Expert opinions and clinical experiences with chlormethine gel as maintenance treatment for patients with mycosis fungoides by Larisa Geskin, Christiane Querfeld, Emmilia Hodak, Neda Nikbakht, Evangelia Papadavid, Marco Ardigò, Marco Ardigò, Marco Ardigò, Ulrike Wehkamp, Ulrike Wehkamp, Martine Bagot

“…The definition of and required duration of durable response are topics that are open to debate and currently have no consensus. Chlormethine gel has several attributes that make it suitable for maintenance therapy; it can be easily applied at home, can be combined with other treatment options for maintenance, and has a manageable safety profile. …”
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Behavioral and Psychological Symptoms of Dementia (BPSD): Clinical Characterization and Genetic Correlates in an Italian Alzheimer’s Disease Cohort by Catia Scassellati, Miriam Ciani, Carlo Maj, Cristina Geroldi, Orazio Zanetti, Massimo Gennarelli, Cristian Bonvicini

“…The definition of the clinical distribution of BPSD symptoms, and the extent to which symptoms are genetically determined, are still open to debate. Moreover, genetic factors that underline BPSD symptoms still need to be identified. …”
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Is 6 Months of Antitubercular Chemotherapy as Effective as More Than 6 Months Regimen in Spinal Tuberculosis? A Systematic Review and Meta-analysis by Aayush Aryal, Bhavuk Garg, Nishank Mehta, Shubhankar Shekhar, Vivek Gupta

“…However, with the success of short-course ATT being demonstrated in other forms of extrapulmonary TB, the subject is open for debate again. Therefore, we systematically reviewed various published literature to determine whether short-course treatment regimen (6 months) of ATT provides equivalent results in terms of disease healing as long-course treatment regimen (≥9 months) in the management of spinal TB. …”
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Daily Clinical Dose (D) poorly predicts trough serum methadone concentration (C trough) in patients undergo methadone maintenance therapy with good adherence by Mohamed Nazar, Nor Ilyani, Sim , Hann Liang, Tan, Soo Choon, Ismail, Rusli, Musa, Ramli, Abu Bakar, Ahmad Zafri

“…However, the effective dose strategy of the therapy is still open to debate. The study aimed to investigate the potential of methadone trough concentration (Ctrough) to be a surrogate marker for such purpose. …”
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Daily clinical dose (D) poorly predicts trough serum methadone concentration (ctrough) in patients undergo methadone maintenance therapy (MMT) with good adherence by Mohamed Nazar, Nor Ilyani, Sim, Hann Liang, Tan, Soo Choon, Ismail, Rusli, Musa, Ramli, Abu Bakar, Ahmad Zafri

“…However, the effective dose strategy of the therapy is still open to debate. The study aimed to investigate the potential of methadone trough concentration (Ctrough)tobe a surrogate marker for such purpose. …”
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Metrics for the emissions of F-gas refrigerants by Miranda, ND, Giovani Palafox-Alcantar, P, Khosla, R, McCulloch, MD

“…Here, we provide the first step to open such debate for short-lived f-gases. We address this, first, with a critical review of the available metrics for carbon foot-printing of f-gases and present a gap analysis between the existing carbon foot printing metrics and the need to better understand warming from f-gases. …”

On the origin of mitochondria: a multilayer network approach by Dérick Gabriel F. Borges, Daniel S. Carvalho, Gilberto C. Bomfim, Pablo Ivan P. Ramos, Jerzy Brzozowski, Aristóteles Góes-Neto, Roberto Andrade, Charbel El-Hani

“…While ample evidence supports the intimate connection of Alphaproteobacteria to the mitochondrial ancestor, pinpointing its closest relative within sampled Alphaproteobacteria is still an open evolutionary debate. Many different phylogenetic methods and approaches have been used to answer this challenging question, further compounded by the heterogeneity of sampled taxa, varying evolutionary rates of mitochondrial proteins, and the inherent biases in each method, all factors that can produce phylogenetic artifacts. …”
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The role of market competition for knowledge competencies, R&D and innovation: an empirical analysis for German firms by Shoaib Abdul Basit, Thomas Kuhn, Uwe Cantner

“…In comparison, the role of the competitive environment for the innovation activities of firms is still open to debate and has not been fully understood yet. …”
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Corrosion behavior of Cr-bearing steels in CO2-O2-H2O multi-thermal-fluid environment by Juntao Yuan, Kaifeng Zhu, Jingjing Jiang, Huihui Zhang, Anqing Fu, Wensheng Li, Chengxian Yin, Fagen Li

“…Multi-thermal fluid is used to enhance heavy oil recovery, but it also causes severe corrosion failure of metallic tubing and its mechanism is still open to debate. In the present work, the c orrosion behavior of commercial steels with different Cr content (3 wt%, 9 wt%, and 25 wt%) in simulated CO _2 -O _2 -H _2 O multi-thermal fluid environments were studied by immersion corrosion test and microstructural characterization. …”
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Pathophysiological Implications of Imbalances in Fibroblast Growth Factor 23 in the Development of Diabetes by Javier Donate-Correa, Ernesto Martín-Núñez, Ainhoa González-Luis, Carla M. Ferri, Desirée Luis-Rodríguez, Víctor G. Tagua, Carmen Mora-Fernández, Juan F. Navarro-González

“…Observational studies have associated the increase in fibroblast growth factor (FGF) 23 levels, the main regulator of phosphate levels, with the onset of diabetes. These studies open the debate on the plausible existence of undescribed diabetogenic mechanisms derived from chronic supraphysiological levels of FGF23, a prevalent condition in chronic kidney disease (CKD) and end-stage renal disease (ESRD) patients. …”
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Metrics for the emissions of F-gas refrigerants by Miranda, ND, Palafox-Alcantar, PG, Khosla, R, McCulloch, M

“…Here, we provide the first step to open such debate for short-lived f-gases. We address this, first, with a critical review of the available metrics for carbon foot-printing of f-gases and present a gap analysis between the existing carbon foot printing metrics and the need to better understand warming from f-gases. …”

Implementing and monitoring the right to health in breast cancer: selection of indicators using a Delphi process by Lisa Montel, Michel P. Coleman, Therese Murphy, Dina Balabanova, Raffaele Ciula, Dabney P. Evans, Claire Lougarre, Didier Verhoeven, Claudia Allemani

“…Results After two rounds, 54 indicators were selected by consensus, three were rejected, three were added, and 97 remained open for debate. For breast cancer, right-to-health features selected as worth implementing and monitoring included the formal recognition of the right to health in breast cancer strategies; a population-based screening programme, prompt diagnosis, strong referral systems and limited waiting times; the provision of palliative, survivorship and end-of-life care; the availability, accessibility, acceptability and quality (AAAQ) of breast cancer services and medicines; the provision of a system of accountability; and the collection of anonymised individual data to target patterns of discrimination. …”
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Distribution pattern of different phenotypes of Limnocythere inopinata (an ostracod) from lakes in the Badain Jaran Desert, northern China by Gaolei Jiang, Nai'ang Wang, Dayou Zhai, Xiangzhong Li, Xin Mao, Meng Li, Linjing Liu

“…However, the factors controlling its morphological variation are currently open to debate, which hinders palaeoecological reconstructions based on this species. …”
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The potential of facial nevi in personal identification by Annalisa Cappella, Riccardo Solazzo, Debora Mazzarelli, Daniele Gibelli, Claudia Dolci, Chiarella Sforza, Cristina Cattaneo

“…Since no data is available on frequencies and distribution of facial PSLs in the general population, this study aims at systematically collecting such data to verify their potential in PI and to open a debate on the aid that “secondary identifiers”, regardless of their specific nature, can give to the identification of the deceased in specific forensic contexts. …”
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The chronology and rotational kinematics in the South-Eastern Jaca Basin (Southern Pyrenees): Las Bellostas section by Emilio L. Pueyo, Adriana Rodríguez-Pintó, Josep Serra-Kiel, Antonio Barnolas

“…These new data still let open the debate on the rotational kinematics along the South Pyrenean basal thrust. …”
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Aluminium Binding to Modified Amyloid-β Peptides: Implications for Alzheimer’s Disease by Cosmin Stefan Mocanu, Monica Jureschi, Gabi Drochioiu

“…Nevertheless, the link between AD pathology and Al is still open to debate. Therefore, we investigated here the interaction of aluminium ions with two Aβ peptide fragments and their analogues. …”
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The chronology and rotational kinematics in the South-Eastern Jaca Basin (Southern Pyrenees): Las Bellostas section by Emilio L. Pueyo, Adriana Rodríguez-Pintó, Josep Serra-Kiel, Antonio Barnolas

“…These new data still let open the debate on the rotational kinematics along the South Pyrenean basal thrust.…”
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Artifacts in postmortem CT-imaging of the brain: A cooling effect? by Frederique Thicot, Vincent Dunet, Virginie Magnin, Christine Bruguier, Johannes-Alexander Lobrinus, Silke Grabherr, Pia Genet

“…We intend to encourage further studies on this topic, to allow correct interpretation of such CT scan findings in forensic cases, and to open the debate about the possible causes of this phenomenon.…”
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La Casa della storia europea: una controversa proposta museale per la storia d’Europa by Beatrice Tioli

“…Does it offer a clear interpretation of European identity? Is it a place open to debate that offers a plural view of European conflicting memories? …”
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Effects of a commercially available branched-chain amino acid-alanine-carbohydrate-based sports supplement on perceived exertion and performance in high intensity endurance cycling... by Marco Gervasi, Davide Sisti, Stefano Amatori, Sabrina Donati Zeppa, Giosuè Annibalini, Giovanni Piccoli, Luciana Vallorani, Piero Benelli, Marco B. L. Rocchi, Elena Barbieri, Anna R. Calavalle, Deborah Agostini, Carmela Fimognari, Vilberto Stocchi, Piero Sestili

“…Background Sports nutritional supplements containing branched-chain amino acids (BCAA) have been widely reported to improve psychological and biological aspects connected to central fatigue and performance in endurance exercise, although the topic is still open to debate. The aim of the present study was to determine whether the intake of a commercially available BCAA-based supplement, taken according to the manufacturer’s recommendations, could affect the rating of perceived exertion (RPE) and performance indexes at the beginning (1d) and end of a 9-week (9w) scheduled high intensity interval training program, with an experimental approach integrating the determination of psychometric, performance, metabolic and blood biochemical parameters. …”
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