Severe infections emerge from commensal bacteria by adaptive evolution by Bernadette C Young, Chieh-Hsi Wu, N Claire Gordon, Kevin Cole, James R Price, Elian Liu, Anna E Sheppard, Sanuki Perera, Jane Charlesworth, Tanya Golubchik, Zamin Iqbal, Rory Bowden, Ruth C Massey, John Paul, Derrick W Crook, Timothy E Peto, A Sarah Walker, Martin J Llewelyn, David H Wyllie, Daniel J Wilson

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PB1930: EPIC: A NON-INTERVENTIONAL, OBSERVATIONAL STUDY OF CHRONIC LYMPHOCYTIC LEUKEMIA PATIENTS TREATED WITH FIRST-LINE ACALABRUTINIB THROUGH THE UK EARLY ACCESS PROGRAMME. INTERI... by Toby Eyre, Nicolas Martinez-Calle, Renata Walewska, Joe Hickey, Betina Blak, Anna Pickin, Sukhjit Hunjan, Orlaith Condon, Satoshi Hori

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Editorial: An update on neurological disorders post COVID-19 infection by Beatrice Paradiso, Beatrice Paradiso, Clara Limback, Tao Su, Weiping Liao, Anastasios Mpotsaris, Anastasios Mpotsaris

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UK media reporting of NICE recommendation of crizanlizumab for patients with sickle cell disease by Richard J Buka, Noémi Roy, Phillip LR Nicolson

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P653: OUTCOMES FOLLOWING TREATMENT WITH A COVALENT BTK AND BCL2 INHIBITOR AMONG PATIENTS WITH CHRONIC LYMPHOCYTIC LEUKEMIA (CLL)/SMALL LYMPHOCYTIC LYMPHOMA (SLL): A REAL-WORLD STUD... by T. A. Eyre, L. Hess, T. Sugihara, R. A. Walgren, P. B. Abada, H. Konig, J. Pagel, L. E. Roeker, A. Mato

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Erratum to “Bleeding green: Sustainability in practice in a clinical skills teaching laboratory” [Journal of Climate Change and Health 8 (2022)-100149] by Wesam Alyeddin, Sarah Peters, Adrianna Aleksandra Zembrzycka, Laura Hudson, San Yu May Tun

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Clinical trial protocol for PanDox: a phase I study of targeted chemotherapy delivery to non-resectable primary pancreatic tumours using thermosensitive liposomal doxorubicin (Ther... by Laura Spiers, Michael Gray, Paul Lyon, Shivan Sivakumar, Noor Bekkali, Shaun Scott, Linda Collins, Robert Carlisle, Feng Wu, Mark Middleton, Constantin Coussios

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P015: Real World Escalated BEACOPDac Delivers Similar Outcomes to Escalated BEACOPP While Potentially Reducing Haematopoietic and Reproductive Toxicity by Anna Santarsieri, Katherine Sturgess, Pauline Brice, Tobias F. Menne, Wendy Osborne, Thomas Creasey, Kirit M. Ardeshna, Sarah Behan, Kaljit Bhuller, Stephen Booth, Nikesh Chavda, Graham P. Collins, Dominic Culligan, Kate Cwynarski, Andrew Davies, David Dutton, Michelle Furtado, Eve Gallop-Evans, Andrew Hodson, David Hopkins, Hannah Hsu, Sunil Iyengar, Stephen G. Jones, Kim Linton, Oliver Lomas, Nicolas Martinez-Calle, Abhinav Mathur, Pamela Mckay, Sateesh K. Nagumantry, Deidre O’Mahony, Beth Phillips, Neil Phillips, John F. Rudge, Nimish Shah, Gwyneth Stafford, Alex Sternberg, Rachel Trickey, Benjamin J. Uttenthal, Natasha Wetherall, Andrew K. Mcmillan, George A. Follows

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Response to review article published titled ‘Total ankle arthroplasty versus ankle arthrodesis - a comparison of outcomes over the last decade’ by Hasan R. Mohammad, Will Debrock, Stephen J. Mellon, Paul Cooke

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Nutritional interventions in the management of endometriosis – review of the literature by Maja Kotowska, Gabriela Różańska-Smuszkiewicz, Paweł Smuszkiewicz-Różański, Wiktoria Zamirska, Anna Zygmunt, Katarzyna Zięba, Karolina Koszyczarek, Albin Ziemiański

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Osteonecrosis in children and young adults treated for acute lymphoblastic leukemia: A scoping review by Michael C. Chapman, Maisie G. Tustian, Joseph D. Wilson, Mark A. Williams, Robyn J. Stiger

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SARS‐CoV‐2 Infections Among Patients With Liver Disease and Liver Transplantation Who Received COVID‐19 Vaccination by Andrew M. Moon, Gwilym J. Webb, Ignacio García‐Juárez, Anand V. Kulkarni, Gupse Adali, David K. Wong, Beth Lusina, George N. Dalekos, Steven Masson, Brandon M. Shore, Eleanor Barnes, A. Sidney Barritt IV, Thomas Marjot

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Long-term Temporal Stability of Peripheral Blood DNA Methylation Profiles in Patients With Inflammatory Bowel DiseaseSummary by Vincent Joustra, Andrew Y.F. Li Yim, Ishtu Hageman, Evgeni Levin, Alex Adams, Jack Satsangi, Wouter J. de Jonge, Peter Henneman, Geert D’Haens

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P51 Who has been diagnosed with obstructive sleep apnoea or narcolepsy in England? A population-based descriptive study by Ellen Nolte, Helen Strongman, Aurélien Belot, Hema Mistry, Krishnan Bhaskaran, Charlotte Warren-Gash, Michelle A Miller, Ian Smith, Sofia Eriksson, Tim Quinnell

P958: REAL-WORLD TREATMENT PATTERNS IN PATIENTS INITIATING THIRD-LINE THERAPY FOR RELAPSED OR REFRACTORY MULTIPLE MYELOMA IN GERMANY, ITALY, THE UK, FRANCE, AND SPAIN by Karthik Ramasamy, K Martin Kortum, Evi Zhuleku, Elena Zamagni, Tim D’estrube, Soham Shukla, Moritz Lehne, Marco Ghiani, Maya Hanna, Ulf Maywald, Thomas Wilke, Lenka Kellermann, Sue Perera

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Advanced and alternative research methods for the acute care surgeon scientist by Deborah M Stein, Elliott R Haut, Vanessa P Ho, James Byrne, Jonathan P Meizoso, Matthew D Neal

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Use of Branched-Chain Amino Acids as a Potential Treatment for Improving Nutrition-Related Outcomes in Advanced Chronic Liver Disease by Santo Colosimo, Simona Bertoli, Francesca Saffioti

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P1149: THE EVOLVING STATE OF PLAY IN 1000 PATIENTS WITH WALDENSTRÖM’S MACROGLOBULINAEMIA IN THE UNITED KINGDOM (UK): A REAL-WORLD DATA ANALYSIS FROM THE WMUK RORY MORRISON REGISTRY... by E. Uppal, A. Otamas, J. Khwaja, H. McCarthy, J. Kothari, A. Rismani, D. El-Sharkawi, C. Kyriakou, S. D’Sa

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Enhancing information support to health and biomedical researchers: A project to support Oxford BRC-funded researchers by Harriss, E, Mackay, D, Coxall, O, Urquhart, C, Yeoman, A

“…Staff at the Bodleian Health Care Libraries conducted a research project during 2017 to explore how embedded library services could support the workflows of the biomedical and translational research community at both the University of Oxford and the Oxford University Hospitals NHS Foundation Trust. The aim of the study was to identify the key services that should be provided to healthcare and biomedical researchers and to explore whether an embedded model, similar to that of the informationist role in the USA, would be appropriate for the Oxford context. …”

Patient Biochemistry and Treatment Need in Chronic Hepatitis B Virus Infection Across Three Continents: Retrospective Cross-Sectional Cohort Studies by Iain A. Gillespie, Eleanor Barnes, Ian C. K. Wong, Philippa C. Matthews, Graham S. Cooke, Craig Tipple, Robert C. Elston, Yunhao Liu, David A. Smith, Tingyan Wang, Jim Davies, Kinga A. Várnai, Oliver Freeman, Kenneth K. C. Man, Wallis C. Y. Lau, Ben Glampson, Xing Meng, Eleonora Morais, Sen Liu, Luca Mercuri, Naomi Boxall, Sarah Jenner, Stuart Kendrick, Jane Dong, Dickens Theodore

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