RNA and imidazoquinolines are sensed by distinct TLR7/8 ectodomain sites resulting in functionally disparate signaling events. by Colak, E, Leslie, A, Zausmer, K, Khatamzas, E, Kubarenko, A, Pichulik, T, Klimosch, SN, Mayer, A, Siggs, O, Hector, A, Fischer, R, Klesser, B, Rautanen, A, Frank, M, Hill, A, Manoury, B, Beutler, B, Hartl, D, Simmons, A, Weber, A

“…The structure-function relationships for RNA ORN and imidazoquinoline sensing and consequent downstream signaling by human TLR7 and TLR8 are unknown. …”

IKK-mediated CYLD phosphorylation and cellular redox activity by Adnan Erol

“…Abstract Oxidative stress is important in the development of obesity-related nephropathy (ORN). A causal relationship between IKK and ORN via CYLD-mediated inhibition of NRF2 has been described. …”
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Risk factors for pathological fracture in patients with mandibular osteoradionecrosis by Hiroaki Ohori, Eiji Iwata, Daisuke Takeda, Junya Kusumoto, Takumi Hasegawa, Masaya Akashi

“…Abstract Osteoradionecrosis (ORN) often results in pathological fractures through progression. …”
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Most primary olfactory neurons have individually neutral effects on behavior by Tayfun Tumkaya, Safwan Burhanudin, Asghar Khalilnezhad, James Stewart, Hyungwon Choi, Adam Claridge-Chang

“…We used optogenetic analysis in Drosophila to map the behavior elicited by olfactory-receptor neuron (ORN) classes: just one-fifth of ORN-types drove either avoidance or attraction. …”
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Manganese Uptake to Wheat Shoot Meristems Is Differentially Influenced by Arbuscular Mycorrhiza Fungal Communities Adapted to Acidic Soil by Jorge M. S. Faria, Dora Martins Teixeira, Diana Ferreira, Pedro Barrulas, Isabel Brito, Ana Paula Pinto, Mário Carvalho

“…In the present study, Mn, Mg, Ca, and K were quantified by ICP–MS in leaves and apical meristems of wheat grown in soil with two different ERM consortia, developed from the native plants <i>Lolium rigidum</i> (LOL) and <i>Ornithopus compressus</i> (ORN). The ORN treatment induced the highest wheat shoot weights and the lowest Mn levels. …”
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Qiangjing tablets ameliorate asthenozoospermia via mitochondrial ubiquitination and mitophagy mediated by LKB1/AMPK/ULK1 signaling by Guangsen Li, Yuanjie Xu, Yingxi Li, Degui Chang, Peihai Zhang, Ziyang Ma, Di’ang Chen, Yaodong You, Xiaopeng Huang, Jian Cai

“…However, the mechanism of action remains unclear.Objective This study investigates the effects of QJT on AZS and the underlying mechanism of action.Materials and methods Sixty Sprague–Dawley rats were randomly divided into six groups: Control, ORN (ornidazole; 200 mg/kg), ORN + QJT-low (0.17 g/mL), ORN + QJT-middle (0.33 g/mL), ORN + QJT-high (0.67 g/mL), and ORN + QJT + Radicicol (0.67 g/mL QJT and 20 mg/kg radicicol) groups. …”
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Natural variation at the Drosophila melanogaster Or22 odorant receptor locus is associated with changes in olfactory behaviour by Katherine H. Shaw, Craig I. Dent, Travis K. Johnson, Alisha Anderson, Marien de Bruyne, Coral G. Warr

“…In insects, many critical olfactory behaviours are mediated by the large odorant receptor (Or) gene family, which determines the response properties of different classes of olfactory receptor neurons (ORNs). While ORN responses are generally conserved within and between Drosophila species, variant alleles of the D. melanogaster Or22 locus have previously been shown to alter the response profile of an ORN class called ab3A. …”
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Osteoradionecrosis of the Mandible: A Case Report by Popovik-Monevska Danica, Muratovska Ilijana, Popovska Mirjana, Dvojakovska Suzana, Koneski Filip

“…Osteoradionecrosis (ORN) of the jaws is a serious complication of radiotherapy of head and neck malignancies. …”
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Study of correlation structure-behavior among cationic lipopeptides by Y. L. Sebyakin, U. A. Budanova

“…Lipopeptides containing ArgGlu, OrnGlu, OrnGln, LysGlu, LysGln where synthesized. …”
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Evidence for the spread of SARS-CoV-2 and olfactory cell lineage impairment in close-contact infection Syrian hamster models by Rumi Ueha, Rumi Ueha, Toshihiro Ito, Satoshi Ueha, Ryutaro Furukawa, Masahiro Kitabatake, Noriko Ouji-Sageshima, Tsukasa Uranaka, Hirotaka Tanaka, Hirotaka Tanaka, Hironobu Nishijima, Kenji Kondo, Tatsuya Yamasoba

“…Next, the impacts on the olfactory epithelium, including olfactory progenitors, immature ORNs, and mature ORNs were examined histologically. …”
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Further refinements of a continuous radon monitor for surface ocean water measurements by Chunqian Li, Chunqian Li, Shibin Zhao, Shibin Zhao, Shibin Zhao, Chenglun Zhang, Meng Li, Jinjia Guo, Natasha T. Dimova, Tong Yang, Wen Liu, Wen Liu, Wen Liu, Guangquan Chen, Huaming Yu, Bochao Xu, Bochao Xu

“…Laboratorial measurements indicated that the new PIC-ORn system responded timely to the change of radon activities in water. …”
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Comparison of Machine-Learning and Deep-Learning Methods for the Prediction of Osteoradionecrosis Resulting From Head and Neck Cancer Radiation Therapy by Brandon Reber, BS, Lisanne Van Dijk, PhD, Brian Anderson, PhD, Abdallah Sherif Radwan Mohamed, MD, PhD, Clifton Fuller, MD, PhD, Stephen Lai, MD, PhD, Kristy Brock, PhD

“…The subjects were followed for ORN development for at least 12 months, with 173 developing ORN and 1086 having no evidence of ORN. …”
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Diagnosis and management of late onset osteoradionecrosis of the mandible by Thamer M Musbah, Mel Mupparapu

“…Osteoradionecrosis (ORN) is frequently encountered in clinical dental practice. …”
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Structural characterization of NrnC identifies unifying features of dinucleases by Justin D Lormand, Soo-Kyoung Kim, George A Walters-Marrah, Bryce A Brownfield, J Christopher Fromme, Wade C Winkler, Jonathan R Goodson, Vincent T Lee, Holger Sondermann

“…Whether such a specific activity exists in organisms that lack Orn-type exoribonucleases remained unclear. Through quantitative structure-function analyses, we show here that NrnC-type RNases share this narrow substrate length preference with Orn. …”
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Türk İşaret Dilinde Anlamsal Bağlantılığın ve Gösterimselliğin Sözlüksel Erişime Etkisi by Bahtiyar Makaroğlu

“…Birincil işaretler şu şekildedir: (i) gösterimsel ve anlamsal bağlantılı (örn. KALEMTRAŞ) (ii) gösterimsel olmayan ve anlamsal olarak bağlantılı (örn. …”
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Serotonin/GABA receptors modulate odor input to olfactory receptor neuron in locusts by Mingyue Lv, Xiao Xu, Xinyang Zhang, Bo Yuwen, Long Zhang, Long Zhang

“…In situ hybridization localized Lmig5-HT2 to accessory cells, while LmigGABAb was localized to olfactory receptor neurons (ORNs) in locust chemosensilla. Single-unit electrophysiological recordings combined with RNA interference (RNAi) experiments indicated ORNs of locusts with knockdown of Lmig5-HT2 (ds-Lmig5-HT2) and LmigGABAb (ds-LmigGABAb) to some odors had significantly higher responses than wild-type and control locusts in the dose-dependent responses. …”
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Responses of olfactory receptor neurons of the large pine weevil to a possible deterrent Neutroil® and two other chemicals by Huotari, Matti, Jaskari, Mareena, Annila, Erkki, Lantto, Vilho

“…Thus, the possible deterrence may be caused by inhibition of some pinene-alcohol ORNs.…”
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Albisporachelin, a New Hydroxamate Type Siderophore from the Deep Ocean Sediment-Derived Actinomycete Amycolatopsis albispora WP1T by Qihao Wu, Robert W. Deering, Gaiyun Zhang, Bixia Wang, Xin Li, Jiadong Sun, Jianwei Chen, Huawei Zhang, David C. Rowley, Hong Wang

“…Albisporachelin is composed of one N-methylated-formylated/hydroxylated l-ornithine (N-Me-fh-l-Orn), one l-serine (l-Ser), one formylated/hydroxylated l-ornithine (fh-l-Orn) and a cyclo-N-methylated-hydroxylated l-ornithine (cyclo-N-Me-h-l-Orn).…”
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Chronic exposure to odors at naturally occurring concentrations triggers limited plasticity in early stages of Drosophila olfactory processing by Zhannetta V Gugel, Elizabeth G Maurais, Elizabeth J Hong

“…When present, plasticity was observed broadly in multiple PN types and thus was not selective for PNs receiving direct input from the chronically active ORNs. We further investigated the DL5 olfactory coding channel and found that chronic odor-mediated excitation of its input ORNs did not affect PN intrinsic properties, local inhibitory innervation, ORN responses or ORN-PN synaptic strength; however, broad-acting lateral excitation evoked by some odors was increased. …”
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Front-end Weber-Fechner gain control enhances the fidelity of combinatorial odor coding by Nirag Kadakia, Thierry Emonet

“…Thus, a common scaling of the gain across Orco-expressing ORNs may be a key feature of ORN adaptation that helps preserve combinatorial odor codes in naturalistic landscapes.…”
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