The second Mexican consensus on hepatocellular carcinoma. Part II: Treatment by L.E. Cisneros-Garza, M.S. González-Huezo, C. Moctezuma-Velázquez, L. Ladrón de Guevara-Cetina, M. Vilatobá, I. García-Juárez, R. Alvarado-Reyes, G.A. Álvarez-Treviño, S. Allende-Pérez, L. Bornstein-Quevedo, G. Calderillo-Ruiz, M.A. Carrillo-Martínez, M. Castillo-Barradas, E. Cerda-Reyes, J.A. Félix-Leyva, J.A. Gabutti-Thomas, J. Guerrero-Ixtlahuac, F. Higuera-de la Tijera, D. Huitzil-Melendez, E. Kimura-Hayama, P.A. López-Hernández, R. Malé-Velázquez, N. Méndez-Sánchez, M.A. Morales-Ruiz, E. Ruíz-García, J.F. Sánchez-Ávila, L. Torrecillas-Torres

“…And finally, there have been radical changes in the systemic approach, with much more optimistic expectations, when compared with the options available a decade ago. …”
Get full text

II Consenso Mexicano de Carcinoma Hepatocelular. Parte I: Epidemiología y diagnóstico by L.E. Cisneros-Garza, M.S. González-Huezo, C. Moctezuma-Velázquez, L. Ladrón de Guevara-Cetina, M. Vilatobá, I. García-Juárez, R. Alvarado-Reyes, G.A. Álvarez-Treviño, S. Allende-Pérez, L. Bornstein-Quevedo, G. Calderillo-Ruiz, M.A. Carrillo-Martínez, M. Castillo-Barradas, E. Cerda-Reyes, J.A. Félix-Leyva, J.A. Gabutti-Thomas, J. Guerrero-Ixtlahuac, F. Higuera-de-la-Tijera, D. Huitzil-Meléndez, E. Kimura-Hayama, P.A. López-Hernández, R. Malé-Velázquez, N. Méndez-Sánchez, M.A. Morales-Ruiz, E. Ruíz-García, J.F. Sánchez-Ávila, L. Torrecillas-Torres

“…And finally, there have been radical changes in the systemic approach, with much more optimistic expectations, when compared with the options available a decade ago.Therefore, the Asociación Mexicana de Hepatología decided to carry out the Second Mexican Consensus on Hepatocellular Carcinoma, which is an updated review of the available national and international evidence on the epidemiology, risk factors, surveillance, diagnosis, and treatment of the disease, to offer the Mexican physician current information on the different topics regarding hepatocellular carcinoma.In this first part of the document, the topics related to epidemiology and diagnosis are presented.…”
Get full text

Impact of malnutrition and sarcopenia on quality of life in patients with inflammatory bowel disease: A multicentre study by Yupeng Zhang, Li Zhang, Xuejin Gao, Cong Dai, Yuhong Huang, Yan Wu, Wei Zhou, Qian Cao, Xue Jing, Haitao Jiang, Yong Zhong, Weiming Zhu, Xinying Wang

“…The co‐occurrence of sarcopenia and malnutrition was not optimistic; 16.4–21.8% of patients suffer from sarcopenia and malnutrition based on different criteria at the same time, which was accompanied by a reduction in quality of life. …”
Get full text

Urban Slums Sustainable Regeneration Through Foresight Approach Case Study: Sanandaj Urban Slums by Mohammad Reza Pourmohammadi, Freydon Babai Aghdam, Kiomars Naimi

“…The second scenario as the most favorable scenario Which reflects better conditions And optimistic with the gradual growth Is to improve And The third likely scenario is more indicative of interstitial and static situations and crisis. …”
Get full text

Production of double heavy quarkonia at super Z factory by Qi-Li Liao, Jun Jiang, Yu-Han Zhao

“…The numerical results show that it might be not optimistic for the experimental observation, but it is still far from excluded at the FCC-ee and also the CEPC running in the Z factory mode.…”
Get full text

Shadow economy growth in Ukraine as a negative factor of its development by Iryna Lukianenko

“…Moreover,  according to the optimistic scenario based on the developed econometric model of panel data, the positive dynamics of the gradual reduction of the level of shadow economy to 30.2% of the country's GDP in 2022 were obtained.  …”
Get full text

Interventions based on early intensive applied behaviour analysis for autistic children: a systematic review and cost-effectiveness analysis by Mark Rodgers, David Marshall, Mark Simmonds, Ann Le Couteur, Mousumi Biswas, Kath Wright, Dheeraj Rai, Stephen Palmer, Lesley Stewart, Robert Hodgson

“…Adopting a public sector perspective and making pessimistic assumptions about long-term effects, the incremental cost-effectiveness ratio for early intensive applied behaviour analysis-based therapy compared with treatment as usual is £189,122 per quality-adjusted life-year. When optimistic assumptions are made, the incremental cost-effectiveness ratio is £46,768 per quality-adjusted life-year. …”
Get full text

Promoting Diversity, Equity, and Inclusion in the VA Scientific Workforce Through Mentored Experiences

“…In summary, we recognize that addressing diversity, equity, and inclusion requires a multifaceted strategy that considers the many touch points where barriers exist. The DEIWG is optimistic that ORD's commitment to these values will facilitate VA's mission of delivering outstanding care and services to our nation's Veterans, and to their families and beneficiaries. …”
Get full text

Global cotton production under climate change – Implications for yield and water consumption by Y. Jans, Y. Jans, W. von Bloh, S. Schaphoff, C. Müller

“…Our results should be regarded as optimistic, because of high uncertainty with respect to CO<span class="inline-formula">₂</span> fertilization and the lack of implementing processes of boll abscission under heat stress. …”
Get full text

Community-based Prevention and Control of Myopia in School-age Children: an Explorative Study by Jie WANG, Shiming LI, Dapeng MU, Li ZHANG, Tiantian CHENG, Ningli WANG

“…Conclusion The visual acuity and refractive status of students in this primary school in Beijing&apos;s Chaoyang District were not optimistic. With the increase in grade, the UDVA decreased and the number of high warning level gradually increased. …”
Get full text

Introducing the Study of Life and Death Education to Support the Importance of Positive Psychology: An Integrated Model of Philosophical Beliefs, Religious Faith, and Spirituality by Huy P. Phan, Huy P. Phan, Bing H. Ngu, Si Chi Chen, Lijuing Wu, Wei-Wen Lin, Chao-Sheng Hsu

“…Such esoteric discourse, we contend, is positive and optimistic, allowing individuals to discard the dividing line between life and death.…”
Get full text

Evaluating Women's Satisfaction of Exclusive Public Spaces Quality with Emphasis on Sense of Safety; Case Study: Boostan-e Madaran Park, Andisheh New Town– Tehran by Mojtaba Rafieian, saghar Jafari

“…However, many women rights activists are not optimistic about such urban projects and see the distinction between these parks as a form of social discrimination. …”
Get full text

Future impact of traffic emissions on atmospheric ozone and OH based on two scenarios by Ø. Hodnebrog, T. K. Berntsen, O. Dessens, M. Gauss, V. Grewe, I. S. A. Isaksen, B. Koffi, G. Myhre, D. Olivié, M. J. Prather, F. Stordal, S. Szopa, Q. Tang, P. van Velthoven, J. E. Williams

“…Our results are compared with optimistic future emission scenarios (B1 and B1 ACARE), presented in a companion paper, and with the recent past (year 2000). …”
Get full text

Assessing the Effects of Climate Change on the Prevalence of Food Insecurity with Emphasis on the Role of Water Resources Management in Hamadan-Bahar Plain by Shiva Soltani, Seyed Habibollah Mosavi, Sadegh Khalilian, Hamed Najafi Alamdarlo

“…Also, the results showed that with the considering an optimistic approach in predicting climate changes (SSP2 scenario), along with the increase of extraction from underground water sources by 13%, the increase in average price of agricultural products by 34% and the decrease in production by 5% in the 20-year planning period compared to the base year, the present value of net producer income and the food security index in the agricultural sector of the region would decrease by 17 and 11 percent, respectively. …”
Get full text

HOXD3 Up-regulating KDM5C Promotes Malignant Progression of Diffuse Large B-Cell Lymphoma by Decreasing p53 Expression by YuYing Cui, Chao LV, Yu Wen, Dongmei Zhao, Yu Yang, Hongbin Qiu, Chennan Wang

“…The prognosis for patients with relapsed/resistant diffuse large B-cell lymphoma who need salvage therapy is not optimistic. Aims: To explore whether homebox D3 binding to lysine (K)-specific demethylase 5C promoted malignant progression of diffuse large B-cell lymphoma by decreasing p53 expression. …”
Get full text

The Association of Conflict-Related Trauma with Markers of Mental Health Among Syrian Refugee Women: The Role of Social Support and Post-Traumatic Growth by Kheirallah KA, Al-Zureikat SH, Al-Mistarehi AH, Alsulaiman JW, AlQudah M, Khassawneh AH, Lorettu L, Bellizzi S, Mzayek F, Elbarazi I, Serlin IA

“…Most women were more optimistic and religious, had feelings of self-reliance and better difficulties adapting, and were stronger than they thought. …”
Get full text

Preparing for Home: a before-and-after study to investigate the effects of a neonatal discharge package aimed at increasing parental knowledge, understanding and confidence in cari... by Jennifer Ingram, Peter S Blair, Jane E Powell, Sarah Manns, Heather Burden, David Pontin, Margaret Redshaw, Lucy Beasant, Claire Rose, Deborah Johnson, Daisy Gaunt, Peter Fleming

“…Many nurses felt that the estimated discharge dates were over-optimistic, despite being based upon recent local data, and accurately predicting discharge dates for almost 75% of babies in the study. …”
Get full text

Real-World Experience of People with Hemophilia A Receiving Turoctocog Alfa Pegol (N8-GP): Results from a Patient Experience Survey by Eichler H, Nagao A, Waller J, Stuber A

“…Compared with previous treatments, patients were feeling optimistic and hopeful about N8-GP and expressed that they have started to think less about the disease.Despite the unique advantages of taking N8-GP, patients overall still perceive their quality-of-life to be less than an average person’s, presenting an opportunity for future advancements. …”
Get full text

Essays in behavioral industrial organization, corruption, and marketing by Lauga, Dominique Olié

Get full text

Spatial Metrics of Interaction between CD163-Positive Macrophages and Cancer Cells and Progression-Free Survival in Chemo-Treated Breast Cancer by Brenton A. Maisel, Misung Yi, Amy R. Peck, Yunguang Sun, Jeffrey A. Hooke, Albert J. Kovatich, Craig D. Shriver, Hai Hu, Marja T. Nevalainen, Takemi Tanaka, Nicole Simone, Li Lily Wang, Hallgeir Rui, Inna Chervoneva

“…Shorter progression-free survival was associated with a high density of CD<inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><msup><mn>163</mn><mo>+</mo></msup></semantics></math></inline-formula> TAMs, shorter median cancer-to-CD<inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><msup><mn>163</mn><mo>+</mo></msup></semantics></math></inline-formula> nearest neighbor distance, and a high number of either directly <i>adjacent</i> CD<inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><msup><mn>163</mn><mo>+</mo></msup></semantics></math></inline-formula> TAMs (within juxtacrine proximity <12 μm to cancer cells) or <i>communicating</i> CD<inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><msup><mn>163</mn><mo>+</mo></msup></semantics></math></inline-formula> TAMs (within paracrine communication distance <250 μm to cancer cells) after multivariable adjustment for clinical and pathological risk factors and correction for optimistic bias due to dichotomization.…”
Get full text