colleen Silky, Courtney Rehak, Raymond Yurko, Patricia Finn, Gary Look, Gilbert Rishton, Hank Safferstein, Miles Miller, Conrad Johanson, Edward Stopa, Manfred Windisch, Birgit Hutter-Paier, Mehrdad Shamloo, Ottavio Arancio, Harry LeVine, Susan M Catalano

“…The therapeutic lead compounds we have found are pharmacological antagonists of Abeta oligomers, reducing the binding of Abeta oligomers to neurons in vitro, preventing spine loss in neurons and preventing and treating oligomer-induced deficits in membrane trafficking. …”
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Genotoxicity of styrene oligomers extracted from polystyrene intended for use in contact with food by Makoto Nakai, Mifumi Tsubokura, Masaru Suzuki, Saori Fujishima, Yoichi Watanabe, Yu Hasegawa, Kazuhiro Oyama, Shozo Ogura

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Synapsin I phosphorylation is dysregulated by beta-amyloid oligomers and restored by valproic acid by Jade Marsh, Saifuddien Haji Bagol, Robin S.B. Williams, George Dickson, Pavlos Alifragis

“…Growing evidence supports a significant role for Aβ42 oligomers in the development and progression of Alzheimer's. …”
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Oligomer Formation Propensities of Dimeric Bundle Peptides Correlate with Cell Penetration Abilities by Soonsil Hyun, Yuno Lee, Sun Mi Jin, Jane Cho, Jeemin Park, Changbong Hyeon, Key-Sun Kim, Yan Lee, Jaehoon Yu

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Bottle-grade polyethylene furanoate from ring-opening polymerisation of cyclic oligomers by Jan-Georg Rosenboom, Diana Kay Hohl, Peter Fleckenstein, Giuseppe Storti, Massimo Morbidelli

“…Here the authors show that bottle-grade polyethylene furanoate can be obtained within minutes from ring-opening polymerisation of its cyclic oligomers, thereby avoiding degradation and discolouration.…”
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Optimization of the All-D Peptide D3 for Aβ Oligomer Elimination. by Antonia Nicole Klein, Tamar Ziehm, Markus Tusche, Johan Buitenhuis, Dirk Bartnik, Annett Boeddrich, Thomas Wiglenda, Erich Wanker, Susanne Aileen Funke, Oleksandr Brener, Lothar Gremer, Janine Kutzsche, Dieter Willbold

“…Therefore, elimination of thesis oligomers represents a potential causal therapy of AD. …”
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Alpha-synuclein oligomers alter the spontaneous firing discharge of cultured midbrain neurons by Giulia Tomagra, Giulia Tomagra, Claudio Franchino, Federico Cesano, Federico Cesano, Giovanni Chiarion, Antonio de lure, Emilio Carbone, Emilio Carbone, Paolo Calabresi, Paolo Calabresi, Luca Mesin, Barbara Picconi, Barbara Picconi, Andrea Marcantoni, Andrea Marcantoni, Valentina Carabelli, Valentina Carabelli

“…On the contrary, after 48 h exposure, the firing activity was drastically altered at late developmental stages (14 days in vitro, DIV, neurons): α-syn oligomers progressively reduced the spontaneous firing discharge (IC50 = 1.03 μM), impaired burst generation and network synchronism, proportionally to the increased oligomer/monomer ratio. …”
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