Why is advance care planning underused in oncology settings? A systematic overview of reviews to identify the benefits, barriers, enablers, and interventions to improve uptake by Lisa Guccione, Lisa Guccione, Sonia Fullerton, Sonia Fullerton, Karla Gough, Karla Gough, Amelia Hyatt, Amelia Hyatt, Amelia Hyatt, Amelia Hyatt, Michelle Tew, Michelle Tew, Sanchia Aranda, Sanchia Aranda, Jill Francis, Jill Francis, Jill Francis, Jill Francis

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Comparison of Diffusion Tensor Imaging Metrics in Normal-Appearing White Matter to Cerebrovascular Lesions and Correlation with Cerebrovascular Disease Risk Factors and Severity by Seyyed M. H. Haddad, Christopher J. M. Scott, Miracle Ozzoude, Courtney Berezuk, Melissa Holmes, Sabrina Adamo, Joel Ramirez, Stephen R. Arnott, Nuwan D. Nanayakkara, Malcolm Binns, Derek Beaton, Wendy Lou, Kelly Sunderland, Sujeevini Sujanthan, Jane Lawrence, Donna Kwan, Brian Tan, Leanne Casaubon, Jennifer Mandzia, Demetrios Sahlas, Gustavo Saposnik, Ayman Hassan, Brian Levine, Paula McLaughlin, J. B. Orange, Angela Roberts, Angela Troyer, Sandra E. Black, Dar Dowlatshahi, Stephen C. Strother, Richard H. Swartz, Sean Symons, Manuel Montero-Odasso, null ONDRI Investigators, Robert Bartha

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Efficacy and safety of metformin for melasma treatment: a systematic review and meta-analysis by Pajaree Mongkhon, Pajaree Mongkhon, Chidchanok Ruengorn, Chidchanok Ruengorn, Ratanaporn Awiphan, Ratanaporn Awiphan, Chabaphai Phosuya, Chabaphai Phosuya, Yongyuth Ruanta, Yongyuth Ruanta, Kednapa Thavorn, Kednapa Thavorn, Kednapa Thavorn, Kednapa Thavorn, Sirinda Jamjanya, Mati Chuamanochan, Mati Chuamanochan, Surapon Nochaiwong, Surapon Nochaiwong

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How firearm legislation impacts firearm mortality internationally: A scoping review by Brianna Greenberg, Alexandria Bennett, Asad Naveed, Raluca Petrut, Sabrina M. Wang, Niyati Vyas, Amir Bachari, Shawn Khan, Tea Christine Sue, Nicole Dryburgh, Faris Almoli, Becky Skidmore, Nicole Shaver, Evan Chung Bui, Melissa Brouwers, David Moher, Julian Little, Julie Maggi, Najma Ahmed

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How are health research partnerships assessed? A systematic review of outcomes, impacts, terminology and the use of theories, models and frameworks by Kelly J. Mrklas, Sera Merali, Masood Khan, Sumair Shergill, Jamie M. Boyd, Lorelli Nowell, Lisa M. Pfadenhauer, Kevin Paul, Amelia Goertzen, Liam Swain, Kathryn M. Sibley, Mathew Vis-Dunbar, Michael D. Hill, Shelley Raffin-Bouchal, Marcello Tonelli, Ian D. Graham

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Variation in Kidney Transplant Referral Across Chronic Kidney Disease Programs in Ontario, Canada by Seychelle Yohanna, Kyla L. Naylor, Bin Luo, Stephanie N. Dixon, Sarah E. Bota, S. Joseph Kim, Peter G. Blake, Lori Elliott, Rebecca Cooper, Gregory A. Knoll, Darin Treleaven, Carol Wang, Amit X. Garg

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Magnesium and Fracture Risk in the General Population and Patients Receiving Dialysis: A Narrative Review by Andrea C. Cowan, Kristin K. Clemens, Jessica M. Sontrop, Stephanie N. Dixon, Lauren Killin, Sierra Anderson, Rey R. Acedillo, Amit Bagga, Clara Bohm, Pierre Antoine Brown, Brenden Cote, Varun Dev, Claire Harris, Swapnil Hiremath, Mercedeh Kiaii, Eduardo Lacson, Amber O. Molnar, Matthew J. Oliver, Malvinder S. Parmar, Jennifer M. McRae, Bharat Nathoo, Kathleen Quinn, Nikhil Shah, Samuel A. Silver, Daniel J. Tascona, Stephanie Thompson, Robert H. Ting, Marcello Tonelli, Hans Vorster, Davinder B. Wadehra, Ron Wald, Myles Wolf, Amit X. Garg

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Entinostat, a histone deacetylase inhibitor, enhances CAR-NK cell anti-tumor activity by sustaining CAR expression by Dong-Hyeon Jo, Dong-Hyeon Jo, Shelby Kaczmarek, Shelby Kaczmarek, Abrar Ul Haq Khan, Abrar Ul Haq Khan, Jannat Pervin, Jannat Pervin, Diana M. Clark, Suresh Gadde, Suresh Gadde, Suresh Gadde, Lisheng Wang, Lisheng Wang, Lisheng Wang, Scott McComb, Scott McComb, Scott McComb, Scott McComb, Alissa Visram, Alissa Visram, Alissa Visram, Seung-Hwan Lee, Seung-Hwan Lee, Seung-Hwan Lee

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Preclinical rationale for entinostat in embryonal rhabdomyosarcoma by Narendra Bharathy, Noah E. Berlow, Eric Wang, Jinu Abraham, Teagan P. Settelmeyer, Jody E. Hooper, Matthew N. Svalina, Zia Bajwa, Martin W. Goros, Brian S. Hernandez, Johannes E. Wolff, Ranadip Pal, Angela M. Davies, Arya Ashok, Darnell Bushby, Maria Mancini, Christopher Noakes, Neal C. Goodwin, Peter Ordentlich, James Keck, Douglas S. Hawkins, Erin R. Rudzinski, Atiya Mansoor, Theodore J. Perkins, Christopher R. Vakoc, Joel E. Michalek, Charles Keller

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Introducing the Strategy for Patient Oriented Research (SPOR) Evidence Alliance: a partnership between researchers, patients and health system decision-makers to support rapid-lear... by Andrea C. Tricco, Wasifa Zarin, Fiona Clement, Ahmed M. Abou-Setta, Janet A. Curran, Annie LeBlanc, Linda C Li, Christina Godfrey, Pertice Moffitt, David Moher, Heather Colquhoun, Ian D. Graham, Ivan D. Florez, Linda Wilhelm, Wanrudee Isaranuwatchaia, Jackie Mann, Marina Hamilton, Vasanthi Srinivasan, Stephen Bornstein, Sharon E. Straus

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Case Mix, Patterns of Care, and Inpatient Outcomes Among Ontario Kidney Transplant Centers: A Population-Based Study by Anne Tsampalieros, Greg A. Knoll, Stephanie Dixon, Shane English, Douglas Manuel, Carl Van Walraven, Monica Taljaard, Dean Fergusson

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An advanced Artificial Intelligence platform for a personalised treatment of Eating Disorders by Francesco Monaco, Francesco Monaco, Annarita Vignapiano, Annarita Vignapiano, Martina Piacente, Claudio Pagano, Carlo Mancuso, Luca Steardo, Alessandra Marenna, Federica Farina, Gianvito Petrillo, Stefano Leo, Emanuela Ferrara, Stefania Palermo, Vassilis Martiadis, Marco Solmi, Marco Solmi, Marco Solmi, Marco Solmi, Marco Solmi, Alessio Maria Monteleone, Alessio Fasano, Alessio Fasano, Alessio Fasano, Giulio Corrivetti, Giulio Corrivetti

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The equitable impact of sugary drink taxation structures on sugary drink consumption among Canadians: a modelling study using the 2015 Canadian Community Health Survey-Nutrition by Brendan T Smith, Christine M Warren, Laura N Anderson, David Hammond, Douglas G Manuel, Ye Li, Alessandra T Andreacchi, Laura C Rosella, Sze Hang Fu, Erin Hobin

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Nerinetide Reduces Early Infarct Growth Among Stroke Patients Undergoing EVT Without Intravenous Alteplase by Nathaniel B. Rex, Johanna M. Ospel, Rosalie V. McDonough, Nima Kashani, Leon A. Rinkel, Brian H. Buck, Jeremy Rempel, Ryan A. McTaggart, Raul G. Nogueira, Alexandre Y. Poppe, Dar Dowlatshahi, Brian A. van Adel, Richard H. Swartz, Ruchir A. Shah, Eric Sauvageau, Andrew M. Demchuk, Michael Tymianski, Michael D. Hill, Mayank Goyal

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Developing a reporting guideline for artificial intelligence-centred diagnostic test accuracy studies: the STARD-AI protocol by Jonathan Pearson-Stuttard, Alastair K Denniston, David Moher, Lotty Hooft, Darren Treanor, Ara Darzi, Sebastian Vollmer, Xiaoxuan Liu, Dominic King, Hutan Ashrafian, Penny Whiting, Gary Collins, Felix Greaves, Pasha Normahani, Trishan Panch, Sheraz R Markar, Viknesh Sounderajah, Leanne Harling, Karel Moons, Patrick M Bossuyt, Bilal Akhter Mateen, Daniel Ting, Alan Karthikesalingam, Matthew McInnes, Robert M Golub, Shravya Shetty, Jeffrey De Fauw, Jonathan Godwin, Nader Rifai, Nenad Tomasev, Ravi Aggarwal

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Best practice guidance for antibiotic audit and feedback interventions in primary care: a modified Delphi study from the Joint Programming Initiative on Antimicrobial resistance: P... by Kevin L. Schwartz, Alice X. T. Xu, Sarah Alderson, Lars Bjerrum, Jamie Brehaut, Benjamin C. Brown, Heiner C. Bucher, An De Sutter, Nick Francis, Jeremy Grimshaw, Ronny Gunnarsson, Sigurd Hoye, Noah Ivers, Donna M. Lecky, Morten Lindbæk, Jeffrey A. Linder, Paul Little, Benedikte Olsen Michalsen, Denise O’Connor, Celine Pulcini, Pär-Daniel Sundvall, Pia Touboul Lundgren, Jan Y. Verbakel, Theo J. Verheij

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A NEW TEMPORARY TRAINING PROSTHESIS FOR PEOPLE WITH TRANSTIBIAL AMPUTATION: A TECHNICAL NOTE by Hossein Gholizadeh, Natalie Baddour, Nancy Dudek, Edward D. Lemaire

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Post-COVID-19 condition symptoms among emergency department patients tested for SARS-CoV-2 infection by Patrick M. Archambault, Rhonda J. Rosychuk, Martyne Audet, Jeffrey P. Hau, Lorraine Graves, Simon Décary, Jeffrey J. Perry, Steven C. Brooks, Laurie J. Morrison, Raoul Daoust, David Seonguk Yeom, Hana Wiemer, Patrick T. Fok, Andrew D. McRae, Kavish Chandra, Michelle E. Kho, Dawn Stacey, Bilkis Vissandjée, Matthew Menear, Eric Mercier, Samuel Vaillancourt, Samina Aziz, Dianne Zakaria, Phil Davis, Katie N. Dainty, Jean-Sébastien Paquette, Murdoch Leeies, Susie Goulding, Elyse Berger Pelletier, Corinne M. Hohl, Canadian COVID−19 Emergency Department Rapid Response Network (CCEDRRN) investigators, Network of Canadian Emergency Researchers, Canadian Critical Care Trials Group investigators

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Proximity-based solutions for optimizing autism spectrum disorder treatment: integrating clinical and process data for personalized care by Annarita Vignapiano, Annarita Vignapiano, Francesco Monaco, Francesco Monaco, Stefania Landi, Luca Steardo, Carlo Mancuso, Claudio Pagano, Gianvito Petrillo, Alessandra Marenna, Martina Piacente, Stefano Leo, Carminia Marina Ingenito, Rossella Bonifacio, Benedetta Di Gruttola, Marco Solmi, Marco Solmi, Marco Solmi, Marco Solmi, Maria Pontillo, Giorgio Di Lorenzo, Giorgio Di Lorenzo, Alessio Fasano, Alessio Fasano, Alessio Fasano, Giulio Corrivetti, Giulio Corrivetti

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The age of blood in pediatric intensive care units (ABC PICU): study protocol for a randomized controlled trial by Marisa Tucci, Jacques Lacroix, Dean Fergusson, Allan Doctor, Paul Hébert, Robert A. Berg, Jaime Caro, Cassandra D. Josephson, Stéphane Leteurtre, Kusum Menon, Kenneth Schechtman, Marie E. Steiner, Alexis F. Turgeon, Lucy Clayton, Tina Bockelmann, Philip C. Spinella, for the Canadian Critical Care Trials Group, the Pediatric Critical Care Blood Research Network (BloodNet), the Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network

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