Comparing the effects of decreasing prescription opioid shipments and the release of an abuse deterrent OxyContin formulation on opioid overdose fatalities in WV: an interrupted time series study by Eric W. Lundstrom, Zheng Dai, Caroline P. Groth, Brian Hendricks, Erin L. Winstanley, Marie Abate, Gordon S. Smith

“…We therefore sought to compare the impact of the ADF OxyContin release to that of decreasing prescription opioid supplies in West Virginia (WV). …”
Get full text

Clinical evaluation of PF614, a novel TAAP prodrug of oxycodone, versus OxyContin in a multi‐ascending dose study with a bioequivalence arm in healthy volunteers by D. Lynn Kirkpatrick, Cari Evans, Linda A. Pestano, Jeffrey Millard, Matthew Johnston, Emily Mick, William K. Schmidt

“…Abstract PF614, a trypsin‐activated abuse protection oxycodone prodrug designed to reduce recreational drug abuse, was compared to OxyContin for safety and pharmacokinetics (PKs) of plasma oxycodone following oral administration. …”
Get full text

Use of Prescription Opioids and Impact of Replacing Oxycontin With Oxyneo On Opioid Use Among Metis Citizens, 2013-2018 by Julianne Sanguins, Nathan C Nickel, Dan Chateau, Carole Taylor, Gilles Detillieux, Olena Kloss, Alan Katz

“…We used an interrupted time series design to test whether replacing OxyContin differentially impacted prevalence of acute and chronic opioid use among Metis when compared with all other Manitobans. …”
Get full text

Meta-analysis of efficacy and safety of sustained release oxycodone hydrochloride rectal administration for moderate to severe pain by Xian Bing Hou, Dan Dan Chen, Tong Fei Cheng, Dan Wang, Xiao Jun Dai, Yao Wang, Bi Xian Cui, Yuan Yuan Wang, Hui Xu, Hong Zhou Chen

“…<h4>Objective</h4> This study aims to evaluate the efficacy and safety of oxycodone hydrochloride (OxyContin) rectal administration in cancer pain patients. …”
Get full text

May 2023 Medical Image of the Month: Methamphetamine Inhalation Leading to Cavitary Pneumonia and Pleural Complications by Kia Ghiassi DO, Colin Jenkins MD, Prateek Juneja DO

“…A 31-year-old man with a self-reported history significant for active methamphetamine and OxyContin use (last use of methamphetamine the same day with confirmation on urine drug screen) presented to the hospital with several hours of dyspnea. …”
Get full text

A qualitative exploration of prescription opioid injection among street-based drug users in Toronto: behaviours, preferences and drug availability by Firestone Michelle, Fischer Benedikt

“…There was consensus that OxyContin and crack were the most commonly available drugs on the streets of Toronto. …”
Get full text

Design and evaluation of an extended-release matrix tablet formulation; the combination of hypromellose acetate succinate and hydroxypropylcellulose by Sachiko Fukui, Hideki Yano, Shuichi Yada, Tsuyoshi Mikkaichi, Hidemi Minami

“…In a USP apparatus 3 (bio-relevant dissolution method), dissolution profiles of the HPMCAS/HPC ER matrix tablets containing oxycodone hydrochloride were similar to that of the reference product (OxyContin). Moreover, in vivo performance after oral administration of the HPMCAS/HPC ER matrix tablets to humans was simulated by GastroPlus based on dissolution profiles from the USP apparatus 3. …”
Get full text

Abuse-deterrent extended-release oxycodone and risk of opioid-related harm by Paljarvi, T, Strang, J, Quinn, PD, Luciano, S, Fazel, S

“…</p> <p><strong>Participants:</strong> Patients aged 18–64 years at index health-care visit with any indication for an oral opioid analgesic, with no past 12-month history of oral oxycodone use or substance use disorder, and who were alive at the end of the 1-year follow-up (new episode of prescription oral ADF oxycodone [OxyContin], n = 45 045; new episode of non-ADF oxycodone opioid preparation, n = 1 377 359).…”

Results and Methodological Implications of the Digital Epidemiology of Prescription Drug References Among Twitter Users: Latent Dirichlet Allocation (LDA) Analyses by Maria A Parker, Danny Valdez, Varun K Rao, Katherine S Eddens, Jon Agley

“…Latent Dirichlet allocation (LDA) with coherence score calculations was performed to compare brand (eg, OxyContin) and street (eg, oxys) name tweets. …”
Get full text

Breaking the news or fueling the epidemic? Temporal association between news media report volume and opioid-related mortality by Dasgupta, Nabarun, Mandl, Kenneth D., Brownstein, John S.

“…Nationally, the number of articles mentioning prescription opioids increased dramatically starting in early 2001, following prominent coverage about the nonmedical use of OxyContin. We found a significant association between news reports and deaths, with media reporting preceding fatal opioid poisonings by two to six months and explaining 88% (p<0.0001, df 78) of the variation in mortality. …”
Get full text

The Ethics of Prescription Drug Monitoring Programs by Ryan Ravanpak

“…Characteristics like this make it harder to see why we should be as worried about the diversion of suboxone as diversion of other opioids like OxyContin. Even when suboxone is diverted, studies suggest that it is diverted to those with opioid addiction who wish to manage their withdrawals – exactly those whom we would want suboxone to be reaching – rather than those who are looking to abuse the medication.[10] In areas without major barriers to suboxone prescription, opioid death and addiction rates have fallen at a dramatic rate. …”
Get full text