Practical help for specifying the target difference in sample size calculations for RCTs: the DELTA2 five-stage study, including a workshop by Jonathan A Cook, Steven A Julious, William Sones, Lisa V Hampson, Catherine Hewitt, Jesse A Berlin, Deborah Ashby, Richard Emsley, Dean A Fergusson, Stephen J Walters, Edward CF Wilson, Graeme MacLennan, Nigel Stallard, Joanne C Rothwell, Martin Bland, Louise Brown, Craig R Ramsay, Andrew Cook, David Armstrong, Douglas Altman, Luke D Vale

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Functional connectivity of the cerebellar vermis in bipolar disorder and associations with mood by Arshaq Saleem, Gail Harmata, Shivangi Jain, Michelle W. Voss, Jess G. Fiedorowicz, Aislinn J. Williams, Joseph J. Shaffer, Joseph J. Shaffer, Jenny Gringer Richards, Ercole John Barsotti, Leela Sathyaputri, Leela Sathyaputri, Samantha L. Schmitz, Samantha L. Schmitz, Gary E. Christensen, Gary E. Christensen, Jeffrey D. Long, Jeffrey D. Long, Jia Xu, John A. Wemmie, John A. Wemmie, John A. Wemmie, John A. Wemmie, Vincent A. Magnotta, Vincent A. Magnotta, Vincent A. Magnotta

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Characteristics and outcome of the COEUR Canadian validation cohort for ovarian cancer biomarkers by Cécile Le Page, Kurosh Rahimi, Martin Köbel, Patricia N. Tonin, Liliane Meunier, Lise Portelance, Monique Bernard, Brad H. Nelson, Marcus Q. Bernardini, John M. S. Bartlett, Dimcho Bachvarov, Walter H. Gotlieb, Blake Gilks, Jessica N. McAlpine, Mark W. Nachtigal, Alain Piché, Peter H. Watson, Barbara Vanderhyden, David G. Huntsman, Diane M. Provencher, Anne-Marie Mes-Masson

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Illustrated State‐of‐the‐Art Capsules of the ISTH 2021 Congress by Sriram Krishnaswamy, Walter Ageno, Yaseen Arabi, Tiziano Barbui, Suzanne Cannegieter, Marc Carrier, Audrey C. Cleuren, Peter Collins, Laurence Panicot‐Dubois, Jane E. Freedman, Kathleen Freson, Philip Hogg, Andra H. James, Colin A. Kretz, Michelle Lavin, Frank W. G. Leebeek, Weikai Li, Coen Maas, Kellie Machlus, Michael Makris, Ida Martinelli, Leonid Medved, Marguerite Neerman‐Arbez, James S. O’Donnell, Jamie O'Sullivan, Madhvi Rajpurkar, Verena Schroeder, Paul Clinton Spiegel Jr, Simon J. Stanworth, Laura Green, Anetta Undas

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Innova4Health: an integrated approach for prevention of recurrence and personalized treatment of Major Depressive Disorder by Francesco Monaco, Francesco Monaco, Annarita Vignapiano, Annarita Vignapiano, Martina Piacente, Federica Farina, Claudio Pagano, Alessandra Marenna, Stefano Leo, Corrado Vecchi, Carlo Mancuso, Vincenzo Prisco, Davide Iodice, Annarosaria Auricchio, Roberto Cavaliere, Amelia D'Agosto, Michele Fornaro, Marco Solmi, Marco Solmi, Marco Solmi, Marco Solmi, Marco Solmi, Giulio Corrivetti, Giulio Corrivetti, Alessio Fasano, Alessio Fasano, Alessio Fasano

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Guidance relevant to the reporting of health equity in observational research: a scoping review protocol by Elizabeth Loder, Taryn Young, Peter Tugwell, Matire Harwood, Tamara Kredo, Xiaoqin Wang, Lawrence Mbuagbaw, Charles Shey Wiysonge, Catherine Chamberlain, Jacqueline Ramke, Elie A Akl, Vivian A Welch, Julian Little, Larissa Shamseer, Zulfiqar Bhutta, Daeria O Lawson, Janet Elizabeth Jull, Tamara Rader, Michelle Kennedy, Stuart Nicholls, Billie-Jo Hardy, Elizabeth Ghogomu, Miriam Nkangu, Michael Johnson J Mahande, Omar Dewidar, Anita Rizvi, Olivia Magwood, Holly Ellingwood, Regina Greer-Smith, Patrick M Okwen, Janice Tufte

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Critical Care Cycling to Improve Lower Extremity Strength (CYCLE): protocol for an international, multicentre randomised clinical trial of early in-bed cycling for mechanically ven... by Avelino C Verceles, Jennifer L Y Tsang, Sangeeta Mehta, Michelle E Kho, Alexander J Molloy, Margaret S Herridge, Bram Rochwerg, Ian M Ball, Joseph R Pellizzari, Jean-Eric Tarride, Diane Heels-Ansdell, John Muscedere, Francois Lamontagne, Tim Karachi, Alison Fox-Robichaud, Shane W English, Karen E A Burns, Frédérick D'Aragon, Sue Berney, Karim Serri, Erick H Duan, Lisa Buckingham, Julie Reid, Andrew J Seely, Christopher Farley, Amy M Pastva, Heather O'Grady, Laurel Kelly, Geoff Strong, Abby H Hurd

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Perioperative Complications During Living Donor Nephrectomy: Results From a Multicenter Cohort Study by Carlos Garcia-Ochoa, Liane S. Feldman, Christopher Nguan, Mauricio Monroy-Cuadros, Jennifer Arnold, Neil Boudville, Meaghan Cuerden, Christine Dipchand, Michael Eng, John Gill, William Gourlay, Martin Karpinski, Scott Klarenbach, Greg Knoll, Krista L. Lentine, Charmaine E. Lok, Patrick Luke, G. V. Ramesh Prasad, Alp Sener, Jessica M. Sontrop, Leroy Storsley, Darin Treleaven, Amit X. Garg

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Evaluation of a targeted, theory-informed implementation intervention designed to increase uptake of emergency management recommendations regarding adult patients with mild traumat... by Marije Bosch, Joanne E. McKenzie, Jennie L. Ponsford, Simon Turner, Marisa Chau, Emma J. Tavender, Jonathan C. Knott, Russell L. Gruen, Jill J. Francis, Sue E. Brennan, Andrew Pearce, Denise A. O’Connor, Duncan Mortimer, Jeremy M. Grimshaw, Jeffrey V. Rosenfeld, Susanne Meares, Tracy Smyth, Susan Michie, Sally E. Green

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EPA guidance on lifestyle interventions for adults with severe mental illness: A meta-review of the evidence by Isabel Maurus, Sarah Wagner, Johanna Spaeth, Anastasia Vogel, Susanne Muenz, Valentina Seitz, Peter von Philipsborn, Marco Solmi, Joseph Firth, Brendon Stubbs, Davy Vancampfort, Mats Hallgren, Tamás Kurimay, Markus Gerber, Christoph U. Correll, Wolfgang Gaebel, Hans-Jürgen Möller, Andrea Schmitt, Alkomiet Hasan, Peter Falkai

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CCEDRRN COVID-19 Infection Score (CCIS): development and validation in a Canadian cohort of a clinical risk score to predict SARS-CoV-2 infection in patients presenting to the emer... by John Taylor, Patrick Archambault, Eddy Lang, Megan Landes, Steven Brooks, Laurie Morrison, Jake Hayward, Corinne M Hohl, Katie Lin, Andrew McRae, Steven C Brooks, Raoul Daoust, Éric Mercier, Patrick M Archambault, Ivy Cheng, Daniel Ting, Tomislav Jelic, Andrew D McRae, Robert Ohle, Shabnam Vatanpour, Philip Davis, Justin Yan, Laurie J Morrison, Ian Martin, Jeffrey Perry, Krishan Yadav, Rhonda Rosychuk, Gelareh Ghaderi, Brian Rowe, Michelle Welsford, Patrick Fok, Hana Wiemer, Samuel Campbell, Kory Arsenault, Tara Dahn, Kavish Chandra, Joel Turner, Greg Clark, Sébastien Robert, Rob Ohle, Rohit Mohindra, Ankit Kapur, Phil Davis, Stephanie VandenBerg, Jaspreet Khangura, Corinne Hohl, Maja Stachura, Frank Scheuermeyer, Balijeet Braar, Craig Murray, Sean Wormsbecker, Matt Bouchard, Lee Graham

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Comparative effectiveness of valproic acid in different serum concentrations for maintenance treatment of bipolar disorder: A retrospective cohort study using target trial emulatio... by Yang-Chieh Brian Chen, Chih-Sung Liang, Liang-Jen Wang, Kuo-Chuan Hung, Andre F. Carvalho, Marco Solmi, Eduard Vieta, Ping-Tao Tseng, Pao-Yen Lin, Yu-Kang Tu, Chih-Wei Hsu, Edward Chia-Cheng Lai

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Protocol for the development of guidance for collaborator and partner engagement in health care evidence syntheses by Peter Tugwell, Vivian Welch, Olivia Magwood, Alex Todhunter-Brown, Elie A. Akl, Thomas W. Concannon, Joanne Khabsa, Richard Morley, Holger Schunemann, Lyubov Lytvyn, Arnav Agarwal, Alba Antequera, Marc T. Avey, Pauline Campbell, Christine Chang, Stephanie Chang, Leonila Dans, Omar Dewidar, Davina Ghersi, Ian D. Graham, Glen Hazlewood, Jennifer Hilgart, Tanya Horsley, Denny John, Janet Jull, Lara J. Maxwell, Chris McCutcheon, Zachary Munn, Francesco Nonino, Jordi Pardo Pardo, Roses Parker, Kevin Pottie, Gabriel Rada, Alison Riddle, Anneliese Synnot, Elizabeth Tanjong Ghogomu, Eve Tomlinson, Karine Toupin-April, Jennifer Petkovic

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A Canadian model for providing high-quality, timely and relevant evidence to meet health system decision-maker needs: the SPOR Evidence Alliance by Wasifa Zarin, Carole Lunny, Sabrina Chaudhry, Sonia M. Thomas, Annie LeBlanc, Fiona Clement, Ahmed M. Abou-Setta, Janet A. Curran, Brian Hutton, Ivan D. Florez, Linda C. Li, Stephen Bornstein, Clayon B. Hamilton, Pertice Moffitt, Christina Godfrey, Louise Zitzelsberger, Leanne Gardiner, Christine Fahim, Sharon E. Straus, Andrea C. Tricco

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Clinical Observation, Management and Function Of low back pain Relief Therapies (COMFORT): A cluster randomised controlled trial protocol by Fiona Blyth, Louisa Degenhardt, Christopher Maher, Kirsten McCaffery, Patrick J Kelly, Thomas Lung, Simon French, Sharon Reid, Hazel Jenkins, Christina Abdel Shaheed, Rachel Thompson, Stephanie Mathieson, Gabrielle Campbell, Andrew McLachlan, Rowena Ivers, Fiona Stanaway, Michael Wright, Carol Bennett, Lisa Vizza, Philip James Clare, Bradley Martin, Rawa Osman, Monika Boogs, Jarrod McMaugh

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Prevalence of schizophrenia spectrum and other psychotic disorders in problem gambling: A systematic review and meta-analysis by Olivier Corbeil, Laurent Béchard, Élizabeth Anderson, Maxime Huot-Lavoie, Charles Desmeules, Lauryann Bachand, Sébastien Brodeur, Pierre-Hugues Carmichael, Christian Jacques, Marco Solmi, Michel Dorval, Isabelle Giroux, Marc-André Roy, Marie-France Demers

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Prediction of medical admissions after psychiatric inpatient hospitalization in bipolar disorder: a retrospective cohort study by Alessandro Miola, Alessandro Miola, Michele De Prisco, Michele De Prisco, Michele De Prisco, Michele De Prisco, Michele De Prisco, Marialaura Lussignoli, Nicola Meda, Elisa Dughiero, Riccardo Costa, Nicolas A. Nunez, Nicolas A. Nunez, Michele Fornaro, Marin Veldic, Mark A. Frye, Eduard Vieta, Eduard Vieta, Eduard Vieta, Eduard Vieta, Eduard Vieta, Marco Solmi, Marco Solmi, Marco Solmi, Marco Solmi, Marco Solmi, Joaquim Radua, Joaquim Radua, Joaquim Radua, Fabio Sambataro

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Study protocol for Attachment & Child Health (ATTACHTM) program: promoting vulnerable Children’s health at scale by Lubna Anis, Nicole Letourneau, Kharah M. Ross, Martha Hart, Ian Graham, Simone Lalonde, Suzanna Varro, Alanna Baldwin, Angela Soulsby, Annette Majnemer, Carlene Donnelly, Caroline Piotrowski, Carrie Collier, Cliff Lindeman, Dan Goldowitz, Dawn Isaac, Denise Thomson, Diane Serré, Elisabeth Citro, Gabrielle Zimmermann, Harold Pliszka, Jackie Mann, Janine Baumann, Joanna Piekarski, Jo-Anne Dalton, Joy Johnson-Green, Karen Wood, Marcia Bruce, Maria Santana, Matt Mayer, Meghan Gould, Michael Kobor, Michelle Flowers, Michelle Haywood, Michelle Koerner, Nancy Parker, Nazeem Muhajarine, Paul Fairie, Rabea Chrishti, Robert Perry, Sarah Merrill, Shellie Pociuk, StephanieTaylor, Steve Cole, Tim Murphy, Tmira Marchment, Virginia Xavier, Zahra Shajani, Zoe West

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Language discordance as a marker of disparities in cerebrovascular risk and stroke outcomes: A multi-center Canadian study by Ryan T. Muir, Arunima Kapoor, Megan L. Cayley, Michelle N Sicard, Karen Lien, Alisia Southwell, Dar Dowlatshahi, Demetrios J. Sahlas, Gustavo Saposnik, Jennifer Mandzia, Leanne K. Casaubon, Ayman Hassan, Yael Perez, Daniel Selchen, Brian J. Murray, Krista Lanctot, Moira K. Kapral, Nathan Herrmann, Stephen Strother, Amy．Y．X Yu, Peter C. Austin, Susan E. Bronskill, Richard H. Swartz

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Rapid antigen-based and rapid molecular tests for the detection of SARS-CoV-2: a rapid review with network meta-analysis of diagnostic test accuracy studies by Areti Angeliki Veroniki, Andrea C. Tricco, Jennifer Watt, Sofia Tsokani, Paul A. Khan, Charlene Soobiah, Ahmed Negm, Amanda Doherty-Kirby, Paul Taylor, Carole Lunny, Jessie McGowan, Julian Little, Patrick Mallon, David Moher, Sabrina Wong, Jacqueline Dinnes, Yemisi Takwoingi, Lynora Saxinger, Adrienne Chan, Wanrudee Isaranuwatchai, Bryn Lander, Adrienne Meyers, Guillaume Poliquin, Sharon E. Straus

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