Formulation and pharmaceutical development of quetiapine fumarate sustained release matrix tablets using a QbD approach by Gavan Alexandru, Porfire Alina, Marina Cristina, Tomuta Ioan

“…The quality target product profile (QTPP) was defined after the pharmaceutical properties and kinetic release of the innovator product, Seroquel XR 200 mg. For the D-optimal experimental design, the level and ratio of matrix forming agents and the type of extragranular diluent were chosen as independent inputs, which represented critical formulation factors. …”
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Production of uronic acids by hydrothermolysis of pectin as a model substance for plant biomass waste by Pińkowska Hanna, Krzywonos Małgorzata, Wolak Paweł, Złocińska Adrianna

“…The effects of the reaction temperature and time on the composition of the products contained in the separated liquid fractions were studied. The optimal experimental design methodology was used for modelling and optimizing the yield of uronic acids. …”
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Experimental design for parameter estimation of gene regulatory networks. by Bernhard Steiert, Andreas Raue, Jens Timmer, Clemens Kreutz

“…In conclusion, we provide a strategy for optimal experimental design and show its successful application on three highly nonlinear dynamic models. …”
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Hellinger Information Matrix and Hellinger Priors by Arkady Shemyakin

“…Hellinger information for the vector parameter was applied by Yin et al. to problems of optimal experimental design. A special class of parametric problems was considered, requiring the directional definition of Hellinger information, but not a full construction of Hellinger information matrix. …”
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Hydrodynamic Interactions of an Unmanned Underwater Vehicle Operating in Close Proximity to a Moving Submarine by Hammond, Brady M.(Brady Meikle)

“…A Gaussian process regression model was used to perform an optimal experimental design and map the resulting hydrodynamic interactions based on the UUVs longitudinal position, lateral position, speed, heading angle, UUV diameter, and UUV length. …”
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Optimisation of an effervescent pineapple tablet by Mohd Rosdan, Faridatul Ain, Yusof, Yus Aniza, Chin, Nyuk Ling, Mohd. Amin, Nor Amaiza, Mohd Ghazali, Hasanah

“…This study is mainly undertaken to design and optimize an effervescent tablet formulation of Josapine pineapple by using the D-optimal experimental design methodology. Josapine pineapple powder, citric acid, sodium carbonate and stevia were used in the formulations as independent variables. …”
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Ancient Metagenomic Studies: Considerations for the Wider Scientific Community by Clio Der Sarkissian, Irina M. Velsko, Anna K. Fotakis, Åshild J. Vågene, Alexander Hübner, James A. Fellows Yates

“…Furthermore, researchers often work with finite sample sizes, which impedes optimal experimental design and control of confounding factors, and with ethically sensitive samples necessitating the consideration of additional guidelines. …”
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Acceleration of CRISPR/Cas9-Mediated Editing at Multiple Sites in the <i>Saccharomyces cerevisiae</i> Genome by Alexey D. Karpukhin, Fanis A. Sabirzyanov, Vsevolod A. Serebrianyi

“…This finding increases the flexibility of choosing the optimal experimental design for multiple editing of the genome of <i>S. cerevisiae</i> and can significantly accelerate such experiments.…”
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Sources of variation in Affymetrix microarray experiments by Parrish Rudolph S, Scheirer Katherine E, Barnes Stephen, Chen Lang, Mehta Tapan, Kim Kyoungmi, Zakharkin Stanislav O, Allison David B, Page Grier P

“…Identifying sources of variation and assessing their magnitude, among other factors, are important for optimal experimental design. The objectives of this study were: (1) to estimate relative magnitudes of different sources of variation and (2) to evaluate agreement between biological and technical replicates.…”
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A Python Clustering Analysis Protocol of Genes Expression Data Sets by Giuseppe Agapito, Marianna Milano, Mario Cannataro

“…Therefore, a basic understanding of these computational tools is necessary for optimal experimental design and meaningful data analysis. This manuscript provides an analysis protocol to effectively analyze gene expression data sets through the K-means and DBSCAN algorithms. …”
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Temporal Data Set Reduction Based on D-Optimality for Quantitative FLIM-FRET Imaging. by Travis Omer, Xavier Intes, Juergen Hahn

“…Herein, an optimal experimental design approach based upon sensitivity analysis is presented in order to identify the time points that provide the best quantitative estimates of the parameters for a determined number of temporal sampling points. …”
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Post hoc experimental designs improve genetic trial analyses: A case study of cherrybark oak (Quercus pagoda Raf.) genetic evaluation in the western Gulf region, USA. by Chen Ding, Yuhui Weng, Tom D Byram, Benjamin D Bartlett, Earl M Raley

“…Oaks (Quercus spp.) are widespread hardwood trees in the Northern Hemisphere and of high ecological, economic, and social values. Optimal experimental design of genetic trials is essential for accurate estimates of genetic parameters and improving the genetic merit of breeding stock. …”
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Mine Vegetation Identification via Ecological Monitoring and Deep Belief Network by Bin Gong, Cheng Shu, Song Han, Sheng-Gao Cheng

“…Parameters and parameter values were selected for identification by establishing the optimal experimental design. The experimental results were compared with remote sensing images to determine the accuracy of deep learning identification and the effectiveness of the algorithm. …”
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Design of experiments assisted the development of inclusion complexes of ramipril using hydrophilic carriers for enhancement of solubility and dissolution rate by Azeez Mohammad, Sumer Singh, Suryakanta Swain, Rabinarayan Parhi

“…The systematic optimization of formulations was performed using I-Optimal experimental design by selecting factors such as type of carriers (X1), drug: carrier ratio (X2), and method of preparation (X3), and response variables including percent yield (Y1), solubility (Y2), Carr’s index (Y3) and drug release in 30 min (Y4). …”
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Digital Twin Concepts with Uncertainty for Nuclear Power Applications by Brendan Kochunas, Xun Huan

“…Optimization under uncertainty facilitates decision support through the formal methods of optimal experimental design and design optimization that maximize information gain, or performance, of the physical asset in an uncertain environment.…”
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An efficient moments-based inference method for within-host bacterial infection dynamics. by David J Price, Alexandre Breuzé, Richard Dybowski, Piero Mastroeni, Olivier Restif

“…Its computational efficiency paves the way for model comparison and optimal experimental design.…”
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Ecotoxicological assessment of recycled aggregate and concrete via aquatic biotests by Klára Anna Mocová, Hedvika Roztočilová, Diana Mariaková

“…From the point of view of sustainability, it is necessary to develop an optimal experimental design for the ecotoxicological evaluation of recycled aggregate and concrete. …”
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Roasting and Cacao Origin Affect the Formation of Volatile Organic Sulfur Compounds in 100% Chocolate by Aaron M. Wiedemer, Alan P. McClure, Erich Leitner, Helene Hopfer

“…Twenty-seven 100% chocolate samples made from cacao from three different origins and roasted according to an I-optimal experimental design were analyzed by comprehensive gas chromatography with sulfur-selective detection (GCxGC-SCD). …”
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Training set designs for prediction of yield and moisture of maize test cross hybrids with unreplicated trials by Jérôme Terraillon, Frank K. Roeber, Christian Flachenecker, Matthias Frisch

“…No results are available on the optimal experimental design when combining both approaches. …”
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D-optimal design of experiments applied to 3D high-performance concrete printing mix design by Vasileios Sergis, Claudiane M. Ouellet-Plamondon

“…In this study, the D-optimal experimental design method is employed to reduce the number of experiments while providing statistically grounded designs with high-quality results. …”
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